当前位置： SCI文献检索 > JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION期刊下所有文献 > Apparent mineralocorticoid excess syndromes.

Apparent mineralocorticoid excess syndromes.

Abstract：

:Apparent mineralocorticoid excess (AME) is a syndrome attributable to congenital deficiency of the enzyme 11 beta-dehydrogenase (11 beta-OHSD) which converts active glucocorticoid cortisol to inactive cortisone. When 11 beta-OHSD activity is impaired, cortisol acts as a potent mineralocorticoid and causes hypertension and hypokalemia with a suppression of the renin-angiotensin-aldosterone system. The increased ratio of urinary cortisol/cortisone metabolites and a prolonged half-life of cortisol are useful for the diagnosis. Dexamethasone and/or potassium sparing diuretics have been used for medication of AME. Licorice ingestion induces a mineralocorticoid excess state, and it seems that this is the result of acquired inhibition of 11 beta-DH by glycyrrhetinic acid. The existence of a second 11 beta-OHSD isoform has been suggested strongly for a long time, and recently, a human 11 beta-OHSD 2 cDNA has been isolated. It appears that 11 beta-OHSD 2 conveys specificity upon the renal MR, and a defect in its activity seems likely to account for the phenotype of AME.

journal_name

J Endocrinol Invest

journal_title

Journal of endocrinological investigation

authors

Shimojo M,Stewart PM

doi

10.1007/BF03349763

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

518-32

issue

7

eissn

0391-4097

issn

1720-8386

journal_volume

18

pub_type

杂志文章,评审

相关文献

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION文献大全
  • Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction.

    abstract：AIM:Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03346397

    authors： Bo S,Gambino R,Durazzo M,Ghione F,Musso G,Gentile L,Cassader M,Cavallo-Perin P,Pagano G

    更新日期：2008-06-01 00:00:00

  • Serum leptin levels in males with delayed puberty during short-term pulsatile GnRH administration.

    abstract：:Leptin may be a possible trigger for puberty. In normal males, it has been shown that leptin increases from the pre-pubertal to the early pubertal stage, and then declines in the late pubertal stage. We examined leptin levels in six male adolescents (mean age 16.3+/-0.6 yr; range 14.2-17.6 yr) with delayed puberty (co...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345471

    authors： Giusti M,Guido R,Valenti S,Giordano G

    更新日期：1999-01-01 00:00:00

  • Should familial disease be considered as a negative prognostic factor in micropapillary thyroid carcinoma?

    abstract：PURPOSE:An increased aggressiveness of familial papillary thyroid carcinoma (FPTC) compared with sporadic form has been reported. On the contrary, the biological behavior of familial microPTC (FmPTC) is still debated. To assess if familial diseases should be considered as a negative prognostic factor in mPTC, the clini...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01039-0

    authors： Capezzone M,Secchi C,Fralassi N,Cantara S,Brilli L,Ciuoli C,Pilli T,Maino F,Forleo R,Pacini F,Castagna MG

    更新日期：2019-10-01 00:00:00

  • Study of bioassayable somatomedin on renal artery and vein.

    abstract：:Somatomedin was measured by rat bioassay in samples obtained from renal artery and vein, in order to study the role of this organ in the production of somatomedin activity. The results showed a significant difference, with an increase of the activity in the venous samples. According to the data reported in the literat...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350423

    authors： Minuto F,Barreca A,Grimaldi P,Cocco R,Garibotto G,Ferrini S,Giordano G

    更新日期：1979-07-01 00:00:00

  • Cognitive functions and mood during chronic thyrotropin-suppressive therapy with L-thyroxine in patients with differentiated thyroid carcinoma.

    abstract：BACKGROUND:Subclinical thyroid dysfunctions may cause cognitive deficits and mood disorders. Chronic TSH-suppressive therapy with L-T(4) causing subclinical hyperthyroidism has been widely used in treatment of patients with thyroid differentiated carcinoma. The impact of this therapy on cognitive functions and mood hav...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.3275/8013

    authors： Jaracz J,Kucharska A,Rajewska-Rager A,Lacka K

    更新日期：2012-09-01 00:00:00

  • Psychosocial issues of ART in aging male.

    abstract：:The role of androgens in human sexuality as regards the mechanism of erection and the pathogenesis of impotence is under debate. In addition, it is difficult to define the psychosocial impact of both hypogonadism and androgen replacement. However, sexual hormones largely influence mood, well-being, and quality of life...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Carosa E,Volpe R,Martini P,Brandetti F,Di Stasi SM,Lombardo F,Salacone P,Sgrò P,Gandini L,Lenzi A,Jannini EA

    更新日期：2005-01-01 00:00:00

  • Effect of propranolol on aldosterone response to heat exposure in sodium-restricted men.

    abstract：:To assess the role of the renin-angiotensin system in the control of aldosterone reease in response to heat exposure, 6 sodium restricted subjects were studied on three random experimental days: a control day and two heat exposure days (46C, 35 mbar, 90 min) with and without propranolol. Plasma aldosterone, renin acti...

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF03349377

    authors： Brandenberger G,Follenius M,Oyono S

    更新日期：1980-10-01 00:00:00

  • Lesion of the amygdala on the right and left side suppresses testosterone secretion but only left-sided intervention decreases serum luteinizing hormone level.

    abstract：:The effect of right- and left-sided intra-amygdaloid injection of kainic acid on the hypothalamo-hypophyseal-testicular axis was studied in rats. Both right- and left-sided injection of the neurotoxin into the amygdala resulted in a significant decrease in basal testosterone secretion in vitro of both testes and in se...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345198

    authors： Banczerowski P,Csaba Z,Csernus V,Gerendai I

    更新日期：2003-05-01 00:00:00

  • Thyrotropin-releasing hormone-like material in human retina.

    abstract：:Thyrotropin-releasing hormone (TRH)-like material was found in human retina obtained at autopsy from eyes used for corneal grafts. The TRH-like material was extracted with methanol and was found to be indistinguishable from synthetic TRH in its immunoreactivity and bioreactivity and in its proteolytic degradation by f...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03348274

    authors： Martino E,Nardi M,Vaudagna G,Simonetti S,Cilotti A,Pinchera A,Venturi G,Seo H,Baschieri L

    更新日期：1980-07-01 00:00:00

  • Painless thyroiditis developed in a patient with Sheehan's syndrome.

    abstract：:We experienced an unusual combination of painless thyroiditis and Sheehan's syndrome in a single patient. A 29-year-old postpartum woman was referred to us for suspected Sheehan's syndrome. Endocrine tests confirmed the diagnosis, but, unexpectedly, her thyroid hormone levels in the plasma were elevated. Based on the ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03350313

    authors： Watanobe H,Kawabe H

    更新日期：1997-06-01 00:00:00

  • Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion.

    abstract：:Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...

    journal_title：Journal of endocrinological investigation

    pub_type：

    doi：

    authors： Valenti G

    更新日期：2002-01-01 00:00:00

  • Bone turnover is reduced in children with juvenile rheumatoid arthritis.

    abstract：:Juvenile Rheumatoid Arthritis (JRA) is frequently associated with osteoporosis. In order to determine if JRA osteoporosis is related to reduced formation or to increased bone resorption or both, serum levels of calcium (Ca), phosphorus (PO4), magnesium (Mg), alkaline phosphatase (ALP), parathormone (PTHi), 25-hydroxyv...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347283

    authors： Falcini F,Ermini M,Bagnoli F

    更新日期：1998-01-01 00:00:00

  • Endocannabinoids and energy metabolism.

    abstract：:Although adjustments to nutritional lifestyle and increased physical activity remain the milestones of weight loss therapy, it is evident from the exponential increase of the number of obese subjects in Western countries that these two approaches alone are no longer able to limit this progression. This alarming phenom...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,评审

    doi：

    authors： Pagotto U,Pasquali R

    更新日期：2006-01-01 00:00:00

  • Two novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1.

    abstract：:Multiple endocrine neoplasia type 1 (MEN1) is characterized by parathyroid, enteropancreatic endocrine and pituitary adenomas as well as germline mutation of the MEN1 gene. We describe 2 families with MEN1 with novel mutations in the MEN1 gene. One family was of Turkish origin, and the index patient had primary hyperp...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03344142

    authors： Ozturk M,Chiu CY,Akdeniz N,Jenq SF,Chang SC,Hsa CY,Jap TS

    更新日期：2006-06-01 00:00:00

  • Monitoring testosterone replacement therapy with transdermal gel: when and how?

    abstract：PURPOSE:Testosterone replacement therapy (TRT) is recommended for the treatment of most cases of male hypogonadism. Transdermal testosterone (T) gels are commonly used in clinical practice; however, there is little evidence concerning how to monitor dosage to bring and maintain serum T levels in the normal physiologic ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-019-01082-x

    authors： Sansone A,Sansone M,Selleri R,Schiavo A,Gianfrilli D,Pozza C,Zitzmann M,Lenzi A,Romanelli F

    更新日期：2019-12-01 00:00:00

  • Positive association of serum interleukin-1beta and CRH levels in women with pre-term labor.

    abstract：OBJECTIVE:The aim of this study was to investigate the hypothesis that interleukin-1beta (IL-1beta) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. SUBJECTS AND METHODS:Forty-eight primigravidae with a singleton viable pregnancy between ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03347393

    authors： Vitoratos N,Mastorakos G,Kountouris A,Papadias K,Creatsas G

    更新日期：2007-01-01 00:00:00

  • Mutations in the CYP21 B gene in a Chilean population with simple virilizing congenital adrenal hyperplasia.

    abstract：:Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343746

    authors： Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

    更新日期：2000-06-01 00:00:00

  • Healthy centenarian subjects: the effect of red wine consumption on liver function tests.

    abstract：:Liver function is well maintained with increasing age. The aim of our study was to investigate if long-term moderate (

    journal_title：Journal of endocrinological investigation

    pub_type： 临床试验,杂志文章

    doi：

    authors： Pinzani P,Petruzzi E,Orlando C,Malentacchi F,Petruzzi I,Pazzagli M,Masotti G

    更新日期：2005-01-01 00:00:00

  • Primary hypothyroidism-associated TSH-secreting pituitary adenoma/hyperplasia presenting as a bleeding nasal mass and extremely elevated TSH level.

    abstract：:A 41-year-old male with primary hypothyroidism and a huge TSH-secreting pituitary tumor presented with a bleeding nasal mass that was initially misdiagnosed as a paraganglioma. Other unique features of the case include lack of complaints related to hypothyroidism, an extremely elevated TSH level of 3474 mU/l, and a lo...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03343584

    authors： Ghannam NN,Hammami MM,Muttair Z,Bakheet SM

    更新日期：1999-06-01 00:00:00

  • The combined effect of adiposity, fat distribution and age on cardiovascular risk factors and motor disability in a cohort of obese women (aged 18-83).

    abstract：:Obesity is associated with a number of serious diseases and with a degree of motor disability, but the extent of the risk and functional derangement within the obese population is not yet completely defined. The study aims to evaluate the combined effect of degree of adiposity, body fat distribution and age on selecte...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349195

    authors： Lafortuna CL,Agosti F,Proietti M,Adorni F,Sartorio A

    更新日期：2006-11-01 00:00:00

  • Intake of seaweed as part of a single sushi meal, iodine excretion and thyroid function in euthyroid subjects: a randomized dinner study.

    abstract：OBJECTIVE:Globalisation has extended to the kitchen and the Asian cuisine has gained international popularity with sushi and seaweed now being widespread. We explored the possible acute adverse effects of an iodine load from a single sushi-and-seaweed meal as seaweed iodine may induce thyroid dysfunction. METHODS:Nine...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s40618-019-01122-6

    authors： Noahsen P,Kleist I,Larsen HM,Andersen S

    更新日期：2020-04-01 00:00:00

  • Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodies.

    abstract：OBJECTIVE:In the mountainous areas of Azerbaijan the schoolchildren suffer from severe Iodine Deficiency (ID) with median Urinary iodine excretion (UIE) 36 mcg/l and prevalence of goiter 99% (estimated by US). In a population of 293,000 schoolchildren aged 8-14 y.o. we administered capsules containing 190 mg of iodized...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：

    authors： Markou KB,Georgopoulos NA,Makri M,Vlasopoulou B,Anastasiou E,Vagenakis GA,Kouloubi K,Theodosopoulos N,Lazarou N,Veizis A,Sakellaropoulos G,Vagenakis AG

    更新日期：2003-01-01 00:00:00

  • Comparison of immuno- and HPLC-assays for the measurement of urinary collagen cross-links.

    abstract：:Pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) are two cross-links of collagen molecules, that are present in the extracellular matrix and released during its degradation. Pyr is present in bone and cartilage, but not in significant amounts in other connective tissues and D-Pyr appears to be specific for bone tissue...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349673

    authors： Calabresi E,Lasagni L,Franceschelli F,de Leonardis V,Becorpi A,Serio M,Brandi ML

    更新日期：1994-09-01 00:00:00

  • Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.

    abstract：:The pineal gland contains many peptides known to be implicated in melatonin production. We examined the effects of a synthetic pineal tetrapeptide Ala-Glu-Asp-Gly on melatonin secretion by the pineal gland. The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months)...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345159

    authors： Djeridane Y,Khavinson VKh,Anisimov VN,Touitou Y

    更新日期：2003-03-01 00:00:00

  • Does early response to intravenous glucocorticoids predict the final outcome in patients with moderate-to-severe and active Graves' orbitopathy?

    abstract：PURPOSE:Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-017-0608-z

    authors： Bartalena L,Veronesi G,Krassas GE,Wiersinga WM,Marcocci C,Marinò M,Salvi M,Daumerie C,Bournaud C,Stahl M,Sassi L,Azzolini C,Boboridis KG,Mourits MP,Soeters MR,Baldeschi L,Nardi M,Currò N,Boschi A,Bernard M,von Arx

    更新日期：2017-05-01 00:00:00

  • A new predictive equation for evaluating women body fat percentage and obesity-related cardiovascular disease risk.

    abstract：BACKGROUND:Obesity represents a global public health problem due to its association with cardiovascular diseases and reduced lifespan. The most widely used classification of obesity is expressed as Body Mass Index (BMI); however, this formula is an imprecise adiposity measurement that ignores several important factors ...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-013-0048-3

    authors： De Lorenzo A,Nardi A,Iacopino L,Domino E,Murdolo G,Gavrila C,Minella D,Scapagnini G,Di Renzo L

    更新日期：2014-06-01 00:00:00

  • The phenotype of newly diagnosed Graves' disease in Italy in recent years is milder than in the past: results of a large observational longitudinal study.

    abstract：OBJECTIVE:The Merseburg triad (hyperthyroidism, goiter, and orbitopathy) characterizes classical description of Graves' disease (GD). Aim of this observational, longitudinal study was to evaluate the current clinical features of newly diagnosed GD in Italy. MATERIALS AND METHODS:In two Northern Italy centers (Varese a...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-016-0516-7

    authors： Bartalena L,Masiello E,Magri F,Veronesi G,Bianconi E,Zerbini F,Gaiti M,Spreafico E,Gallo D,Premoli P,Piantanida E,Tanda ML,Ferrario M,Vitti P,Chiovato L

    更新日期：2016-12-01 00:00:00

  • Extensive spherical amyloid deposition presenting as a pituitary tumor.

    abstract：:A 71-yr-old man was admitted for further evaluation and trans-sphenoidal surgery of a pituitary tumor. He complained of impotence and decreased libido over a period of about 40 yr. Thirty-eight yr ago he was treated for bilateral gynecomastia with galactorrhea. Endocrinological investigation at presentation revealed o...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03345219

    authors： Wiesli P,Brändle M,Brandner S,Kollias SS,Bernays RL

    更新日期：2003-06-01 00:00:00

  • Varicocele and concomitant dilation of the periprostatic venous plexus: effects on semen viscosity sperm parameters.

    abstract：INTRODUCTION:Since varicocele is often associated with other venous abnormalities, this study was undertaken to evaluate the frequency of dilation of the periprostatic venous plexus (DPVP) in these patients and the effects of this association on sperm parameters before and after varicocelectomy. MATERIALS AND METHODS:...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/s40618-015-0401-9

    authors： Condorelli RA,Calogero AE,Mongioi' L,Vicari E,Russo GI,Lanzafame F,La Vignera S

    更新日期：2016-05-01 00:00:00

  • Long term thyroid function after subtotal thyroidectomy for Graves' disease.

    abstract：:Between 1973 and 1980, 93 patients with Graves' disease underwent subtotal thyroidectomy by the same surgeon (the size of thyroid remnant was 4 g per side). No case of operative mortality, no case of thyroid storm nor of surgical complications occurred. Three months after surgery 40% of patients were euthyroid, 25% ha...

    journal_title：Journal of endocrinological investigation

    pub_type： 杂志文章

    doi：10.1007/BF03349057

    authors： Busnardo B,Girelli ME,Rubello D,Eccher C,Betterle C

    更新日期：1988-05-01 00:00:00