Effects of 17 beta-oestradiol on vascular responses in the in situ blood-perfused mesentery of Wistar-Kyoto rats.


:1. To determine whether endogenous oestrogen plays a role in pregnancy induced decreased vascular reactivity we have examined the effects of 17 beta-oestradiol on vasoconstrictor responses to various stimuli using an in situ blood-perfused mesenteric vascular preparation in Wistar-Kyoto (WKY) rats. 2. Daily administration of 17 beta-oestradiol (500 micrograms/kg, s.c.) for 15 days significantly enhanced mesenteric vasoconstrictor responses to noradrenaline (NA), without affecting responses to the electrical stimulation of sympathetic nerves (ES) and angiotensin II (AngII). 3. Nitric oxide (NO) synthesis inhibition by nitro-L-arginine methyl ester (L-NAME; 100 mg/kg, i.v.) significantly potentiated mesenteric vasoconstrictor responses to all stimuli in both 17 beta-oestradiol-treated and control animals. The difference in NA responses between groups was diminished following NO synthesis inhibition. 4. These findings do not support the hypothesis that increased endogenous oestrogen plays a role in decreased mesenteric vascular reactivity in pregnancy. However, responses to oestrogen may be dose-dependent and enhancement of vasoconstrictor responses to NA may be relevant to oral contraceptive-induced hypertension.


Chu ZM,Beilin LJ




Has Abstract


1997-06-01 00:00:00












  • The anticholinergic drug oxybutynin inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells.

    abstract::This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Li H,Seo MS,An JR,Jung HS,Ha KS,Han ET,Hong SH,Bae YM,Ryu DR,Park WS

    更新日期:2019-11-01 00:00:00

  • Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.

    abstract::1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

    更新日期:2003-07-01 00:00:00

  • Stimulation of phosphatidylinositol turnover in adult rat left atria does not involve release of inositol(1,4,5)trisphosphate.

    abstract::1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Anderson KE,Myers D,Woodcock EA

    更新日期:1993-05-01 00:00:00

  • Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitro.

    abstract::1. It has been suggested that Na+/K(+)-ATPase and Na(+)-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K(+)-ATPase activity using Rb+ uptake by 'minislices' (prisms) of the cerebral cortex. This preparation preserves the morphology of neurons, sy...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nanitsos EK,Acosta GB,Saihara Y,Stanton D,Liao LP,Shin JW,Rae C,Balcar VJ

    更新日期:2004-11-01 00:00:00

  • Effect of acute administration of prazosin on blood pressure, heart rate and plasma renin level in the conscious normotensive rat.

    abstract::This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Furthermore the beta-adrenergic nervous system was also investigated to ascertain whether it was involved in this effect. Prazosin (0.1 or 1 mg/kg) was injected subcutaneously (s.c.) to conscio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Atkinson J,Luthi P,Sonnay M,Boillat N

    更新日期:1986-07-01 00:00:00

  • Renin gene expression in various tissues determined by single-step polymerase chain reaction.

    abstract::1. Renin mRNA is present in the kidney and, in lower concentrations, in many extrarenal tissues and serves as an index of renin gene activity, as well as potential renin or prorenin synthesis in cell populations within those tissues. Unfortunately the quantity can be very low. 2. A new, highly sensitive technique is d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lou YK,Smith DL,Robinson BG,Morris BJ

    更新日期:1991-05-01 00:00:00

  • Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.

    abstract::Autophagy promotes cell survival or induces apoptosis in cancer cells. While SIRT1 and AMPK induce autophagy in both normal and cancer cells, Akt and mTOR can inhibit it. Calycosin, a methoxyisoflavone, protects against several types of solid tumours including colorectal cancer. However, the mechanisms behind the anti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: El-Kott AF,Al-Kahtani MA,Shati AA

    更新日期:2019-10-01 00:00:00

  • Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit.

    abstract::1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang MD,Rahman M,Johansson IM,Bäckström T

    更新日期:2010-07-01 00:00:00

  • Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.

    abstract::1. The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction. 2. Japanese white rabbits underwent 30 min of coronary occlusion, followed by 48 h of reperfusion. Cilostazol (1 and 5 mg/kg) or vehicle was given intr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Bai Y,Muqier,Murakami H,Iwasa M,Sumi S,Yamada Y,Ushikoshi H,Aoyama T,Nishigaki K,Takemura G,Uno B,Minatoguchi S

    更新日期:2011-10-01 00:00:00

  • Existence of beta(3)-adrenoceptors in rat heart: functional implications.

    abstract::1. beta(3)-Adrenoceptors (AR) have been reported to be present in numerous species, where they mediate multiple responses. 2. The aim of the present study was to determine whether beta(3)-AR are present in intact rat heart and the functional implications of beta(3)-AR stimulation. The response to the cardiac beta(3)-A...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Barbier J,Mouas C,Rannou-Bekono F,Carré F

    更新日期:2007-08-01 00:00:00

  • The influence of diethylmaleate on the biliary excretion of infused sulphobromophthalein sodium and its glutathione conjugate in guinea-pigs.

    abstract::1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Whelan G

    更新日期:1980-11-01 00:00:00

  • Postnatal outcomes in term and preterm lambs following fetal growth restriction.

    abstract::1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

    更新日期:2001-11-01 00:00:00

  • Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats.

    abstract::Heart rate recovery (HRR) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR. Acetylcholinesterase inhibitors, such as pyridostigmine, can e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Bharadwaj M,Pope C,Davis M,Katz S,Cook C,Maxwell L

    更新日期:2017-08-01 00:00:00

  • Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.

    abstract::Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

    更新日期:2016-02-01 00:00:00

  • Reperfusion injury in the human forearm is mild and not attenuated by short-term ischaemic preconditioning.

    abstract::1. Ischaemia-reperfusion (IR) injury is an important contributor to tissue damage and has been shown to be attenuated by preconditioning (PC) in some animal models. A recent report has suggested that the forearm can be used for the study of this phenomenon in humans. We aimed to reproduce and further characterize this...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章


    authors: Kilian JG,Nakhla S,Griffith K,Harmer J,Skilton M,Celermajer DS

    更新日期:2005-01-01 00:00:00

  • Deleterious effects of salt intake other than effects on blood pressure.

    abstract::1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Antonios TF,MacGregor GA

    更新日期:1995-03-01 00:00:00

  • Ageing has no effect on the volume density of hepatocytes, reticulo-endothelial cells or the extracellular space in livers of female Sprague-Dawley rats.

    abstract::1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Martin G,Sewell RB,Yeomans ND,Smallwood RA

    更新日期:1992-07-01 00:00:00

  • Recent developments concerning diet and hypertension.

    abstract::1. Recent data from randomized controlled dietary trials have shown blood pressure-lowering effects of foodstuffs and dietary patterns to be of practical importance for both individual and population blood pressure control. 2. The salient studies include Dietary Approaches to Stop Hypertension (DASH) trials, on comple...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Beilin LJ,Burke V,Puddey IB,Mori TA,Hodgson JM

    更新日期:2001-12-01 00:00:00

  • Molecular genetics of schizophrenia.

    abstract::1. Schizophrenia is a chronic, disabling brain disease that affects approximately 1% of the world's population. It is characterized by delusions, hallucinations and formal thought disorder, together with a decline in socio-occupational functioning. While the causes for schizophrenia remain unknown, evidence from famil...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Mowry BJ,Nancarrow DJ

    更新日期:2001-01-01 00:00:00

  • Formation of a ternary complex with serum albumin: an explanation for the effect of alpha-mercapto-beta-(2-furan) acrylic acid on rat plasma zinc clearance.

    abstract::1. Four, six and eight hours after gavage of rats with alpha-mercapto-beta-(2-furan)acrylic acid (MFA) (25 mg/kg) serum zinc concentration was increased ten-fold over control levels and a mean molar ratio of 1 albumin:0-4 zinc:0-8 MFA was found for seventeen sera. 2. At pH 7-5 a maximum of 1 mole of MFA could be bound...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Giroux E,Prakash NJ,Schechter PJ

    更新日期:1977-01-01 00:00:00

  • Acute changes in blood pressure and vasoactive hormones after captopril in hypertensive patients.

    abstract::1. The acute effects of captopril on blood pressure, renin, angiotensin, bradykinin and catecholamines were examined in patients with essential (n = 10, Group 1), accelerated (n = 6, Group 2) and renal hypertension (n = 14, Group 3). 2. Blood pressure showed little change in Group 1, fell significantly in Group 2, wit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: McGrath BP,Matthews PG,Johnston CI

    更新日期:1980-09-01 00:00:00

  • In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin.

    abstract::1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ajith TA,Riji T,Anu V

    更新日期:2008-05-01 00:00:00

  • Feasibility of conducting cardiovascular outcome research in Australian general practice: results from the ANBP2 pilot study. Australian National Blood Pressure Study.

    abstract::1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Reid CM,Nelson M,Beckinsale P,Ryan P,Wing LM,Beilin LJ,Brown MA,Jennings GL,Johnston CI,Marley J,McNeil JJ,Morgan TO,Shaw J,Steven ID,West MJ

    更新日期:1997-05-01 00:00:00

  • Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.

    abstract::Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Shang D,Wu Y,Ding Y,Lu Z,Shen Y,Zhu F,Liu H,Zhu C,Tu Z

    更新日期:2018-05-01 00:00:00

  • Intracerebroventricular ANP(1-28) has no obvious effects on renal blood flow and function in conscious sheep.

    abstract::1. The study examines whether intracerebroventricular (ICV) infusion of atrial natriuretic peptide (human ANP,1-28) influences renal electrolyte and water excretion, vasopressin release, renal and femoral blood flows in conscious ewes. The blood flow was measured by chronically implanted ultrasonic flow probes. 2. ICV...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gunnarsson U

    更新日期:1994-03-01 00:00:00

  • Contrasting effects of isoproterenol and phosphodiesterase III inhibitor on intracellular calcium transients in cardiac myocytes from failing hearts.

    abstract::1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

    更新日期:1994-12-01 00:00:00

  • Nerve growth factor mRNA content parallels altered sympathetic innervation in the spontaneously hypertensive rat.

    abstract::1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Falckh PH,Harkin LA,Head RJ

    更新日期:1992-08-01 00:00:00

  • Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle.

    abstract::1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

    更新日期:2008-07-01 00:00:00

  • cAMP produced by pituitary adenylate cyclase-activating polypeptide 27 inhibits atrial natriuretic peptide secretion in rabbit beating atria.

    abstract::The aim of the present study was to determine the effects of increased cAMP levels in response to pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) on atrial atrial natriuretic peptide (ANP) secretion in rabbit atria. A perfused beating atrial model was used in the present study and cAMP efflux and ANP l...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang Y,Liu LP,Liang ZL,Li XL,Jin YZ,Cui X

    更新日期:2008-10-01 00:00:00

  • Protecting murine hearts from ischaemia-reperfusion using selective inhibitors of adenosine metabolism.

    abstract::1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Willems L,Headrick JP

    更新日期:2005-03-01 00:00:00