Abstract:
:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and mortality may have been shown most conclusively with diuretics and beta-blockers, but the effects on coronary events with these drugs were less than predicted and the other agents have a number of theoretical advantages. 3. Recent worries regarding the possible adverse effects of calcium antagonists have led to a reappraisal of the risks and benefits of these drugs and antihypertensives in general. 4. Many patients, particularly the elderly, have other conditions that influence the choice of first-line therapy and ethnic variations in the effects of hypertension or the efficacy or side effects of drugs should also be taken into account. 5. There is considerable heterogeneity within the major categories of antihypertensive drugs, so it is important to distinguish the different subgroups, dosages and formulations that may be used.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Tomlinson Bdoi
10.1111/j.1440-1681.1997.tb02733.xsubject
Has Abstractpub_date
1997-12-01 00:00:00pages
978-81issue
12eissn
0305-1870issn
1440-1681journal_volume
24pub_type
杂志文章,评审abstract::1. Adenosine A(1) receptors (A(1)R) play an important role in cardioprotection against hypoxic damage and the opening of mitochondrial permeability transition pores (MPTP) is central to the regulation of cell apoptosis and necrosis. However, it is still unclear whether A(1)R open MPTP in hypoxic cardiomyocytes. 2. The...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.2009.05300.x
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abstract::1. The ethyl acetate (EtOAc) extract and 3-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-d-glucose (3OG46HG) of Euphorbia thymifolia Linnea have been shown to exhibit anti-herpes simplex virus (HSV)-2 activity in vitro. In the present study, we investigated the mode of action of these two compounds in suppressing HSV-2 multi...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1986.tb00926.x
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更新日期:2008-04-01 00:00:00
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doi:10.1111/j.1440-1681.1996.tb01769.x
更新日期:1996-08-01 00:00:00
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更新日期:1993-07-01 00:00:00
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更新日期:1994-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1984.tb00290.x
更新日期:1984-07-01 00:00:00
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pub_type:
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更新日期:2018-10-01 00:00:00
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更新日期:2008-02-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1997-12-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1988.tb01053.x
更新日期:1988-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1995.tb02083.x
更新日期:1995-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00