解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Transforming growth factor-β1 (TGF-β1) is a multifaceted factor in cancer biology that regulates cell proliferation and migration. Overactivation of nuclear factor erythroid 2-like 2 (NFE2L2; NRF2) in cancers has been associated with facilitated tumor growth and therapy resistance; however, role in cancer migration ha...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01298-z
更新日期:2020-12-01 00:00:00
abstract::The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular-organ interaction is a key mechanism and a concept that enables an understanding of all biological phenomena and normal physiology that is essential for human survival under pathological conditions. Recently, vascular endothelia...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-020-01287-2
更新日期:2020-11-23 00:00:00
abstract::Losartan has been shown to be a substrate of the drug-efflux transporter MDR1, encoded by the ABCB1 gene. ABCB1 c.2677G>T and c.3435C>T variants are known to be associated with reduced expression and function of P-glycoprotein (P-gp). We investigated the effects of ABCB1 diplotype on the pharmacokinetics of losartan. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01294-3
更新日期:2020-11-01 00:00:00
abstract::Zolpidem, a widely prescribed hypnotic agent, is extensively metabolized by cytochrome P450 (CYP) 3A4, and CYP2C9, CYP1A2 and CYP2D6 are also involved in the metabolism of zolpidem. The aim of the study was to investigate the effects of CYP2D6 genotypes on the exposure of zolpidem. The healthy male volunteers were div...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01250-1
更新日期:2020-09-01 00:00:00
abstract::Genome editing is a useful tool in basic and clinical research. Among the several approaches used in genome editing, the CRISPR-Cas9 system using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) along with a guide RNA has been developed recently. The CRISPR/Cas9...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01226-1
更新日期:2020-06-01 00:00:00
abstract::Curcumin derivatives have been shown to inhibit replication of human influenza A viruses (IAVs). However, it is not clear whether curcumin and its derivatives can inhibit neuraminidase (NA) of influenza virus. In this study, a meaningful 3D quantitative structure-activity relationship model (comparative molecular fiel...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01230-5
更新日期:2020-05-01 00:00:00
abstract::Gymnopilus junonius (Fr.) P. D. Orton (Cortinariaceae) is a hallucinogenic mushroom, a well-known poisonous mushroom that is widely known as "big laughter mushroom" because it causes excessive laughter in those who consume it. Chemical investigation of G. junonius fruiting bodies was performed, resulting in the isolat...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01213-6
更新日期:2020-02-01 00:00:00
abstract::Preeclampsia is an inflammatory disease which can induce oxidative stress in placenta. Oxidative stress in preeclampsia is regulated by the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. Mangiferin, an anti-oxidative molecule, is reported to ameliorate oxidative stress in the ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-020-01220-7
更新日期:2020-02-01 00:00:00
abstract::In this study, we investigated the synergistic effect of L-buthionine sulfoximine (BSO) on the chlorin e6 (Ce6)-based photodynamic therapy (PDT) of cancer cells. Among various cancer cells, HCT116 cells have highest intracellular L-glutathione (GSH) level and SNU478 cells showed the lowest GSH level. BSO alone showed ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-019-01179-0
更新日期:2019-11-01 00:00:00
abstract::Isoorientin (ISO) is considered one of the most important flavonoids with various pharmacological effects such as antioxidant, anti-inflammatory, and anti-cancer activities. Despite these beneficial activities, the effects of ISO on learning and memory have not been investigated so far. The current study evaluated the...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-019-01172-7
更新日期:2019-08-01 00:00:00
abstract::Asymmetric distribution of phospholipids across the plasma membrane is a unique characteristic of eukaryotic cells. Phosphatidylcholine and sphingomyelin are exposed in the outer leaflet, and phosphatidylserine (PS) is predominantly located in the inner leaflet. Redistribution of PS to the cell surface can be observed...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01167-4
更新日期:2019-07-01 00:00:00
abstract::Cancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer. Among diverse immune populations, invariant natural killer T (iNKT) cells have shown potent antitumor activity by linking innate and adaptive immune systems. Upon activation by lipid antigens on CD1d molecules, iNKT cells rapidly pr...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01139-8
更新日期:2019-07-01 00:00:00
abstract::Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation that accompanies brain damage in neurodegenerative diseases. In Parkinson's disease (PD), dopaminergic neuronal loss is accompanied by inflammatory changes in microglia, astrocytes, innate immune cells, and infiltrating periph...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01133-0
更新日期:2019-05-01 00:00:00
abstract::Five isocoumarin derivatives including three new compounds, aspergisocoumrins A-C (1-3), together with two known analogues, 8-dihydroxyisocoumarin-3-carboxylic acid (4) and dichlorodiaportin (5) were obtained from the culture of the endophytic fungus Aspergillus sp. HN15-5D derived from the fresh leaves of the mangrov...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1019-1
更新日期:2019-04-01 00:00:00
abstract::Sphingolipid metabolism plays an important role in determining the fate of a cell. Among several sphingolipid metabolites, ceramide is a key player in intracellular signal transduction. Ceramide is usually converted to various metabolites such as sphingomyelin, sphingosine, ceramide-1-phosphate, and glucosylceramide. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01114-3
更新日期:2019-03-01 00:00:00
abstract::Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortal...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01130-3
更新日期:2019-03-01 00:00:00
abstract::Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targe...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-019-01125-0
更新日期:2019-02-01 00:00:00
abstract::In efforts to develop effective anticancer therapeutics with greater selectivity toward cancerous cell and reduced side-effects, such as emetic effects due to detrimental action of the drug toward the intestinal flora, a series of linear diarylheptanoids (LDHs) were designed and synthesized in 7 steps with good-to-mod...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1004-8
更新日期:2018-12-01 00:00:00
abstract::Sepsis is a clinical syndrome with no effective protective or therapeutic treatments. Acacetin, a natural flavonoid compound, has anti-oxidative and anti-inflammatory effects which can potentially work to reduce sepsis. We investigated the potential protective effect of acacetin on sepsis-induced acute lung injury (AL...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0991-1
更新日期:2018-12-01 00:00:00
abstract::Diterpenoids are important and widely distributed natural compounds with various biological effects, including antitumor, anti-inflammatory and so on. Great efforts have been put in phytochemistry research on diterpenoids. A number of structural modified derivatives and pharmacophore incorporated hybrids were also des...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-018-1078-3
更新日期:2018-11-01 00:00:00
abstract::Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder, is associated with various factors, including lifestyle, infection, stress, intestinal flora, and related diseases. The pharmacotherapeutic stimulation of receptors and downstream signaling pathways is effective in reducing IBS symptoms; however,...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-018-1068-5
更新日期:2018-10-01 00:00:00
abstract::Toxicarioside N (Tox N), a natural product extract from Antiaris toxicaria, has been reported to induce apoptosis in human gastric cancer cells. However, the mechanism and actual role of autophagy in Tox N-induced apoptosis of human gastric cancer cells remains poorly understood. In the current study, we demonstrated ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1049-8
更新日期:2018-10-01 00:00:00
abstract::Unfortunately, there are some errors in Fig. 1b and Fig. 3a of the article. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12272-018-1073-8
更新日期:2018-09-01 00:00:00
abstract::We regret that there is an error in the labeling of Fig. 4 of the published original article. The concentration of MPP+ should be corrected to 1.0 mM instead of 0.5 mM. The corrected figure should be. ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12272-018-1072-9
更新日期:2018-09-01 00:00:00
abstract::Cytochrome P450 (CYP) 2D6 is present in less than about 2% of all CYP enzymes in the liver, but it is involved in the metabolism of about 25% of currently used drugs. CYP2D6 is the most polymorphic among the CYP enzymes. We determined alleles and genotypes of CYP2D6 in 3417 Koreans, compared the frequencies of CYP2D6 ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1075-6
更新日期:2018-09-01 00:00:00
abstract::Zolpidem is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C9, CYP1A2, CYP2D6 and CYP2C19. The aim of this study was to identify the effects of CYP2C9*3 allele on the pharmacokinetics of zolpidem. Healthy male subjects were divided into two genotype groups, CYP2C9*1/*1 and CYP2C9*1/*3. They receive...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1070-y
更新日期:2018-09-01 00:00:00
abstract::Rufinamide (RUF) is a structurally unique anti-epileptic drug, used in the treatment of seizure disorders such as Lennox-Gastaut syndrome. In the present study, we investigated whether RUF protected against excitotoxic neuronal damage in the mouse hippocampal CA3 region after intraperitoneal kainic acid (KA) injection...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1043-1
更新日期:2018-07-01 00:00:00
abstract::In the present study, we investigated the anti-Alzheimer's disease (AD) potential of six dihydroxanthyletin-type coumarins, 4'-hydroxy Pd-C-III (1), decursidin (2), Pd-C-I (3), 4'-methoxy Pd-C-I (4), Pd-C-II (5), and Pd-C-III (6) from Angelica decursiva by evaluating their ability to inhibit acetylcholinesterase (AChE...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1056-9
更新日期:2018-07-01 00:00:00
abstract::Sanguisorba officinalis L. (Rosaceae) is a perennial herbaceous plant and its roots have been used as an important astringent medicine in Eastern Asian countries over many thousand years. In this phytochemical research, 23 compounds (1-23) were isolated from the roots of S. officinalis. Their chemical structures were ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1035-1
更新日期:2018-05-01 00:00:00
abstract::Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB's carboxylic acid using conventional amidation protocols is often problematic. We discovered that an amidation protocol utilizing methyl Boc-aminoisobu...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-018-1009-3
更新日期:2018-03-01 00:00:00
abstract::Alantolactone is a sesquiterpene lactone isolated from Inula helenium L. Although alantolactone possesses anti-inflammation and apoptosis-induction activities, the underlying mechanism of anti-cancer effect on human breast cancer cells remains largely unknown. In this study, we explored the possibility of alantolacton...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0990-2
更新日期:2018-03-01 00:00:00
abstract::Five new pyrazin-2(1H)-one derivatives, ochramides A-D (1-4) and ochralate A (5), as well as three known analogues (6-8) were isolated from the fermentation broth of the marine coral-derived halotolerant Aspergillus ochraceus LCJ11-102 in a nutrient-limited medium containing 10% NaI. Their chemical structures were det...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0928-8
更新日期:2018-02-01 00:00:00
abstract::The formation of advanced glycation end-products (AGE) and aldose reductase activity have been implicated in the development of diabetic complications. The present study was aimed to evaluate human recombinant aldose reductase (HRAR) and AGE inhibitory activity of seven natural dihydroxanthyletin-type coumarins, 4-hyd...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0999-6
更新日期:2018-02-01 00:00:00
abstract::Bromodomain-containing protein 4 (BRD4) is known to regulate the expression of c-Myc to control the proliferation of cancer cells. Therefore, development of small-molecule inhibitors targeting the bromodomain has been widely studied. However, some clinical trials on BRD4 inhibitors have shown its drawbacks such as tox...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0978-y
更新日期:2018-01-01 00:00:00
abstract::Ten caffeic acid derivatives (1-10) were isolated from the roots of Salvia miltiorrhiza by using various chromatographic methods and their chemical structures were spectroscopically elucidated. The absolute configurations of chiral centers were determined by comparison with reported coupling constants, optical rotatio...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0983-1
更新日期:2018-01-01 00:00:00
abstract::The intestinal mucosa and liver have long been considered as the main sites of drug metabolism, and the contribution of gut microbiota to drug metabolism has been under-estimated. However, it is now generally accepted that the gut microbiota plays an important role in drug metabolism prior to drug absorption or during...
journal_title:Archives of pharmacal research
pub_type: 杂志文章,评审
doi:10.1007/s12272-017-0986-y
更新日期:2017-12-01 00:00:00
abstract::Platycodon grandiflorum root is a traditional medicine and food material rich in triterpenoid saponins. Its major constituent, platycodin D (PD), is known to have various pharmacological properties, but processing methods may influence the PD content. In this study, a fully validated HPLC-ELSD method was developed for...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0946-6
更新日期:2017-09-01 00:00:00
abstract::Capillary zone electrophoresis was successfully applied to the enantiomeric purity determination of dexlansoprazole using sulfobutyl ether-β-cyclodextrin and methyl-β-cyclodextrin as chiral selectors. Separations were carried out in a 50 μm, 64/56 cm fused-silica capillary. The optimized conditions included 90 mM phos...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0936-8
更新日期:2017-08-01 00:00:00
abstract::G-protein-coupled receptor 119 (GPR119) represents a promising target for the treatment of type 2 diabetes as it can increase both GLP-1 secretion from intestinal L cells and glucose-stimulated insulin secretion (GSIS) from pancreatic β cells. Due to this dual mechanism of action, the development of small molecule GPR...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0925-y
更新日期:2017-06-01 00:00:00
abstract::We previously reported a de novo design of antimicrobial heptapeptide helices using Verdine's all-hydrocarbon peptide stapling system. One of the important structure-activity relationships we found from these previous studies was that extending of the hydrophobic face by replacing of alanine with leucine in positon 5 ...
journal_title:Archives of pharmacal research
pub_type: 杂志文章
doi:10.1007/s12272-017-0922-1
更新日期:2017-06-01 00:00:00