Long term follow up of severely ill patients who underwent urgent cardiac transplantation.

Abstract:

OBJECTIVE:To assess long term survival (> 5 years) and quality of life in severely ill patients referred for urgent cardiac transplantation. SETTING:Tertiary referral centres: before transplantation at the National Heart Hospital (late 1984 to end 1986); after transplantation at Harefield Hospital. SUBJECTS:Eighteen patients (15 men; three women) who had required intensive support in hospital before cardiac transplantation and were alive at short term follow up. INTERVENTIONS:Intravenous infusions of cardiac drugs (mean 2.2 infusions), intravenous diuretics (17 patients), and many other drugs before transplantation. Intra-aortic balloon counterpulsation (four patients), temporary pacing (two), and resuscitation from cardiac arrest (three). Patients had specialised nursing care on a medical intensive care unit in almost every case. MAIN OUTCOME MEASURES:Long term survival in patients after urgent cardiac transplantation and perceived quality of life. RESULTS:Of 18 patients who were alive at short term follow up (mean (range) 19.4 (10-33) months), 14 were still alive in 1992 (69 (61-83) months). Ten still worked full time, and 11 reported no restrictions in their daily activities. Three of four patients who died in the intervening period survived > 5 years after transplantation. Overall, 17 of 18 patients survived at least 5 years. CONCLUSIONS:In severely ill patients who undergo urgent cardiac transplantation and survive in the short term, long term (5-7 year) survival and quality of life seem good.

journal_name

BMJ

authors

Mulcahy D,Fitzgerald M,Wright C,Sparrow J,Pepper J,Yacoub M,Fox KM

doi

10.1136/bmj.306.6870.98

subject

Has Abstract

pub_date

1993-01-09 00:00:00

pages

98-101

issue

6870

eissn

0959-8138

issn

1756-1833

journal_volume

306

pub_type

杂志文章
  • Is an information booklet for patients leaving hospital helpful and useful?

    abstract:OBJECTIVE:To determine whether a booklet given to patients being discharged from hospital giving details of their admission and treatment increased their knowledge and recall when reviewed in outpatient clinics. DESIGN:Patients alternately allocated to receive a booklet or to serve as controls. Assessment by a questio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.298.6677.870

    authors: Sandler DA,Mitchell JR,Fellows A,Garner ST

    更新日期:1989-04-01 00:00:00

  • When somebody loses weight, where does the fat go?

    abstract::Ruben Meerman and Andrew Brown explain why the answer might not be what you expect. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.g7257

    authors: Meerman R,Brown AJ

    更新日期:2014-12-16 00:00:00

  • Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs.

    abstract:OBJECTIVE:To estimate the risk of acute hepatotoxicity associated with nimesulide compared with other non-steroidal anti-inflammatory drugs. DESIGN:Retrospective cohort and nested case-control study. SETTING:Umbria region, Italy. PARTICIPANTS:400 000 current, recent, and past users (almost 2 million prescriptions) o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.327.7405.18

    authors: Traversa G,Bianchi C,Da Cas R,Abraha I,Menniti-Ippolito F,Venegoni M

    更新日期:2003-07-05 00:00:00

  • Children on hunger strike: child abuse or legitimate protest?

    abstract::The issue of children on hunger strike (voluntary total fasting) has not been reported before. The World Medical Association Declaration of Tokyo 1975 and the Declaration of Malta 1991 (revised 1992) provide clinicians with guidelines for the management of adult patients on hunger strike but do not mention children. W...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7029.501

    authors: Mok A,Nelson EA,Murphy J,Hampson A,Hendriks JH

    更新日期:1996-02-24 00:00:00

  • Potential impact of missing outcome data on treatment effects in systematic reviews: imputation study.

    abstract:OBJECTIVE:To assess the risk of bias associated with missing outcome data in systematic reviews. DESIGN:Imputation study. SETTING:Systematic reviews. POPULATION:100 systematic reviews that included a group level meta-analysis with a statistically significant effect on a patient important dichotomous efficacy outcome...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.m2898

    authors: Kahale LA,Khamis AM,Diab B,Chang Y,Lopes LC,Agarwal A,Li L,Mustafa RA,Koujanian S,Waziry R,Busse JW,Dakik A,Schünemann HJ,Hooft L,Scholten RJ,Guyatt GH,Akl EA

    更新日期:2020-08-26 00:00:00

  • Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study.

    abstract:OBJECTIVE:To assess the safety and effectiveness of eflornithine as first line treatment for human African trypanosomiasis. DESIGN:Cohort study. SETTING:Control programme in Ibba, southern Sudan. PARTICIPANTS:1055 adults and children newly diagnosed with second stage disease in a 16 month period. MAIN OUTCOME MEASU...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.39485.592674.BE

    authors: Priotto G,Pinoges L,Fursa IB,Burke B,Nicolay N,Grillet G,Hewison C,Balasegaram M

    更新日期:2008-03-29 00:00:00

  • Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanisms of action.

    abstract:OBJECTIVE:To investigate the effects of spinal cord stimulation on myocardial ischaemia, coronary blood flow, and myocardial oxygen consumption in angina pectoris induced by atrial pacing. DESIGN:The heart was paced to angina during a control phase and treatment with spinal cord stimulation. Blood samples were drawn f...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.307.6902.477

    authors: Mannheimer C,Eliasson T,Andersson B,Bergh CH,Augustinsson LE,Emanuelsson H,Waagstein F

    更新日期:1993-08-21 00:00:00

  • The social origins of infantile colic: questionnaire study covering 76,747 infants.

    abstract:OBJECTIVE:To describe risk factors for infantile colic. DESIGN:Questionnaire administered by health visitors. SETTING:Sheffield. SUBJECTS:Mothers of 76,747 infants born between 1 August 1975 and 31 May 1988, interviewed when the infant was 1 month old. MAIN OUTCOME MEASURES:Reporting of infantile colic and its dura...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.314.7090.1325

    authors: Crowcroft NS,Strachan DP

    更新日期:1997-05-03 00:00:00

  • Tea drinking habits and oesophageal cancer in a high risk area in northern Iran: population based case-control study.

    abstract:OBJECTIVE:To investigate the association between tea drinking habits in Golestan province, northern Iran, and risk of oesophageal squamous cell carcinoma. DESIGN:Population based case-control study. In addition, patterns of tea drinking and temperature at which tea was drunk were measured among healthy participants in...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.b929

    authors: Islami F,Pourshams A,Nasrollahzadeh D,Kamangar F,Fahimi S,Shakeri R,Abedi-Ardekani B,Merat S,Vahedi H,Semnani S,Abnet CC,Brennan P,Møller H,Saidi F,Dawsey SM,Malekzadeh R,Boffetta P

    更新日期:2009-03-26 00:00:00

  • Primary total hip arthroplasty versus hemiarthroplasty for displaced intracapsular hip fractures in older patients: systematic review.

    abstract:OBJECTIVE:To determine whether total hip arthroplasty is associated with lower reoperation rates, mortality, and complications, and better function and quality of life than hemiarthroplasty for displaced fractures of the femoral neck in older patients. DESIGN:Systematic review and meta-analysis of randomised trials, q...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.c2332

    authors: Hopley C,Stengel D,Ekkernkamp A,Wich M

    更新日期:2010-06-11 00:00:00

  • Evaluation of extended training for general practice in Northern Ireland: qualitative study.

    abstract:OBJECTIVE:To evaluate participants' perceptions of the impact on them of an additional six months' training beyond the standard 12 month general practice vocational training scheme. DESIGN:Qualitative study using focus groups. SETTING:General practice vocational training in Northern Ireland. PARTICIPANTS:13 general ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.327.7421.971

    authors: Sibbett CH,Thompson WT,Crawford M,McKnight A

    更新日期:2003-10-25 00:00:00

  • Impact of rice based oral rehydration solution on stool output and duration of diarrhoea: meta-analysis of 13 clinical trials.

    abstract:OBJECTIVE:To define the benefit of rice oral rehydration salts solution in relation to the glucose based World Health Organisation oral rehydration salts solution for treating and preventing dehydration in patients with severe dehydrating diarrhoea. DESIGN:Meta-analysis using data from 13 available randomised trials t...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.304.6822.287

    authors: Gore SM,Fontaine O,Pierce NF

    更新日期:1992-02-01 00:00:00

  • Demographic shifts and medical training.

    abstract::The rapid aging of populations in developing countries as compared to those in the developed world has implications for medical training in these places. Moreover, the growing globalization of employment for many health professionals means that demographic shifts have implications for the training of health professio...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.319.7221.1358

    authors: Ebrahim S

    更新日期:1999-11-20 00:00:00

  • Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publications.

    abstract:OBJECTIVE:To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits an...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.g3510

    authors: Maund E,Tendal B,Hróbjartsson A,Jørgensen KJ,Lundh A,Schroll J,Gøtzsche PC

    更新日期:2014-06-04 00:00:00

  • Informing participants of allocation to placebo at trial closure: postal survey.

    abstract:OBJECTIVES:To assess whether and how investigators of placebo controlled randomised trials inform participants of their treatment allocation at trial closure and to assess barriers to feedback. DESIGN:Postal survey with a semistructured questionnaire. PARTICIPANTS:All investigators who published a placebo controlled ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.325.7376.1329

    authors: Di Blasi Z,Kaptchuk TJ,Weinman J,Kleijnen J

    更新日期:2002-12-07 00:00:00

  • Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.

    abstract:OBJECTIVE:To assess the effects of Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation in the prevention of gastric cancer. DESIGN:Blinded randomized placebo controlled trial. SETTING:Linqu County, Shandong province, China. PARTICIPANTS:3365 residents of a high risk region for gastric ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.l5016

    authors: Li WQ,Zhang JY,Ma JL,Li ZX,Zhang L,Zhang Y,Guo Y,Zhou T,Li JY,Shen L,Liu WD,Han ZX,Blot WJ,Gail MH,Pan KF,You WC

    更新日期:2019-09-11 00:00:00

  • Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.

    abstract:OBJECTIVE:To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications. DESIGN:Prospective, propensity score matched cohort study. SETTING:General teaching hospital in Boston, Massachusetts, United States, 20...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e6329

    authors: Grosse-Sundrup M,Henneman JP,Sandberg WS,Bateman BT,Uribe JV,Nguyen NT,Ehrenfeld JM,Martinez EA,Kurth T,Eikermann M

    更新日期:2012-10-15 00:00:00

  • Risk of disability and mortality due to overweight in a Finnish population.

    abstract:OBJECTIVE:To investigate the effect of overweight on premature mortality and work disability in young and middle aged Finns. DESIGN:Prospective cohort study based on data collected in the multiphasic health examinations by the Social Insurance Institution of Finland from 1966 to 1972 and follow up until 1982. SETTING...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6756.835

    authors: Rissanen A,Heliövaara M,Knekt P,Reunanen A,Aromaa A,Maatela J

    更新日期:1990-10-13 00:00:00

  • Risk factors for neonatal encephalopathy in Kathmandu, Nepal, a developing country: unmatched case-control study.

    abstract:OBJECTIVE:To determine the risk factors for neonatal encephalopathy among term infants in a developing country. DESIGN:Unmatched case-control study. SETTING:Principal maternity hospital of Kathmandu, Nepal. SUBJECTS:All 131 infants with neonatal encephalopathy from a population of 21 609 infants born over an 18 mont...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.320.7244.1229

    authors: Ellis M,Manandhar N,Manandhar DS,Costello AM

    更新日期:2000-05-06 00:00:00

  • Antiretroviral treatment can reduce the risk of HIV transmission between male partners to 'zero'.

    abstract::The studyA Rodger, V Cambiano, T Bruun, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study. Lancet 2019;393:2428-38.This project was funde...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 评论,杂志文章

    doi:10.1136/bmj.l4915

    authors: Cook R,Davidson P,clinical adviser,.,Martin R,NIHR Dissemination Centre.

    更新日期:2019-08-27 00:00:00

  • When is it futile for ambulance personnel to initiate cardiopulmonary resuscitation?

    abstract:OBJECTIVE:To determine whether patients with unexpected prehospital cardiac arrest could be identified in whom ambulance resuscitation attempts would be futile. DESIGN:Review of ambulance and hospital records; detailed review of automated external defibrillator rhythm strips of patients in whom no shock was advised. ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.6996.49

    authors: Marsden AK,Ng GA,Dalziel K,Cobbe SM

    更新日期:1995-07-01 00:00:00

  • Effect of different forms of information produced for cancer patients on their use of the information, social support, and anxiety: randomised trial.

    abstract:OBJECTIVE:To explore the hypothesis that different methods of selecting and printing information for cancer patients could improve emotional support by affecting interaction with others, and so lead to improved psychological wellbeing. DESIGN:Randomised trial with eight groups (three factors, 2x2x2). Data collected at...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.38807.571042.68

    authors: Jones RB,Pearson J,Cawsey AJ,Bental D,Barrett A,White J,White CA,Gilmour WH

    更新日期:2006-04-22 00:00:00

  • Intravenous methylprednisolone in the treatment of Graves' ophthalmopathy.

    abstract::Eleven euthyroid patients with severe Graves' eye disease were treated with intravenous methylprednisolone and followed up for six months or more by ophthalmological assessment, orbital computed tomography (CT), photographs, and antibody measurements. Papilloedema resolved in the single patient in whom it was present;...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6663.1574

    authors: Kendall-Taylor P,Crombie AL,Stephenson AM,Hardwick M,Hall K

    更新日期:1988-12-17 00:00:00

  • Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK).

    abstract:OBJECTIVE:To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. DESIGN:Retrospective cohort study (GENE-RAD-RISK). SETTING:Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, PARTICIPANTS:1993 female carriers of BRC...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e5660

    authors: Pijpe A,Andrieu N,Easton DF,Kesminiene A,Cardis E,Noguès C,Gauthier-Villars M,Lasset C,Fricker JP,Peock S,Frost D,Evans DG,Eeles RA,Paterson J,Manders P,van Asperen CJ,Ausems MG,Meijers-Heijboer H,Thierry-Chef I,Hau

    更新日期:2012-09-06 00:00:00

  • Avoidable waste of research related to inadequate methods in clinical trials.

    abstract:OBJECTIVE:To assess the waste of research related to inadequate methods in trials included in Cochrane reviews and to examine to what extent this waste could be avoided. A secondary objective was to perform a simulation study to re-estimate this avoidable waste if all trials were adequately reported. DESIGN:Methodolog...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h809

    authors: Yordanov Y,Dechartres A,Porcher R,Boutron I,Altman DG,Ravaud P

    更新日期:2015-03-24 00:00:00

  • High mortality by natural and unnatural causes: a 10 year follow up study of patients admitted to a poisoning treatment centre after suicide attempts.

    abstract:OBJECTIVE:To describe mortality by suicide and other causes of death in a group of patients who attempted suicide, and to identify predictive factors. DESIGN:10 year follow up study based on records of suicide attempters in 1980. SETTING:Poisoning treatment centre at a general hospital. SUBJECTS:974 patients aged 15...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6893.1637

    authors: Nordentoft M,Breum L,Munck LK,Nordestgaard AG,Hunding A,Laursen Bjaeldager PA

    更新日期:1993-06-19 00:00:00

  • External validation and comparison of three prediction tools for risk of osteoporotic fractures using data from population based electronic health records: retrospective cohort study.

    abstract:OBJECTIVE: To directly compare the performance and externally validate the three most studied prediction tools for osteoporotic fractures-QFracture, FRAX, and Garvan-using data from electronic health records. DESIGN: Retrospective cohort study. SETTING: Payer provider healthcare organisation in Israel. PARTICIPANTS:...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.i6755

    authors: Dagan N,Cohen-Stavi C,Leventer-Roberts M,Balicer RD

    更新日期:2017-01-19 00:00:00

  • Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies.

    abstract:OBJECTIVE:To assess the association between genotype at the insertion or deletion polymorphism of the angiotensin converting enzyme gene and risk of coronary restenosis after percutaneous coronary intervention. DESIGN:Meta-analysis of studies before July 2001 that reported on these genotypes and risk of coronary reste...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.325.7363.517

    authors: Bonnici F,Keavney B,Collins R,Danesh J

    更新日期:2002-09-07 00:00:00

  • Referral letters and replies from orthopaedic departments: opportunities missed.

    abstract:OBJECTIVE:To study delays between sending referral letters and the outpatient appointment and to assess the content of referral and reply letters, their educational value, and the extent to which questions asked are answered by reply letters. DESIGN:Retrospective review of referrals to 16 consultant orthopaedic surgeo...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6750.470

    authors: Jacobs LG,Pringle MA

    更新日期:1990-09-08 00:00:00

  • Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial.

    abstract:OBJECTIVES:To determine the effectiveness of tai chi interventions compared with aerobic exercise, a current core standard treatment in patients with fibromyalgia, and to test whether the effectiveness of tai chi depends on its dosage or duration. DESIGN:Prospective, randomized, 52 week, single blind comparative effec...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.k851

    authors: Wang C,Schmid CH,Fielding RA,Harvey WF,Reid KF,Price LL,Driban JB,Kalish R,Rones R,McAlindon T

    更新日期:2018-03-21 00:00:00