解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Maintaining homeostasis of the decidual immune microenvironment at the maternal-fetal interface is essential for placentation and reproductive success. Although distinct decidual immune cell subpopulations have been identified under normal conditions, systematic understanding of the spectrum and heterogeneity of leuko...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-020-00236-z
更新日期:2021-01-04 00:00:00
abstract::The cell entry of SARS-CoV-2 has emerged as an attractive drug repurposing target for COVID-19. Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS bios...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-020-00222-5
更新日期:2020-11-04 00:00:00
abstract::[This corrects the article DOI: 10.1038/s41421-020-0168-9.]. ...
journal_title:Cell discovery
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41421-020-00187-5
更新日期:2020-06-20 00:00:00
abstract::Aberrant activation of Wnt/β-catenin signaling has been associated with the onset and progression of many types of tumors and thus β-catenin represents one attractive intracellular target for cancer therapy. Based on the Axin-derived peptide that binds to β-catenin, two stapled peptides SAHPA1 and xStAx were reported ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-020-0171-1
更新日期:2020-06-09 00:00:00
abstract::Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, re...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-020-0153-3
更新日期:2020-03-16 00:00:00
abstract::Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. The most well-studied form of autophagy is macroautophagy, which delivers cytoplasmic material to lysosomes via the double-membraned autophagosome. Other forms of autophagy, namely chaperone-mediated autopha...
journal_title:Cell discovery
pub_type: 杂志文章,评审
doi:10.1038/s41421-020-0141-7
更新日期:2020-02-11 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is a common subtype of head and neck squamous cell carcinoma (HNSCC), but the pathogenesis underlying familial OSCCs is unknown. Here, we analyzed whole-genome sequences of a family with autosomal dominant expression of oral tongue cancer and identified proto-oncogenes VAV2 and IQGA...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-019-0126-6
更新日期:2019-11-26 00:00:00
abstract::The functional properties of mucosal surfaces are dependent on establishing the correct proportions of specialized epithelial cell types. Multiciliated cells (also known as ciliated cells) are evolutionarily conserved and functionally indispensable epithelial cells, as suggested by the link between ciliated cell dysfu...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-019-0104-z
更新日期:2019-07-16 00:00:00
abstract::Primary cilia are critically involved in the coordination of diverse signaling pathways and ciliary defects are associated with a variety of human diseases. The past decades have witnessed great progress in the core machinery orchestrating ciliary assembly. However, the upstream epigenetic cues that direct ciliogenesi...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-019-0100-3
更新日期:2019-06-25 00:00:00
abstract::While it is recognized that there are low levels of new cardiomyocyte (CM) formation throughout life, the source of these new CM generates much debate. One hypothesis is that these new CMs arise from the proliferation of existing CMs potentially after dedifferentiation although direct evidence for this is lacking. Her...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-019-0095-9
更新日期:2019-06-04 00:00:00
abstract::The isolation of human monoclonal antibodies with broadly neutralizing breadth can provide a promising countermeasure for influenza A viruses infection. Most broadly neutralizing antibodies against influenza A viruses bind to the conserved stem region or the receptor-binding cavity of hemagglutinin and the interaction...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-019-0086-x
更新日期:2019-04-16 00:00:00
abstract::Metacaspase enzymes are critical regulatory factors that paradoxically engage apoptosis and also maintain cell viability. For example, the Saccharomyces cerevisiae metacaspase Yca1 has been shown to be important for maintaining cellular proteostasis during stress, and the loss of this enzyme results in increased reten...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-018-0071-9
更新日期:2019-01-22 00:00:00
abstract::The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cle...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-018-0069-3
更新日期:2018-11-27 00:00:00
abstract::Lgr5+ intestinal stem cells (ISCs) drive the fast renewal of intestinal epithelium. Several signaling pathways have been shown to regulate ISC fates. However, it is unclear what are the essential signals to sustain the ISC self-renewal. Here we show that coordination between Wnt and BMP signaling activity is necessary...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-018-0051-0
更新日期:2018-09-04 00:00:00
abstract::DNA methylation plays important roles during development. However, the DNA methylation reprogramming of functional elements has not been fully investigated during mammalian embryonic development. Herein, using our modified MethylC-Seq library generation method and published post-bisulphite adapter-tagging (PBAT) metho...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-018-0039-9
更新日期:2018-08-07 00:00:00
abstract::The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhi...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-018-0034-1
更新日期:2018-06-05 00:00:00
abstract::Loss of organelle homeostasis is a hallmark of aging. However, it remains elusive how this occurs at gene expression level. Here, we report that human mesenchymal stem cell (hMSC) aging is associated with dysfunction of double-membrane organelles and downregulation of transcription factor ATF6. CRISPR/Cas9-mediated in...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/s41421-017-0003-0
更新日期:2018-01-05 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) signal-transduction pathway plays a key role in regulating many aspects of metabolic processes. The central player of the mTOR signaling pathway, mTOR complex 1 (mTORC1), is recruited by the pentameric Ragulator complex and the heterodimeric Rag GTPase complex to the lysosoma...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.49
更新日期:2017-12-26 00:00:00
abstract::Reactive astrogliosis is a hallmark of many neurological disorders, yet its functions and molecular mechanisms remain elusive. Particularly, the upstream signaling that regulates pathological responses of astrocytes is largely undetermined. We used a mouse traumatic brain injury model to induce astrogliosis and reveal...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.44
更新日期:2017-12-05 00:00:00
abstract::Imprinted genes are vulnerable to environmental influences during early embryonic development, thereby contributing to the onset of disease in adulthood. Monoallelic methylation at several germline imprints has been reported as DNMT1-dependent. However, which of these two epigenetic attributes, DNMT1-dependence or all...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.38
更新日期:2017-11-14 00:00:00
abstract::Yin Yang 1 (YY1) is a multifunctional DNA-binding transcription factor shown to be critical in a variety of biological processes, and its activity and function have been shown to be regulated by multitude of mechanisms, which include but are not limited to post-translational modifications (PTMs), its associated protei...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.35
更新日期:2017-10-03 00:00:00
abstract::The organophosphate-induced delayed neuropathy (OPIDN), often leads to paresthesias, ataxia and paralysis, occurs in the late-stage of acute poisoning or after repeated exposures to organophosphate (OP) insecticides or nerve agents, and may contribute to the Gulf War Syndrome. The acute phase of OP poisoning is often ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.24
更新日期:2017-08-01 00:00:00
abstract::Metformin is a commonly prescribed type II diabetes medication that exhibits promising anticancer effects. Recently, these effects were found to be associated, at least in part, with a modulation of microRNA expression. However, the mechanisms by which single modulated microRNAs mediate the anticancer effects of metfo...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.22
更新日期:2017-07-04 00:00:00
abstract::Epidemiological data provide strong evidence of dramatically increasing incidences of many autoimmune diseases in the past few decades, mainly in western and westernized countries. Recent studies clearly revealed that 'Western diet' increases the risk of autoimmune diseases at least partially via disrupting intestinal...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.20
更新日期:2017-06-20 00:00:00
abstract::Mannose-6-phosphate receptor (M6PR) that facilitates cellular uptake of M6P-bearing proteins, including serine-protease granzyme-B (Gzm-B) has an important role in T-cell activation, migration and contraction. However, molecular mechanisms controlling M6PR expression in T cells remain poorly understood. Here, we show ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.11
更新日期:2017-04-25 00:00:00
abstract::Malat1 is one of the most abundant long non-coding RNAs in various cell types; its exact cellular function is still a matter of intense investigation. In this study we characterized the function of Malat1 in skeletal muscle cells and muscle regeneration. Utilizing both in vitro and in vivo assays, we demonstrate that ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.2
更新日期:2017-03-14 00:00:00
abstract::The use of antibodies to target immune checkpoints, particularly PD-1/PD-L1, has made a profound impact in the field of cancer immunotherapy. Here, we identified KN035, an anti-PD-L1 nanobody that can strongly induce T-cell responses and inhibit tumor growth. The crystal structures of KN035 complexed with PD-L1 and fr...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.4
更新日期:2017-03-07 00:00:00
abstract::Plasminogen activation is involved in many processes within the central nervous system, including synaptic plasticity, neuroinflammation and neurodegeneration. However, the mechanisms that regulate plasminogen activation in the brain still remain unknown. Here we demonstrate that astrocytes participate in this regulat...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2017.1
更新日期:2017-02-21 00:00:00
abstract::The recruitment of FANCM, a conserved DNA translocase and key component of several DNA repair protein complexes, to replication forks stalled by DNA interstrand crosslinks (ICLs) is a step upstream of the Fanconi anemia (FA) repair and replication traverse pathways of ICLs. However, detection of the FANCM recruitment ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2016.47
更新日期:2016-12-20 00:00:00
abstract::The mechanistic Target Of Rapamycin Complex 1 (mTORC1) is central to the cellular response to changes in nutrient signals such as amino acids. CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway. In the deficiency of arginine, CASTOR1 interacts with GATOR2, ...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2016.35
更新日期:2016-09-13 00:00:00
abstract::Mutations in the amyloid precursor protein (APP) gene and the aberrant cleavage of APP by γ-secretase are associated with Alzheimer's disease (AD). Here we have developed a simple and sensitive cell-based assay to detect APP cleavage by γ-secretase. Unexpectedly, most familial AD (FAD)-linked APP mutations make APP pa...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2016.26
更新日期:2016-08-23 00:00:00
abstract::The DNA damage response involves coordinated control of gene expression and DNA repair. Using deep sequencing, we found widespread changes of alternative cleavage and polyadenylation site usage on ultraviolet-treatment in mammalian cells. Alternative cleavage and polyadenylation regulation in the 3' untranslated regio...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2016.13
更新日期:2016-06-14 00:00:00
abstract::The biogenesis of photosystem I (PSI), cytochrome b 6 f (Cytb 6 f) and NADH dehydrogenase (NDH) complexes relies on the spatially and temporally coordinated expression and translation of both nuclear and chloroplast genes. Here we report the identification of photosystem biogenesis regulator 1 (PBR1), a nuclear-encode...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2016.3
更新日期:2016-05-10 00:00:00
abstract::Monocyte/macrophage differentiation represents a major branch of hematopoiesis and is a central event in the immune response, but the molecular mechanisms underlying are not fully delineated. Here we show that p38 mitogen-activated protein kinase (MAPK) interacting protein (p38IP) is downregulated during monocyte/macr...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2015.43
更新日期:2016-01-26 00:00:00
abstract::Genetic variations in the human dysbindin-1 gene (DTNBP1) have been associated with schizophrenia. As a result of alternative splicing, the human DTNBP1 gene generates at least three distinct protein isoforms, dysbindin-1A, -1B and -1C. Significant effort has focused on dysbindin-1A, an important player in multiple st...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2015.32
更新日期:2015-11-10 00:00:00
abstract::Despite decades of intense global effort, no disease-modifying drugs for Alzheimer's disease have emerged. Molecules targeting catalytic activities of γ-secretase or β-site APP-cleaving enzyme 1 (BACE1) have been beset by undesired side effects. We hypothesized that blocking the interaction between BACE1 and γ-secreta...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2015.21
更新日期:2015-08-18 00:00:00
abstract::JmjC domain containing protein 14 (JMJ14) is an H3K4-specific histone demethylase that plays important roles in RNA-mediated gene silencing and flowering time regulation in Arabidopsis. However, how JMJ14 is recruited to its target genes remains unclear. Here, we show that the C-terminal FYRN and FYRC domains of JMJ14...
journal_title:Cell discovery
pub_type: 杂志文章
doi:10.1038/celldisc.2015.3
更新日期:2015-01-01 00:00:00