Abstract：
PURPOSE:To determine levels of Peptidyl arginine deiminase 2 (PAD2) and its product protein-bound citrulline in cadaver eyes that suffered from normal tension glaucoma (NTG) compared to primary open angle glaucoma (POAG), and controls. METHODS:Western analysis, ELISA, and immunohistochemical analysis were performed with human tissues. RESULTS:We report over expression of PAD2 and higher levels of its product protein-bound citrulline in the optic nerve of normal tension glaucoma patients (NTG). CONCLUSIONS:This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline.
journal_name
Mol Visjournal_title
Molecular visionauthors
Cafaro TA,Santo S,Robles LA,Crim N,Urrets-Zavalia JA,Serra HMsubject
Has Abstractpub_date
2010-08-17 00:00:00pages
1654-8issn
1090-0535pii
178journal_volume
16pub_type
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