Abstract：
:ACTH, beta lipotropin (beta LPH), beta endorphin (beta EP), Prolactin (PRL) and Cortisol were measured in the first five days of puerperium at 9:00, before and 30 minutes after suckling, in 7 healthy lactating women. With the exception of PRL plasma levels which decline, although remaining at high concentrations during the observation period, all the other parameters showed a sudden fall from the high levels found at delivery, reaching stable normal levels (beta LPH, beta EP, Cortisol) or concentrations which were 50% lower than normal (ACTH), from the second day of puerperium. Suckling confirms its capacity to release plasma PRL, while all the other indices remain unmodified. Despite the experimental evidence that serotoninergic neurons are involved both in the PRL response to suckling and the circadian rhythmicity and stress response of proopiocortin-related peptides, the present results suggest that breast feeding is not a stressful situation, as no typical proopiocortin-related peptide response is evident, and that the activation of PRL release is related to stimulation of serotoninergic neurons which differ from those involved in the control of proopiocortin-related peptide secretion.
journal_name
J Endocrinol Investjournal_title
Journal of endocrinological investigationauthors
Genazzani AR,Facchinetti F,Parrini D,Petraglia F,La Rosa R,Puggioni R,D'Antona Ndoi
10.1007/BF03350534subject
Has Abstractpub_date
1982-11-01 00:00:00pages
367-71issue
6eissn
0391-4097issn
1720-8386journal_volume
5pub_type
杂志文章abstract：:Over the last decade, there has been an alarming increase of Type 2 diabetes mellitus (T2DM) in youths, concomitant with the rise of obesity in this age group. T2DM is a progressive disease with a gradual increase in insulin resistance associated later with a decline in insulin secretion with fasting hyperglycemia. Pr...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03347581
更新日期：2005-10-01 00:00:00
abstract：:A strong relationship was previously described between the nocturnal oscillations of plasma renin activity (PRA) and the sleep cycles, with levels of PRA that increase during non rapid eye movement sleep and decrease during rapid eye movement sleep. This study was designed to determine whether ritanserin, a 5-hydroxyt...
journal_title：Journal of endocrinological investigation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF03349016
更新日期：1996-09-01 00:00:00
abstract：:Rats bearing mammosomatotropic tumors have raised insulin but lowered glucose concentrations. To determine if growth hormone (GH) secreted by these tumors causes insulin antagonism, pancreatic suppression tests utilizing infusions (per kg per min) of glucose (8 mg), insulin (200 ng) and somatostatin (1.4 micrograms) f...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
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更新日期：1987-12-01 00:00:00
abstract：:Pendred syndrome is an autosomal recessive disorder characterized by congenital sensorineural deafness, goiter, and impaired iodide organification. It is caused by mutations in the PDS gene. Most published mutation studies of Pendred syndrome have dealt with Western populations. In this study, we examined clinical and...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349236
更新日期：2007-12-01 00:00:00
abstract：:The 24-h profiles of plasma cortisol (F), 11-beta-hydroxyandrostenedione (11OHAD), androstenedione (AD), dehydroisoandrosterone (DHEA) and testosterone (T) were obtained simultaneously in 11 normal males sampled at 15-min intervals. The data were submitted to a detailed quantitative analysis including the estimation o...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348129
更新日期：1987-06-01 00:00:00
abstract：:Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a cli...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347227
更新日期：2005-05-01 00:00:00
abstract：:Pituitary collision tumors are rare. They may create difficult diagnostic problems and their histogenesis is not clear. We report here an unusual case of a somatotroph adenoma colliding with a gonadotroph adenoma.The 64-year-old man had clinical acromegaly. His blood growth hormone level was elevated and magnetic reso...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03343674
更新日期：2000-01-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03346835
更新日期：1991-06-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,meta分析
doi：10.1007/s40618-018-0853-9
更新日期：2018-10-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-019-1007-4
更新日期：2019-08-01 00:00:00
abstract：:Erectile dysfunction (ED) increases in prevalence and severity because of aging processes and related organic, iatrogenic and social problems. Decline of testosterone (T) levels is observed with age and also in illnesses with a common basis of endothelial damage. The T deficiency may lead to decreased energy, mood dep...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-016-0452-6
更新日期：2016-08-01 00:00:00
abstract：:Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to ...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03343777
更新日期：2000-10-01 00:00:00
abstract：:Nutritional and hormonal milieu in utero affect fetal growth. Both parties involved have an independent chance, for the occurrence of a developmental error at any stage of their constant developing system. Studies suggest that pregnancy outcome is associated with fetal demand for nutrients and the materno-placental ca...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345248
更新日期：2003-09-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347667
更新日期：1993-02-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type：
doi：
更新日期：2002-01-01 00:00:00
abstract：:To analyze the inhibitory effect of hormone replacement therapy (HRT) on bone resorption, we measured urinary excretion of C-telopeptide (CTX) and N-telopeptide (NTX) of type I collagen as new markers of bone resorption and assessed their correlation with bone mineral density, in comparison with urinary pyridinoline (...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03347294
更新日期：1998-03-01 00:00:00
abstract：PURPOSE:Metastases to the thyroid gland are uncommon and they represent 1-3% of all thyroid malignancy. The aim of this study is to analyze the diagnostic problems and the role of surgery in metastatic lesions to the thyroid. METHODS:We retrospectively analyzed all patients who had undergone thyroidectomy at our Cente...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-020-01282-w
更新日期：2020-11-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-018-0946-5
更新日期：2018-12-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03350225
更新日期：1988-12-01 00:00:00
abstract：:Orbital fibroblasts exhibit a unique phenotype including exaggerated responses to proinflammatory cytokines. We hypothesize that the unusual susceptability of these fibroblasts to molecular cues underlies the involvement of the orbit in Graves' ophthalmopathy. A number of attributes of orbital fibroblasts are reviewed...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/BF03345273
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-017-0751-6
更新日期：2018-01-01 00:00:00
abstract：:To determine whether G proteins are involved in the regulation of mouse placental lactogen-I (mPL-I) and/or mPL-II secretion before midpregnancy, mouse placental tissue from day 7 of pregnancy was dispersed with collagenase, cells were fractionated on a percoll gradient, and the purified trophoblast cells were culture...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03349006
更新日期：1996-09-01 00:00:00
abstract：:Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,评审
doi：10.1007/s40618-016-0473-1
更新日期：2016-10-01 00:00:00
abstract：PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,多中心研究
doi：10.1007/s40618-016-0595-5
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章,随机对照试验
doi：10.3275/7749
更新日期：2012-01-01 00:00:00
abstract：:Short stature homeobox-containing (SHOX) gene mutations causing haploinsufficiency have been reported in idiopathic short stature, but the real prevalence of this defect in the population with growth failure is debated. Based on current data, the prevalence of SHOXdefect (SHOX-D) has been calculated to have occurred i...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:Initial surgery for medullary thyroid cancer (MTC) with no evidence of lymph node involvement in neck compartments consists of total thyroidectomy and prophylactic central neck dissection. This study evaluated the reliability of a radiotracer technique for the intraoperative detection of sentinel lymph nodes (S...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-014-0112-7
更新日期：2014-09-01 00:00:00
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journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/s40618-016-0441-9
更新日期：2016-06-01 00:00:00
abstract：:Forty-three euthyroid patients with a single, solid, nonfunctioning thyroid nodule were submitted to fine needle aspiration biopsy and serum thyroglobulin (Tg) was measured before and after (48h) 10 U of bovine TSH. Twenty-two normal subjects were also submitted to the bTSH test. Patients with nonfunctioning nodules w...
journal_title：Journal of endocrinological investigation
pub_type： 杂志文章
doi：10.1007/BF03348125
更新日期：1987-06-01 00:00:00
