Early growth and death from cardiovascular disease in women.

Abstract:

OBJECTIVE:To determine whether the link suggested between growth in utero and during infancy and death from cardiovascular disease in men is also present in women. DESIGN:Follow up study of women and men whose birth weight and weight at 1 year of age had been recorded. SETTING:Hertfordshire, England. SUBJECTS:5585 women and 10,141 men born during 1911-30. MAIN OUTCOME MEASURES:Standardised mortality ratios for cardiovascular disease. RESULTS:Among women and men death rates from cardiovascular disease fell progressively between the low and high birth weights groups (chi 2 = 4.3, p = 0.04 for women, chi 2 = 8.5, p < 0.005 for men). Cardiovascular deaths in men but not women were also strongly related to weight at 1 year, falling progressively between the low and high weight groups (chi 2 = 27.5, p < 0.0001). The highest cardiovascular death rates in women were among those with below average birth weight but above average weight at 1 year. In men the highest rates were among those with below average birth weight and below average weight at 1 year. CONCLUSION:Relations between cardiovascular disease and birth weight are similar in men and women. In men cardiovascular disease is also related to weight gain in infancy.

journal_name

BMJ

authors

Osmond C,Barker DJ,Winter PD,Fall CH,Simmonds SJ

doi

10.1136/bmj.307.6918.1519

subject

Has Abstract

pub_date

1993-12-11 00:00:00

pages

1519-24

issue

6918

eissn

0959-8138

issn

1756-1833

journal_volume

307

pub_type

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