解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
康复学
生殖生物学
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风湿病学
运动科学
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热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In response to muscle injury, muscle stem cells integrate environmental cues in the damaged tissue to mediate regeneration. These environmental cues are tightly regulated to ensure expansion of muscle stem cell population to repair the damaged myofibers while allowing repopulation of the stem cell niche. These changes...
journal_title:Skeletal muscle
pub_type: 杂志文章,评审
doi:10.1186/s13395-020-00259-w
更新日期:2021-01-11 00:00:00
abstract::Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which is a requirement for...
journal_title:Skeletal muscle
pub_type: 杂志文章,评审
doi:10.1186/s13395-020-00258-x
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Nonsense or loss-of-function mutations in the non-lysosomal cysteine protease calpain-3 result in limb-girdle muscular dystrophy type 2A (LGMD2A). While calpain-3 is implicated in muscle cell differentiation, sarcomere formation, and muscle cytoskeletal remodeling, the physiological basis for LGMD2A has rema...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-020-00254-1
更新日期:2020-12-11 00:00:00
abstract::The nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as a master cytoprotective factor regulating the expression of genes encoding anti-oxidant, anti-inflammatory, and detoxifying proteins. The role of Nrf2 in the pathophysiology of skeletal muscles has been evaluated in different experimental models, ...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-020-00255-0
更新日期:2020-12-08 00:00:00
abstract:BACKGROUND:Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the incidence or mitigate the consequences of repetitive mechanical insults...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-020-00249-y
更新日期:2020-10-22 00:00:00
abstract:BACKGROUND:Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by mutations in the dystrophin gene. Loss of dystrophin prevents the formation of a critical connection between the muscle cell membrane and the extracellular matrix. Overexpression of sarcospan (SSPN) in the mouse model of DMD restore...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-020-00244-3
更新日期:2020-09-18 00:00:00
abstract::Following the publication of this paper [1], it was brought to the authors' attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight. In this correction paper, they have included Dr. Paola Tonino in the author list section. ...
journal_title:Skeletal muscle
pub_type: 已发布勘误
doi:10.1186/s13395-020-00223-8
更新日期:2020-04-20 00:00:00
abstract:BACKGROUND:Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active glucocorticoids, but the wider understanding of H6PD in ER/SR NAD(P...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-019-0216-z
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its binding to extracellular glycosaminoglycans (GAG) by modulating its presentation to its receptors an...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-019-0210-5
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via a unique heteropolysaccharide [-GlcA-beta1,3-Xyl-alpha1,3-]n called matriglycan. Changes in expressi...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-019-0195-0
更新日期:2019-05-04 00:00:00
abstract:BACKGROUND:Critical illness myopathy (CIM) is associated with severe skeletal muscle wasting and impaired function in intensive care unit (ICU) patients. The mechanisms underlying CIM remain incompletely understood. To elucidate the biological activities occurring at the transcriptional level in the skeletal muscle of ...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-019-0194-1
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstrated that Pak1 and Pak2 function redundantly to promote skeletal myoblast differentiation during pos...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-019-0191-4
更新日期:2019-02-21 00:00:00
abstract:BACKGROUND:Satellite cells are residential muscle stem cells that express a paired box protein, PAX7. RESULTS:Here, we report a knock-in mouse line expressing a PAX7-enhanced yellow fluorescent protein (YFP) fusion protein that enables visualization of PAX7 protein dynamics in living satellite cells through YFP fluore...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-018-0174-x
更新日期:2018-08-24 00:00:00
abstract:BACKGROUND:Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immunostained skeletal muscle. Muscle cross-sectional area, fiber typing, localization of nuclei within t...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-018-0171-0
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:Transport protein particle (TRAPP) is a supramolecular protein complex that functions in localizing proteins to the Golgi compartment. The TRAPPC11 subunit has been implicated in muscle disease by virtue of homozygous and compound heterozygous deleterious mutations being identified in individuals with limb g...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-018-0163-0
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:A low-protein diet supplemented with ketoacids (LPD + KA) maintains the nutritional status of patients with chronic kidney disease (CKD). Oxidative damage and mitochondrial dysfunction associated with the upregulation of p66SHC and FoxO3a have been shown to contribute to muscle atrophy. This study aimed to d...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-018-0164-z
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:Due to the post-mitotic nature of myonuclei, postnatal myogenesis is essential for skeletal muscle growth, repair, and regeneration. This process is facilitated by satellite cells through proliferation, differentiation, and subsequent fusion with a pre-existing muscle fiber (i.e., myonuclear accretion). Curr...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-018-0151-4
更新日期:2018-02-14 00:00:00
abstract:BACKGROUND:Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog DUX4c are induced. DUX4c is immunodetected in every myonucleus of proliferative cells, while DUX4 is present in only 1/1000 of myonuclei where it initi...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-017-0148-4
更新日期:2018-01-12 00:00:00
abstract::Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the DMD gene and loss of the protein dystrophin. The absence of dystrophin leads to myofiber membrane fragility and necrosis, with eventual muscle atrophy and contractures. Affected boys typically die in their second or third decade due to...
journal_title:Skeletal muscle
pub_type: 杂志文章,评审
doi:10.1186/s13395-017-0124-z
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:shRNA lentiviral vectors are extensively used for gene knockdowns in mammalian cells, and non-target shRNAs typically are considered the proper experimental control for general changes caused by RNAi. However, the effects of non-target lentivirus controls on the modulation of cell signaling pathways remain l...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-017-0125-y
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production in muscle, whereas t...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-017-0123-0
更新日期:2017-04-10 00:00:00
abstract:BACKGROUND:The spatial organization of eukaryotic genomes facilitates and reflects the underlying nuclear processes that are occurring in the cell. As such, the spatial organization of a genome represents a window on the genome biology that enables analysis of the nuclear regulatory processes that contribute to mammali...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-017-0122-1
更新日期:2017-04-05 00:00:00
abstract:BACKGROUND:Large-scale expansion of myogenic progenitors is necessary to support the development of high-throughput cellular assays in vitro and to advance genetic engineering approaches necessary to develop cellular therapies for rare muscle diseases. However, optimization has not been performed in order to maintain t...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-016-0116-4
更新日期:2016-12-13 00:00:00
abstract:BACKGROUND:hTERT/cdk4 immortalized myogenic human cell lines represent an important tool for skeletal muscle research, being used as therapeutically pertinent models of various neuromuscular disorders and in numerous fundamental studies of muscle cell function. However, the cell cycle is linked to other cellular proces...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-016-0115-5
更新日期:2016-12-08 00:00:00
abstract::The circadian oscillations of muscle genes are controlled either directly by the intrinsic muscle clock or by extrinsic factors, such as feeding, hormonal signals, or neural influences, which are in turn regulated by the central pacemaker, the suprachiasmatic nucleus of the hypothalamus. A unique feature of circadian ...
journal_title:Skeletal muscle
pub_type: 杂志文章,评审
doi:10.1186/s13395-016-0107-5
更新日期:2016-10-13 00:00:00
abstract:BACKGROUND:Abnormal branched myofibers within skeletal muscles are commonly found in diverse animal models of muscular dystrophy as well as in patients. Branched myofibers from dystrophic mice are more susceptible to break than unbranched myofibers suggesting that muscles containing a high percentage of these myofibers...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-016-0077-7
更新日期:2016-01-21 00:00:00
abstract:BACKGROUND:Gene therapy strategies are promising therapeutic options for monogenic muscular dystrophies, with several currently underways. The adeno-associated viral (AAV) vector is among the most effective gene delivery systems. However, transduction efficiency in skeletal muscles varies between AAV serotypes, with th...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-015-0064-4
更新日期:2015-11-10 00:00:00
abstract:BACKGROUND:Interleukin 15 (IL-15) is thought to be abundant in the skeletal muscle under steady state conditions based on RNA expression; however, the IL-15 RNA level may not reflect the protein level due to post-transcriptional regulation. Although exogenous protein treatment and overexpression studies indicated IL-15...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-015-0058-2
更新日期:2015-09-28 00:00:00
abstract:BACKGROUND:Although excitation-contraction (EC) coupling in skeletal muscle relies on physical activation of the skeletal ryanodine receptor (RyR1) Ca(2+) release channel by dihydropyridine receptors (DHPRs), the activation pathway between the DHPR and RyR1 remains unknown. However, the pathway includes the DHPR β1a su...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-015-0049-3
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Ca(2+) influx through CaV1.1 is not required for skeletal muscle excitation-contraction coupling, but whether Ca(2+) permeation through CaV1.1 during sustained muscle activity plays a functional role in mammalian skeletal muscle has not been assessed. METHODS:We generated a mouse with a Ca(2+) binding and/o...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/s13395-014-0027-1
更新日期:2015-01-29 00:00:00
abstract:BACKGROUND:Muscle hypertrophy in the mdx mouse model of Duchenne muscular dystrophy (DMD) can partially compensate for the loss of dystrophin by maintaining peak force production. Histopathology examination of the hypertrophic muscles suggests the hypertrophy primarily results from the addition of myofibers, and is acc...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/2044-5040-4-10
更新日期:2014-05-23 00:00:00
abstract:: In skeletal muscle, the excitation-contraction (EC) coupling machinery mediates the translation of the action potential transmitted by the nerve into intracellular calcium release and muscle contraction. EC coupling requires a highly specialized membranous structure, the triad, composed of a central T-tubule surround...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/2044-5040-1-26
更新日期:2011-07-13 00:00:00
abstract::Muscular dystrophies are a large heterogeneous group of inherited diseases that cause progressive muscle weakness and permanent muscle damage. Very few muscular dystrophies show sufficient specific clinical features to allow a definite diagnosis. Because of the currently limited capacity to screen for numerous genes s...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/2044-5040-1-24
更新日期:2011-06-24 00:00:00
abstract:BACKGROUND:A hallmark of muscular dystrophies is the replacement of muscle by connective tissue. Muscle biopsies from patients severely affected with facioscapulohumeral muscular dystrophy (FSHD) may contain few myogenic cells. Because the chromosomal contraction at 4q35 linked to FSHD is thought to cause a defect with...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/2044-5040-1-12
更新日期:2011-03-08 00:00:00
abstract::Skeletal muscle wasting is a major component of cachectic states found in a variety of disease settings, including cancer. As increasing caloric intake often provides little benefit in combating muscle loss in cachectic patients, a major research focus has been to develop strategies stimulating muscle anabolic pathway...
journal_title:Skeletal muscle
pub_type: 杂志文章
doi:10.1186/2044-5040-1-2
更新日期:2011-01-24 00:00:00