听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Annual Review of Pharmacology and Toxicology期刊下所有文献
  • Hormonal Signaling Actions on Kv7.1 (KCNQ1) Channels.

    abstract::Kv7 channels (Kv7.1-7.5) are voltage-gated K+ channels that can be modulated by five β-subunits (KCNE1-5). Kv7.1-KCNE1 channels produce the slow-delayed rectifying K+ current, IKs, which is important during the repolarization phase of the cardiac action potential. Kv7.2-7.5 are predominantly neuronally expressed and c...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章

    doi:10.1146/annurev-pharmtox-010919-023645

    authors: Thompson E,Eldstrom J,Fedida D

    更新日期:2021-01-06 00:00:00

  • Mechanism of Action of TiO2: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential.

    abstract::The Risk Assessment Committee of the European Chemicals Agency issued an opinion on classifying titanium dioxide (TiO2) as a suspected human carcinogen upon inhalation. Recent animal studies indicate that TiO2 may be carcinogenic through the oral route. There is considerable uncertainty on the carcinogenicity of TiO2,...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章

    doi:10.1146/annurev-pharmtox-101419-100049

    authors: Braakhuis HM,Gosens I,Heringa MB,Oomen AG,Vandebriel RJ,Groenewold M,Cassee FR

    更新日期:2021-01-06 00:00:00

  • Use of Model-Informed Drug Development to Streamline Development of Long-Acting Products: Can These Successes Be Translated to Long-Acting Hormonal Contraceptives?

    abstract::Long-acting contraceptives are the most effective reversible contraceptive methods. Increasing patients' access to these contraceptives may translate into fewer unintended pregnancies and lead to substantial individual and public health benefits. However, development of long-acting products can be complex and challeng...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章

    doi:10.1146/annurev-pharmtox-031120-015212

    authors: Li L,Tran D,Zhu H,Balimane P,Willett G,Zhao P,Gerrard SE,Vogelsong KM,Wang Y,Seo SK

    更新日期:2021-01-06 00:00:00

  • Arsenic: A Global Environmental Challenge.

    abstract::Arsenic is a naturally occurring metalloid and one of the few metals that can be metabolized inside the human body. The pervasive presence of arsenic in nature and anthropogenic sources from agricultural and medical use have perpetuated human exposure to this toxic and carcinogenic element. Highly exposed individuals ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章

    doi:10.1146/annurev-pharmtox-030220-013418

    authors: Chen QY,Costa M

    更新日期:2021-01-06 00:00:00

  • Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics.

    abstract::Oral vaccination enables pain-free and self-administrable vaccine delivery for rapid mass vaccination during pandemic outbreaks. Furthermore, it elicits systemic and mucosal immune responses. This protects against infection at mucosal surfaces, which may further enhance protection and minimize the spread of disease. T...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章

    doi:10.1146/annurev-pharmtox-030320-092348

    authors: Coffey JW,Gaiha GD,Traverso G

    更新日期:2021-01-06 00:00:00

  • Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.

    abstract::The promise of drug repurposing is to accelerate the translation of knowledge to treatment of human disease, bypassing common challenges associated with drug development to be more time- and cost-efficient. Repurposing has an increased chance of success due to the previous validation of drug safety and allows for the ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010919-023537

    authors: Pulley JM,Rhoads JP,Jerome RN,Challa AP,Erreger KB,Joly MM,Lavieri RR,Perry KE,Zaleski NM,Shirey-Rice JK,Aronoff DM

    更新日期:2020-01-06 00:00:00

  • Retinal Pigment Epithelium Replacement Therapy for Age-Related Macular Degeneration: Are We There Yet?

    abstract::Pluripotent stem cells (PSCs) are a potential replacement tissue source for degenerative diseases. Age-related macular degeneration (AMD) is a blinding disease triggered by degeneration of the retinal pigment epithelium (RPE), a monolayer tissue that functionally supports retinal photoreceptors. Recently published cli...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010919-023245

    authors: Sharma R,Bose D,Maminishkis A,Bharti K

    更新日期:2020-01-06 00:00:00

  • Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development.

    abstract::Electron cryo-microscopy (cryo-EM) has revolutionized structure determination of membrane proteins and holds great potential for structure-based drug discovery. Here we discuss the potential of cryo-EM in the rational design of therapeutics for membrane proteins compared to X-ray crystallography. We also detail recent...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010919-023545

    authors: García-Nafría J,Tate CG

    更新日期:2020-01-06 00:00:00

  • Lipid-Dependent Regulation of Ion Channels and G Protein-Coupled Receptors: Insights from Structures and Simulations.

    abstract::Ion channels and G protein-coupled receptors (GPCRs) are regulated by lipids in their membrane environment. Structural studies combined with biophysical and molecular simulation investigations reveal interaction sites for specific lipids on membrane protein structures. For K channels, PIP2 plays a key role in regulati...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010919-023411

    authors: Duncan AL,Song W,Sansom MSP

    更新日期:2020-01-06 00:00:00

  • Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning.

    abstract::Organophosphorus insecticide self-poisoning is a major global health problem, killing over 100,000 people annually. It is a complex multi-organ condition, involving the inhibition of cholinesterases, and perhaps other enzymes, and the effects of large doses of ingested solvents. Variability between organophosphorus in...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010818-021842

    authors: Eddleston M

    更新日期:2019-01-06 00:00:00

  • Therapeutic Oligonucleotides: State of the Art.

    abstract::Oligonucleotides (ONs) can interfere with biomolecules representing the entire extended central dogma. Antisense gapmer, steric block, splice-switching ONs, and short interfering RNA drugs have been successfully developed. Moreover, antagomirs (antimicroRNAs), microRNA mimics, aptamers, DNA decoys, DNAzymes, synthetic...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010818-021050

    authors: Smith CIE,Zain R

    更新日期:2019-01-06 00:00:00

  • Introduction to the Theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development".

    abstract::The theme "New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development" links 13 articles in this volume of the Annual Review of Pharmacology and Toxicology (ARPT). The engaging prefatory articles by Arthur Cho and Robert Lefkowitz set the stage for this theme and for the revie...

    journal_title:Annual review of pharmacology and toxicology

    pub_type:

    doi:10.1146/annurev-pharmtox-092617-121952

    authors: Insel PA,Amara SG,Blaschke TF,Meyer UA

    更新日期:2018-01-06 00:00:00

  • The Conducted Vasomotor Response: Function, Biophysical Basis, and Pharmacological Control.

    abstract::Arterial tone is coordinated among vessel segments to optimize nutrient transport and organ function. Coordinated vasomotor activity is remarkable to observe and depends on stimuli, sparsely generated in tissue, eliciting electrical responses that conduct lengthwise among electrically coupled vascular cells. The condu...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010617-052623

    authors: Welsh DG,Tran CHT,Hald BO,Sancho M

    更新日期:2018-01-06 00:00:00

  • Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems.

    abstract::Billions of US dollars are invested every year by the pharmaceutical industry in drug development, with the aim of introducing new drugs that are effective and have minimal side effects. Thirty percent of in-pipeline drugs are excluded in an early phase of preclinical and clinical screening owing to cardiovascular saf...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010617-053110

    authors: Magdy T,Schuldt AJT,Wu JC,Bernstein D,Burridge PW

    更新日期:2018-01-06 00:00:00

  • Pharmacology of Antisense Drugs.

    abstract::Recent studies have led to a greater appreciation of the diverse roles RNAs play in maintaining normal cellular function and how they contribute to disease pathology, broadening the number of potential therapeutic targets. Antisense oligonucleotides are the most direct means to target RNA in a selective manner and hav...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010716-104846

    authors: Bennett CF,Baker BF,Pham N,Swayze E,Geary RS

    更新日期:2017-01-06 00:00:00

  • Introduction to the Theme "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology".

    abstract::Major advances in scientific discovery and insights can result from the development and use of new techniques, as exemplified by the work of Solomon Snyder, who writes a prefatory article in this volume. The Editors have chosen "New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology" as the Theme ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type:

    doi:10.1146/annurev-pharmtox-091616-023708

    authors: Insel PA,Amara SG,Blaschke TF,Meyer UA

    更新日期:2017-01-06 00:00:00

  • Organophosphorus Xenobiotic Toxicology.

    abstract::Originally, organophosphorus (OP) toxicology consisted of acetylcholinesterase inhibition by insecticides and chemical threat agents acting as phosphorylating agents for serine in the catalytic triad, but this is no longer the case. Other serine hydrolases can be secondary OP targets, depending on the OP structure, an...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010716-104926

    authors: Casida JE

    更新日期:2017-01-06 00:00:00

  • A Life of Neurotransmitters.

    abstract::Development of scientific creativity is often tied closely to mentorship. In my case, two years with Julius Axelrod, the sum total of my research training, was transformative. My mentoring generations of graduate students and postdoctoral fellows has been as nurturing for me as it has been for them. Work in our lab ov...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 历史文章,杂志文章

    doi:10.1146/annurev-pharmtox-010716-104511

    authors: Snyder SH

    更新日期:2017-01-06 00:00:00

  • Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

    abstract::Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in cell differentiation, development, proliferation, and metabolism and are associated with numerous liver pathologies such as cancer, steatosis, inflammation, fibrosis, cholestasis, and xenobiotic/drug-induced liver injury. The ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010715-103209

    authors: Rudraiah S,Zhang X,Wang L

    更新日期:2016-01-01 00:00:00

  • Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy.

    abstract::Research spanning (genetically engineered) animal models, healthy volunteers, and sleep-disordered patients has identified the neurotransmitters and neuromodulators dopamine, serotonin, norepinephrine, histamine, hypocretin, melatonin, glutamate, acetylcholine, γ-amino-butyric acid, and adenosine as important players ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010715-103801

    authors: Holst SC,Valomon A,Landolt HP

    更新日期:2016-01-01 00:00:00

  • Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.

    abstract::Human syndromes and mouse mutants that exhibit accelerated but bona fide aging in multiple organs and tissues have been invaluable for the identification of nine denominators of aging: telomere attrition, genome instability, epigenetic alterations, mitochondrial dysfunction, deregulated nutrient sensing, altered inter...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010814-124316

    authors: Vermeij WP,Hoeijmakers JH,Pothof J

    更新日期:2016-01-01 00:00:00

  • Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

    abstract::γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved in many physiological processes. Their clinical relevance comes from their involvement in Alzheimer's disease, cancer, and other disorders. A clinical trial with the wide-spectrum γ-secretase inhibitor semagacestat has, however, de...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010814-124309

    authors: De Strooper B,Chávez Gutiérrez L

    更新日期:2015-01-01 00:00:00

  • The ethics and economics of pharmaceutical pricing.

    abstract::The cost of drugs is a major and rapidly rising component of health-care expenditures. We survey recent literature on the ethics and economics of skyrocketing pharmaceutical prices and find that advances in economic research have increased the sharpness and focus of the ethically based calls to increase access by modi...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010814-124649

    authors: Parker-Lue S,Santoro M,Koski G

    更新日期:2015-01-01 00:00:00

  • DNA methylation and its implications and accessibility for neuropsychiatric therapeutics.

    abstract::In this review, we discuss the potential pharmacological targeting of a set of powerful epigenetic mechanisms: DNA methylation control systems in the central nervous system (CNS). Specifically, we focus on the possible use of these targets for novel future treatments for learning and memory disorders. We first describ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010814-124527

    authors: Day JJ,Kennedy AJ,Sweatt JD

    更新日期:2015-01-01 00:00:00

  • Environmental toxins and Parkinson's disease.

    abstract::Parkinson's disease (PD) is a chronic, progressive, disabling neurodegenerative disorder that begins in mid to late life and is characterized by motor impairment, autonomic dysfunction, and, in many, psychological and cognitive changes. Recent advances have helped delineate pathogenetic mechanisms, yet the cause of PD...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-011613-135937

    authors: Goldman SM

    更新日期:2014-01-01 00:00:00

  • Drugs for allosteric sites on receptors.

    abstract::The presence of druggable, topographically distinct allosteric sites on a wide range of receptor families has offered new paradigms for small molecules to modulate receptor function. Moreover, ligands that target allosteric sites offer significant advantages over the corresponding orthosteric ligands in terms of selec...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010611-134525

    authors: Wenthur CJ,Gentry PR,Mathews TP,Lindsley CW

    更新日期:2014-01-01 00:00:00

  • Chronopharmacology: new insights and therapeutic implications.

    abstract::Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that many aspects of pharmacology and toxicology also oscillate according to the same 24-h clocks. Daily oscillations in abundance of proteins necessary for either drug...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-011613-135923

    authors: Dallmann R,Brown SA,Gachon F

    更新日期:2014-01-01 00:00:00

  • Autophagy in toxicology: cause or consequence?

    abstract::Research on autophagy and its effects on cell metabolism and physiology has increased dramatically during recent years. Multiple forms of autophagy have been characterized, and many of the genes involved in the regulation of this process have been identified. The importance of autophagy for embryonic development and m...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-011112-140210

    authors: Orrenius S,Kaminskyy VO,Zhivotovsky B

    更新日期:2013-01-01 00:00:00

  • Hepatic and intestinal drug transporters: prediction of pharmacokinetic effects caused by drug-drug interactions and genetic polymorphisms.

    abstract::Recent studies of membrane transporters have revealed their importance in determining the pharmacokinetics of transporter substrates. When drug-drug interactions (DDIs) or genetic polymorphisms (i.e., pharmacogenetics) affect the activities of transporters, the pharmacokinetics of transporter substrate drugs is altere...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-011112-140309

    authors: Yoshida K,Maeda K,Sugiyama Y

    更新日期:2013-01-01 00:00:00

  • The potential of HDAC inhibitors as cognitive enhancers.

    abstract::Histone acetylation is a prominent epigenetic modification of the central nervous system that is unequivocally associated with an increase in the rate of gene transcription. Because gene transcription, in turn, plays an important role in long-lasting forms of memory, histone acetylation generally favors long-term memo...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-011112-140216

    authors: Gräff J,Tsai LH

    更新日期:2013-01-01 00:00:00

  • Systems pharmacology: network analysis to identify multiscale mechanisms of drug action.

    abstract::Systems approaches have long been used in pharmacology to understand drug action at the organ and organismal levels. The application of computational and experimental systems biology approaches to pharmacology allows us to expand the definition of systems pharmacology to include network analyses at multiple scales of ...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010611-134520

    authors: Zhao S,Iyengar R

    更新日期:2012-01-01 00:00:00

  • Drug transporters in drug efficacy and toxicity.

    abstract::Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or enviro...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-pharmtox-010611-134529

    authors: DeGorter MK,Xia CQ,Yang JJ,Kim RB

    更新日期:2012-01-01 00:00:00

  • The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.

    abstract::The RNA polymerase I (Pol I) transcription machinery in the nucleolus is the key convergence point that collects and integrates a vast array of information from cellular signaling cascades to regulate ribosome production that in turn guides cell growth and proliferation. Cancer cells commonly harbor mutations that ina...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.010909.105844

    authors: Drygin D,Rice WG,Grummt I

    更新日期:2010-01-01 00:00:00

  • Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy.

    abstract::The renin-angiotensin-aldosterone system is one of the most important systems in cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is already a very successful drug target for the therapy of these diseases. However, angiotensins are generated not only in the plasma but also local...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.010909.105610

    authors: Bader M

    更新日期:2010-01-01 00:00:00

  • Sorting out astrocyte physiology from pharmacology.

    abstract::A number of exciting findings have been made in astrocytes during the past 15 years that have led many researchers to redefine how the brain works. Astrocytes are now widely regarded as cells that propagate Ca(2+) over long distances in response to stimulation, and, similar to neurons, release transmitters (called gli...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.011008.145602

    authors: Fiacco TA,Agulhon C,McCarthy KD

    更新日期:2009-01-01 00:00:00

  • Topical microbicides to prevent HIV: clinical drug development challenges.

    abstract::Microbicides, substances applied topically to prevent sexual HIV infection, are needed to empower receptive sexual partners with effective prevention methods. Several large microbicide trials, however, failed to demonstrate efficacy, thus motivating a reevaluation of the current microbicide development paradigm, which...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.48.113006.094906

    authors: Hendrix CW,Cao YJ,Fuchs EJ

    更新日期:2009-01-01 00:00:00

  • The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations.

    abstract::The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of seque...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.48.113006.094928

    authors: Birnbaumer L

    更新日期:2009-01-01 00:00:00

  • Caveolae as organizers of pharmacologically relevant signal transduction molecules.

    abstract::Caveolae, a subset of membrane (lipid) rafts, are flask-like invaginations of the plasma membrane that contain caveolin proteins, which serve as organizing centers for cellular signal transduction. Caveolins (-1, -2, and -3) have cytoplasmic N and C termini, palmitolylation sites, and a scaffolding domain that facilit...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.48.121506.124841

    authors: Patel HH,Murray F,Insel PA

    更新日期:2008-01-01 00:00:00

  • Apoptosis signal-regulating kinase 1 in stress and immune response.

    abstract::Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. ASK1 is preferentially activated by various cytotoxic stressors and plays pivotal roles in a wide variety of cellular response to them. Recent analyses of A...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.48.113006.094606

    authors: Takeda K,Noguchi T,Naguro I,Ichijo H

    更新日期:2008-01-01 00:00:00

  • G protein-coupled receptor sorting to endosomes and lysosomes.

    abstract::The heptahelical G protein-coupled receptors (GPCRs) belong to the largest family of cell surface signaling receptors encoded in the human genome. GPCRs signal to diverse extracellular stimuli and control a vast number of physiological responses, making this receptor class the target of nearly half the drugs currently...

    journal_title:Annual review of pharmacology and toxicology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.pharmtox.48.113006.094646

    authors: Marchese A,Paing MM,Temple BR,Trejo J

    更新日期:2008-01-01 00:00:00

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