Meta-analysis of short-term low dose prednisolone versus placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis.

Abstract:

OBJECTIVE:To determine whether short-term, oral low dose prednisolone (< or = 15 mg daily) is superior to placebo and non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis. DESIGN:Meta-analysis of randomised trials of oral corticosteroids compared with placebo or a non-steroidal anti-inflammatory drug. SETTING:Trials conducted anywhere in the world. SUBJECTS:Patients with rheumatoid arthritis. MAIN OUTCOME MEASURES:Joint tenderness, pain, and grip strength. Outcomes measured on different scales were combined by using the standardised effect size (difference in effect divided by SD of the measurements). RESULTS:Ten studies were included in the meta-analysis. Prednisolone had a marked effect over placebo on joint tenderness (standardised effect size 1.31; 95% confidence interval 0.78 to 1.83), pain (1.75; 0.87 to 2.64), and grip strength (0.41; 0.13 to 0.69). Measured in the original units the differences were 12 (6 to 18) tender joints and 22 mm Hg (5 mm Hg to 40 mm Hg) for grip strength. Prednisolone also had a greater effect than non-steroidal anti-inflammatory drugs on joint tenderness (0.63; 0.11 to 1.16) and pain (1.25; 0.26 to 2.24), whereas the difference in grip strength was not significant (0.31; -0.02 to 0.64). Measured in the original units the differences were 9 (5 to 12) tender joints and 12 mm Hg (-6 mm Hg to 31 mm Hg). The risk of adverse effects during moderate and long term use seemed acceptable. CONCLUSION:Prednisolone in low doses (< or = 15 mg daily) may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means.

journal_name

BMJ

authors

Gøtzsche PC,Johansen HK

doi

10.1136/bmj.316.7134.811

subject

Has Abstract

pub_date

1998-03-14 00:00:00

pages

811-8

issue

7134

eissn

0959-8138

issn

1756-1833

journal_volume

316

pub_type

杂志文章,meta分析
  • Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults.

    abstract:OBJECTIVES:To determine whether over the counter cough medicines are effective for acute cough in adults. DESIGN:Systematic review of randomised controlled trials. DATA SOURCES:Search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.324.7333.329

    authors: Schroeder K,Fahey T

    更新日期:2002-02-09 00:00:00

  • Large outbreak of food poisoning caused by Salmonella typhimurium definitive type 49 in mayonnaise.

    abstract::An investigation was conducted to determine the vehicle of infection of an outbreak of food poisoning in a large metropolitan building early in 1988. A questionnaire was distributed to 700 people who had eaten in the building during the week of the outbreak, and attack rates for specific food were calculated. Food and...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.298.6666.99

    authors: Mitchell E,O'Mahony M,Lynch D,Ward LR,Rowe B,Uttley A,Rogers T,Cunningham DG,Watson R

    更新日期:1989-01-14 00:00:00

  • Heat related mortality in warm and cold regions of Europe: observational study.

    abstract:OBJECTIVES:To assess heat related mortalities in relation to climate within Europe. DESIGN:Observational population study. SETTING:North Finland, south Finland, Baden-Württemberg, Netherlands, London, north Italy, and Athens. SUBJECTS:People aged 65-74. MAIN OUTCOME MEASURES:Mortalities at temperatures above, below...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.321.7262.670

    authors: Keatinge WR,Donaldson GC,Cordioli E,Martinelli M,Kunst AE,Mackenbach JP,Nayha S,Vuori I

    更新日期:2000-09-16 00:00:00

  • Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies.

    abstract:OBJECTIVE:To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN:Prospective national cohort studies, EPICure and EPICure 2. SETTING:Hospital and home based evaluations, ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e7961

    authors: Moore T,Hennessy EM,Myles J,Johnson SJ,Draper ES,Costeloe KL,Marlow N

    更新日期:2012-12-04 00:00:00

  • Cost effectiveness of primary stroke prevention in atrial fibrillation: Swedish national perspective.

    abstract:OBJECTIVE:To assess the potential effects of primary prevention with anticoagulants or aspirin in atrial fibrillation on Swedish population. DESIGN:Analysis of cost effectiveness based on the following assumptions: about 83,000 people have atrial fibrillation in Sweden, of whom 22,000 would be potential candidates for...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.305.6867.1457

    authors: Gustafsson C,Asplund K,Britton M,Norrving B,Olsson B,Marké LA

    更新日期:1992-12-12 00:00:00

  • Investigation of long term problems after obstetric epidural anaesthesia.

    abstract:OBJECTIVE:To examine the association between obstetric epidural anaesthesia and subsequent long term problems. DESIGN:Postal questionnaire on health problems after childbirth linked to maternity case note data. SETTING:Maternity hospital in Birmingham. SUBJECTS:11701 women who delivered their most recent child durin...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.304.6837.1279

    authors: MacArthur C,Lewis M,Knox EG

    更新日期:1992-05-16 00:00:00

  • Process and impact of mergers of NHS trusts: multicentre case study and management cost analysis.

    abstract:OBJECTIVE:To study the processes involved in and impact of mergers between NHS trusts, including the effect on management costs. DESIGN:Cross sectional study involving in depth interviews and documentary analysis; case study to compare savings in management costs between case trusts and control trusts. SETTING:Nine t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.325.7358.246

    authors: Fulop N,Protopsaltis G,Hutchings A,King A,Allen P,Normand C,Walters R

    更新日期:2002-08-03 00:00:00

  • Randomised controlled trial comparing oral and intravenous rehydration therapy in children with diarrhoea.

    abstract:OBJECTIVE:To determine the effectiveness of oral rehydration in children with moderate dehydration caused by gastroenteritis, and to compare the complications of oral and intravenous treatment. DESIGN:Randomised controlled trial. SETTING:Emergency department and infectious diseases ward in a large urban teaching hosp...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.303.6799.393

    authors: Mackenzie A,Barnes G

    更新日期:1991-08-17 00:00:00

  • The New Zealand cervical cancer study: could it happen again?

    abstract::The author is one of the medical advisers to the judge who led a government inquiry into allegations that an experimental research program at the National Women's Hospital in Auckland, New Zealand, to study the natural course of cervical carcinoma in situ had withheld conventional treatment from some patients. She ar...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6647.533

    authors: Paul C

    更新日期:1988-08-20 00:00:00

  • Income distribution and life expectancy: a critical appraisal.

    abstract::In a series of papers published during the past decade Richard Wilkinson has advanced the view that income inequality is the key determinant of variations in average life expectancy at birth among developed countries. Yet a careful examination of the two sources of data on income distribution most often used by Wilkin...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7015.1282

    authors: Judge K

    更新日期:1995-11-11 00:00:00

  • International variation in radiation dose for computed tomography examinations: prospective cohort study.

    abstract:OBJECTIVE:To determine patient, institution, and machine characteristics that contribute to variation in radiation doses used for computed tomography (CT). DESIGN:Prospective cohort study. SETTING:Data were assembled and analyzed from the University of California San Francisco CT International Dose Registry. PARTICI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.k4931

    authors: Smith-Bindman R,Wang Y,Chu P,Chung R,Einstein AJ,Balcombe J,Cocker M,Das M,Delman BN,Flynn M,Gould R,Lee RK,Yellen-Nelson T,Schindera S,Seibert A,Starkey J,Suntharalingam S,Wetter A,Wildberger JE,Miglioretti DL

    更新日期:2019-01-02 00:00:00

  • Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies.

    abstract:OBJECTIVE:To quantify the association of indices of central obesity, including waist circumference, hip circumference, thigh circumference, waist-to-hip ratio, waist-to-height ratio, waist-to-thigh ratio, body adiposity index, and A body shape index, with the risk of all cause mortality in the general population, and t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.m3324

    authors: Jayedi A,Soltani S,Zargar MS,Khan TA,Shab-Bidar S

    更新日期:2020-09-23 00:00:00

  • Drug injection and HIV prevalence in inmates of Glenochil prison.

    abstract:OBJECTIVE:To determine prevalence of HIV infection and drug injecting behaviour among inmates of Glenochil Prison on a specified date a year after an outbreak of hepatitis B and HIV infection. DESIGN:Cross sectional: voluntary, anonymous HIV salivary antibody surveillance and linked self completion questionnaire on ri...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6975.293

    authors: Gore SM,Bird AG,Burns SM,Goldberg DJ,Ross AJ,Macgregor J

    更新日期:1995-02-04 00:00:00

  • Cost effectiveness of magnetic resonance imaging in the neurosciences.

    abstract:OBJECTIVES:To measure, in a service setting, the effect of magnetic resonance imaging on diagnosis, diagnostic certainty, and patient management in the neurosciences; to measure the cost per patient scanned; to estimate the marginal cost of imaging and compare this with its diagnostic impact; to measure changes in pati...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6815.1435

    authors: Szczepura AK,Fletcher J,Fitz-Patrick JD

    更新日期:1991-12-07 00:00:00

  • Identifying problems with data collection at a local level: survey of NHS maternity units in England.

    abstract:OBJECTIVES:To document the extent to which maternity data are collected and how they are recorded, and to identify problems that may affect their availability throughout the NHS. METHODS:Postal survey in September 1997 with structured questionnaires. SETTING:207 NHS trusts with maternity units in England. PARTICIPAN...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.319.7210.619

    authors: Kenney N,Macfarlane A

    更新日期:1999-09-04 00:00:00

  • Reliability of ultrasonography in identification of reflux nephropathy in children.

    abstract:OBJECTIVE:To assess the ability of ultrasonography to identify reflux nephropathy in children after urinary tract infection. DESIGN:Ten experienced radiologists performed a total of 240 ultrasonographic examinations of kidneys in a one day study. The examiners were unaware of the results of previous radiological and c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6949.235

    authors: Stokland E,Hellström M,Hansson S,Jodal U,Odén A,Jacobsson B

    更新日期:1994-07-23 00:00:00

  • Association between teenage pregnancy rates and the age and sex of general practitioners: cross sectional survey in Trent 1994-7.

    abstract:OBJECTIVE:To examine variations in teenage pregnancy rates in Trent region and to determine possible associations with local general practice characteristics such as the age and sex of the doctors. DESIGN:Cross sectional survey. SETTING:All 826 general practices in Trent region in existence between 1994 and 1997. SU...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.320.7238.842

    authors: Hippisley-Cox J,Allen J,Pringle M,Ebdon D,McPhearson M,Churchill D,Bradley S

    更新日期:2000-03-25 00:00:00

  • Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis.

    abstract:OBJECTIVE:To estimate the comparative clinical efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults. DESIGN:Systematic review with pairwise and network meta-analysis. DATA SOURCES:Electronic search of Embase, PubMed/Medline, and PsycINFO up to 8 M...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.l1079

    authors: Mutz J,Vipulananthan V,Carter B,Hurlemann R,Fu CHY,Young AH

    更新日期:2019-03-27 00:00:00

  • Painful crises in sickle cell disease--patients' perspectives.

    abstract::One hundred and two patients returned structured questionnaires sent to clinics for sickle cell disease in the United Kingdom in order to gain greater insight into the patients' perception of painful crises. Most patients who suffer pain crises experience a prodromal stage that should be investigated further to find o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6646.452

    authors: Murray N,May A

    更新日期:1988-08-13 00:00:00

  • Effects of locality based community hospital care on independence in older people needing rehabilitation: randomised controlled trial.

    abstract:OBJECTIVE:To determine the effects on independence in older people needing rehabilitation in a locality based community hospital compared with care on a ward for elderly people in a district general hospital. DESIGN:Randomised controlled trial. SETTING:Care in a community hospital and district general hospital in Bra...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.38498.387569.8F

    authors: Green J,Young J,Forster A,Mallinder K,Bogle S,Lowson K,Small N

    更新日期:2005-08-06 00:00:00

  • Low back pain.

    abstract::The studies reviewed here show that the duration and severity of individual episodes of back pain can be lessened, reducing recurrences and their cost in terms of suffering and lost work. Frank examines differential diagnosis; acute, chronic, and intractable pain; and service implications. Modern management emphasises...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.306.6882.901

    authors: Frank A

    更新日期:1993-04-03 00:00:00

  • Molecular genetics in clinical practice: evolution of a DNA diagnostic service.

    abstract::The development of a molecular genetics diagnostic service over a three year period was studied in a National Health Service region with a population of three million. Starting from a time when few diagnostic applications were possible, the number of disorders and the overall demand had grown rapidly. Conditions for w...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6652.843

    authors: Meredith AL,Upadhyaya M,Harper PS

    更新日期:1988-10-01 00:00:00

  • Modifiable factors influencing relatives' decision to offer organ donation: systematic review.

    abstract:OBJECTIVE:To identify modifiable factors that influence relatives' decision to allow organ donation. DESIGN:Systematic review. DATA SOURCES:Medline, Embase, and CINAHL, without language restriction, searched to April 2008. Review methods Three authors independently assessed the eligibility of the identified studies. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.b991

    authors: Simpkin AL,Robertson LC,Barber VS,Young JD

    更新日期:2009-04-21 00:00:00

  • Effect of reducing total fat intake on body weight: systematic review and meta-analysis of randomised controlled trials and cohort studies.

    abstract:OBJECTIVE:To investigate the relation between total fat intake and body weight in adults and children. DESIGN:Systematic review and meta-analysis of randomised controlled trials and cohort studies. DATA SOURCES:Medline, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials to June 2010. INCLUSION CR...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.e7666

    authors: Hooper L,Abdelhamid A,Moore HJ,Douthwaite W,Skeaff CM,Summerbell CD

    更新日期:2012-12-06 00:00:00

  • Dealing with extracontractual referrals.

    abstract:OBJECTIVE:To describe the mechanism established by Richmond, Twickenham, and Roehampton Health Authority to manage extracontractual referral requests made on behalf of its resident population and to examine its working in the first three months of the new arrangements. DESIGN:Description of the procedures for managing...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6801.499

    authors: Williamson JD

    更新日期:1991-08-31 00:00:00

  • Combined resynchronisation and implantable defibrillator therapy in left ventricular dysfunction: Bayesian network meta-analysis of randomised controlled trials.

    abstract:OBJECTIVE:To review the evidence base from randomised controlled trials of combined cardiac resynchronisation therapy and implantable cardioverter defibrillator therapy in left ventricular impairment and symptomatic heart failure. DESIGN:Bayesian network meta-analysis. DATA SOURCES:Medline, Embase, and Cochrane datab...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.39343.511389.BE

    authors: Lam SK,Owen A

    更新日期:2007-11-03 00:00:00

  • Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE: To evaluate the effectiveness of antenatal corticosteroids given at ≥34 weeks' gestation. DESIGN: Systematic review with meta-analysis. DATA SOURCES: Electronic databases were searched from their inception to February 2016. ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomized clinical trials comparing ant...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.i5044

    authors: Saccone G,Berghella V

    更新日期:2016-10-12 00:00:00

  • Respiratory tract infections and concomitant pericoronitis of the wisdom teeth.

    abstract:OBJECTIVE:To discover if there is an association between respiratory tract infections and pericoronitis of erupting third molars in young adults. DESIGN:Data from male military conscripts' medical records were collected over five years and the incidence of respiratory tract infection before and after acute pericoronit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6983.834

    authors: Meurman JH,Rajasuo A,Murtomaa H,Savolainen S

    更新日期:1995-04-01 00:00:00

  • Preventing iron deficiency in preschool children by implementing an educational and screening programme in an inner city practice.

    abstract:OBJECTIVE:To assess the feasibility and acceptability of screening young children for iron deficiency in a deprived inner city practice and to assess the effects of a programme of dietary education. DESIGN:Prospective study of children in general practice, comparison with historical controls. SETTING:A deprived inner...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6703.838

    authors: James J,Lawson P,Male P,Oakhill A

    更新日期:1989-09-30 00:00:00

  • Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort study.

    abstract:OBJECTIVE:To assess the role of rhinoviruses in elderly people living in the community. DESIGN:Prospective community based surveillance of elderly people, without intervention. Subjects were telephoned weekly to identify symptomatic upper respiratory tract infections. Symptoms and impact of illnesses were monitored, a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.313.7065.1119

    authors: Nicholson KG,Kent J,Hammersley V,Cancio E

    更新日期:1996-11-02 00:00:00