abstract：INTRODUCTION:The therapeutic role of pelvic lymph node dissection (PLND) in prostate cancer (PCa) is unknown due to absence of randomized trials. OBJECTIVE:to present a critical review on the therapeutic benefits of PLND in high risk localized PCa patients. MATERIALS AND METHODS:A search of the literature on PLND was...

authors： Haiquel L,Cathelineau X,Sanchez-Salas R,Macek P,Secin F

更新日期：2022-02-11 00:00:00

abstract：:Inhibitory control may be vital in elite sport. The authors examined the link between athletic expertise, inhibitory control, and sport performance in a two-part quasi experiment. Inhibitory control was indexed using the Stop-Signal Task, athlete expertise was categorized on literary recommendations, and sport perform...

authors： Hagyard J,Brimmell J,Edwards EJ,Vaughan RS

更新日期：2021-12-31 00:00:00

abstract：BACKGROUND:In Denmark, most children are not sufficiently physically active and only a few interventions have been found to increase long-term physical activity among overweight and obese children. The aim of our study was to investigate if children are physically active in correspondence to Danish recommendations afte...

authors： Jakobsen DD,Schipperijn J,Bruun JM

更新日期：2021-12-29 00:00:00

abstract：BACKGROUND:Rehabilitation has often been seen as a disability-specific service needed by only few of the population. Despite its individual and societal benefits, rehabilitation has not been prioritised in countries and is under-resourced. We present global, regional, and country data for the number of people who would...

authors： Cieza A,Causey K,Kamenov K,Hanson SW,Chatterji S,Vos T

更新日期：2021-12-19 00:00:00

abstract：:In order to answer the question whether coronaviruses (CoVs) can be transmitted via foods, this review made a comparison between CoVs with the most recognized foodborne virus, human noroviruses (NoVs). As a result, although CoVs indeed have shown the possibilities to remain infectious on foods and/or food packaging ma...

authors： Li D,Zhao MY,Tan THM

更新日期：2021-12-01 00:00:00

abstract：:Methods of anatomical education have, as with many facets of normal life, been forced to evolve rapidly due to the Covid-19 pandemic. Whilst some authors claim that cadaver dissection is now under threat, we believe the centuries-old practice can and must be upheld. ...

authors： Bond G,Franchi T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The knowledge on bovine vaccines against respiratory viruses on bronchoalveolar fluid cells is scarce. OBJECTIVE:To compare the effects of a commercial intranasal (IN) and intramuscular (IM) vaccine against bovine respiratory disease (BRD) complex viruses on bronchoalveolar fluid cells of healthy heifers. ...

authors： Rossi PS,Mattei RI,Schllemer NR,Thomaz GR,Antunes AV,Virmond MP,Taube MJ,Bertagnon HG

更新日期：2021-12-01 00:00:00

abstract：:The effects of the learning environment on academic performance can be investigated according to a broad range of factors using a diversity of approaches. Many differences in academic performance have been associated with the sex of the student. Objectives: This study aims to understand the impact of absenteeism on th...

authors： Hakami AR

更新日期：2021-12-01 00:00:00

abstract：:Changes in medical student learning preferences help drive innovation in teaching and require schools and commercial resources to quickly adapt. However, few studies have detailed the relationship of learner preferences to the environment and teaching modalities used in the pre-clerkship years, nor do they incorporate...

authors： Wong K,Kapoor V,Tso A,OConnor M,Convissar D,Kothari N,Traba C

更新日期：2021-12-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was isolated from the oro/pharyngeal swabs of two Italian COVID-19 patients, physicians in a COVID-19 division hospital, with different courses of the disease. The complete genome sequences show that the two isolates belong to the B1.1 lineage, but contain a...

authors： Delbue S,D'Alessandro S,Signorini L,Dolci M,Pariani E,Bianchi M,Fattori S,Modenese A,Galli C,Eberini I,Ferrante P

更新日期：2021-12-01 00:00:00

abstract：:Syphilis is the prime example of a "new disease" which triggered a transnational (European) discussion among physicians. It appeared between the end of the Middle Ages and the beginning of the Modern Times (at the beginning of the sixteenth century), a time in which medicine was changing from a dogmatic to an experime...

authors： Martini M,Armocida E,Lo Basso L,Beri E,Bragazzi NL,Parodi A

更新日期：2021-12-01 00:00:00

abstract：:Atypical porcine pestivirus (APPV) is an emerging porcine virus that threatens global swine production. Pestiviruses can prevent interferon (IFN) production to avoid the host innate immune response, and the Npro viral protein can play a critical role. Knowledge of the host immune response to APPV infection is limited....

authors： Mou C,Pan S,Wu H,Chen Z

更新日期：2021-12-01 00:00:00

abstract：:Francisella tularensis, a tier 1 select agent, is the causative bacterium of tularemia, a zoonosis with a large animal reservoir. However, F. tularensis, like many other Francisella species, is assumed to have an aquatic reservoir. The mechanisms of Francisella species persistence in surface water remain poorly charac...

authors： Hennebique A,Peyroux J,Brunet C,Martin A,Henry T,Knezevic M,Santic M,Boisset S,Maurin M

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Berberine (Ber) can increase the survival rate of septic mice and inhibit inflammation, but whether it has a protective effect on septic cardiomyopathy (SCM) is unclear. OBJECTIVE:To investigate whether Ber ameliorates SCM in a rat model and its potential mechanism. MATERIALS AND METHODS:Male SD rats were ran...

authors： Chen H,Liu Q,Liu X,Jin J

更新日期：2021-12-01 00:00:00

abstract：:Breast cancer is one of the cancers leading to most death cases among women and metastasis is the major cause of breast cancer mortality. In this study, Corylin, the flavonoid compound which is extracted and purified from Psoralea corylifolia L., the effect on breast cancer metastasis was investigated. Corylin showed ...

authors： Liu S,Wang L,Zhang R

更新日期：2021-12-01 00:00:00

abstract：:The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small and large animal mode...

authors： Li Y,Bi Y,Xiao H,Yao Y,Liu X,Hu Z,Duan J,Yang Y,Li Z,Li Y,Zhang H,Ding C,Yang J,Li H,He Z,Liu L,Hu G,Liu S,Che Y,Wang S,Li Q,Lu S,Cun W

更新日期：2021-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is a common malignant tumour of human digestive tract. The high mortality rate of CRC is closely related to the limitations of existing treatments. Thus, there is an urgent need to search for new anti-CRC agents. In this work, twenty novel coumarin-dithiocarbamate derivatives (IDs) were designe...

authors： Zhu H,Ying S,Zhou B,Hu X,Liang X,Li W,Wang D,Jin H,Pan Y

更新日期：2021-12-01 00:00:00

abstract：:Listeria monocytogenes is an important foodborne pathogen, and is ubiquitously distributed in the natural environment. Cattle and sheep, as natural hosts, can transmit L. monocytogenes to related meat and dairy products. In this study, the prevalence, distribution, and transmission characteristics of Listeria were ana...

authors： Zhao Q,Hu P,Li Q,Zhang S,Li H,Chang J,Jiang Q,Zheng Y,Li Y,Liu Z,Ren H,Lu S

更新日期：2021-12-01 00:00:00

abstract：:Biotransformations of stemofoline (1a), (2'S)-hydroxystemofoline (2a), (11Z)-1',2'-didehydrostemofoline (3a) and stemocurtisine (4) were studied through fermentation with Cunninghamella elegans TISTR 3370. Three new stemofoline derivatives; 6 R-hydroxystemofoline (1b), (2'S, 6 R)-dihydroxystemofoline (2b) and (11Z,6R)...

authors： Phaya M,Chalom S,Ingkaninan K,Ounnunkad K,Chandet N,Pyne SG,Mungkornasawakul P

更新日期：2021-12-01 00:00:00

abstract：:In view of limited resources during the COVID-19 pandemic, there is an urgent need to create novel programs to meet the changing demands of trainees towards developing and strengthening their skills in healthcare research. During the COVID-19 pandemic, digital learning has become an invaluable tool by providing more l...

authors： Afghani B

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Evodiamine, which is isolated from Evodia rutaecarpa (Rutaceae), possess strong anti-inflammatory, immunomodulatory, and antibacterial properties. OBJECTIVE:The protective effects of evodiamine in asthma were evaluated. MATERIALS AND METHODS:Thirty-two Sprague-Dawley (SD) rats were used, asthma was induced by...

authors： Wang Q,Cui Y,Wu X,Wang J

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to compare the cost-effectiveness of these two regimens in hemophilia A patients, under-12-years-old in southern Iran. METHODS:A cost-effectiveness study comparing prophylaxis versus on-demand was conducted on 34 hemophilia patients (24 and 10 patients were on the prophylaxis and on-demand r...

authors： Zahedi Z,Karimi M,Keshavarz K,Haghpanah S,Ravangard R

更新日期：2021-12-01 00:00:00

abstract：:Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support mitochondrial energy metabolism. However, the efficacy of oral administrated NR is limited due to its quick degradation in circulation and low bioavailability in targeted organs. In thi...

authors： Nie H,Zhang Y,Yu H,Xiao H,Li T,Yang Q

更新日期：2021-12-01 00:00:00

abstract：:Brucellosis not only represents an important health restraint on livestock but also causes high economic losses in many developing countries worldwide. Despite considerable efforts made for the control of brucellosis, the disease is still spreading in many regions (such as the Middle East) where it represents one of t...

authors： Dadar M,Tiwari R,Sharun K,Dhama K

更新日期：2021-12-01 00:00:00

abstract：:l-Ascorbic acid (LAA) is considered a powerful antioxidant that protects skin from premature aging. Maintaining the stability of vitamin C remains the biggest challenge in cosmeceuticals. Our main aim is the entrapment of high dose of vitamin C in spanlastic vesicles to provide maximum stability and efficacy. LAA-load...

authors： Elhabak M,Ibrahim S,Abouelatta SM

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Coronavirus disease 2019 (COVID-19) has a high burden on the healthcare system. Prediction models may assist in triaging patients. We aimed to assess the value of several prediction models in COVID-19 patients in the emergency department (ED). METHODS:In this retrospective study, ED patients with COVID-19...

authors： van Dam PMEL,Zelis N,van Kuijk SMJ,Linkens AEMJH,Brüggemann RAG,Spaetgens B,van der Horst ICC,Stassen PM

更新日期：2021-12-01 00:00:00

abstract：:Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature ...

authors： Alsfouk A

更新日期：2021-12-01 00:00:00

abstract：:For efficient intranasal transport of parathyroid hormone (1-34) [PTH(1-34)], there is a great medical need to investigate permeation enhancers for intranasal formulations. In this study, the development of PTH(1-34) intranasal formulations was conducted. Based on conformation and chemical stability studies, the most ...

authors： Wang D,Du Y,Zhang W,Han X,Zhang H,Wang Z,Liu N,Li M,Gao X,Zhuang X,Gao J,Zheng A

更新日期：2021-12-01 00:00:00

abstract：:HIV-1 CRF08_BC has become a major epidemic in heterosexuals and intravenous drug users (IDUs) in southern China. In order to evaluate the trends of its epidemic and facilitate targeted HIV prevention, we constructed the genetic transmission networks based on its pol sequences, derived from the National HIV Molecular E...

authors： Li K,Liu M,Chen H,Li J,Liang Y,Feng Y,Xing H,Shao Y

更新日期：2021-12-01 00:00:00

abstract：:The invertebrate Galleria mellonella has increasingly and widely been used in the last few years to study complex host-microbe interactions. Aspergillus fumigatus is one of the most pathogenic fungi causing life-threatening diseases in humans and animals. Galleria mellonella larvae has been proven as a reliable model ...

authors： Durieux MF,Melloul É,Jemel S,Roisin L,Dardé ML,Guillot J,Dannaoui É,Botterel F

更新日期：2021-12-01 00:00:00

abstract：:MNX1-AS1 expression has been proposed to be abnormally upregulated in multiple human malignancies and be linked with the survival outcome of patients. However, relevant conclusions were yielded based on the limited samples. Therefore, we herein implemented a meta-analysis of the published cohort studies to further dec...

authors： Chen K,Gan JX,Huang ZP,Liu J,Liu HP

更新日期：2021-12-01 00:00:00

abstract：:In eSwatini and across sub-Saharan Africa, adolescent girls and young women (AGYW) are at significantly higher risk of HIV infection and poorer sexual and reproductive health (SRH) than their male counterparts. AGYW demonstrate low demand for SRH services, further contributing to poor outcomes. Strategic marketing app...

authors： Brault MA,Christie S,Aquino S,Rendin A,Manchia A,Curry LA,Linnander EL

更新日期：2021-12-01 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) is a common infectious disease in western Asia area and the full range of the long-term sequelae of HFMD remains poorly described. We conducted a retrospective hospital-based cohort study of HFMD patients with central nervous system (CNS) complications caused by EV-A71 or CV-A16 bet...

authors： Liang L,Cheng Y,Li Y,Shang Q,Huang J,Ma C,Fang S,Long L,Zhou C,Chen Z,Cui P,Lv N,Lou P,Cui Y,Sabanathan S,van Doorn HR,Luan R,Turtle L,Yu H

更新日期：2021-12-01 00:00:00

abstract：:Background: Wellness is an important concept for medical students to learn, both for their own health and for their patients. Since nutrition is an essential part of one's wellness that can positively or negatively impact one's health, it is important for medical students to learn approaches to nutritional wellness. S...

authors： Coleman MT,Brantley PR,Wiseman PM,English MR,Byerley L

更新日期：2021-12-01 00:00:00

abstract：:Alport syndrome (AS) is a hereditary glomerular nephritis caused by mutation in one of the type IV collagen genes α3/α4/α5 that encode the heterotrimer COL4A3/4/5. Failure to form a heterotrimer due to mutation leads to the dysfunction of the glomerular basement membrane, and end-stage renal disease. Previous reports ...

authors： Sannomiya Y,Kaseda S,Kamura M,Yamamoto H,Yamada H,Inamoto M,Kuwazuru J,Niino S,Shuto T,Suico MA,Kai H

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Physcion (Phy) exerts several pharmacological effects including anti-inflammatory, antioxidant, and antitumor properties. OBJECTIVE:This study investigates the cytotoxicity and its underlying mechanisms of Phy on breast cancer. MATERIALS AND METHODS:Human breast cancer cell MCF-7 was treated with 5-400 µM Phy...

authors： Zhang L,Dong R,Wang Y,Wang L,Zhou T,Jia D,Meng Z

更新日期：2021-12-01 00:00:00

abstract：:Objectives: Although glutamate is an essential factor in the neuronal system, excess glutamate can produce excitotoxicity. We previously reported that Peroxiredoxin 5 (Prx5) protects neuronal cells from glutamate toxicity via its antioxidant effects. However, it is unclear whether cytosolic or mitochondrial Prx5 provi...

authors： Kim MH,Kim DY,Lee HJ,Park YH,Huh JW,Lee DS

更新日期：2021-12-01 00:00:00

abstract：:The goal of this study was to determine the impact and experience of radiation oncology (RO) education in the undergraduate medical experience in the USA. A list of American medical schools was complied from various sources including the Association of American Medical Colleges (AAMC) and American Association of Colle...

authors： Odiase OM,Huang D,Sura KT

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:To estimate the ability of fasting, 1-h, and 2-h post-load glucose to predict cardiovascular outcomes. METHODS:We examined a population-based study consisting of 977 middle-aged subjects who underwent an oral glucose tolerance test with glucose values measured at 0, 60, and 120 min. Participants were follow...

authors： Saunajoki A,Auvinen J,Bloigu A,Ukkola O,Keinänen-Kiukaanniemi S,Timonen M

更新日期：2021-12-01 00:00:00

abstract：:In the USA, numerous summer programs are available for undergraduate students that seek to increase the number of individuals from groups underrepresented in medicine (URM) that matriculate to medical school. These programs have typically been conducted at research-focused institutions, involving hands-on-research and...

authors： Zhou C,Okafor C,Hagood J,DeLisser HM

更新日期：2021-12-01 00:00:00