Abstract:
:KAAT1 and CAATCH1 are amino acid transporters cloned from the intestine of the lepidoptera Manduca sexta. They are members of the SLC6/NSS family, which groups membrane proteins that use Na(+), K(+), and Cl⁻ gradients for the coupled transport of amines and amino acids. The report of the atomic-resolution x-ray crystal structure of the eubacterium Aquifex aeolicus leucine transporter (AaLeuT) has contributed significantly to understanding of the structure-function relationship in NSS proteins. Transport by AaLeuT is Cl⁻ independent, whereas many neurotransmitter:sodium symporters like serotonin transporter (SERT), GABA transporter (GAT1), dopamine transporter, and norephinephrine transporter, among others, are strongly Cl⁻ dependent.
journal_name
Channels (Austin)journal_title
Channels (Austin, Tex.)authors
Bettè S,Castagna M,Bossi E,Peres A,Sacchi VFdoi
10.4161/chan.2.5.6901subject
Has Abstractpub_date
2008-09-01 00:00:00pages
358-62issue
5eissn
1933-6950issn
1933-6969pii
6901journal_volume
2pub_type
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