Integrative role of the lamina terminalis in the regulation of cardiovascular and body fluid homeostasis.

abstract：:Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Song JF,Wang T,Zhu J,Zhou XY,Lu Q,Guo H,Zhang F,Wang Y,Li W,Wang DD,Cui YW,Lv DM,Yin XX

更新日期：2015-01-01 00:00:00

abstract：:1. The neuronal release of acetylcholine (ACh) and its autoregulation by neuromodulators, substance P (SP) and methionine enkephalin (MEK), have been studied using superfused rodent cerebral slices. Nicotine exerts significant effects on autoregulation of ACh release, which may have toxicological implications. 2. Posi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sastry BV

更新日期：1995-04-01 00:00:00

abstract：:The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang X,Jia Z,Shi H,Pan C

更新日期：2018-10-01 00:00:00

abstract：:1. We examined the proliferative rates of cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR). Wistar-Kyoto rats (WKY) were used as a control for SHRSP and SHRSR. 2. In the presence of 10% fetal bovine serum (FBS), the doub...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamagata K,Nara Y,Tagami M,Yamori Y

更新日期：1995-09-01 00:00:00

abstract：:1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle. 2. Non-pregnant adult Wistar rats were decapitated and dissected to isolate myometrial strips. The tissue was mounted in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ayar A

更新日期：2007-08-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:1. In coronary artery disease, the typical atheromatous plaque consists of a lipid core containing various inflammatory cells and a fibrous cap composed mostly of extracellular matrix. Both matrix metalloproteinases (MMPs) and inflammation are involved in the initiation of atherosclerotic plaques and plaque instabilit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang W,Wang CH,Li F,Zhu WZ

更新日期：2008-03-01 00:00:00

abstract：:The kidney has a unique environment that results in relatively low tissue oxygen tension (Po2). However, recent studies have shown that renal hypoxia is more severe during hypertension and may reflect changes in the way O2 is used. The present review summarizes studies that explore the relationship between renal oxyge...

journal_title：Clinical and experimental pharmacology & physiology

authors： Welch WJ

更新日期：2006-10-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. The choice of initial pharmacological therapy is one area where the different hypertension management guidelines vary in recommending either the use of diuretics and beta-blockers as preferred drugs or choosing from any of the five major classes of antihypertensives. 2. Improvement in cardiovascular morbidity and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomlinson B

更新日期：1997-12-01 00:00:00

abstract：:The combined administration of metronidazole and ampicillin increased faecal weights by 198% in normal male subjects on controlled diets with constant energy, protein and dietary fibre content. Intestinal transit times were unaltered despite marked increase in faecal weights. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurpad AV,Shetty PS

更新日期：1984-09-01 00:00:00

abstract：:1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fagard RH

更新日期：2006-09-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

更新日期：2018-10-01 00:00:00

abstract：:Despite the presence of many studies on the role of mechanistic target of rapamycin (mTOR) in cardiorenal tissues, the definitive role of mTOR in the pathogenesis of renal injury subsequent to ischaemia-reperfusion (IR) remains unclear. The aims of the current study were to characterize the role of mTOR in normal kidn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alshaman R,Truong L,Oyekan A

更新日期：2016-11-01 00:00:00

abstract：:1. The effects of cold saline (25 mL) injected over the fetal skin on fetal heart rate (HR) and HR variability (HRV), measured as the coefficient of variation (CV) in pulse interval (PI) and by power spectral analysis (PSA), were measured in 10 chronically catheterized fetal sheep aged 140-144 days. To determine the e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yu ZY,Lumbers ER

更新日期：2000-08-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:The therapeutic potential of the antimicrobial peptide cathelicidin (Camp) administration in sepsis has been widely investigated. However, little is known about the pathophysiological roles of cathelicidin in septic cardiomyopathy. In a lipopolysaccharide (LPS)-induced endotoxaemic model, we found that the mRNA and pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhai T,Zhang J,Zhang Y,Wu Y

更新日期：2020-04-01 00:00:00

abstract：:The effect of pancuronium in the rabbit ear artery was investigated in order to measure the inhibition it produces at the prejunctional muscarinic receptor on sympathetic nerve endings in this tissue. Pancuronium (0.1-0.2 mmol/l) produced an enhancement of responses to transmural electrical stimulation but this effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Leung E,Mitchelson F

更新日期：1983-11-01 00:00:00

abstract：:1. Mathematical modelling is useful in pharmacology, allowing the investigator to obtain insights into the biological processes under study that may not always be intuitively obvious. Examples are presented in this review using the pharmacology of the muscarinic acetylcholine receptor (mAChR) agonist xanomeline. 2. Xa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christopoulos A

更新日期：2001-03-01 00:00:00

abstract：:1. Treatment with heparin has beneficial effects in diabetic nephropathy. The occurrence of increased urinary albumin excretion in diabetic patients reflects general vascular dysfunction, including increased transcapillary permeability of macromolecules. The aim of the present study was to evaluate the effects of hepa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oturai PS

更新日期：1999-05-01 00:00:00

abstract：:1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivory LP

更新日期：1996-10-01 00:00:00

abstract：:1. We examined the effects of torasemide (0.3 and 1 mg/kg i.v.) on renal haemodynamics and function employing renal clearance and stop-flow techniques in anaesthetized dogs and compared these with furosemide (1 and 3 mg/kg i.v.). 2. Torasemide and furosemide did not influence renal haemodynamics, in the renal clearanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uchida T,Hayashi K,Suzuki Y,Matsumura Y

更新日期：1991-07-01 00:00:00

abstract：:1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

更新日期：2001-11-01 00:00:00

abstract：:1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

journal_title：Clinical and experimental pharmacology & physiology

authors： Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

更新日期：1994-12-01 00:00:00

abstract：:Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

更新日期：2018-12-01 00:00:00

abstract：:The activity of dopamine-beta-hydroxylase (D beta H) in the serum was measured in patients with quadriplegia and in healthy subjects. We assume that the plasma D beta H levels reflect sympathetic tone. Quadriplegics had significantly lower D beta H levels at rest. After head-up tilting a significant decrease in D beta...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ohry A,Rabinowitz R,Korczyn AD

更新日期：1980-07-01 00:00:00

abstract：:Epidemiological studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, whereas in postnatal life ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang KC,Botting KJ,Padhee M,Zhang S,McMillen IC,Suter CM,Brooks DA,Morrison JL

更新日期：2012-11-01 00:00:00

abstract：:1. Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution. 2. Herein, we introduc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fouras A,Dusting J,Sheridan J,Kawahashi M,Hirahara H,Hourigan K

更新日期：2009-02-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00