Abstract：
:1. In a controlled, randomized double-blind trial, 15 patients with essential hypertension were treated with enalapril 5-20 mg/day, or doxazosin 1-8 mg/day, during a 7 week dose titration phase. This was followed by 7 weeks of combined treatment with doxazosin and enalapril. 2. Blood was taken after a 2 week placebo run-in phase, and at 3 and 7 weeks in the single-agent and combined treatment phases, for measurement of plasma renin activity (PRA), plasma angiotensin II (AII), plasma aldosterone and serum free and total angiotensin-converting enzyme (ACE) activities. 3. Doxazosin had no effect on serum free or total ACE activities. 4. Enalapril reduced serum free ACE activity and increased serum total ACE activity, which at 7 weeks was significantly greater than in patients receiving doxazosin. 5. In those patients who received enalapril, 10 mg/day for 3 weeks and then 20 mg/day for 4 weeks (n = 12), with or without doxazosin, mean serum total ACE activity increased by 51%. PRA was also increased in this group, but there were no changes in plasma AII or aldosterone concentrations.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Stokes GS,Monaghan JC,Marwood JF,Okoro EO,Johnston Hdoi
10.1111/j.1440-1681.1992.tb00456.xkeywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
297-9issue
5eissn
0305-1870issn
1440-1681journal_volume
19pub_type
临床试验,杂志文章,随机对照试验abstract：:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...
journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1995-12-01 00:00:00
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doi：10.1111/j.1440-1681.1992.tb00444.x
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更新日期：1997-09-01 00:00:00
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更新日期：2007-12-01 00:00:00
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更新日期：1976-01-01 00:00:00
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更新日期：2014-02-01 00:00:00
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更新日期：1980-03-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1996-01-01 00:00:00
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更新日期：2005-09-01 00:00:00
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更新日期：2010-09-01 00:00:00
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journal_title：Clinical and experimental pharmacology & physiology
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更新日期：1998-06-01 00:00:00
