Abstract：
:1. We set out to investigate whether the administration of naloxone alone, naloxone plus vasopressin (AVP) or naloxone plus alprazolam to patients with Cushing's syndrome would result in a blunted dynamic response of the pituitary-adrenal axis compared with normal volunteers. Cushing's syndrome is often difficult to diagnose. It would be helpful if new tests were available to help in the biochemical distinction between Cushing's syndrome and non-Cushing's syndrome patients. 2. Naloxone testing correctly distinguished all seven patients with Cushing's syndrome (four pituitary Cushing's, two adrenal adenomas, one ectopic ACTH) from normal. Six patients were distinguished by the per cent change of plasma ACTH from basal being less than the normal range of 10 volunteers. The seventh patient (a pituitary Cushing's) was distinguished by the per cent change from basal of plasma cortisol being less than the normal range. 3. Naloxone plus AVP testing of two of four patients with pituitary Cushing's showed a smaller per cent change for both ACTH and cortisol compared with five normal volunteers, correctly distinguishing Cushing's from the normals. 4. Naloxone plus alprazolam did not distinguish Cushing's from normal. 5. Naloxone testing and naloxone plus AVP testing appear to be promising methods of distinguishing Cushing's syndrome from normal. Further experience with these tests, especially with obese and pseudo-Cushing's individuals, will be necessary to determine their place in the diagnosis and differential diagnosis of the cause of Cushing's syndrome.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Jackson RV,Hockings GI,Torpy DJ,Grice JE,Crosbie GV,Walters MM,Strakosch CRdoi
10.1111/j.1440-1681.1996.tb02785.xsubject
Has Abstractpub_date
1996-06-01 00:00:00pages
579-81issue
6-7eissn
0305-1870issn
1440-1681journal_volume
23pub_type
临床试验,杂志文章abstract：:1. Tissue plasminogen activator (tPA) has both fibrinolytic and anti-inflammatory activity. These properties may be useful in treating inflammatory lung diseases, such as acute respiratory distress syndrome (ARDS). 2. We have previously demonstrated the feasibility of targeted pulmonary delivery of tPA. As part of our...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2008.05011.x
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abstract：:Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb00946.x
更新日期：1986-08-01 00:00:00
abstract：:1. Oxygen (O2) transfer from the blood to tissues is a function of the red blood cell (RBC) O2 saturation (SO2), the plasma O2 content being negligible. Under conditions of increased tissue O2 demand, the SO2 of arterial blood does not change appreciably (97%); however, the SO2 of mixed venous blood, equal to that of ...
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pub_type： 杂志文章,评审
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更新日期：2000-12-01 00:00:00
abstract：:1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-s...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1988.tb01075.x
更新日期：1988-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb00339.x
更新日期：1986-03-01 00:00:00
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doi：10.1111/j.1440-1681.1988.tb01068.x
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doi：10.1111/j.1440-1681.1995.tb02027.x
更新日期：1995-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2002-04-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1999-10-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.2010.05416.x
更新日期：2010-09-01 00:00:00
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doi：10.1111/1440-1681.12767
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journal_title：Clinical and experimental pharmacology & physiology
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doi：10.1111/1440-1681.12485
更新日期：2015-12-01 00:00:00
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更新日期：2008-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2005-05-01 00:00:00
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更新日期：1989-06-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1986.tb00337.x
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
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更新日期：1988-06-01 00:00:00
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doi：10.1111/j.1440-1681.1984.tb00866.x
更新日期：1984-09-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1988-12-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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doi：10.1111/j.1440-1681.1997.tb02723.x
更新日期：1997-12-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/1440-1681.12763
更新日期：2017-07-01 00:00:00
abstract：:1. The administration of coumarin resulted in a two-fold increase in the entry of 51Cr-labelled rat plasma protein into otherwise normal tissues. 2. Prior treatment of rats with coumarin allowed about 50% more radio-labelled protein to enter the tissues immediately after thermal injury than occurred with thermal injur...
journal_title：Clinical and experimental pharmacology & physiology
pub_type： 杂志文章
doi：10.1111/j.1440-1681.1976.tb00633.x
更新日期：1976-11-01 00:00:00
