Abstract:
:1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid. 2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the acetylcholine-induced response was inhibited by lignocaine, tetraethylammonium and hexamethonium. The responses to both acetylcholine and field stimulation were resistant to atropine, practolol, and sotalol. 3. Relatively high concentrations of ATP caused relaxation. 4. Histological investigation did not show any cells resembling autonomic ganglion cells. 5. It is suggested that both acetylcholine and field stimulation release an inhibitory transmitter from nerve endings and that the release by acetylcholine is mediated through nicotinic receptor stimulation.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Wai SS,Coupar IMdoi
10.1111/j.1440-1681.1976.tb00598.xsubject
Has Abstractpub_date
1976-03-01 00:00:00pages
141-5issue
2eissn
0305-1870issn
1440-1681journal_volume
3pub_type
杂志文章abstract::The inhibitory effect of morphine on intestine was observed by following the intestinal transit of a charcoal meal. This inhibitory effect of morphine was antagonized by naloxone. In addition, the inhibitory effect of morphine was also suppressed by prior administration of yohimbine and phentolamine. However, prazosin...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1984.tb00873.x
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abstract::1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis. In the present study, we tested the hypothesis that emodin may attenuate the development of pulmonary fibrosis. 2. Mice...
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1440-1681.2006.04453.x
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1987.tb02420.x
更新日期:1987-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
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更新日期:1995-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1991-07-01 00:00:00
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更新日期:1989-06-01 00:00:00
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更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-09-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1976.tb00607.x
更新日期:1976-07-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1989.tb01611.x
更新日期:1989-07-01 00:00:00
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更新日期:1984-11-01 00:00:00
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更新日期:2000-04-01 00:00:00
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doi:10.1111/1440-1681.13402
更新日期:2020-09-05 00:00:00
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更新日期:1997-06-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1983.tb00231.x
更新日期:1983-09-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1046/j.1440-1681.2001.03399.x
更新日期:2001-01-01 00:00:00
abstract::The therapeutic potential of the antimicrobial peptide cathelicidin (Camp) administration in sepsis has been widely investigated. However, little is known about the pathophysiological roles of cathelicidin in septic cardiomyopathy. In a lipopolysaccharide (LPS)-induced endotoxaemic model, we found that the mRNA and pr...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/1440-1681.13234
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.2009.05291.x
更新日期:2010-02-01 00:00:00
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doi:10.1111/1440-1681.13283
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.2007.04855.x
更新日期:2008-09-01 00:00:00