Commissioning a national programme of research and development on the interface between primary and secondary care.

abstract：OBJECTIVE:To estimate the risk of acute myocardial infarction (AMI) or stroke in adults with non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). DESIGN:Matched cohort study. SETTING:Population based, electronic primary healthcare databases before 31 December 2015 from four European coun...

journal_title：BMJ (Clinical research ed.)

authors： Alexander M,Loomis AK,van der Lei J,Duarte-Salles T,Prieto-Alhambra D,Ansell D,Pasqua A,Lapi F,Rijnbeek P,Mosseveld M,Avillach P,Egger P,Dhalwani NN,Kendrick S,Celis-Morales C,Waterworth DM,Alazawi W,Sattar N

更新日期：2019-10-08 00:00:00

abstract：:This review summarises the literature on shift work and its relation to insufficient sleep, chronic diseases, and accidents. It is based on 38 meta-analyses and 24 systematic reviews, with additional narrative reviews and articles used for outlining possible mechanisms by which shift work may cause accidents and adver...

journal_title：BMJ (Clinical research ed.)

authors： Kecklund G,Axelsson J

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To examine differences in morbidity and mortality due to non-insulin dependent diabetes in African Caribbeans and Europeans. DESIGN:Cohort study of patients with non-insulin dependent diabetes drawn from diabetes clinics in London. Baseline investigations were performed in 1975-7; follow up continued until 1...

journal_title：BMJ (Clinical research ed.)

authors： Chaturvedi N,Jarrett J,Morrish N,Keen H,Fuller JH

更新日期：1996-10-05 00:00:00

abstract：:Objective To determine the efficacy of low intensity pulsed ultrasound (LIPUS) for healing of fracture or osteotomy.Design Systematic review and meta-analysis.Data sources Medline, Embase, CINAHL, Cochrane Central Register of Controlled Trials, and trial registries up to November 2016.Study selection Randomized contro...

journal_title：BMJ (Clinical research ed.)

authors： Schandelmaier S,Kaushal A,Lytvyn L,Heels-Ansdell D,Siemieniuk RA,Agoritsas T,Guyatt GH,Vandvik PO,Couban R,Mollon B,Busse JW

更新日期：2017-02-22 00:00:00

abstract：OBJECTIVES:To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. DESIGN:Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument fo...

journal_title：BMJ (Clinical research ed.)

authors： Palmer TM,Nordestgaard BG,Benn M,Tybjærg-Hansen A,Davey Smith G,Lawlor DA,Timpson NJ

更新日期：2013-07-18 00:00:00

abstract：OBJECTIVE:To describe the association between epithelial cell IgM, which has previously been associated with an increased incidence of loss of renal graft in children, with a novel cutaneous eruption and unexplained native renal disease. DESIGN:Observational study on children with epithelial cell antibody presenting w...

journal_title：BMJ (Clinical research ed.)

authors： Deal JE,Groves RW,Harmer AW,Welsh KI,MacDonald DM,Rigden SP

更新日期：1991-07-20 00:00:00

abstract：OBJECTIVES:To examine the association between income inequality and the risk of mortality and readmission within 30 days of hospitalization. DESIGN:Retrospective cohort study of Medicare beneficiaries in the United States. Hierarchical, logistic regression models were developed to estimate the association between inco...

journal_title：BMJ (Clinical research ed.)

authors： Lindenauer PK,Lagu T,Rothberg MB,Avrunin J,Pekow PS,Wang Y,Krumholz HM

更新日期：2013-02-14 00:00:00

abstract：OBJECTIVE:To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits an...

journal_title：BMJ (Clinical research ed.)

authors： Maund E,Tendal B,Hróbjartsson A,Jørgensen KJ,Lundh A,Schroll J,Gøtzsche PC

更新日期：2014-06-04 00:00:00

abstract：OBJECTIVE:To systematically evaluate the published evidence regarding the characteristics and effectiveness of disease management programmes. DESIGN:Meta-analysis. DATA SOURCES:Computerised databases for English language articles during 1987-2001. STUDY SELECTION:102 articles evaluating 118 disease management progra...

journal_title：BMJ (Clinical research ed.)

authors： Weingarten SR,Henning JM,Badamgarav E,Knight K,Hasselblad V,Gano A Jr,Ofman JJ

更新日期：2002-10-26 00:00:00

abstract：OBJECTIVE:To appraise a new method of prenatal screening for Down's syndrome based on maternal serum concentrations of alpha fetoprotein, unconjugated oestriol, and human chorionic gonadotrophin combined with maternal age--the "triple test." DESIGN:Examination of the cost effectiveness of the triple test relative to s...

journal_title：BMJ (Clinical research ed.)

authors： Sheldon TA,Simpson J

更新日期：1991-05-11 00:00:00

abstract：OBJECTIVE:To evaluate the associations between personal use of permanent hair dyes and cancer risk and mortality. DESIGN:Prospective cohort study. SETTING AND PARTICIPANTS:117 200 women enrolled in the Nurses' Health Study, an ongoing prospective cohort study of female nurses in the United States. The women were free...

journal_title：BMJ (Clinical research ed.)

authors： Zhang Y,Birmann BM,Han J,Giovannucci EL,Speizer FE,Stampfer MJ,Rosner BA,Schernhammer ES

更新日期：2020-09-02 00:00:00

abstract：:On 1 April the Department of Health introduced the mandatory collection of data on the ethnic group of patients admitted to hospital. Its coding was based on a national minimum standard for classifying ethnic groups, ostensibly using the categories in the 1991 census. In the census, however, one in four people from et...

journal_title：BMJ (Clinical research ed.)

authors： Aspinall PJ

更新日期：1995-10-14 00:00:00

abstract：:All developmental screening in Somerset is performed by general practitioners and health visitors. A retrospective review of a cohort of 1504 7 year old children living in semirural Somerset found that the development assessment by a health visitor at age 3 1/2 years had a sensitivity of 45% for identifying the 103 ch...

journal_title：BMJ (Clinical research ed.)

authors： Dearlove J,Kearney D

更新日期：1990-05-05 00:00:00

abstract：:A sample of 106 senior house officers who had graduated from Nottingham University in 1987 was surveyed about their experience of and need for careers guidance, performance appraisal, and stress counselling. Of the 80 who replied, a quarter had received no careers guidance and a quarter no feedback about their work pe...

journal_title：BMJ (Clinical research ed.)

authors： Garrud P

更新日期：1990-02-17 00:00:00

abstract：:Care in the community for insane people today is more a matter of expert provision than communal support. In consequence, although they are no longer confined to hospital, mentally ill people largely remain marginalised in a society that does not have the resources, nor often the inclination, to take responsibility fo...

journal_title：BMJ (Clinical research ed.)

authors： Roffe D,Roffe C

更新日期：1995-12-23 00:00:00

abstract：:Cancers of unknown primary (CUPs) are histologically confirmed, metastatic malignancies with a primary tumor site that is unidentifiable on the basis of standard evaluation and imaging studies. CUP comprises 2-5% of all diagnosed cancers worldwide and is characterized by early and aggressive metastasis. Current standa...

journal_title：BMJ (Clinical research ed.)

authors： Lee MS,Sanoff HK

更新日期：2020-12-07 00:00:00

abstract：OBJECTIVE:To investigate the association between long term intake of dietary and supplemental calcium and death from all causes and cardiovascular disease. DESIGN:Prospective longitudinal cohort study. SETTING:Swedish mammography cohort, a population based cohort established in 1987-90. PARTICIPANTS:61 433 women (bo...

journal_title：BMJ (Clinical research ed.)

authors： Michaëlsson K,Melhus H,Warensjö Lemming E,Wolk A,Byberg L

更新日期：2013-02-12 00:00:00

abstract：OBJECTIVE:To assess the effect of the timing of first postnatal home visit by community health workers on neonatal mortality. DESIGN:Analysis of prospectively collected data using time varying discrete hazard models to estimate hazard ratios for neonatal mortality according to day of first postnatal home visit. DATA ...

journal_title：BMJ (Clinical research ed.)

authors： Baqui AH,Ahmed S,El Arifeen S,Darmstadt GL,Rosecrans AM,Mannan I,Rahman SM,Begum N,Mahmud AB,Seraji HR,Williams EK,Winch PJ,Santosham M,Black RE,Projahnmo 1 Study Group.

更新日期：2009-08-14 00:00:00

abstract：OBJECTIVE:To examine the association between intake of different types of alcoholic drinks and mortality. DESIGN:Prospective population study with baseline assessment of alcohol intake, smoking habit, income, education, and body mass index, and 10-12 years' follow up of mortality. SETTING:Copenhagen city heart study,...

journal_title：BMJ (Clinical research ed.)

authors： Grønbaek M,Deis A,Sørensen TI,Becker U,Schnohr P,Jensen G

更新日期：1995-05-06 00:00:00

abstract：OBJECTIVE:To do an indirect comparison analysis of apixaban against dabigatran etexilate (2 doses) and rivaroxaban (1 dose), as well as of rivaroxaban against dabigatranetexilate (2 doses), for their relative efficacy and safety against each other, with particular focus on the secondary prevention population for stroke...

journal_title：BMJ (Clinical research ed.)

authors： Rasmussen LH,Larsen TB,Graungaard T,Skjøth F,Lip GY

更新日期：2012-11-05 00:00:00

abstract：OBJECTIVES:To determine the effectiveness of tai chi interventions compared with aerobic exercise, a current core standard treatment in patients with fibromyalgia, and to test whether the effectiveness of tai chi depends on its dosage or duration. DESIGN:Prospective, randomized, 52 week, single blind comparative effec...

journal_title：BMJ (Clinical research ed.)

authors： Wang C,Schmid CH,Fielding RA,Harvey WF,Reid KF,Price LL,Driban JB,Kalish R,Rones R,McAlindon T

更新日期：2018-03-21 00:00:00

abstract：OBJECTIVES:To compare the costs of admission to a hospital at home scheme with those of acute hospital admission. DESIGN:Cost minimisation analysis within a pragmatic randomised controlled trial. SETTING:Hospital at home scheme in Leicester and the city's three acute hospitals. PARTICIPANTS:199 consecutive patients ...

journal_title：BMJ (Clinical research ed.)

authors： Jones J,Wilson A,Parker H,Wynn A,Jagger C,Spiers N,Parker G

更新日期：1999-12-11 00:00:00

abstract：:I have attempted to adopt the perspective of a patient--albeit one with a rather atypical background--to explore what I want from health research and researchers. This has left me with the impression that health researchers could serve the interests of the public more effectively in a variety of ways, and that they wo...

journal_title：BMJ (Clinical research ed.)

authors： Chalmers I

更新日期：1995-05-20 00:00:00

abstract：:The numbers of patients being admitted to hospital with aortic aneurysms have increased recently. A study was carried out to try to find out whether this was a true increase in incidence or whether it could be attributable to more accurate diagnosis and better surgical techniques. From analyses of routine statistics i...

journal_title：BMJ (Clinical research ed.)

authors： Fowkes FG,Macintyre CC,Ruckley CV

更新日期：1989-01-07 00:00:00

abstract：OBJECTIVE:To assess the cost effectiveness of different screening strategies for abdominal aortic aneurysm in men, from the perspective of a national health service. SETTING:Screening units at regional hospitals. PARTICIPANTS:Hypothetical cohort of 65 year old men from the general population. MAIN OUTCOME MEASURES:C...

journal_title：BMJ (Clinical research ed.)

authors： Søgaard R,Laustsen J,Lindholt JS

更新日期：2012-07-05 00:00:00

abstract：OBJECTIVE:To compare the risk profile of women receiving public and private obstetric care and to compare the rates of obstetric intervention among women at low risk in these groups. DESIGN:Population based descriptive study. SETTING:New South Wales, Australia. SUBJECTS:All 171,157 women having a live baby during 19...

journal_title：BMJ (Clinical research ed.)

authors： Roberts CL,Tracy S,Peat B

更新日期：2000-07-15 00:00:00

abstract：OBJECTIVES:To examine how insurance companies assess proposals for life assurance from applicants with raised cholesterol concentrations and to determine the excess mortality rating applied. DESIGN:Survey of 49 companies underwriting term life assurance. SETTING:United Kingdom. SUBJECTS:Four fictional men aged 30 se...

journal_title：BMJ (Clinical research ed.)

authors： Neil HA,Mant D

更新日期：1991-04-13 00:00:00

abstract：OBJECTIVE:To identify additional factors, such as maternal age or factors related to previous reproductive outcome or family history, and the corresponding probability of carrying a chromosome abnormality in couples with two or more miscarriages. DESIGN:Nested case-control study. SETTING:Six centres for clinical gene...

journal_title：BMJ (Clinical research ed.)

authors： Franssen MT,Korevaar JC,Leschot NJ,Bossuyt PM,Knegt AC,Gerssen-Schoorl KB,Wouters CH,Hansson KB,Hochstenbach R,Madan K,van der Veen F,Goddijn M

更新日期：2005-07-16 00:00:00

abstract：OBJECTIVE:To determine whether short-term, oral low dose prednisolone (< or = 15 mg daily) is superior to placebo and non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis. DESIGN:Meta-analysis of randomised trials of oral corticosteroids compared with placebo or a non-steroidal anti-inflammatory...

journal_title：BMJ (Clinical research ed.)

authors： Gøtzsche PC,Johansen HK

更新日期：1998-03-14 00:00:00

abstract：:Managed care has entered the lexicon of healthcare reform, but confusion and ignorance surround its meaning and purpose. It seeks to cut the costs of health care while maintaining its quality, but the evidence that it is able to achieve these aims is mixed. As well as raising awareness and understanding of the issues ...

journal_title：BMJ (Clinical research ed.)

authors： Fairfield G,Hunter DJ,Mechanic D,Rosleff F

更新日期：1997-06-21 00:00:00