Magnesium administration provokes motor unit survival, after sciatic nerve injury in neonatal rats.


BACKGROUND:We examined the time course of the functional alterations in two types of muscles following sciatic nerve crush in neonatal rats and the neuroprotective effect of Mg2+. METHODS:The nerve crush was performed on the 2nd postnatal day. MgSO4*7H2O was administered daily for two weeks. Animals were examined for the contractile properties and for the number of motor units of extensor digitorum longus and soleus muscles at three postnatal stages and adulthood. Four experimental groups were included in this study: i) controls, ii) axotomized rats, iii) magnesium treated controls and iv) axotomized and Mg2+-treated rats. RESULTS:Axotomy resulted in 20% MU survival in EDL and 50% in soleus. In contrast, magnesium treatment resulted in a significant motor unit survival (40% survival in EDL and 80% in soleus). The neuroprotective effects of Mg2+ were evident immediately after the Mg2+-treatment. Immature EDL and soleus muscles were slow and fatigueable. Soleus gradually became fatigue resistant, whereas, after axotomy, soleus remained fatigueable up to adulthood. EDL gradually became fastcontracting. Tetanic contraction in axotomized EDL was just 3,3% of the control side, compared to 15,2% in Mg2+-treated adult rats. The same parameter for axotomized soleus was 12% compared to 97% in Mg2+-treated adult rats. CONCLUSIONS:These results demonstrate that motoneuron death occurs mostly within two weeks of axotomy. Magnesium administration rescues motoneurons and increases the number of motor units surviving into adulthood. Fast and slow muscles respond differently to axotomy and to subsequent Mg2+ treatment in vivo.


Gougoulias N,Hatzisotiriou A,Kapoukranidou D,Albani M





Has Abstract


2004-09-24 00:00:00












  • Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells.

    abstract:BACKGROUND:A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and the impact of loading and exposure to glucocorticoids on the glutamate signaling machinery. METHOD...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Spang C,Backman LJ,Le Roux S,Chen J,Danielson P

    更新日期:2017-05-25 00:00:00

  • The effectiveness of motorised lumbar traction in the management of LBP with lumbo sacral nerve root involvement: a feasibility study.

    abstract:BACKGROUND:Traction is commonly used for the treatment of low back pain (LBP), predominately with nerve root involvement; however its benefits remain to be established. The aim of this study was to test the feasibility of a pragmatic randomized controlled trial to compare the difference between two treatment protocols ...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Harte AA,Baxter GD,Gracey JH

    更新日期:2007-11-29 00:00:00

  • Minimally invasive surgery for intra-articular calcaneus fractures: a 9-year, single-center, retrospective study of a standardized technique using a 2-point distractor.

    abstract:BACKGROUND:A fracture of the calcaneus can be a painful and disabling injury. Treatment modalities may be conservative or operative. Surgical treatment strategies include open reduction and internal fixation (ORIF) techniques, as well as a variety of minimally invasive methods. The aim of this study was to evaluate the...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Rodemund C,Krenn R,Kihm C,Leister I,Ortmaier R,Litzlbauer W,Schwarz AM,Mattiassich G

    更新日期:2020-11-14 00:00:00

  • Modified osteotomy of posterolateral overhanging part of the trochanter via posterior approach for hip arthroplasty: an anatomical study.

    abstract:BACKGROUD:The osteotomy of the posterolateral overhanging part (PLOP) of the greater trochanter via posterior approach has been used for the hip arthroplasty for decades with good results. However, the osteotomy method remains undefined and the precise adjacent structures around PLOP have not been reported. The purpose...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Zhou X,Ji H,Guo J,Yang Y,Cai P,Zhang X

    更新日期:2020-02-24 00:00:00

  • Quantifying intervertebral disc mechanics: a new definition of the neutral zone.

    abstract:BACKGROUND:The neutral zone (NZ) is the range over which a spinal motion segment (SMS) moves with minimal resistance. Clear as this may seem, the various methods to quantify NZ described in the literature depend on rather arbitrary criteria. Here we present a stricter, more objective definition. METHODS:To mathematica...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Smit TH,van Tunen MS,van der Veen AJ,Kingma I,van Dieën JH

    更新日期:2011-02-07 00:00:00

  • Mortality as an indicator of patient safety in orthopaedics: lessons from qualitative analysis of a database of medical errors.

    abstract:BACKGROUND:Orthopaedic surgery is a high-risk specialty in which errors will undoubtedly occur. Patient safety incidents can yield valuable information to generate solutions and prevent future cases of avoidable harm. The aim of this study was to understand the causative factors leading to all unnecessary deaths in ort...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Panesar SS,Carson-Stevens A,Mann BS,Bhandari M,Madhok R

    更新日期:2012-06-08 00:00:00

  • Clinical evaluation of ankle arthrodesis with Ilizarov fixation and internal fixation.

    abstract:BACKGROUND:Ankle arthrodesis may have internal or external stabilization. We assessed whether the type of stabilization after ankle arthrodesis will affect: (1) functional outcome in Foot and Ankle Ability Measure (FAAM) scale, (2) pain level, (3) period of hospitalization, (4) rate of complications. METHODS:We retros...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Morasiewicz P,Dejnek M,Orzechowski W,Urbański W,Kulej M,Dragan SŁ,Dragan SF,Pawik Ł

    更新日期:2019-04-11 00:00:00

  • Clinical and radiographic outcomes of the treatment of adolescent idiopathic scoliosis with segmental pedicle screws and combined local autograft and allograft bone for spinal fusion: a retrospective case series.

    abstract:BACKGROUND:High morbidity has been reported with iliac crest bone graft harvesting; however, donor bone is typically necessary for posterior spinal fusion. Autograft bone combined with allograft may reduce the morbidity associated with iliac crest bone harvesting and improve the fusion rate. Our aim in this study was t...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Yang X,Xu H,Li M,Gu S,Fang X,Wang J,Ni J,Wu D

    更新日期:2010-07-14 00:00:00

  • Tibiofemoral osteoarthritis affects quality of life and function in elderly Koreans, with women more adversely affected than men.

    abstract:BACKGROUND:The prevalence of knee osteoarthritis(OA) in East Asia is as common for men and even higher for women than that reported in the Caucasian population. Since both population aging and economic growth have taken place at a much faster pace in Asian countries, such as South Korea, one would expect knee OA to bec...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Kim I,Kim HA,Seo YI,Song YW,Hunter DJ,Jeong JY,Kim DH

    更新日期:2010-06-22 00:00:00

  • Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review.

    abstract:BACKGROUND:Osteoradionecrosis (ORN) is a complication that occurs after radiotherapy for head or neck malignancies. ORN of the spine is rare, with only few cases affecting the cervical spine reported to date. To our knowledge, no case of lumbar ORN has been reported. We report a rare case of ORN in the lumbar spine tha...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,评审


    authors: Jin C,Xie M,Liang W,Qian Y

    更新日期:2020-01-04 00:00:00

  • Differences in Achilles tendon stiffness in people with gout: a pilot study.

    abstract:BACKGROUND:Gout has been associated with weaker foot/leg muscles and altered gait patterns. There is also evidence of on-going foot pain and an increased risk of tendinopathy, with the Achilles and patella tendons most frequently affected in gout. Additionally, the inflammation associated with gout may change tissue el...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Otter S,Payne C,Jones AM,Webborn N,Watt P

    更新日期:2020-10-07 00:00:00

  • Topical co-administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment.

    abstract:BACKGROUND:Bone morphogenetic proteins (BMPs) induce osteogenesis in various environments. However, when BMPs are used alone in the bone marrow environment, the maintenance of new bone formation is difficult owing to vigorous bone resorption. This is because BMPs stimulate the differentiation of not only osteoblast pre...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Ueyama H,Ohta Y,Imai Y,Suzuki A,Sugama R,Minoda Y,Takaoka K,Nakamura H

    更新日期:2021-01-20 00:00:00

  • Reverse LISS plating for intertrochanteric hip fractures in elderly patients.

    abstract:BACKGROUND:Fractures of the intertrochanteric hip are common and the treatment of unstable fractures generally requires an operative approach. In elderly patients, osteoporosis makes internal fixation problematic and frequently contributes to failed fixation and poor clinical results. We have attempted to apply the Les...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Zhang CQ,Sun Y,Jin DX,Yao C,Chen SB,Zeng BF

    更新日期:2010-07-21 00:00:00

  • Influence of disruption of the acromioclavicular and coracoclavicular ligaments on glenohumeral motion: a kinematic evaluation.

    abstract:BACKGROUND:Changes to the integrity of the acromioclavicular (AC) joint impact scapulothoracic and clavicular kinematics. AC ligaments provide anterior-posterior stability, while the coracoclavicular (CC) ligaments provide superior-inferior stability and a restraint to scapular internal rotation. The purpose of this ca...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Walley KC,Haghpanah B,Hingsammer A,Harlow ER,Vaziri A,DeAngelis JP,Nazarian A,Ramappa AJ

    更新日期:2016-11-17 00:00:00

  • Involvement of the multidisciplinary team and outcomes in inpatient rehabilitation among patients with inflammatory rheumatic disease.

    abstract:BACKGROUND:The last decades have for patients with inflammatory rheumatic diseases seen a shift towards more physically active rehabilitation programs, often provided as out-patients with less use of inpatient facilities. There is little research on which effect the multidisciplinary team has on health outcomes for pat...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究


    authors: Uhlig T,Bjørneboe O,Krøll F,Palm Ø,Olsen IC,Grotle M

    更新日期:2016-01-13 00:00:00

  • Effect of workplace- versus home-based physical exercise on pain in healthcare workers: study protocol for a single blinded cluster randomized controlled trial.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Jakobsen MD,Sundstrup E,Brandt M,Kristensen AZ,Jay K,Stelter R,Lavendt E,Aagaard P,Andersen LL

    更新日期:2014-04-07 00:00:00

  • Bone mineral density reference values in Singaporean adults and comparisons for osteoporosis establishment - The Yishun Study.

    abstract:BACKGROUND:While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of oste...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Chen KK,Wee SL,Pang BWJ,Lau LK,Jabbar KA,Seah WT,Srinivasan S,Jagadish MU,Ng TP

    更新日期:2020-09-25 00:00:00

  • The effects of bending speed on the lumbo-pelvic kinematics and movement pattern during forward bending in people with and without low back pain.

    abstract:BACKGROUND:Impaired lumbo-pelvic movement in people with low back pain during bending task has been reported previously. However, the regional mobility and the pattern of the lumbo-pelvic movement were found to vary across studies. The inconsistency of the findings may partly be related to variations in the speed at wh...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Tsang SMH,Szeto GPY,Li LMK,Wong DCM,Yip MMP,Lee RYW

    更新日期:2017-04-17 00:00:00

  • Atypical osteochondroma of the hamate that presented clinically as carpal tunnel syndrome: report of an extremely rare case and literature review.

    abstract:BACKGROUND:Osteochondroma is a benign tumor that occurs mainly at the metaphysis of long bones and seldom arises from carpal bones. We describe an extremely rare case of osteochondroma of the hamate without a typical cartilaginous cap and with a spiky bony protrusion in an elderly patient. CASE PRESENTATION:A 78-year-...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,评审


    authors: Motomiya M,Sakazaki T,Iwasaki N

    更新日期:2020-04-13 00:00:00

  • Functioning and equality according to International Classification of Functioning, Disability and Health (ICF) in people with skeletal dysplasia compared to matched control subjects - a cross-sectional survey study.

    abstract:BACKGROUND:Skeletal dysplasias are rare disorders often leading to severe short stature. This study aimed to gain new comprehensive information about functioning and equality in people affected by skeletal dysplasia compared to matched controls without skeletal dysplasia. METHODS:Functioning was assessed by questionna...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Hyvönen H,Anttila H,Tallqvist S,Muñoz M,Leppäjoki-Tiistola S,Teittinen A,Mäkitie O,Hiekkala S

    更新日期:2020-12-04 00:00:00

  • Unipedicular versus bipedicular percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a prospective randomized study.

    abstract:BACKGROUND:Percutaneous vertebroplasty (PVP) typically involves conventional lower-viscosity cement injection via bipedicular approach. Limited evidence is available comparing the clinical outcomes and complications in treating osteoporotic vertebral compression fractures (OVCFs) with PVP using high-viscosity cement th...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,随机对照试验


    authors: Zhang L,Liu Z,Wang J,Feng X,Yang J,Tao Y,Zhang S

    更新日期:2015-06-14 00:00:00

  • Increasing incidence of primary shoulder arthroplasty in Finland - a nationwide registry study.

    abstract:BACKGROUND:The incidence of shoulder arthroplasties is reportedly increasing and the types of arthroplasty are changing. The purpose of this study was to investigate the incidence of primary shoulder arthroplasty in Finland. METHODS:We analyzed nationwide data from the Finnish Arthroplasty Register (FAR) and the Finni...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Harjula JNE,Paloneva J,Haapakoski J,Kukkonen J,Äärimaa V,Finnish Shoulder Arthroplasty Registry Group.

    更新日期:2018-07-21 00:00:00

  • Calculation method to predict postoperative limb length in patients undergoing THA following developmental dysplasia of hips.

    abstract:BACKGROUND:Limb length discrepancy (LLD) is one of the main cause of dissatisfaction after total hip arthroplasty (THA). The teardrop-lesser trochanter method can accurately predict and analyze LLD for healthy people. However, for patients with preoperative LLD, no method for predicting postoperative LLD is currently a...

    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Guo R,Chen JY,Zhang G,Zhou Y,Chen J,Chai W

    更新日期:2019-11-03 00:00:00

  • Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Dieckmeyer M,Ruschke S,Rohrmeier A,Syväri J,Einspieler I,Seifert-Klauss V,Schmidmayr M,Metz S,Kirschke JS,Rummeny EJ,Zimmer C,Karampinos DC,Baum T

    更新日期:2019-11-06 00:00:00

  • Tarsal tunnel syndrome secondary to osteochondroma of the calcaneus: a case report.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Won SH,Kim J,Min TH,Chun DI,Yi Y,Han SH,Cho J

    更新日期:2020-07-25 00:00:00

  • Patterns of analgesic use, pain and self-efficacy: a cross-sectional study of patients attending a hospital rheumatology clinic.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Blamey R,Jolly K,Greenfield S,Jobanputra P

    更新日期:2009-11-10 00:00:00

  • Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Heard BJ,Martin L,Rattner JB,Frank CB,Hart DA,Krawetz R

    更新日期:2012-07-23 00:00:00

  • Sequential activation of the AKT pathway in human osteoblasts treated with Oscarvit: a bioactive product with positive effect both on skeletal pain and mineralization in osteoblasts.

    abstract:BACKGROUND:Oscarvit (OSC) is an in-house preparation consisting of calcium, magnesium, phosphorus, strontium, Vitamin D, and eggshell membrane hydrolysate containing naturally occurring glycosaminoglycans and sulfated glycoproteins. OSC has been used both in an open-label human study and in vitro in osteoblasts. METHO...

    journal_title:BMC musculoskeletal disorders

    pub_type: 临床试验,杂志文章


    authors: Görögh T,Quabius ES,Georgitsis A,Hoffmann M,Lippross S

    更新日期:2017-11-28 00:00:00

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章,多中心研究


    authors: Aloumanis K,Kapetanos G,Bartzis N,Drossinos V,Hellenic ExFOS study group.

    更新日期:2015-06-05 00:00:00

  • Temperature influence on DXA measurements: bone mineral density acquisition in frozen and thawed human femora.

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    journal_title:BMC musculoskeletal disorders

    pub_type: 杂志文章


    authors: Wähnert D,Hoffmeier KL,Lehmann G,Fröber R,Hofmann GO,Mückley T

    更新日期:2009-02-24 00:00:00