听力与言语-语言病理学

行为科学

医学伦理学

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  • Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the prominent forms of cancer in developed countries. Incidence of HCC is well correlated with fatty liver disease and cirrhosis; the underlying chronic inflammation and lipotoxicity are thought to drive the process of HCC. Several biochemical cycles and molecular pat...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467214666210120152657

    authors: Narayanankutty A

    更新日期:2021-01-20 00:00:00

  • Possibility that the Onset of Autism Spectrum Disorder is Induced by Failure of the Glutamine-Glutamate Cycle.

    abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disease, and the number of patients has increased rapidly in recent years. The causes of ASD involve both genetic and environmental factors, but the details of causation have not yet been fully elucidated. Many reports have investigated genetic factors related to ...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213666200319125109

    authors: Kawada K,Kuramoto N,Mimori S

    更新日期:2021-01-01 00:00:00

  • Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver.

    abstract:BACKGROUND:Mutations in the brain-derived neurotrophic factor (BDNF) gene and its receptor, tyrosine receptor kinase B (TrkB), have been reported to cause severe obesity in rodents. Our previous study demonstrated that the oral administration of 5% Eucommia leaf extract (ELE) or ELE aroma treatment (ELE aroma) produced...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213666200505094631

    authors: Oikawa H,Miyazaki S,Kurata R,Hattori M,Hayashi N,Kawaguchi N,Hirata T,Ueda T,Fujikawa T

    更新日期:2021-01-01 00:00:00

  • Ligand Decorated Primaquine loaded Nanocarriers for Liver Targeting for Triggered Antimalarial Activity.

    abstract:OBJECTIVE:The aim of the current research to formulate a nano delivery system for effective delivery of primaquine for liver targeting to achieve the potential antimalarial activity. An objective of current development is to formulate a lactobionic acid conjugated polyphosphazene based nanodelivery of primaquine for li...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213999201125220729

    authors: Mehan P,Garg A,Ajay K,Mishra N

    更新日期:2020-11-25 00:00:00

  • Withdrawal Notice: Molecular Mechanism of TLR4 Mediated T Cell Immune Effect in Transfusion-induced Acute Lung Injury based on Slit2/Robo4 Signaling Pathway

    abstract::Bentham Science has decided to withdraw this article due to the purposeful breach of COPE guidelines and the copyright agreement by the authors as they had submitted this paper simultaneously to another journal. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Be...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213666201007125021

    authors: Xiao K,Zhao F,Xie W,Ding J,Gong X,OuYang C,Le A

    更新日期:2020-10-07 00:00:00

  • The Effect of PAOPA, A Novel Allosteric Modulator of Dopamine D2 Receptors, on Signaling Proteins Following Sub-Chronic Administration in Rats

    abstract:BACKGROUND:Allosteric modulators of G-protein coupled receptors regulate receptor activity by binding to sites other than the active site and have emerged as a new and highly desirable class of drugs. PAOPA (3(R)-[(2(S)- pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide), a peptidomimetic analog of Prolyl-Leucyl...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213666200910091007

    authors: Daya R,Ho J,Thomson S,Bhandari J,Mishra RK

    更新日期:2020-09-09 00:00:00

  • Epigenetic Evaluation of N-(2-hydroxyphenyl)-2-propylpentanamide, a Valproic Acid Aryl Derivative with activity against HeLa cells.

    abstract:BACKGROUND:Valproic acid (VPA) is an HDAC inhibitor (HDACI) with anticancer activity, but it is hepatotoxic. N-(2-hydroxyphenyl)-2-propylpentanamide (o-OH-VPA) is a VPA aryl derivative designed in silico as a selective inhibitor of HDAC8 with biological properties against HeLa, rhabdomyosarcoma and breast cancer cell c...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467213666200730113828

    authors: Gabriela Rebeca LP,José CB,José TF,Antonio MM,Ismael VM

    更新日期:2020-07-29 00:00:00

  • Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in Isolated Rat Aorta: Involvement of cGMP Mediated sGC and Potassium Channel Activation.

    abstract:BACKGROUND AND OBJECTIVE:Recently, nitric oxide (NO) and hydrogen sulfide (H2S) donating moieties were extensively studied for their role in the vasculature as they are responsible for many cellular and pathophysiological functioning. The objective of the present study is to evaluate novel NO and H2S donating chalcone ...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467212666191025092346

    authors: Sherikar A,Dhavale R,Bhatia M

    更新日期:2020-01-01 00:00:00

  • Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage.

    abstract:BACKGROUND:The ancient and highly evolutionarily conserved Wnt signaling pathway is critical in nearly all tissues and organs for an organism to develop normally from embryo through adult. Wnt signaling is generally parsed into "canonical" or Wnt-β-catenin-dependent or "non-canonical" β-catenin-independent signaling. E...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467212666190304121131

    authors: Lai KKY,Nguyen C,Lee KS,Lee A,Lin DP,Teo JL,Kahn M

    更新日期:2019-01-01 00:00:00

  • Mephedrone Impact on Matrix Metalloproteinases Activity - Do they Influence the Memory Processes?

    abstract:BACKGROUND:The use of drugs of addiction, as mephedrone, is associated with functional neuronal disorders due to remodeling of the nervous tissue. Key enzymes in remodeling are extracellular matrix (ECM) proteases like matrix metalloproteases (MMPs). Recently, MMPs have been of great interest as some studies point to a...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467212666190114154307

    authors: Boguszewska-Czubara A,Kurzepa J,Biała G,Kaszubska K,Grot K,Tarkowski P,Kowalczyk J,Silvestro S,Faggio C,Budzyńska B

    更新日期:2019-01-01 00:00:00

  • MiR-597 Targeting 14-3-3σ Enhances Cellular Invasion and EMT in Nasopharyngeal Carcinoma Cells.

    abstract:BACKGROUND:Alterations in microRNAs (miRNAs) are related to the occurrence of nasopharyngeal carcinoma (NPC) and play an important role in the molecular mechanism of NPC. Our previous studies show low expression of 14-3-3σ (SFN) is related to the metastasis and differentiation of NPC, but the underlying molecular mecha...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467212666181218113930

    authors: Xie L,Jiang T,Cheng A,Zhang T,Huang P,Li P,Wen G,Lei F,Huang Y,Tang X,Gong J,Lin Y,Kuai J,Huang W

    更新日期:2019-01-01 00:00:00

  • Impact of Sphingolipid Mediators on the Determination of Cochlear Survival in Ototoxicity.

    abstract:BACKGROUND AND OBJECTIVE:Sphingolipid metabolites, including ceramide, sphingosine, and their phosphorylates (ceramide-1-phosphonate [C1P] and sphingosine-1-phosphate [S1P]), regulate diverse cellular processes including apoptosis, the cell cycle, and cellular differentiation. Recent studies have shown that these sphin...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467211666180516101111

    authors: Tabuchi K,Hara A

    更新日期:2018-01-01 00:00:00

  • Socialization Alleviates Burden of Oxidative-Stress in Hippocampus and Prefrontal Cortex in Morphine Addiction Period in Male Rats.

    abstract:INTRODUCTION:Addiction is a compulsive drug-seeking and drug-taking behavior. Reduction of high-risk behaviors can reduce the burden of addiction in society and can improve the overall prognosis of drug addiction. The aim of this study is to show that reduction of oxidative stress with socialization will reduce occurre...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467210666170919161045

    authors: Famitafreshi H,Karimian M

    更新日期:2018-01-01 00:00:00

  • Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?

    abstract:BACKGROUND:There has been a constant pursuit for development of newer therapies which can contribute to the relatively nascent field of cardioprotection in the setting of myocardial ischemiareperfusion injury. One novel cardioprotective agent among others, that has shown promising results in the limited number of resea...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210666170223101422

    authors: Basman C,Agrawal P,Knight R,Saravolatz L,McRee C,Chen-Scarabelli C,Narula J,Scarabelli T

    更新日期:2018-01-01 00:00:00

  • Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense.

    abstract::The mevalonic acid synthesis pathway, cholesterol, and lipoproteins play fundamental roles in lung physiology and the innate immune response. Recent literature investigating roles for cholesterol synthesis and trafficking in host defense against respiratory infection was critically reviewed. The innate immune response...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1874467209666160112123603

    authors: Gabor KA,Fessler MB

    更新日期:2017-01-01 00:00:00

  • Structure, Function and Metabolism of Hepatic and Adipose Tissue Lipid Droplets: Implications in Alcoholic Liver Disease.

    abstract::For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for ...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150817111727

    authors: Natarajan SK,Rasineni K,Ganesan M,Feng D,McVicker BL,McNiven MA,Osna NA,Mott JL,Casey CA,Kharbanda KK

    更新日期:2017-01-01 00:00:00

  • In vitro Differentiation of Germ Cells from Stem Cells.

    abstract::Stem cells are unique cell types with the ability of self-renewal and differentiation, which mainly include embryonic stem cells, induced pluripotent stem cells, and adult stem cells. Recently, several research groups have reported that stem cells can differentiate into germ cells under appropriate conditions in vitro...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150928154053

    authors: Ding X,Wang J,Wu J

    更新日期:2016-01-01 00:00:00

  • Novel Immunotherapies for Hematological Malignancies.

    abstract::The successful treatment of hematological malignancies remains challenging. Prognosis is often dismal given the frequency of disease relapse or treatment refractory disease. Cytotoxic and cytostatic chemotherapy remain mainstream therapeutics for most hematological malignancies. However, improved understanding of tumo...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150716121253

    authors: Vasekar M,Rizvi S,Liu X,Vrana KE,Zheng H

    更新日期:2016-01-01 00:00:00

  • The Role of Androgen Under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy.

    abstract::The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and its associate with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous dis...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150710120217

    authors: Azmahani A,Nakamura Y,McNamara KM,Sasano H

    更新日期:2016-01-01 00:00:00

  • Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C.

    abstract::Ca(2+) influx via L-type Ca(2+) channel (L-VDCC; CaV1.2) is required for cardiac and smooth muscle contraction. These channels are located in the plasma membrane and along the T-tubules (in cardiomyocytes), along with various scaffold and trafficking proteins. CaV1.2 is modulated by different hormones and transmitters...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150507094733

    authors: Weiss S,Dascal N

    更新日期:2015-01-01 00:00:00

  • Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

    abstract::Inhibition of voltage-gated L-type calcium channels by organic calcium channel blockers is a well-established pharmacodynamic concept for the treatment of hypertension and cardiac ischemia. Since decades these antihypertensives (such as the dihydropyridines amlodipine, felodipine or nifedipine) belong to the most wide...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150507105845

    authors: Striessnig J,Ortner NJ,Pinggera A

    更新日期:2015-01-01 00:00:00

  • Recent Progress in FKBP Ligand Development.

    abstract::FK506-binding proteins have been implicated in numerous human diseases suggesting novel therapeutic opportunities. In particular, the large FKBP51 has emerged as an important regulator of the stress-coping system and as an established risk factor for stress-related disorders. The principal druggabilty of FKBPs is evid...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150519113313

    authors: Feng X,Pomplun S,Hausch F

    更新日期:2015-01-01 00:00:00

  • Natural products as modulators of spermatogenesis: the search for a male contraceptive.

    abstract::Population growth in the last century has raised important social and economic questions. Thus, current methods of fertility control have been under debate for a long period. Birth rates are essentially dependent on several environmental and social factors but women, who are great users of contraceptives, play a major...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467208666150126155912

    authors: Dias TR,Alves MG,Oliveira PF,Silva BM

    更新日期:2014-01-01 00:00:00

  • The glucocorticoid analog dexamethasone alters the expression and the distribution of dopamine receptors and enkephalin within cortico-subcortical regions.

    abstract::In humans, glucocorticoid excess may cause neuropsychiatric symptoms, including psychosis and cognitive impairment, and glucocorticoid signaling hyperactivation may sensitize to substance of abuse. The aim of this work was to evaluate whether exposure to glucocorticoid excess triggers molecular changes in dopaminergic...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:10.2174/187446720603140415215941

    authors: Iasevoli F,Aloj L,Latte G,Avvisati L,Marmo F,Tomasetti C,Buonaguro EF,Simeoli C,Pivonello R,Colao A,de Bartolomeis A

    更新日期:2013-11-01 00:00:00

  • SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain.

    abstract::The solute carrier family 1 (SLC1) consists of two neutral amino acid transporters and five high-affinity excitatory amino acid transporters (EAAT1-5). EAATs are expressed in glial cells (EAAT1/GLAST and EAAT2/GLT-1), neurons (EAAT3/EAAC1 and EAAT4), and the retina (EAAT5), where they precisely regulate extracellular ...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/18744672113069990033

    authors: Nakagawa T,Kaneko S

    更新日期:2013-07-01 00:00:00

  • ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art.

    abstract::Cystic fibrosis (CF) is a hereditary disease caused by mutations in the gene encoding the chloride channel "cystic fibrosis transmembrane conductance regulator" (CFTR). The lack of functional CFTR in CF airways leads to impaired ion and fluid homeostasis of the fluid layer which lines the airway surfaces (ASL). The AS...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/18744672112059990025

    authors: Althaus M

    更新日期:2013-03-01 00:00:00

  • The role of BMPs in bone anabolism and their potential targets SOST and DKK1.

    abstract::Bone morphogenetic proteins (BMPs) were discovered in 1965 as potent inducers of ectopic bone formation when implanted subcutaneously. BMP2, BMP4, BMP6, and BMP7 are osteoinductive, and BMP2 and BMP7 are currently approved for clinical applications such as bone fracture healing and spine surgery. Although BMPs' role i...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467211205020153

    authors: Kamiya N

    更新日期:2012-06-01 00:00:00

  • Crosstalk Signalling Role in Modulation of Drugs Side Effects.

    abstract::Tumorigenesis is regulated by the complex cell-matrix signalling interactions that incorporate feedback mechanisms from constantly evolving microenvironments. Under normal circumstances, these matrix signalling processes together with infiltrating immune cells tightly control the extent of tissue remodelling. They are...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章

    doi:

    authors: Garamszegi SP,Garamszegi N

    更新日期:2011-05-10 00:00:00

  • New prospects for nelfinavir in non-HIV-related diseases.

    abstract::Nelfinavir (Viracept) was originally designed as a specific HIV protease inhibitor and, since its introduction in 1997, has served as an effective, reliable, and well-tolerated HIV drug. Although nelfinavir is being increasingly displaced by second generation HIV protease inhibitors that allow better combination treat...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467211003020091

    authors: Brüning A,Gingelmaier A,Friese K,Mylonas I

    更新日期:2010-06-01 00:00:00

  • Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders.

    abstract::Estrogens are hormones that modulate a diverse array of effects during development and adulthood. The effects of estrogen are mediated by two estrogen receptor (ER) isotypes, ERalpha and ERbeta, which classically function as transcription factors to modulate specific target gene expression and in addition regulate a g...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210902030215

    authors: Hughes ZA,Liu F,Marquis K,Muniz L,Pangalos MN,Ring RH,Whiteside GT,Brandon NJ

    更新日期:2009-11-01 00:00:00

  • Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection.

    abstract::Valproic acid (VPA, 2-propylpentanoic acid) has been widely used as an antiepileptic drug and for the therapy of bipolar disorders for several years. Its mechanism of action was initially found to be primarily related to neurotransmission and modulation of intracellular pathways. More recently, it emerged as an anti-n...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210902010095

    authors: Monti B,Polazzi E,Contestabile A

    更新日期:2009-01-01 00:00:00

  • Functional selectivity in cannabinoid signaling.

    abstract::Cannabinoid (CB) agonists exhibit numerous potentially useful pharmacological properties, but unwanted side effects limit their use in clinical practice. Thus, novel strategies are needed to identify potential CB pharmaceuticals with fewer side effects. Activated CB receptors initiate multiple parallel intracellular s...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210801030273

    authors: Varga EV,Georgieva T,Tumati S,Alves I,Salamon Z,Tollin G,Yamamura HI,Roeske WR

    更新日期:2008-11-01 00:00:00

  • DNA polymerases and oxidative damage: friends or foes?

    abstract::DNA is modified by many mutagens, including reactive oxygen species (ROS). When ROS react with DNA, various kinds of modified base and/or sugar moieties are produced. One of the most important oxidative DNA lesions is 7,8-dihydro-8-oxoguanine (8-oxo-G). Contrary to normal deoxyguanosine, 8-oxo-G favors a syn conformat...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210801020162

    authors: Amoroso A,Crespan E,Wimmer U,Hubscher U,Maga G

    更新日期:2008-06-01 00:00:00

  • Gene therapy: the first approved gene-based medicines, molecular mechanisms and clinical indications.

    abstract::As gene therapy has matured from clinical trials to the first commercial products, understanding of the mechanisms of gene delivery has increased tremendously. This has also been reflected in viral vector development, creating a number of new approaches to tackle issues in transduction efficiency, biodistribution and ...

    journal_title:Current molecular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1874467210801010013

    authors: Räty JK,Pikkarainen JT,Wirth T,Ylä-Herttuala S

    更新日期:2008-01-01 00:00:00