Breaching biological barriers: protein translocation domains as tools for molecular imaging and therapy.

abstract：:Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabric...

journal_title：Molecular imaging

authors： Roney CA,Xu B,Xie J,Yuan S,Wierwille J,Chen CW,Chen Y,Griffiths GL,Summers RM

更新日期：2011-08-01 00:00:00

abstract：:Imaging of glutamate carboxypeptidase II (GCP II), also known as N-acetylated alpha-linked L-amino dipeptidase (NAALADase), may enable study of glutamatergic transmission, prostate cancer, and tumor neovasculature in vivo. Our goal was to develop a probe for GCP II for use with positron emission tomography (PET). Radi...

journal_title：Molecular imaging

authors： Pomper MG,Musachio JL,Zhang J,Scheffel U,Zhou Y,Hilton J,Maini A,Dannals RF,Wong DF,Kozikowski AP

更新日期：2002-04-01 00:00:00

abstract：:High spectral and spatial resolution (HiSS) data, acquired with echo-planar spectroscopic imaging (EPSI), can be used to acquire water spectra from each small image voxel. These images are sensitive to changes in local susceptibility caused by superparamagnetic iron oxide particles (SPIO); therefore, we hypothesized t...

journal_title：Molecular imaging

authors： Haney CR,Pelizzari CA,Foxley S,Zamora MA,Mustafi D,Tretiakova M,Li S,Fan X,Karczmar GS

更新日期：2011-06-01 00:00:00

abstract：:The recent success of autologous T cell-based therapies in hematological malignancies has spurred interest in applying similar immunotherapy strategies to the treatment of solid tumors. Identified nearly 4 decades ago, natural killer (NK) cells represent an arguably better cell type for immunotherapy development. Natu...

journal_title：Molecular imaging

authors： Shapovalova M,Pyper SR,Moriarity BS,LeBeau AM

更新日期：2018-01-01 00:00:00

abstract：:We generated a transgenic mouse model (RIP-luc) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the rat insulin promoter fused to firefly luciferase, and noninvasive technology to detect luciferase activity, we tracked changes in reporter signal during metabolic...

journal_title：Molecular imaging

authors： Smith SJ,Zhang H,Clermont AO,Powers AC,Kaufman DB,Purchio AF,West DB

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Near-infrared photoimmunotherapy (NIR-PIT) is a cancer therapy that causes an increase in tumor perfusion, a phenomenon termed the super-enhanced permeability and retention effect. Currently, in vivo treatment efficacy of NIR-PIT is observable days after treatment, but monitoring would be improved by more ac...

journal_title：Molecular imaging

authors： Rosenberg A,Fujimura D,Okada R,Furusawa A,Inagaki F,Wakiyama H,Kato T,Choyke PL,Kobayashi H

更新日期：2020-01-01 00:00:00

abstract：:The purpose of this study was to validate (99m)Tc-3P-RGD(2) single-photon emission computed tomography/computed tomography (SPECT/CT) as an imaging tool to monitor α(v)β(3) expression and tumor necrosis. The animal model was established by subcutaneous injection of 5 × 10(6) U87MG cells into the shoulder flank of each...

journal_title：Molecular imaging

authors： Shao G,Zhou Y,Wang F,Liu S

更新日期：2013-01-01 00:00:00

abstract：:Macrophage infiltration is a prominent feature of abdominal aortic aneurysm (AAA) progression. We used a combined imaging approach with bioluminescence (BLI) and magnetic resonance imaging (MRI) to study macrophage homing and accumulation in experimental AAA disease. Murine AAAs were created via intra-aortic infusion ...

journal_title：Molecular imaging

authors： Miyama N,Dua MM,Schultz GM,Kosuge H,Terashima M,Pisani LJ,Dalman RL,McConnell MV

更新日期：2012-04-01 00:00:00

abstract：:The lung remains one of the most challenging organs to image using magnetic resonance imaging (MRI) due to intrinsic rapid signal decay. However, unlike conventional modalities such as computed tomography, MRI does not involve radiation and can provide functional and morphologic information on a regional basis. Here w...

journal_title：Molecular imaging

authors： Tchouala Nofiele J,Cheng W,Haedicke IE,Ganesh T,Zhang XA,Cheng HL

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study is to determine and characterize factors influencing in vivo bioluminescence imaging (BLI) and apply them to the specific application of imaging transplanted pancreatic islets. Noninvasive quantitative assessment of transplanted pancreatic islets poses a formidable challenge. Murine pancreatic is...

journal_title：Molecular imaging

authors： Virostko J,Chen Z,Fowler M,Poffenberger G,Powers AC,Jansen ED

更新日期：2004-10-01 00:00:00

abstract：:Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. BF-227 has been described as an α-Syn binder and hence was employed as a lead to generate a library of α-Syn-binding compounds. [3H...

journal_title：Molecular imaging

authors： Josephson L,Stratman N,Liu Y,Qian F,Liang SH,Vasdev N,Patel S

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the time course of contrast enhancement of spleen, liver, and blood using eXIA 160 XL in healthy mice. eXIA 160 XL was intravenously injected in C57bl/6 mice (n  =  12) at a dose of 0.1 mL/20 g (16 mg iodine [I]/20 g) (n  =  6) or 0.2 mL/20 g (32 mg I/20 g) (n  =  6). The dist...

journal_title：Molecular imaging

authors： Willekens I,Buls N,De Maeseneer M,Lahoutte T,de Mey J

更新日期：2013-09-01 00:00:00

abstract：:Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed t...

journal_title：Molecular imaging

authors： Okusanya OT,Deshpande C,Barbosa EM Jr,Aggarwal C,Simone CB 2nd,Jiang J,Judy R,DeJesus E,Albelda S,Nie S,Low PS,Singhal S

更新日期：2014-01-01 00:00:00

abstract：:We delivered adenovirus vector (Ad) via intravitreous injection and monitored transgene (luciferase) expression in living mice (BALB/c) at multiple time points. In vivo live imaging technology was able to assess dynamically intraocular luciferase expression in a single animal population throughout the entire experimen...

journal_title：Molecular imaging

authors： Gehlbach PL,Chuck RS,Park CG,Park CY

更新日期：2012-09-01 00:00:00

abstract：:The use of micro-CT in small animals has increased in recent years. Although the radiation levels used for micro-CT are generally not lethal to the animal, they are high enough where changes in the immune response and other biological pathways may alter the experimental outcomes. Therefore, it is important to understa...

journal_title：Molecular imaging

authors： Boone JM,Velazquez O,Cherry SR

更新日期：2004-07-01 00:00:00

abstract：:Transfection agent (TFA)-induced magnetic cell labeling with Feridex IV is an attractive method of loading cells because it employs a pharmaceutical source of iron oxide. Although attractive, the method has two significant drawbacks. First, it requires mixing positively charged transfection agents and negatively charg...

journal_title：Molecular imaging

authors： Montet-Abou K,Montet X,Weissleder R,Josephson L

更新日期：2007-01-01 00:00:00

abstract：:We introduce and demonstrate the utility of coded aperture (CA) nuclear scintigraphy for imaging small animals. CA imaging uses multiple pinholes in a carefully designed mask pattern, mounted on a conventional gamma camera. System performance was assessed using point sources and phantoms, while several animal experime...

journal_title：Molecular imaging

authors： Schellingerhout D,Accorsi R,Mahmood U,Idoine J,Lanza RC,Weissleder R

更新日期：2002-10-01 00:00:00

abstract：:Positive margins after breast conservation surgery represent a significant problem in the treatment of breast cancer. The near-infrared fluorescence agent CLR1502 (Cellectar Biosciences, Madison, WI) was studied in a preclinical breast cancer model to determine imaging properties and ability to detect small islands of...

journal_title：Molecular imaging

authors： Korb ML,Warram JM,Grudzinski J,Weichert J,Jeffery J,Rosenthal EL

更新日期：2014-01-01 00:00:00

abstract：:In a previous study, we demonstrated that pcDNA3.1/hNIS (human sodium iodide symporter) vaccination generated hNIS-associated CD8+IFN-gamma+ (interferon-gamma) T cells, which are known to be involved in antitumor immunity. However, the immune response induced was insufficient to control tumor growth in vivo, which req...

journal_title：Molecular imaging

authors： Choi Y,Jeon YH,Paik JH,Ko J,Choi DH,Chung JK,Kim CW

更新日期：2010-06-01 00:00:00

abstract：:This article presents and validates a newly developed GATE model of the Siemens Inveon trimodal imaging platform. Fully incorporating the positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT) data acquisition subsystems, this model enables feasibility stud...

journal_title：Molecular imaging

authors： Lee S,Gregor J,Osborne D

更新日期：2013-10-01 00:00:00

abstract：:Vascular endothelial leukocyte adhesion molecules, such as E-selectin, are acutely upregulated in myocardial ischemia/reperfusion and are thus "ischemic memory" biomarkers for recent cardiac ischemia. We sought to develop an ultrasound molecular imaging agent composed of microbubbles (MBs) targeted to E-selectin to en...

journal_title：Molecular imaging

authors： Leng X,Wang J,Carson A,Chen X,Fu H,Ottoboni S,Wagner WR,Villanueva FS

更新日期：2014-01-01 00:00:00

abstract：:We investigated the capacity of normalized transillumination methods in imaging fluorescent proteins in visible light, in phantoms and in live mice. We demonstrate significant imaging improvements over epi-illumination imaging, as commonly applied today. Of particular importance is the significant betterment in contra...

journal_title：Molecular imaging

authors： Zacharakis G,Shih H,Ripoll J,Weissleder R,Ntziachristos V

更新日期：2006-07-01 00:00:00

abstract：:Mannose receptor is considered as a hallmark of M2-oriented tumor-associated macrophages (TAMs), but its utility in TAMs was rarely reported. Therefore, deoxymannose (DM), a high-affinity ligand of mannose receptor, was labeled with near-infrared dye cyanine 7 (Cy7), and its feasibility of targeted imaging on TAMs was...

journal_title：Molecular imaging

authors： Jiang C,Cai H,Peng X,Zhang P,Wu X,Tian R

更新日期：2017-01-01 00:00:00

abstract：:We evaluated CNA35 as a collagen marker in healthy and atherosclerotic arteries of mice after both ex vivo and in vivo administration and as a molecular imaging agent for the detection of atherosclerosis. CNA35 conjugated with fluorescent Oregon Green 488 (CNA35/OG488) was administered ex vivo to mounted viable muscul...

journal_title：Molecular imaging

authors： Megens RT,Oude Egbrink MG,Cleutjens JP,Kuijpers MJ,Schiffers PH,Merkx M,Slaaf DW,van Zandvoort MA

更新日期：2007-07-01 00:00:00

abstract：:Bacterial genes involved in the biomineralization of magnetic nanoparticles in magnetotactic bacteria have recently been proposed as reporters for magnetic resonance imaging (MRI). In such systems, the expression of the bacterial genes in mammalian cells purportedly leads to greater concentrations of intracellular iro...

journal_title：Molecular imaging

authors： Pereira SM,Williams SR,Murray P,Taylor A

更新日期：2016-04-26 00:00:00

abstract：PURPOSE:We evaluated the relationship between isocitrate dehydrogenase 1 (IDH1) mutation status and metabolic imaging in patients with nonenhancing supratentorial diffuse gliomas using 11C-methionine positron emission tomography (11C-MET PET). MATERIALS AND METHODS:Between June 2012 and November 2017, we enrolled 86 (...

journal_title：Molecular imaging

authors： Kudulaiti N,Zhang H,Qiu T,Lu J,Aibaidula A,Zhang Z,Guan Y,Zhuang D

更新日期：2019-01-01 00:00:00

abstract：:[68Ga]Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate marker for apoptosis. We tested this technique for therapy monitoring in a murine model of myocardial infarction (MI) including parathyroid hormone (PTH) treatment. MI was induced in mice, and they were...

journal_title：Molecular imaging

authors： Lehner S,Todica A,Vanchev Y,Uebleis C,Wang H,Herrler T,Wängler C,Cumming P,Böning G,Franz WM,Bartenstein P,Hacker M,Brunner S

更新日期：2014-01-01 00:00:00

abstract：:Molecular imaging with magnetic resonance imaging (MRI) may benefit from the ferrimagnetic properties of magnetosomes, membrane-enclosed iron biominerals whose formation in magnetotactic bacteria is encoded by multiple genes. One such gene is MagA, a putative iron transporter. We have examined expression of MagA in mo...

journal_title：Molecular imaging

authors： Goldhawk DE,Lemaire C,McCreary CR,McGirr R,Dhanvantari S,Thompson RT,Figueredo R,Koropatnick J,Foster P,Prato FS

更新日期：2009-05-01 00:00:00

abstract：:Bioluminescence imaging (BLI) detects light generated by luciferase-mediated oxidation of substrate and is used widely for evaluating transgene expression in cell-based assays and in vivo in relevant preclinical models. The most commonly used luciferase for in vivo applications is firefly luciferase (fLuc), for which ...

journal_title：Molecular imaging

authors： Zhang Y,Pullambhatla M,Laterra J,Pomper MG

更新日期：2012-11-01 00:00:00

abstract：:Our purpose was to enable an in vivo imaging technology that can assess the anatomy and function of peripheral nerve tissue (neurography). To do this, we designed and tested a fluorescently labeled molecular probe based on the nontoxic C fragment of tetanus toxin (TTc). TTc was purified, labeled, and subjected to immu...

journal_title：Molecular imaging

authors： Schellingerhout D,Le Roux LG,Bredow S,Gelovani JG

更新日期：2009-12-01 00:00:00