Urinary excretion of glycosaminoglycans, hydroxyproline and hydroxylysine in rabbits after excessive ingestion of fluoride.

abstract：:1. Accumulating animal and human data suggest that nitric oxide (NO) is important for both coronary and peripheral haemodynamic control and metabolic regulation during performance of exercise. 2. While still controversial, NO of endothelial origin is thought to potentiate exercise-induced hyperaemia, both in the perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA

更新日期：2000-04-01 00:00:00

abstract：:An efficient animal model is fundamental for studies on the underlying mechanisms of constrictive pericarditis (CP). A novel CP rat model was established by pericardial injection composing of lipopolysaccharides (LPS) and talcum powder without thoracotomy. Pathological changes were confirmed by histological staining. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qiao W,Xiao YJ,Wang X,Sun LJ,Chen YX,Ren WD

更新日期：2020-12-21 00:00:00

abstract：:1. The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dammanahalli KJ,Sun Z

更新日期：2008-01-01 00:00:00

abstract：:1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

更新日期：2008-07-01 00:00:00

abstract：:1. Previous clinical and experimental reports have suggested that the systemic administration of ethyl alcohol permits lower body temperatures before the onset of hypothermic cardiac arrest. 2. In the investigations described here, the effect of ethyl alcohol on the temperature at which cardiac arrest occurred in rats...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duthie AM,White JF

更新日期：1977-07-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Geraghty DP,Maguire CM

更新日期：2002-12-01 00:00:00

abstract：:1. The neuronal release of acetylcholine (ACh) and its autoregulation by neuromodulators, substance P (SP) and methionine enkephalin (MEK), have been studied using superfused rodent cerebral slices. Nicotine exerts significant effects on autoregulation of ACh release, which may have toxicological implications. 2. Posi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sastry BV

更新日期：1995-04-01 00:00:00

abstract：:Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pringle KG,Zakar T,Lumbers ER

更新日期：2017-05-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. Arterial baroreflexes are suppressed in stressful conditions. Intense visual stimuli can cause a threatening sensation and produce defensive reactions. 2. The present study was designed to determine whether and how electrical stimulation of the optic tract (OT) affects arterial baroreflexes, especially the heart ra...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cheng ZB,Kobayashi M,Nosaka S

更新日期：2001-09-01 00:00:00

abstract：:1. Resistance changes of the afferent and efferent arterioles determine blood flow and filtration rate in the kidney. The tone of both vessels results from the influence of nerves and humoral and paracrine factors, through a balance of constrictor and dilator systems. Angiotensin (Ang) II and nitric oxide (NO) are imp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Patzak A,Lai E,Persson PB,Persson AE

更新日期：2005-05-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

更新日期：1983-03-01 00:00:00

abstract：:1. Recent reports have described the role of osteocalcin in glucose metabolism and glycaemic variability has been proven to be associated with an increased risk of diabetes complications. However, the relationship between osteocalcin and glycaemic variability remains unclear. The aim of the present study was to examin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bao YQ,Zhou M,Zhou J,Lu W,Gao YC,Pan XP,Tang JL,Lu HJ,Jia WP

更新日期：2011-01-01 00:00:00

abstract：:1. Contraction assays and patch clamp methods were used to determine the role of K+ channels in the regulation of contractile tone of human mesangial cells (MC) in culture. 2. MC contraction was induced by vasoconstrictor agents, such as angiotensin II (AngII; 100 nmol/L) and glybenclamide (Glyb), but not by iberiotox...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sansom SC,Stockand JD

更新日期：1996-01-01 00:00:00

abstract：:  NADPH oxidases (Nox) are reactive oxygen species (ROS)-generating enzymes that play important physiological roles in host defence and redox signalling. However, Nox activity is upregulated in the vascular wall during atherosclerosis and contributes to plaque formation by promoting oxidative stress and inflammation. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivera J,Walduck AK,Strugnell RA,Sobey CG,Drummond GR

更新日期：2012-03-01 00:00:00

abstract：:1. Rats fed high dietary fructose are documented to form an acquired model of insulin resistance. The present study measured the effects of administration of L-carnitine (CA) on lens protein glycation, oxidative stress and redox homeostasis in rats fed a high-fructose diet. 2. Animals were divided into four groups: (i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Balasaraswathi K,Rajasekar P,Anuradha CV

更新日期：2008-02-01 00:00:00

abstract：:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka S

更新日期：1996-10-01 00:00:00

abstract：:Despite the presence of many studies on the role of mechanistic target of rapamycin (mTOR) in cardiorenal tissues, the definitive role of mTOR in the pathogenesis of renal injury subsequent to ischaemia-reperfusion (IR) remains unclear. The aims of the current study were to characterize the role of mTOR in normal kidn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alshaman R,Truong L,Oyekan A

更新日期：2016-11-01 00:00:00

abstract：:1. We set out to investigate whether the administration of naloxone alone, naloxone plus vasopressin (AVP) or naloxone plus alprazolam to patients with Cushing's syndrome would result in a blunted dynamic response of the pituitary-adrenal axis compared with normal volunteers. Cushing's syndrome is often difficult to d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jackson RV,Hockings GI,Torpy DJ,Grice JE,Crosbie GV,Walters MM,Strakosch CR

更新日期：1996-06-01 00:00:00

abstract：:1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ratan RR,Baraban JM

更新日期：1995-04-01 00:00:00

abstract：:1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

journal_title：Clinical and experimental pharmacology & physiology

authors： Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

更新日期：2005-10-01 00:00:00

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measure...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Q,Yu MF,Zhang WJ,Liu BB,Zhao QY,Luo X,Xu H,She YS,Zang DA,Qiu JY,Shen J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Nie X,Shen C,Chen S,Chen S,Liu Q,Dai J,Qin G,Zheng YM,Wang YX,ZhuGe R,Chen J,Liu QH

更新日期：2019-04-01 00:00:00

abstract：:Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and perip...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joksić J,Sopić M,Spasojević-Kalimanovska V,Gojković T,Zeljković A,Vekić J,Andjelkovic K,Kalimanovska-Oštrić D,Jelić-Ivanović Z

更新日期：2016-01-01 00:00:00

abstract：:This study describes the pharmacodynamic interaction between propofol and remifentanil. Sixty patients who were scheduled for elective surgery under general anaesthesia (30 males/30 females) were enrolled. Patients were randomly allocated to receive one of 15 combinations of drug levels. Baseline electroencephalograms...

journal_title：Clinical and experimental pharmacology & physiology

authors： Choe S,Choi BM,Lee YH,Lee SH,Lee EK,Kim KS,Noh GJ

更新日期：2017-01-01 00:00:00

abstract：:1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wing LM,Bune AJ,Chalmers JP,Graham JR,West MJ

更新日期：1981-09-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

更新日期：2003-07-01 00:00:00