Abstract：
:1. Reactive oxygen species (ROS) are a diverse family of molecules that are produced throughout the vascular wall. Many ROS, such as the superoxide anion (*O2-) and hydrogen peroxide (H2O2), are now known to act as cellular signalling molecules within blood vessels. In particular, these molecules can exert powerful effects on vascular tone. 2. Cerebral arteries are relatively unusual in their responsiveness to ROS. Unlike in many systemic vessels, both *O2- and H2O2 can cause vasodilatation in the cerebral microcirculation. 3. Reactive oxygen species can be produced in the vasculature via a variety of mechanisms; however, it appears that the primary source of *O2- within blood vessels is the enzyme NADPH-oxidase. 4. In cerebral vessels, activation of NADPH-oxidase causes both *O2- production and vasodilatation, indicating that NADPH-oxidase-derived ROS may have a functional role in the regulation of cerebral vascular tone. 5. Elevated levels of NADPH-oxidase activity and expression occur in cardiovascular disease states such as hypertension, atherosclerosis and subarachnoid haemorrhage. 6. Thus, ROS may contribute to the regulation of cerebral vascular tone during both physiological and pathological conditions.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Paravicini TM,Sobey CGdoi
10.1046/j.1440-1681.2003.03920.xkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
855-9issue
11eissn
0305-1870issn
1440-1681journal_volume
30pub_type
杂志文章,评审abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...
journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1997-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1988.tb01036.x
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pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1977-01-01 00:00:00
abstract：:1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystr...
journal_title：Clinical and experimental pharmacology & physiology
pub_type：
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更新日期：2004-08-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：2004-12-01 00:00:00
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更新日期：2011-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1992-04-01 00:00:00
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更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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更新日期：1998-10-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：2008-07-01 00:00:00
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更新日期：2018-01-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：2010-03-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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更新日期：2003-03-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1979-03-01 00:00:00
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更新日期：2017-02-01 00:00:00
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更新日期：2006-09-01 00:00:00
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更新日期：2007-03-01 00:00:00
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更新日期：1997-09-01 00:00:00
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更新日期：1988-09-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：1975-03-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：2005-12-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1997.tb02694.x
更新日期：1997-11-01 00:00:00
