abstract：BACKGROUND:Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there has been very limited research on the effects of NO on metamorphosis in bivalve shellfish. RESULTS:...

journal_title：BMC developmental biology

authors： Vogeler S,Carboni S,Li X,Nevejan N,Monaghan SJ,Ireland JH,Joyce A

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Monocyte chemoattractant protein-1(MCP-1) is a chemokine secreted by Leydig cells and peritubular myoid cells in the rat testis. Its role in regulating the development of Leydig cells via autocrine and paracrine is still unclear. The objective of the current study was to investigate the effects of MCP-1 on L...

journal_title：BMC developmental biology

authors： Zhan X,Zhang J,Li S,Zhang X,Li L,Song T,Liu Q,Lu J,Xu Y,Ge RS

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Changes in transcellular bioelectrical patterns are known to play important roles during developmental and regenerative processes. The Drosophila follicular epithelium has proven to be an appropriate model system for studying the mechanisms by which bioelectrical signals emerge and act. Fluorescent indicator...

journal_title：BMC developmental biology

authors： Schotthöfer SK,Bohrmann J

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Scaffold proteins support a variety of key processes during animal development. Mutant mouse for the MAGUK protein Discs large 5 (Dlg5) presents a general growth impairment and moderate morphogenetic defects. RESULTS:Here, we generated null mutants for Drosophila Dlg5 and show that it owns similar functions...

journal_title：BMC developmental biology

authors： Venugopal P,Veyssière H,Couderc JL,Richard G,Vachias C,Mirouse V

更新日期：2020-06-18 00:00:00

abstract：BACKGROUND:Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas organoid (hPO) cultures do not expand efficiently long-term in a chemic...

journal_title：BMC developmental biology

authors： Georgakopoulos N,Prior N,Angres B,Mastrogiovanni G,Cagan A,Harrison D,Hindley CJ,Arnes-Benito R,Liau SS,Curd A,Ivory N,Simons BD,Martincorena I,Wurst H,Saeb-Parsy K,Huch M

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been widely known to have an appreciable effect in physiology and pathology. In tooth regeneration, periodontal ligament stem cells (PDLSCs) are regarded as a key effector, whereas, how lncRNA acts in the osteogenic differentiation of PDLSCs have not been completely unders...

journal_title：BMC developmental biology

authors： Wang Z,Huang Y,Tan L

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:During Drosophila oogenesis, the follicular epithelium differentiates into several morphologically distinct follicle-cell populations. Characteristic bioelectrical properties make this tissue a suitable model system for studying connections between electrochemical signals and the organisation of the cytoskel...

journal_title：BMC developmental biology

authors： Weiß I,Bohrmann J

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the bl...

journal_title：BMC developmental biology

authors： Zolini AM,Negrón-Pérez VM,Hansen PJ

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth...

journal_title：BMC developmental biology

authors： Wang K,Shen H,Gan P,Cavallero S,Kumar SR,Lien CL,Sucov HM

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:Work in other species suggests that interleukin-6 (IL6) promotes early embryo development. It was unclear whether IL6 serves as an embryokine in cultured bovine embryos. This work was undertaken to elucidate the role of IL6 during in vitro bovine embryo production. RESULTS:Transcripts for IL6 and its two co...

journal_title：BMC developmental biology

authors： Wooldridge LK,Ealy AD

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:MiR-9 is a small non-coding RNA that is highly conserved between species and primarily expressed in the central nervous system (CNS). It is known to influence proliferation and neuronal differentiation in the brain and spinal cord of different vertebrates. Different studies have pointed to regional and speci...

journal_title：BMC developmental biology

authors： Alwin Prem Anand A,Huber C,Asnet Mary J,Gallus N,Leucht C,Klafke R,Hirt B,Wizenmann A

更新日期：2018-02-22 00:00:00

abstract：BACKGROUND:Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-tran...

journal_title：BMC developmental biology

authors： Gupta K,Pilli VS,Aradhyam GK

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Definitive endoderm (DE) gives rise to the respiratory apparatus and digestive tract. Sox17 and Cxcr4 are useful markers of the DE. Previously, we identified a novel DE marker, Decay accelerating factor 1(Daf1/CD55), by identifying DE specific genes from the expression profile of DE derived from mouse embryo...

journal_title：BMC developmental biology

authors： Ogaki S,Omori H,Morooka M,Shiraki N,Ishida S,Kume S

更新日期：2016-05-31 00:00:00

abstract：BACKGROUND:The pituitary gland is a highly vascularized tissue that requires coordinated interactions between the neural ectoderm, oral ectoderm, and head mesenchyme during development for proper physiological function. The interactions between the neural ectoderm and oral ectoderm, especially the role of the pituitary...

journal_title：BMC developmental biology

authors： Davis SW,Mortensen AH,Keisler JL,Zacharias AL,Gage PJ,Yamamura K,Camper SA

更新日期：2016-05-16 00:00:00

abstract：BACKGROUND:Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, round and large. Scanning whole mount mammalian embryos with 3D-SIM is prone to failure due to the mov...

journal_title：BMC developmental biology

authors： Popken J,Dahlhoff M,Guengoer T,Wolf E,Zakhartchenko V

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:The developing eye receives blood supply from two vascular systems, the intraocular hyaloid system and the superficial choroidal vessels. In zebrafish, a highly stereotypic and simple set of vessels develops on the surface of the eye prior to development of choroidal vessels. The origins and formation of thi...

journal_title：BMC developmental biology

authors： Kaufman R,Weiss O,Sebbagh M,Ravid R,Gibbs-Bar L,Yaniv K,Inbal A

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintained by the mRNA-binding protein, Musashi1 through repression of translation of key mRNAs encoding cel...

journal_title：BMC developmental biology

authors： MacNicol AM,Hardy LL,Spencer HJ,MacNicol MC

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:Tissue fixation is crucial for preserving the morphology of biological structures and cytological details to prevent postmortem degradation and autolysis. Improper fixation conditions could lead to artifacts and thus incorrect conclusions in immunofluorescence or histology experiments. To resolve reported st...

journal_title：BMC developmental biology

authors： Nie J,Mahato S,Zelhof AC

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF)...

journal_title：BMC developmental biology

authors： Hirose K,Shiomi T,Hozumi S,Kikuchi Y

更新日期：2014-12-06 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this s...

journal_title：BMC developmental biology

authors： Tiwari S,Dharmarajan S,Shivanna M,Otteson DC,Belecky-Adams TL

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Dimethyl sulfoxide (DMSO) is used extensively as a permeable cryoprotectant and is a common solvent utilized for several water-insoluble substances. DMSO has various biological and pharmacological activities; however, the effect of DMSO on mouse oocyte meiotic maturation remains unknown. RESULTS:In DMSO-tre...

journal_title：BMC developmental biology

authors： Zhou D,Shen X,Gu Y,Zhang N,Li T,Wu X,Lei L

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, inflammation and endothelial tubulogenesis. Despite over a decade of research, no comprehensive in situ ...

journal_title：BMC developmental biology

authors： Padmakumar V,Masiuk KE,Luger D,Lee C,Coppola V,Tessarollo L,Hoover SB,Karavanova I,Buonanno A,Simpson RM,Yuspa SH

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from an extremely short G1 cell phase and lacking G1 checkpoint to lengthening G1 phase and the establishm...

journal_title：BMC developmental biology

authors： Wang XQ,Chan KK,Ming X,Lui VC,Poon RY,Lo CM,Norbury C,Poon RT

更新日期：2014-05-19 00:00:00

abstract：BACKGROUND:The miniature pig provides an excellent experimental model for tooth morphogenesis because its diphyodont and heterodont dentition resembles that of humans. However, little information is available on the process of tooth development or the exact molecular mechanisms controlling tooth development in miniatur...

journal_title：BMC developmental biology

authors： Song T,Wu T,Wei F,Li A,Wang F,Xie Y,Liu D,Fan Z,Wang X,Cheng S,Zhang C,He J,Wang S

更新日期：2014-04-21 00:00:00

abstract：:Notch signalling acts in virtually every tissue during the lifetime of metazoans. Recent studies have pointed to multiple roles for Notch in stem cells during quiescence, proliferation, temporal specification, and maintenance of the niche architecture. Skeletal muscle has served as an excellent paradigm to examine the...

journal_title：BMC developmental biology

authors： Mourikis P,Tajbakhsh S

更新日期：2014-01-24 00:00:00

abstract：BACKGROUND:Disabled-2 (Dab2) is an endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking. Since its expression is lost in several cancer types, Dab2 has been suggested to be a tumor suppressor. In vitro studies indicate that Dab2 establishes epithelial cell polarity and organization ...

journal_title：BMC developmental biology

authors： Moore R,Cai KQ,Tao W,Smith ER,Xu XX

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:The Drosophila larval head is evolutionarily derived at the genetic and morphological level. In the beetle Tribolium castaneum, development of the larval head more closely resembles the ancestral arthropod condition. Unlike in Drosophila, a knirps homologue (Tc-kni) is required for development of the antenna...

journal_title：BMC developmental biology

authors： Peel AD,Schanda J,Grossmann D,Ruge F,Oberhofer G,Gilles AF,Schinko JB,Klingler M,Bucher G

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:The purpose of the study was an evaluation of fetal hip joint morphology during the second and the third trimester of pregnancy. Serial sections were performed on 23 cadaver infants. RESULTS:The mean lunar age was 6.6 months. Femoral shaft length (FSL) and width of the proximal and distal epiphysis were x-r...

journal_title：BMC developmental biology

authors： Masłoń A,Sibiński M,Topol M,Krajewski K,Grzegorzewski A

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Our current knowledge on tooth development derives primarily from studies in mice. Very little is known about gene expression and function during human odontogenesis. Sonic Hedgehog (SHH) signaling has been demonstrated to play crucial roles in the development of multiple organs in mice, including the tooth....

journal_title：BMC developmental biology

authors： Hu X,Zhang S,Chen G,Lin C,Huang Z,Chen Y,Zhang Y

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:The freshwater planarian Schmidtea mediterranea has emerged as a powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in situ hybridization (WISH) and whole-mount fluorescent in situ hybridization (FISH) are critical methods for determining gene expression patterns in pla...

journal_title：BMC developmental biology

authors： King RS,Newmark PA

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:The contribution of cell proliferation to regeneration varies greatly between different metazoan models. Planarians rely on pluripotent neoblasts and amphibian limb regeneration depends upon formation of a proliferative blastema, while regeneration in Hydra can occur in the absence of cell proliferation. Rec...

journal_title：BMC developmental biology

authors： Passamaneck YJ,Martindale MQ

更新日期：2012-12-04 00:00:00

abstract：BACKGROUND:The first distinct differentiation event in mammals occurs at the blastocyst stage when totipotent blastomeres differentiate into either pluripotent inner cell mass (ICM) or multipotent trophectoderm (TE). Here we determined, for the first time, global gene expression patterns in the ICM and TE isolated from...

journal_title：BMC developmental biology

authors： Ozawa M,Sakatani M,Yao J,Shanker S,Yu F,Yamashita R,Wakabayashi S,Nakai K,Dobbs KB,Sudano MJ,Farmerie WG,Hansen PJ

更新日期：2012-11-06 00:00:00

abstract：BACKGROUND:In chondrichthyans, basal osteichthyans and tetrapods, vertebral bodies have cartilaginous anlagen that subsequently mineralize (chondrichthyans) or ossify (osteichthyans). Chondrocytes that form the vertebral centra derive from somites. In teleost fish, vertebral centrum formation starts in the absence of c...

journal_title：BMC developmental biology

authors： Bensimon-Brito A,Cardeira J,Cancela ML,Huysseune A,Witten PE

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:FGF signaling plays numerous roles during organogenesis of the embryonic gut tube. Mouse explant studies suggest that different thresholds of FGF signaling from the cardiogenic mesoderm induce lung, liver, and pancreas lineages from the ventral foregut progenitor cells. The mechanisms that regulate FGF dose ...

journal_title：BMC developmental biology

authors： Shifley ET,Kenny AP,Rankin SA,Zorn AM

更新日期：2012-09-18 00:00:00

abstract：BACKGROUND:Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature cells via dedifferentiation and/or from stem cells. Several studies in urodele amphibians (salamanders...

journal_title：BMC developmental biology

authors： Rodrigues AM,Christen B,Martí M,Izpisúa Belmonte JC

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:Germline stem cells (GSCs) are present in the gonads of Drosophila females and males, and their proper maintenance, as well as their correct differentiation, is essential for fertility and fecundity. The molecular characterization of factors involved in maintenance and differentiation is a major goal both in...

journal_title：BMC developmental biology

authors： Cash AC,Andrews J

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Hemangioblasts are known as the common precursors for primitive hematopoietic and endothelial lineages. Their existence has been supported mainly by the observation that both cell types develop in close proximity and by in vitro differentiation and genetic studies. However, more compelling evidence will aris...

journal_title：BMC developmental biology

authors： Teixeira V,Arede N,Gardner R,Rodríguez-León J,Tavares AT

更新日期：2011-12-28 00:00:00

abstract：BACKGROUND:Determining the type and source of cells involved in regenerative processes has been one of the most important goals of researchers in the field of regeneration biology. We have previously used several cellular markers to characterize the cells involved in the regeneration of the intestine in the sea cucumbe...

journal_title：BMC developmental biology

authors： García-Arrarás JE,Valentín-Tirado G,Flores JE,Rosa RJ,Rivera-Cruz A,San Miguel-Ruiz JE,Tossas K

更新日期：2011-10-17 00:00:00

abstract：BACKGROUND:Heparan sulfate (HS) biosynthesis is tightly regulated during vertebrate embryo development. However, potential roles for HS biosynthesis in regulating the function of paracrine signaling molecules that bind to HS are incompletely understood. RESULTS:In this report we have studied Fgf, Wnt and Hedgehog (Hh)...

journal_title：BMC developmental biology

authors： Fischer S,Filipek-Gorniok B,Ledin J

更新日期：2011-09-05 00:00:00

abstract：BACKGROUND:Epimorphic regeneration results in the restoration of lost tissues and structures from an aggregation of proliferating cells known as a blastema. Among amniotes the most striking example of epimorphic regeneration comes from tail regenerating lizards. Although tail regeneration is often studied in the contex...

journal_title：BMC developmental biology

authors： McLean KE,Vickaryous MK

更新日期：2011-08-16 00:00:00