Effects of thyroid hormones, antithyroid drugs and iodide on in vitro conversion of thyroxine to triiodothyronine.

abstract：:Propofol (2,6-diisopropylphenol) is an anaesthetic agent with anti-oxidant properties. The aim of the present study was to determine whether propofol can protect pulmonary epithelial (A549) cells against lipopolysaccharide (LPS)-induced cell death and, if so, the mechanisms involved. The effects of LPS alone and in co...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gu X,Lu Y,Chen J,He H,Li P,Yang T,Li L,Liu G,Chen Y,Zhang L

更新日期：2012-05-01 00:00:00

abstract：:1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lüllmann H,Peters T

更新日期：1977-01-01 00:00:00

abstract：:1. Prenatal dexamethasone leads to low birth weight and compromises organogenesis, but its effects on nephrogenesis in male and female rats have not yet been investigated extensively. Reduced renal mass may be responsible for hypertension and renal haemodynamic and morphological adjustments to maintain the glomerular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martins JP,Monteiro JC,Paixão AD

更新日期：2003-01-01 00:00:00

abstract：:1. Alpha-terpineol is a monoterpene found in the essential oils of several aromatic plant species. In the present study, we investigated the mechanisms underlying the cardiovascular changes induced by alpha-terpineol in rats. 2. In normotensive rats, administration of alpha-terpineol (1, 5, 10, 20 and 30 mg/kg, i.v.) ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ribeiro TP,Porto DL,Menezes CP,Antunes AA,Silva DF,De Sousa DP,Nakao LS,Braga VA,Medeiros IA

更新日期：2010-08-01 00:00:00

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:1. Piretanide is a new loop diuretic resembling furosemide. The effects of this diuretic on various parameters of renal function and on the excretion of the major ions were studied on anaesthetized, hydrated rats. 2. Piretanide induced a marked diuresis and increased sodium, potassium, chloride and calcium excretion. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nguyen-Simonnet H,Gauthier C,Pellet M

更新日期：1981-07-01 00:00:00

abstract：:1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

更新日期：1998-02-01 00:00:00

abstract：:The effect of cyclic GMP was investigated using guinea-pig tracheal smooth muscle. 8-Bromo-cyclic GMP showed a dose-dependent relaxation of spontaneous tension of tracheal smooth muscle. Administration of sodium nitroprusside induced dose-dependent relaxation of tracheal smooth muscle as well as an increase in tissue ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Suzuki K,Takagi K,Satake T,Sugiyama S,Ozawa T

更新日期：1986-01-01 00:00:00

abstract：:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

journal_title：Clinical and experimental pharmacology & physiology

authors： Anderson KE,Myers D,Woodcock EA

更新日期：1993-05-01 00:00:00

abstract：:1. We have studied the role of kallikrein (KK) in the maintenance of renal function in chronic hypoxic rats (high altitude; HA), compared with control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (198-290 g) in an altitude chamber (5500 m) 15 h/day for 4 weeks. Experiments were also c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chen LW,Chien CT,Wu MS,Tsai TJ

更新日期：1996-09-01 00:00:00

abstract：:The purpose of the present study was to identify the differential proteins that synchronously change in urine and glomeruli and could be used to monitor glomerular lesions of IgA nephropathy (IgAN). The proteomes of urine and glomeruli from four IgAN patients who were graded III/IV according to the grading system of L...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ning X,Yin Z,Li Z,Xu J,Wang L,Shen W,Lu Y,Cai G,Zhang X,Chen X

更新日期：2017-05-01 00:00:00

abstract：:1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,Choo LK,Darroch S

更新日期：1989-06-01 00:00:00

abstract：:1. The development of microneurography, in which an insulated tungsten microelectrode is inserted into an accessible peripheral or cranial nerve in awake human subjects, has allowed detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we kn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macefield VG

更新日期：2005-01-01 00:00:00

abstract：:1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawakami K,Kawamoto M,Nomura M,Otani H,Nabika T,Gonda T

更新日期：2004-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. We foun...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fu X,Shen Y,Wang W,Li X

更新日期：2018-01-01 00:00:00

abstract：:1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

更新日期：1979-01-01 00:00:00

abstract：:1. Rats fed high dietary fructose are documented to form an acquired model of insulin resistance. The present study measured the effects of administration of L-carnitine (CA) on lens protein glycation, oxidative stress and redox homeostasis in rats fed a high-fructose diet. 2. Animals were divided into four groups: (i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Balasaraswathi K,Rajasekar P,Anuradha CV

更新日期：2008-02-01 00:00:00

abstract：:1. In the present study, we attempted to clarify whether the antidiabetic drug miglitol, an alpha-glucosidase inhibitor, has a protective effect against anginal ischaemia. We had reported previously that miglitol reduces myocardial infarct size through inhibition of glycogenolysis during ischaemia in rabbits. However,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Uno Y,Minatoguchi S,Arai M,Wang N,Chen XH,Hashimoto K,Lu C,Takemura G,Fujiwara H

更新日期：2005-10-01 00:00:00

abstract：:C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

更新日期：2020-06-01 00:00:00

abstract：:1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

更新日期：2004-01-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) has become a major disease that threatens human health. Neurotransmitters and the amygdala are found to be critical in the development and maintenance of PTSD. We aim to investigate the role of glycyrrhizin in treating PTSD. Contextual fear extinction and elevated plus maze test w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lai S,Shi L,Jiang Z,Lin Z

更新日期：2020-01-01 00:00:00

abstract：:The distribution and binding characteristics of the radioligand (-)-[125I]-cyanopindolol (CYP) have been examined in slide mounted mouse kidney sections, using the technique of in vitro labelling and autoradiography. (-)-[125I]-CYP binding to sections was of high affinity (KD = 55.8 pmol/l, s.e.m. = 8.1, n = 4) to a s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1986-03-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:1. Combined treatment of spontaneously hypertensive rats (SHR) with AT1 receptor antagonists and angiotensin-converting enzyme (ACE) inhibitors has been shown to reduce mean arterial pressure (MAP) more than monotherapy with either agent. The aims of the present study were to investigate the effects of chronic dual re...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duke LM,Paull JR,Widdop RE

更新日期：2003-05-01 00:00:00

abstract：:1. Elevated plasma lipoprotein (a) (Lp(a)) concentrations have been correlated with an increased risk of premature cardiovascular disease. The plasma Lp(a) concentration is quantitatively heritable and the apolipoprotein (Apo) A gene is known as a major locus-determining Lp(a) concentration. 2. The aim of the present ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Park HY,Nabika T,Notsu Y,Kobayashi S,Masuda J

更新日期：1999-04-01 00:00:00

abstract：:This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Millington WR,Yilmaz MS,Feleder C

更新日期：2016-06-01 00:00:00

abstract：:Ulcerative colitis is a major form of inflammatory bowel disease and increases the risk of the development of colorectal carcinoma. The anti-inflammatory and immunomodulatory properties of mesenchymal stem cells (MSC) make them promising tools for treating immune-mediated and inflammatory diseases. However, the lack o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lin Y,Lin L,Wang Q,Jin Y,Zhang Y,Cao Y,Zheng C

更新日期：2015-01-01 00:00:00

abstract：:1. In rat isolated tail arteries and atria in which transmitter stores are labelled with (3H)-noradrenaline, isoprenaline in low concentrations facilitates the stimulation-induced efflux of tritium. 2. This effect is dependent on the frequency and duration of electrical stimulation, being observed only at low frequenc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Medgett IC,McCulloch MW,Rand MJ,Story DF

更新日期：1980-09-01 00:00:00

abstract：:Cardiotoxin (CTX) III, a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. In the present study, we investigated the mechanisms underlying the anticancer activity of CTX III in human leukaemia (HL-60 cells). Cardiotoxin III activated the en...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chien CM,Yang SH,Chang LS,Lin SR

更新日期：2008-09-01 00:00:00

abstract：:1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

journal_title：Clinical and experimental pharmacology & physiology

authors： Waller J,Siney L,Hoult JR,Brain SD

更新日期：1997-11-01 00:00:00