Serum screening for Down's syndrome: experiences of obstetricians in England and Wales.

abstract：OBJECTIVE:To examine the patterns of physical activity among British schoolchildren aged 11 to 16 and to assess whether the children experience the intensity and duration of physical activity that are believed to stress the cardiopulmonary system appropriately. DESIGN:Cross sectional study of a sample of children draw...

journal_title：BMJ (Clinical research ed.)

authors： Armstrong N,Balding J,Gentle P,Kirby B

更新日期：1990-07-28 00:00:00

abstract：OBJECTIVES:To investigate the claim that 90% of episodes of low back pain that present to general practice have resolved within one month. DESIGN:Prospective study of all adults consulting in general practice because of low back pain over 12 months with follow up at 1 week, 3 months, and 12 months after consultation. ...

journal_title：BMJ (Clinical research ed.)

authors： Croft PR,Macfarlane GJ,Papageorgiou AC,Thomas E,Silman AJ

更新日期：1998-05-02 00:00:00

abstract：OBJECTIVE:To estimate changes in the risk of autism and assess the relation of autism to the mumps, measles, and rubella (MMR) vaccine. DESIGN:Time trend analysis of data from the UK general practice research database (GPRD). SETTING:General practices in the United Kingdom. SUBJECTS:Children aged 12 years or younger...

journal_title：BMJ (Clinical research ed.)

authors： Kaye JA,del Mar Melero-Montes M,Jick H

更新日期：2001-02-24 00:00:00

abstract：OBJECTIVE:To study the comparative importance of environment and genes in the development of islet cell autoimmunity associated with insulin dependent diabetes mellitus. DESIGN:Population based study of diabetic twins. SETTING:Danish population. SUBJECTS:18 monozygotic and 36 dizygotic twin pairs with one or both pa...

journal_title：BMJ (Clinical research ed.)

authors： Petersen JS,Kyvik KO,Bingley PJ,Gale EA,Green A,Dyrberg T,Beck-Nielsen H

更新日期：1997-05-31 00:00:00

abstract：OBJECTIVE:To determine whether maternal smoking during pregnancy causes impairment in growth after birth. DESIGN:Longitudinal study. SETTING:Six medical university centres of six towns of north, central, and south Italy. SUBJECTS:12,987 babies (10,238 born from non-smoking mothers, 2276 from mothers smoking one to n...

journal_title：BMJ (Clinical research ed.)

authors： Conter V,Cortinovis I,Rogari P,Riva L

更新日期：1995-03-25 00:00:00

abstract：:In July 1992 Dr Keith Mumby, a clinical ecologist, appeared before the professional conduct committee of the General Medical Council on five charges to do with his practice of clinical ecology. He was found guilty of two of the charges--touting for publicity and failing to give a patient adequate medical attention--an...

journal_title：BMJ (Clinical research ed.)

authors： Kay AB

更新日期：1993-01-09 00:00:00

abstract：OBJECTIVE:To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. DESIGN:Cohort study. SETTING:Patients registered with UK general practices contributing data to the QResearch database. PARTICIPANTS:238,963 patients...

journal_title：BMJ (Clinical research ed.)

authors： Coupland C,Hill T,Morriss R,Arthur A,Moore M,Hippisley-Cox J

更新日期：2015-02-18 00:00:00

abstract：OBJECTIVE:To examine the absolute risks or benefits on cancer associated with oral contraception, using incident data. DESIGN:Inception cohort study. SETTING:Royal College of General Practitioners' oral contraception study. PARTICIPANTS:Directly standardised data from the Royal College of General Practitioners' oral...

journal_title：BMJ (Clinical research ed.)

authors： Hannaford PC,Selvaraj S,Elliott AM,Angus V,Iversen L,Lee AJ

更新日期：2007-09-29 00:00:00

abstract：OBJECTIVE:To determine whether a decision aid designed for adults with low education and literacy can support informed choice and involvement in decisions about screening for bowel cancer. DESIGN:Randomised controlled trial. SETTING:Areas in New South Wales, Australia identified as socioeconomically disadvantaged (lo...

journal_title：BMJ (Clinical research ed.)

authors： Smith SK,Trevena L,Simpson JM,Barratt A,Nutbeam D,McCaffery KJ

更新日期：2010-10-26 00:00:00

abstract：OBJECTIVE:To show the influence of variations in case mix on clinical outcome indicators for patients admitted to hospital with acute stroke. DESIGN:"Before and after" cohort study, with prospective, consecutive identification of patients and prospective follow up; multiple logistic regression analyses to correct for ...

journal_title：BMJ (Clinical research ed.)

authors： Davenport RJ,Dennis MS,Warlow CP

更新日期：1996-06-15 00:00:00

abstract：OBJECTIVE:To describe and quantify the patients and clinical activities of independent short stay hospitals. DESIGN:Retrospective survey of hospital records for sampled periods of one financial year and comparison with data from 1981 to 1986. SETTING:217 independent hospitals in England and Wales, 1992-3. MAIN OUTCO...

journal_title：BMJ (Clinical research ed.)

authors： Williams BT,Nicholl JP

更新日期：1994-06-25 00:00:00

abstract：OBJECTIVE:To assess the performance and impact of a two tier neonatal screening programme for cystic fibrosis based on an initial estimation of immunoreactive trypsinogen followed by direct gene analysis. DESIGN:Four year prospective study of two tier screening strategy. First tier: immunoreactive trypsinogen measured...

journal_title：BMJ (Clinical research ed.)

authors： Ranieri E,Lewis BD,Gerace RL,Ryall RG,Morris CP,Nelson PV,Carey WF,Robertson EF

更新日期：1994-06-04 00:00:00

abstract：OBJECTIVE:To assess long term survival (> 5 years) and quality of life in severely ill patients referred for urgent cardiac transplantation. SETTING:Tertiary referral centres: before transplantation at the National Heart Hospital (late 1984 to end 1986); after transplantation at Harefield Hospital. SUBJECTS:Eighteen ...

journal_title：BMJ (Clinical research ed.)

authors： Mulcahy D,Fitzgerald M,Wright C,Sparrow J,Pepper J,Yacoub M,Fox KM

更新日期：1993-01-09 00:00:00

abstract：OBJECTIVE:To find out whether enalapril or ramipril causes the sensitivity of the cough reflex to change or symptomatic cough to develop in patients with hypertension. DESIGN:Prospective, placebo controlled, double blind, randomised crossover study. SETTING:Academic units of clinical pharmacology and medicine. PATIE...

journal_title：BMJ (Clinical research ed.)

authors： McEwan JR,Choudry N,Street R,Fuller RW

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVES:To determine whether fibrinogen and lipid concentrations are risk factors for ischaemic stroke. DESIGN:Case-control study with a population based comparison within the overall study. SETTING:Oxfordshire community stroke project and a neurology clinic. SUBJECTS:105 patients who had a transient ischaemic at...

journal_title：BMJ (Clinical research ed.)

authors： Qizilbash N,Jones L,Warlow C,Mann J

更新日期：1991-09-14 00:00:00

abstract：OBJECTIVE:To test whether the relation between income inequality and mortality found in US states is because of different levels of formal education. DESIGN:Cross sectional, multiple regression analysis. SETTING:All US states and the District of Columbia (n=51). DATA SOURCES:US census statistics and vital statistics...

journal_title：BMJ (Clinical research ed.)

authors： Muller A

更新日期：2002-01-05 00:00:00

abstract：OBJECTIVES:To clarify the type of fetal growth impairment associated with increased blood pressure in adult life, and to establish whether this association is influenced by obesity and is mediated through impairment of insulin action. DESIGN:Cross sectional survey with retrospective ascertainment of size at birth from...

journal_title：BMJ (Clinical research ed.)

authors： Leon DA,Koupilova I,Lithell HO,Berglund L,Mohsen R,Vagero D,Lithell UB,McKeigue PM

更新日期：1996-02-17 00:00:00

abstract：OBJECTIVE:To assess the effectiveness of early treatment for amblyopia in children. DESIGN:Follow up of outcomes of treatment for amblyopia in a randomised controlled trial comparing intensive orthoptic screening at 8, 12, 18, 25, 31, and 37 months (intensive group) with orthoptic screening at 37 months only (control ...

journal_title：BMJ (Clinical research ed.)

authors： Williams C,Northstone K,Harrad RA,Sparrow JM,Harvey I,ALSPAC Study Team.

更新日期：2002-06-29 00:00:00

abstract：OBJECTIVE:To compare the rate of moderate to severe exacerbations between triple therapy and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease (COPD). DESIGN:Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES:PubMed, Embase, Cochrane databases, and clini...

journal_title：BMJ (Clinical research ed.)

authors： Zheng Y,Zhu J,Liu Y,Lai W,Lin C,Qiu K,Wu J,Yao W

更新日期：2018-11-06 00:00:00

abstract：OBJECTIVE:To compare the efficacy of surgery with disc prosthesis versus non-surgical treatment for patients with chronic low back pain. DESIGN:A prospective randomised multicentre study. SETTING:Five university hospitals in Norway. PARTICIPANTS:173 patients with a history of low back pain for at least one year, Osw...

journal_title：BMJ (Clinical research ed.)

authors： Hellum C,Johnsen LG,Storheim K,Nygaard OP,Brox JI,Rossvoll I,Rø M,Sandvik L,Grundnes O,Norwegian Spine Study Group.

更新日期：2011-05-19 00:00:00

abstract：:Care in the community for insane people today is more a matter of expert provision than communal support. In consequence, although they are no longer confined to hospital, mentally ill people largely remain marginalised in a society that does not have the resources, nor often the inclination, to take responsibility fo...

journal_title：BMJ (Clinical research ed.)

authors： Roffe D,Roffe C

更新日期：1995-12-23 00:00:00

abstract：OBJECTIVE:To determine the effectiveness of exercise as an intervention in the management of depression. DESIGN:Systematic review and meta-regression analysis of randomised controlled trials obtained from five electronic databases (Medline, Embase, Sports Discus, PsycLIT, Cochrane Library) and through contact with exp...

journal_title：BMJ (Clinical research ed.)

authors： Lawlor DA,Hopker SW

更新日期：2001-03-31 00:00:00

abstract：OBJECTIVE:To describe the experiences of authors of Cochrane reviews in searching for, getting access to, and using unpublished data. DESIGN:Cross sectional study. SETTING:Cochrane reviews. PARTICIPANTS:2184 corresponding authors of Cochrane reviews as of May 2012. MAIN OUTCOME MEASURE:Frequencies of responses to o...

journal_title：BMJ (Clinical research ed.)

authors： Schroll JB,Bero L,Gøtzsche PC

更新日期：2013-04-23 00:00:00

abstract：CLINICAL QUESTION:Do adults with atraumatic shoulder pain for more than 3 months diagnosed as subacromial pain syndrome (SAPS), also labelled as rotator cuff disease, benefit from subacromial decompression surgery? This guideline builds on to two recent high quality trials of shoulder surgery. CURRENT PRACTICE:SAPS is...

journal_title：BMJ (Clinical research ed.)

authors： Vandvik PO,Lähdeoja T,Ardern C,Buchbinder R,Moro J,Brox JI,Burgers J,Hao Q,Karjalainen T,van den Bekerom M,Noorduyn J,Lytvyn L,Siemieniuk RAC,Albin A,Shunjie SC,Fisch F,Proulx L,Guyatt G,Agoritsas T,Poolman RW

更新日期：2019-02-06 00:00:00

abstract：OBJECTIVES:To explore general practitioners' reasons for recent changes in their prescribing behaviour. DESIGN:Qualitative analysis of semistructured interviews. SETTING:General practice in south east London. SUBJECTS:A heterogeneous sample of 18 general practitioners. RESULTS:Interviewees were able to identify bet...

journal_title：BMJ (Clinical research ed.)

authors： Armstrong D,Reyburn H,Jones R

更新日期：1996-04-13 00:00:00

abstract：OBJECTIVE:To assess the effect of the timing of first postnatal home visit by community health workers on neonatal mortality. DESIGN:Analysis of prospectively collected data using time varying discrete hazard models to estimate hazard ratios for neonatal mortality according to day of first postnatal home visit. DATA ...

journal_title：BMJ (Clinical research ed.)

authors： Baqui AH,Ahmed S,El Arifeen S,Darmstadt GL,Rosecrans AM,Mannan I,Rahman SM,Begum N,Mahmud AB,Seraji HR,Williams EK,Winch PJ,Santosham M,Black RE,Projahnmo 1 Study Group.

更新日期：2009-08-14 00:00:00

abstract：OBJECTIVE:To determine whether diurnal variation occurs in the onset of stroke. DESIGN:Community based study over four years. SETTING:Oxfordshire, United Kingdom. SUBJECTS:105,000 people, of whom 675 had a first ever stroke. 545 had a cerebral infarction, 66 had primary intracerebral haemorrhage, 33 had subarachnoid...

journal_title：BMJ (Clinical research ed.)

authors： Wroe SJ,Sandercock P,Bamford J,Dennis M,Slattery J,Warlow C

更新日期：1992-01-18 00:00:00

abstract：OBJECTIVE:To assess the association between mind wandering (thinking unrelated to the task at hand) and the risk of being responsible for a motor vehicle crash. DESIGN:Responsibility case-control study. SETTING:Adult emergency department of a university hospital in France, April 2010 to August 2011. PARTICIPANTS:955...

journal_title：BMJ (Clinical research ed.)

authors： Galéra C,Orriols L,M'Bailara K,Laborey M,Contrand B,Ribéreau-Gayon R,Masson F,Bakiri S,Gabaude C,Fort A,Maury B,Lemercier C,Cours M,Bouvard MP,Lagarde E

更新日期：2012-12-13 00:00:00

abstract：OBJECTIVE:To compare effectiveness and acceptability of early discharge to a hospital at home scheme with that of routine discharge from acute hospital. DESIGN:Pragmatic randomised controlled trial. SETTING:Acute hospital wards and community in north of Bristol, with a catchment population of about 224 000 people. S...

journal_title：BMJ (Clinical research ed.)

authors： Richards SH,Coast J,Gunnell DJ,Peters TJ,Pounsford J,Darlow MA

更新日期：1998-06-13 00:00:00

abstract：:Objective To estimate the incidence and prevalence of resistant hypertension among a UK population treated for hypertension from 1995 to 2015.Design Cohort study.Setting Electronic health records from the UK Clinical Practice Research Datalink in primary care.Participants 1 317 290 users of antihypertensive drugs with...

journal_title：BMJ (Clinical research ed.)

authors： Sinnott SJ,Smeeth L,Williamson E,Douglas IJ

更新日期：2017-09-22 00:00:00