Recovery of bone density in women who stop using medroxyprogesterone acetate.

Abstract:

:In order to determine whether the loss in bone density seen in users of depot medroxyprogesterone acetate is reversible, a comparative study was undertaken in three groups of women. Group 1 consisted of 14 women who had used the contraceptive for at least 3 years and then discontinued use. Group 2 was 22 longterm users, and Group 3 contained 18 women who had never used the drug and served as controls. Estrogen production resumed in all of the Group 1 women after discontinuation. Two bone density measurements were taken twice in each woman. At first measurement, lumbar spine density was an average of 9% lower in Groups 1 and 2 than in controls. At the second measurement, however, lumbar spine density had significantly increased in Group 1 while it remained the same for the other groups. No significant changes in femoral neck density were observed. Additional measurements in 8 women from Group 1 taken 2 years after discontinuation revealed a further significant increase in lumbar spine bone density. Thus, it was concluded that bone density loss is reversible, even in cases where women experience a significant weight loss after discontinuation.

journal_name

BMJ

authors

Cundy T,Cornish J,Evans MC,Roberts H,Reid IR

doi

10.1136/bmj.308.6923.247

subject

Has Abstract

pub_date

1994-01-22 00:00:00

pages

247-8

issue

6923

eissn

0959-8138

issn

1756-1833

journal_volume

308

pub_type

杂志文章
  • Patients' and family members' views on how clinicians enact and how they should enact incident disclosure: the "100 patient stories" qualitative study.

    abstract:OBJECTIVES:To investigate patients' and family members' perceptions and experiences of disclosure of healthcare incidents and to derive principles of effective disclosure. DESIGN:Retrospective qualitative study based on 100 semi-structured, in depth interviews with patients and family members. SETTING:Nationwide mult...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.d4423

    authors: Iedema R,Allen S,Britton K,Piper D,Baker A,Grbich C,Allan A,Jones L,Tuckett A,Williams A,Manias E,Gallagher TH

    更新日期:2011-07-25 00:00:00

  • Impact of autologous blood injections in treatment of mid-portion Achilles tendinopathy: double blind randomised controlled trial.

    abstract:OBJECTIVE:To assess the effectiveness of two peritendinous autologous blood injections in addition to a standardised eccentric calf strengthening programme in improving pain and function in patients with mid-portion Achilles tendinopathy. DESIGN:Single centre, participant and single assessor blinded, parallel group, r...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bmj.f2310

    authors: Bell KJ,Fulcher ML,Rowlands DS,Kerse N

    更新日期:2013-04-18 00:00:00

  • Melting the Iron Curtain: opportunities for public health collaboration through international joint ventures.

    abstract::The opportunities for international public health collaboration through joint business ventures between the USSR and Western nations, an arrangement that would benefit the public, industry, and the medical community, are discussed. Evidence indicates that the state of health of the Soviet population is declining rapi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6777.633

    authors: Gellert GA,Kaznady SI

    更新日期:1991-03-16 00:00:00

  • Weighting in the dark: resource allocation in the new NHS.

    abstract::National allocation of resources to regional health authorities and by them to districts is now determined by a weighted capitation formula. The national formula was derived from regression analysis, with hospital utilisation as an index of need for health care--a method which has fundamental limitations. This paper a...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6881.835

    authors: Sheldon TA,Smith GD,Bevan G

    更新日期:1993-03-27 00:00:00

  • Readmission after hysterectomy and prophylactic low molecular weight heparin: retrospective case-control study.

    abstract:OBJECTIVE:To determine whether use of tinzaparin, a low molecular weight heparin introduced for prophylactic management of deep vein thrombosis, increases the risk of serious postoperative bleeding leading to a higher than expected 28 day readmission rate after discharge for hysterectomy. DESIGN:Retrospective case-con...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38783.624444.55

    authors: Cook G,Depares J,Singh M,McElduff P

    更新日期:2006-04-08 00:00:00

  • Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database.

    abstract:OBJECTIVE:To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. DESIGN:Cohort study. SETTING:Patients registered with UK general practices contributing data to the QResearch database. PARTICIPANTS:238,963 patients...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h517

    authors: Coupland C,Hill T,Morriss R,Arthur A,Moore M,Hippisley-Cox J

    更新日期:2015-02-18 00:00:00

  • Changing patterns of teenage pregnancy: population based study of small areas.

    abstract:OBJECTIVES:To measure the impact of socioeconomic deprivation on rates of teenage pregnancy and the extent of local variation in pregnancy rates in Scotland, and to examine how both have changed over time. DESIGN:Population study using routine data from hospital records, aggregated for small areas. SUBJECTS:Female te...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.323.7306.199

    authors: McLeod A

    更新日期:2001-07-28 00:00:00

  • Renal disease, epidermal necrosis, and epithelial cell antibodies.

    abstract:OBJECTIVE:To describe the association between epithelial cell IgM, which has previously been associated with an increased incidence of loss of renal graft in children, with a novel cutaneous eruption and unexplained native renal disease. DESIGN:Observational study on children with epithelial cell antibody presenting w...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.303.6795.161

    authors: Deal JE,Groves RW,Harmer AW,Welsh KI,MacDonald DM,Rigden SP

    更新日期:1991-07-20 00:00:00

  • Randomised controlled trial of lymphoblastoid interferon alfa in Europid men with chronic hepatitis B virus infection.

    abstract:OBJECTIVE:To confirm the findings of pilot studies that interferon alfa is an effective treatment of Europid men with chronic hepatitis B virus infection. DESIGN:Randomised controlled trial of three months treatment with interferon alfa followed by 12 months of observation. SETTING:Outpatient clinic of a tertiary ref...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.299.6700.652

    authors: Brook MG,Chan G,Yap I,Karayiannis P,Lever AM,Jacyna M,Main J,Thomas HC

    更新日期:1989-09-09 00:00:00

  • Scottish attitudes to blood donation and AIDS.

    abstract:OBJECTIVE:To see whether the issue of AIDS has influenced the observed decline in blood donation in Scotland. DESIGN:Two methods: a quantitative survey using personal interviews based on a questionnaire and a qualitative survey based on group discussions. SETTING:Interviews based on the questionnaire were conducted i...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.298.6679.1012

    authors: MacAskill SG,Hastings GB,McNeill RE,Gillon J

    更新日期:1989-04-15 00:00:00

  • Incidence of cancer among Finnish airline cabin attendants, 1967-92.

    abstract:OBJECTIVE:To assess whether occupational exposure among commercial airline cabin attendants are associated with risk of cancer. DESIGN:Record linkage study. SETTING:Finland. SUBJECTS-1577 female and 187 male cabin attendants who had worked for the Finnish airline companies. MAIN OUTCOME MEASURE:Standardised incidenc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7006.649

    authors: Pukkala E,Auvinen A,Wahlberg G

    更新日期:1995-09-09 00:00:00

  • Cohort study of effect of being overweight and change in weight on risk of coronary heart disease in old age.

    abstract:OBJECTIVE:To evaluate risk of late life coronary heart disease associated with being overweight in late middle or old age and to assess whether weight change modifies this risk. DESIGN:Longitudinal study of subjects in the epidemiological follow up study of the national health and nutrition examination survey I. SETT...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.314.7097.1791

    authors: Harris TB,Launer LJ,Madans J,Feldman JJ

    更新日期:1997-06-21 00:00:00

  • Setting priorities, can Britain learn from Sweden?

    abstract::The Swedish government recently published a report on priorities in health care. It was written by a cross party group of politicians and drew extensively on the views of the public, health professionals, experience of earlier local exercises in priority setting, and research based evidence. It laid down an ethical fr...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7032.691

    authors: McKee M,Figueras J

    更新日期:1996-03-16 00:00:00

  • Experience with screening newborns for Duchenne muscular dystrophy in Wales.

    abstract:OBJECTIVES:To assess the acceptability of screening newborn boys for Duchenne muscular dystrophy. DESIGN:Screening is offered on the basis of informed consent in response to an information sheet entitled "A new test for baby boys--Do you want it?" The programme includes a prospective long term evaluation of family res...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6874.357

    authors: Bradley DM,Parsons EP,Clarke AJ

    更新日期:1993-02-06 00:00:00

  • The New Zealand cervical cancer study: could it happen again?

    abstract::The author is one of the medical advisers to the judge who led a government inquiry into allegations that an experimental research program at the National Women's Hospital in Auckland, New Zealand, to study the natural course of cervical carcinoma in situ had withheld conventional treatment from some patients. She ar...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6647.533

    authors: Paul C

    更新日期:1988-08-20 00:00:00

  • Behavioural counselling to increase consumption of fruit and vegetables in low income adults: randomised trial.

    abstract:OBJECTIVE:To measure the effect of brief behavioural counselling in general practice on patients' consumption of fruit and vegetables in adults from a low income population. DESIGN:Parallel group randomised controlled trial. SETTING:Primary health centre in a deprived, ethnically mixed inner city area. PARTICIPANTS:...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.326.7394.855

    authors: Steptoe A,Perkins-Porras L,McKay C,Rink E,Hilton S,Cappuccio FP

    更新日期:2003-04-19 00:00:00

  • Acceptability of low molecular weight heparin thromboprophylaxis for inpatients receiving palliative care: qualitative study.

    abstract:OBJECTIVE:To find out what inpatients with advanced cancer who are receiving palliative care think about the effect of thromoprophylaxis on overall quality of life. DESIGN:Qualitative study using audiotaping of semistructured interviews. SETTING:Regional cancer centre in Wales. PARTICIPANTS:28 inpatients with advanc...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38733.616065.802

    authors: Noble SI,Nelson A,Turner C,Finlay IG

    更新日期:2006-03-11 00:00:00

  • Long term follow up of severely ill patients who underwent urgent cardiac transplantation.

    abstract:OBJECTIVE:To assess long term survival (> 5 years) and quality of life in severely ill patients referred for urgent cardiac transplantation. SETTING:Tertiary referral centres: before transplantation at the National Heart Hospital (late 1984 to end 1986); after transplantation at Harefield Hospital. SUBJECTS:Eighteen ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6870.98

    authors: Mulcahy D,Fitzgerald M,Wright C,Sparrow J,Pepper J,Yacoub M,Fox KM

    更新日期:1993-01-09 00:00:00

  • Passive smoking and cardiorespiratory health in a general population in the west of Scotland.

    abstract:UNLABELLED:OBJECTIVE-To assess the risk of cardiorespiratory symptoms and mortality in non-smokers who were passively exposed to environmental smoke. DESIGN:Prospective study of cohort from general population first screened between 1972 and 1976 and followed up for an average of 11.5 years, with linkage of data from p...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6696.423

    authors: Hole DJ,Gillis CR,Chopra C,Hawthorne VM

    更新日期:1989-08-12 00:00:00

  • Single or multiple daily doses of aminoglycosides: a meta-analysis.

    abstract:OBJECTIVE:To assess relative efficacy and toxicity of aminoglycosides given by single daily dose compared with multiple daily doses. DESIGN:Meta-analysis of 21 randomised trials identified through MEDLARS (1966 to January 1995). Data were overviewed with fixed effects and random effects models and with meta-regression...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.312.7027.338

    authors: Barza M,Ioannidis JP,Cappelleri JC,Lau J

    更新日期:1996-02-10 00:00:00

  • Randomised trial of personalised computer based information for cancer patients.

    abstract:OBJECTIVE:To compare the use and effect of a computer based information system for cancer patients that is personalised using each patient's medical record with a system providing only general information and with information provided in booklets. DESIGN:Randomised trial with three groups. Data collected at start of r...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.319.7219.1241

    authors: Jones R,Pearson J,McGregor S,Cawsey AJ,Barrett A,Craig N,Atkinson JM,Gilmour WH,McEwen J

    更新日期:1999-11-06 00:00:00

  • Blood pressure control by home monitoring: meta-analysis of randomised trials.

    abstract:OBJECTIVE:To determine the effect of home blood pressure monitoring on blood pressure levels and proportion of people with essential hypertension achieving targets. DESIGN:Meta-analysis of 18 randomised controlled trials. PARTICIPANTS:1359 people with essential hypertension allocated to home blood pressure monitoring...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.38121.684410.AE

    authors: Cappuccio FP,Kerry SM,Forbes L,Donald A

    更新日期:2004-07-17 00:00:00

  • Physical work environment risk factors for long term sickness absence: prospective findings among a cohort of 5357 employees in Denmark.

    abstract:OBJECTIVES:To examine the effects of physical work environment on long term sickness absence and to investigate interaction between physical and psychosocial risk factors. DESIGN AND SETTING:Prospective cohort study of long term sickness absence among employees in Denmark. PARTICIPANTS:5357 employees interviewed in 2...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38731.622975.3A

    authors: Lund T,Labriola M,Christensen KB,Bültmann U,Villadsen E

    更新日期:2006-02-25 00:00:00

  • Appraisal of a new scheme for prenatal screening for Down's syndrome.

    abstract:OBJECTIVE:To appraise a new method of prenatal screening for Down's syndrome based on maternal serum concentrations of alpha fetoprotein, unconjugated oestriol, and human chorionic gonadotrophin combined with maternal age--the "triple test." DESIGN:Examination of the cost effectiveness of the triple test relative to s...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6785.1133

    authors: Sheldon TA,Simpson J

    更新日期:1991-05-11 00:00:00

  • Evaluation of aid to diagnosis of pigmented skin lesions in general practice: controlled trial randomised by practice.

    abstract:OBJECTIVES:To determine whether an aid to the diagnosis of pigmented skin lesions reduces the ratio of benign lesions to melanomas excised in general practice. DESIGN:Controlled trial randomised by practice. SETTING:General practices in Perth, Western Australia. PARTICIPANTS:468 general practitioners in 223 practice...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.327.7411.375

    authors: English DR,Burton RC,del Mar CB,Donovan RJ,Ireland PD,Emery G

    更新日期:2003-08-16 00:00:00

  • Association between stressful life events and exacerbation in multiple sclerosis: a meta-analysis.

    abstract:OBJECTIVE:To quantify the association between stressful life events and exacerbations of multiple sclerosis. DATA SOURCES:PubMed, PsychInfo, and Psychological Abstracts searched for empirical papers from 1965 to February 2003 with terms "stress", "trauma", and "multiple sclerosis". REVIEW METHODS:Three investigators ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.38041.724421.55

    authors: Mohr DC,Hart SL,Julian L,Cox D,Pelletier D

    更新日期:2004-03-27 00:00:00

  • Distribution of NHS funds between fundholding and non-fundholding practices.

    abstract:OBJECTIVES:To estimate the amount spent on specific hospital care by health agencies in 1993-4 and compare it with the resources allocated to patients registered with fundholding practices for the same type of care. To investigate whether fundholding practices and health agencies pay different amounts for inpatient car...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6946.30

    authors: Dixon J,Dinwoodie M,Hodson D,Dodd S,Poltorak T,Garrett C,Rice P,Doncaster I,Williams M

    更新日期:1994-07-02 00:00:00

  • Evaluation of modernisation of adult critical care services in England: time series and cost effectiveness analysis.

    abstract:OBJECTIVE:To evaluate the impact and cost effectiveness of a programme to transform adult critical care throughout England initiated in late 2000. DESIGN:Evaluation of trends in inputs, processes, and outcomes during 1998-2000 compared with last quarter of 2000-6. SETTING:96 critical care units in England. PARTICIPA...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究

    doi:10.1136/bmj.b4353

    authors: Hutchings A,Durand MA,Grieve R,Harrison D,Rowan K,Green J,Cairns J,Black N

    更新日期:2009-11-11 00:00:00

  • Patients' views of priority setting in health care: an interview survey in one practice.

    abstract:OBJECTIVES:To explore the assumptions underlying consumers' responses to questions of resource priorities in the NHS. DESIGN:Qualitative analysis of semi-structured interviews with a heterogeneous sample of 16 patients drawn from a general practice. RESULTS:Interviewees were not persuaded that they had a legitimate r...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.311.7013.1137

    authors: Dicker A,Armstrong D

    更新日期:1995-10-28 00:00:00

  • AIDS spreads eastward.

    abstract::In just 3 months in 1991, WHO increased its estimate of the number of people infected with HIV in all of Asia 2 fold (500,000-1 million). By 2000, WHO estimated that there will be 250,000 new cases each year in India and Thailand alone where HIV infection has spread most rapidly. A professor from the All India Insti...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 新闻

    doi:10.1136/bmj.302.6792.1557

    authors: Tanne JH

    更新日期:1991-06-29 00:00:00