Abstract：
:Volume receptors are situated in many organs and are capable of modulating ADH secretion. We have evaluated the variation of plasma ADH concentration after an experimentally induced increase of cerebrospinal fluid (CSF) pressure (PCSF). The experiment was performed in controlled environmental conditions to avoid pain or stress-related ADH release. In 15 rats (10 experimental, 5 control) a cannula was positioned in the left cerebral ventricle: in the experimental group artificial CSF was infused at a rate of 0.6 (microliter/min for 6h: this manoeuvre, in a separate set of animals obtained an increase from 13.03 +/- 0.8 to 25.4 +/- 2.5 cmH2O of PCSF. The same conditions were reproduced in the control group without infusion into lateral ventricle. At the end of the experiment, plasma ADH had fallen significantly in the experimental group from 18.9 +/- 4.8 to 11.9 +/- 2.3 pg/ml (p < 0.05), while it was not changed in the control group (from 25.5 +/- 13.7 to 23.7 +/- 16.2 pg/ml). Heart rate, arterial pressure, plasma Na+ and osmolality, did not change significantly. Plasma K+ fell significantly in both groups: from 5.5 +/- 0.6 to 4.3 +/- 0.3 (p < 0.05) and from 5.4 +/- 0.7 to 4.3 +/- 0.15 mEq/l (p < 0.05) in the experimental and control group respectively. Plasma creatinine was normal, checked only at the end of the experiment. Our results demonstrate that a relationship exists between PCSF variations and plasma ADH concentration. We believe this relationship is due to the pressure receptors in the cerebral ventricles or in structures connected to it, such as the inner ear, and we hypothesize the existence of a control system of body fluids, more diffused than though to be, up till now.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Satta A,Palomba D,Demontis MP,Varoni MV,Faedda R,Ginanni A,Anania Vdoi
10.1007/BF03349891subject
Has Abstractpub_date
1996-07-01 00:00:00pages
455-62issue
7eissn
0391-4097issn
1720-8386journal_volume
19pub_type
杂志文章abstract：BACKGROUND:Levothyroxine (L-T4) treatment aims to minimize the risk of differentiated thyroid cancer (DTC) recurrence and should be tailored to patient risk stratification and potential morbidity from adverse effects. AIM:To evaluate the effectiveness of current recommendations on L-T4 treatment of DTC patients in cli...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8369
更新日期：2012-11-01 00:00:00
abstract：:The research suggests that adiponectin plays an important role in sensitizing insulin action. It is interesting to find that the lower levels of adiponectin exist in the plasma of obese and Type 2 diabetes subjects and in the adipose tissue of obese, db/db mice, and insulin-resistant individuals. However, the underlyi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346688
更新日期：2011-01-01 00:00:00
abstract：:Keratoconus is a bilateral non-inflammatory corneal ectasia with an incidence of approximately 1 per 2000 in the general population. The etiology of keratoconus is multifactorial, although not completely understood. Several clinical observations suggest that thyroid gland dysfunction is associated with keratoconus pat...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345600
更新日期：2008-03-01 00:00:00
abstract：:Puberty is a major developmental stage. Damaging mutations, considered as "mistakes of nature", have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic-pituitary-gonadal (HPG) axis development, in the normosmic idiopathic hypogonado...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-017-0627-9
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:One of the major topics in modern societies is the study of relationships between diet, stress and incidence of metabolic disorders. AIM:This study aimed to investigate possible impairment in glucose-stimulated insulin secretion induced by a high-fat (cow intra-abdominal fat) diet in response to acute stres...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.3275/8959
更新日期：2013-11-01 00:00:00
abstract：:In the literature, few studies analyze the effect of GH therapy on height, preferring a more indirect approach, where factors influencing the total pubertal and pre-pubertal growth in GH-deficient patients are evaluated and subsequently used to estimate the overall effect at the end of the therapy; unfortunately, this...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345420
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Insulin-like growth factor I (IGF-I) represents an essential tool in the diagnostic work-up and in the monitoring of treatment efficacy for somatotrophic axis disorders both in children and adults. A large number of factors including, but not limited to, age, sex and weight as well as analytical variables influ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-015-0265-z
更新日期：2015-09-01 00:00:00
abstract：:The physiological pulsatile secretion of GH in humans might be important for the metabolic effects of GH. In the treatment of GH-deficient (GHD) patients, the most common regimen is a single sc injection at bedtime. It has not been completely established if this is the optimal mode of GH administration during long-ter...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,随机对照试验
doi：10.1007/BF03349206
更新日期：2006-12-01 00:00:00
abstract：:Several clinical signs might be related to the decline of DHEA secretion in aged people: sarcopenia, osteopenia, atherosclerosis progression, impairment of cognitive and affective performances, deterioration of immunocompetence are the most significant evidences. In addition, in aged people this clinical condition mig...
journal_title：Journal of endocrinological investigation
pub_type：
doi：
更新日期：2002-01-01 00:00:00
abstract：:To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349006
更新日期：1996-09-01 00:00:00
abstract：:Serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) responses to exposure to sea-level altitude (LA) were examined in 13 eugonadal males, age 21-22 yr, 3 and 5 days after residing at LA and on the second day of return to basal altitude 90 days later. After 3 days at the...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350195
更新日期：1988-09-01 00:00:00
abstract：:Raloxifene (RLX), a selective estrogen receptor modulator (SERM), is currently indicated for the prevention and treatment of post-menopausal osteoporosis. At present, RLX is evaluated in other areas of study that include the reduction of the risk of breast cancer and cardiovascular (CV) disease in post-menopausal wome...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:Recently, bromocriptine has been successfully introduced as medical therapy for the pituitary hypersecreting syndromes of hyperprolactinemia and acromegaly. Subsequently, an inhibitory effect on ACTH secretion was reported using bromocriptine in Cushing's disease. While most studies have focused on the acute response ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350502
更新日期：1982-03-01 00:00:00
abstract：PURPOSE:The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters. METHODS:Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution wit...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0100-y
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Results of circulating Ghrelin levels in hyper- or hypothyroidism are conflicting and only overt thyroid dysfunction has been evaluated. AIM:To evaluate in a large number of patients with thyroid disfunction whether: a) hyper- and hypothyroidism (clinical or subclinical) are associated with variations in bo...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345683
更新日期：2009-01-01 00:00:00
abstract：:The cause of a poor response to human menopausal gonadotropin (hMG) remains unexplained. To determine whether aromatase activity of cultured granulosa cells obtained from relatively low estradiol (E2) responders (serum E2 < 1000 pg/ml) to hMG therapy differed from that of good responders (E2 > or = 1000 pg/ml), we pro...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03344926
更新日期：1992-09-01 00:00:00
abstract：:A 57-year-old man with pituitary metastasis from renal cell carcinoma is reported. He underwent right nephrectomy and total pancreatectomy for renal cell carcinoma and its pancreatic metastasis, respectively. Imaging studies showed an intrasellar mass lesion. The examination revealed panhypopituitarism, diabetes insip...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345815
更新日期：1992-10-01 00:00:00
abstract：:The intravenous injection of calcium gluconate (0.11 mM/kg body weight) into conscious thyroidectomized pigs elicits a 30% rise in both ionized and total calcium concentrations of plasma, which return to basal levels within 180 min. The administration of calcitonin (2.5-10 MRC U/kg body weight) reduces this time to 30...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350579
更新日期：1983-04-01 00:00:00
abstract：:Severe bleeding into the peritoneal cavity from a ruptured ovulatory follicle is a rare complication in women receiving anticoagulation therapy. A number of both surgical and non surgical methods have been proposed to solve this problem. We adopted a novel therapeutic approach in a 40-year old patient who presented wi...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348998
更新日期：1994-05-01 00:00:00
abstract：:Peroxisome proliferator activated receptor (PPAR)gamma plays a pivotal role in regulating adipocyte differentiation and metabolism, but also has an antiproliferative effect in several tissues, including colonic mucosa, where it is highly expressed. Loss-of-function mutations have been reported in about 10% of sporadic...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345249
更新日期：2003-11-01 00:00:00
abstract：:Because women affected by polycystic ovary syndrome (PCOS) present an increased cardiovascular risk, the safety of estroprogestin treatment is debated and contrasting data have been reported. However, cardiovascular risk is not the same in all PCOS women and individual cardiovascular risk should be assessed before sta...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.3275/8882
更新日期：2013-05-01 00:00:00
abstract：:We describe a unique case of spontaneous resolution of hyperparathyroidism in a lady with combined parathyroid adenoma and prolactinoma, raising the possibility of underlying multiple endocrine neoplasia (MEN) 1 syndrome. We also discuss the mechanism and natural history of such spontaneous remission. ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03345292
更新日期：2004-05-01 00:00:00
abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349528
更新日期：1990-02-01 00:00:00
abstract：PURPOSE:Iodine plays a pivotal role in adaptation during the transition from intrauterine to extrauterine life. Although it is well known that the placenta plays a role in iodine storage, a relationship between the neonatal thyroid stimulating hormone (TSH) peak and placental iodine concentration has not been establish...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-020-01399-y
更新日期：2020-08-28 00:00:00
abstract：:Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PT...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-016-0477-x
更新日期：2016-11-01 00:00:00
abstract：:ACTH, beta lipotropin (beta LPH), beta endorphin (beta EP), Prolactin (PRL) and Cortisol were measured in the first five days of puerperium at 9:00, before and 30 minutes after suckling, in 7 healthy lactating women. With the exception of PRL plasma levels which decline, although remaining at high concentrations durin...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350534
更新日期：1982-11-01 00:00:00
abstract：:Adolescent girls with a history of premature pubarche have an increased incidence of functional ovarian hyperandrogenism [a form of polycystic ovary syndrome (PCOS)] at adolescence, which is usually associated with hyperinsulinemia and dyslipemia. The hyperinsulinemia and lipid disturbances can often be detected in th...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03350781
更新日期：1998-10-01 00:00:00
abstract：:Growth hormone (GH), insulin-like growth factor-1 (IGF-1) and prolactin (PRL) in blood and urine were observed in 20 patients with acromegaly in a double-blind placebo-controlled 14-day clinical trial with the somatostatin analog octreotide. Hormones were determined by the same radioimmunoassays in blood and urine. Si...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章
doi：10.1007/BF03348824
更新日期：1993-04-01 00:00:00
abstract：:Bone matrix is composed mainly of inorganic materials, while the bone organic compartment is a minor and complex structural entity, surrounding and supporting cells. Three major classes of biomolecules are involved in this organic part: structural proteins, specialized proteins, and proteoglycans. This review will bri...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347227
更新日期：2005-05-01 00:00:00
