Medical therapy of sexual dysfunction.

Abstract:

:The recent development of new medications for the treatment of the sexual dysfunction increased the possibility of improving the altered sexual performance. Although initially designed for the treatment of male sexual dysfunction, erectile dysfunction in particular, these substances have now been tested for the therapy of a broad range of sexual dysfunction also in the female. Here we will briefly review the therapeutic options currently available and the potential of new pharmacological treatments for male and female sexual dysfunction.

journal_name

J Endocrinol Invest

authors

Spera G,Pili M,Gnessi L,Spera E,Mariani S

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

132-6

issue

3 Suppl

eissn

0391-4097

issn

1720-8386

journal_volume

26

pub_type

杂志文章,评审
  • Mutations in the CYP21 B gene in a Chilean population with simple virilizing congenital adrenal hyperplasia.

    abstract::Steroid 21-hydroxylase deficiency (21OHD) compromises about 95% of all cases of congenital adrenal hyperplasia. We have characterized the disease-causing mutations in the steroid 21-hydroxylase genes of 19 Chilean patients (12 females and 7 males) with the simple virilizing (SV) form of 21OHD and compared them with ot...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343746

    authors: Fardella CE,Poggi H,Soto J,Torrealba I,Cattani A,Ugarte F,Cortinez A,Foradori A

    更新日期:2000-06-01 00:00:00

  • Early occurrence of a thyroid carcinoma in a patient who developed Graves' disease after treatment for Hodgkin's disease.

    abstract::We report the case of a patient who developed Graves' disease and a papillary thyroid cancer only 5 years after irradiation and adjuvant chemotherapy for Hodgkin's disease. This case is peculiar for the very short latency time between Hodgkin's disease treatment and thyroid cancer development, an event possibly relate...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349835

    authors: Belfiore A,Pellegriti G,Milone G,Vigneri G,Gangemi P,Fiumara A,Vigneri R

    更新日期:1995-12-01 00:00:00

  • Exercise-induced endocrine pathologies.

    abstract::There has been a substantial increase in women practicing sports over the past 30 yr. While exercise provides many health benefits, there appears to be a unique set of risks associated with intense exercise for the female athlete. The female athlete triad encompasses these risks, including amenorrhea, osteoporosis and...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345238

    authors: Warren MP,Goodman LR

    更新日期:2003-09-01 00:00:00

  • Metastases to the thyroid gland: review of incidence, clinical presentation, diagnostic problems and surgery, our experience.

    abstract:PURPOSE:Metastases to the thyroid gland are uncommon and they represent 1-3% of all thyroid malignancy. The aim of this study is to analyze the diagnostic problems and the role of surgery in metastatic lesions to the thyroid. METHODS:We retrospectively analyzed all patients who had undergone thyroidectomy at our Cente...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-020-01282-w

    authors: Battistella E,Pomba L,Mattara G,Franzato B,Toniato A

    更新日期:2020-11-01 00:00:00

  • Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients.

    abstract:BACKGROUND:Increasing evidence showed that telomere length was shorter in age-related diseases, but the mechanism of this phenomenon is still unclear. AIM:To determine whether telomere shortening occurs in Type 1 diabetes (T1D) and Type 2 diabetes (T2D), and explore the effect of antioxidant status on the telomere len...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.3275/9036

    authors: Ma D,Zhu W,Hu S,Yu X,Yang Y

    更新日期:2013-12-01 00:00:00

  • Intrinsic abnormality of thyroid cells from a patient with a Brobdingnagian goiter.

    abstract::Thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize DNA, and secrete Tg and T4 were assessed. Tg, T4 and the ratio Tg/T4 in media at 72 h were 120 micrograms/dl, 1.6 microg...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348184

    authors: Tseng YC,Burman KD,Baker JR Jr,D'Avis J,Wartofsky L

    更新日期:1987-10-01 00:00:00

  • Prolactin secretion in idiopathic hypogonadotropic hypogonadism during pulsatile luteinizing hormone-releasing hormone long-term administration.

    abstract::Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350751

    authors: Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

    更新日期:1989-09-01 00:00:00

  • A new test for the diagnosis of growth hormone deficiency due to primary pituitary impairment: combined administration of pyridostigmine and growth hormone-releasing hormone.

    abstract::The diagnosis of growth hormone (GH) deficiency (GHD) is currently based on failure to increase plasma GH levels to an arbitrary cutoff point of 7 or 10 micrograms/l in response to two provocative stimuli. False negative responses to these tests, however, frequently occur thus reducing their diagnostic reliability. Th...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349569

    authors: Ghigo E,Imperiale E,Boffano GM,Mazza E,Bellone J,Arvat E,Procopio M,Goffi S,Barreca A,Chiabotto P

    更新日期:1990-04-01 00:00:00

  • Hexarelin-induced growth hormone response in short stature. Comparison with growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen.

    abstract:UNLABELLED:Hexarelin (HEX) is a synthetic hexapeptide with strong GH-stimulating activity. We evaluated GH response (expressed as maximum value after stimulus [Cmax] and as area under the curve [AUC]) to HEX at the doses of 1 microg/kg i.v. (HEX 1) and 2 microg/kg i.v. (HEX 2), in comparison with the responses to GHRH ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343574

    authors: Guzzaloni G,Grugni G,Morabito F

    更新日期:1999-05-01 00:00:00

  • Sandwich-type enzyme immunoassay for human chorionic gonadotropin.

    abstract::We have developed a sandwich-type enzyme immunoassay for human chorionic gonadotropin (hCG), in which antibody Fab'-beta-D-galactosidase complex and an antibody-immobilized silicone rubber solid phase were used. Despite the fact this assay system crossreacted about 40% with human luteinizing hormone (LH) that contains...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349444

    authors: Sekiya T,Furuhashi Y,Goto S,Kaseki S,Tomoda Y,Kato K

    更新日期:1981-07-01 00:00:00

  • Growth hormone and somatostatin directly inhibit gastric ghrelin secretion. An in vitro organ culture system.

    abstract::Ghrelin is a 28-amino-acid hormone produced mainly by the stomach which strongly promotes food intake. It is the only known peripheral orexigenic hormone that induces the release of GH. Ghrelin has been proposed as a link between the enteric system and central regulation of energy balance and growth. Although it has r...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03350806

    authors: Seoane LM,Al-Massadi O,Barreiro F,Dieguez C,Casanueva FF

    更新日期:2007-10-01 00:00:00

  • Actions of calcium ions and a calcium-influx blocker on basal and TRH- and GnRH-stimulated hormone release in patients with pituitary adenomas.

    abstract::We investigated the influence of calcium ions on the secretion of anterior pituitary hormones basally and in response to exogenous hypothalamic releasing factors in 6 men with pituitary tumors. To this end, concentrations of LH, FSH, TSH, growth hormone and prolactin were measured in blood collected at 10-min interval...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03348164

    authors: Davis M,Nassberg B,Borges JL,Iranmanesh A,Lizzaralde G,Santen RJ,Drake C,Rogol AD,Kaiser DL,Thorner MO

    更新日期:1987-10-01 00:00:00

  • Epigenetics: spotlight on type 2 diabetes and obesity.

    abstract::Type 2 diabetes (T2D) and obesity are the major public health problems. Substantial efforts have been made to define loci and variants contributing to the individual risk of these disorders. However, the overall risk explained by genetic variation is very modest. Epigenetics is one of the fastest growing research area...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-016-0473-1

    authors: Desiderio A,Spinelli R,Ciccarelli M,Nigro C,Miele C,Beguinot F,Raciti GA

    更新日期:2016-10-01 00:00:00

  • The dynamics of 11-beta-hydroxy-androstenedione (11 OHAD) metabolism in man.

    abstract::The aim of the study was to determine the main metabolic parameters of 11-beta-hydroxy-androstenedione (11 OHAD) in man. Seven normal subjects were investigated at 1-3 months interval by 2 types of isotope dilution techniques using a tritiated tracer: constant infusion and bolus iv injection. 3H-11 OHAD and 3H-11-beta...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03349485

    authors: Lejeune-Lenain C,Courtois P,Art G,Franckson JR

    更新日期:1984-12-01 00:00:00

  • Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report.

    abstract::An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordi...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347017

    authors: Wallerius S,Rosmond R,Ljung T,Holm G,Björntorp P

    更新日期:2003-07-01 00:00:00

  • Are there alternative tests for diagnosis of acromegaly?

    abstract::In acromegaly, clinical features are of the utmost importance, and biochemical confirmation is rarely difficult. However, some clinically manifest acromegalics have subtle abnormalities in GH secretion resulting in post-glucose GH nadir in the designated "normal" range with high IGF-I levels. Clinical decision may be ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Popovic V

    更新日期:2005-01-01 00:00:00

  • Hypothyroidism in the "Arnolfini Portrait" (1434) by Jan Van Eyck (1390-1441).

    abstract:BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-017-0751-6

    authors: Ashrafian H

    更新日期:2018-01-01 00:00:00

  • Fuel homeostasis and locomotor behavior: role of leptin and melanocortin pathways.

    abstract:BACKGROUND:While it is now accepted that genes and their products affect food intake, the concept that locomotor behavior or the propensity for physical activity is controlled by neuro hum oral regulators is frequently underappreciated. In mammals, complex interactions have developed to allow the cross-talk between fue...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/s40618-014-0225-z

    authors: Ceccarini G,Maffei M,Vitti P,Santini F

    更新日期:2015-02-01 00:00:00

  • Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin.

    abstract::Circulating TSH bioactivity may vary in several clinical and experimental conditions. Since the reliability of the current methods for the measurement of TSH bioactivity is limited, a new bioassay based on cAMP accumulation in Chinese Hamster Ovary cells transfected with recombinant human TSH receptor (CHO-R) was set ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348894

    authors: Persani L,Tonacchera M,Beck-Peccoz P,Vitti P,Mammoli C,Chiovato L,Elisei R,Faglia G,Ludgate M,Vassart G

    更新日期:1993-07-01 00:00:00

  • In vitro detection of glycoprotein production and secretion by human nonfunctioning pituitary adenomas.

    abstract::This study, carried out on 9 nonfunctioning pituitary adenomas, was undertaken in order to evaluate the ability of these tumors to synthesize and release gonadotropins and/or free alpha-subunit (alpha-SU) of glycoproteins. The morphological study included electron microscopy and immunofluorescence analysis while hormo...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03347659

    authors: Saccomanno K,Gil del Alamo P,Bassetti M,Reza-Elahi F,Spada A

    更新日期:1993-02-01 00:00:00

  • Parathyroid incidentaloma discovered during thyroid ultrasound imaging.

    abstract::We report two patients with incidentally discovered enlarged parathyroid glands while performing neck ultrasonography (US) for thyroid nodules. The parathyroid masses were seen as hypoechoic, homogeneous, oval nodules, separated from the thyroid gland. Both patients were completely asymptomatic, although subclinical e...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03343646

    authors: Pesenti M,Frasoldati A,Azzarito C,Valcavi R

    更新日期:1999-11-01 00:00:00

  • Bilateral testicular enlargement due to adrenal remnant in a patient with C11 hydroxylase deficiency congenital adrenal hyperplasia.

    abstract::The case of a 15-yr-old boy with C11 hydroxylase deficiency congenital adrenal hyperplasia is reported who was diagnosed and treated as true precocious puberty at the age of 2 yr because of virilization and bilateral testicular enlargement. He later developed hyperpigmentation, hypertension and short stature and becau...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:10.1007/BF03345128

    authors: Ghazi AA,Hadayegh F,Khakpour G,Azizi F,Melby JC

    更新日期:2003-01-01 00:00:00

  • Vitamin D levels in a paediatric population of normal weight and obese subjects.

    abstract:BACKGROUND:Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. AIM:Aim of our study was to evaluate vitamin D status in children living in Northern Italy. METHODS:We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal an...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-014-0108-3

    authors: Bellone S,Esposito S,Giglione E,Genoni G,Fiorito C,Petri A,Bona G,Prodam F

    更新日期:2014-09-01 00:00:00

  • Effect of maternal nicotine/thiocyanate exposure during gestational period upon pituitary, thyroid and parathyroid function/morphology of 1-month-old rat offspring.

    abstract:INTRODUCTION:Impact of in utero exposure to nicotine, on the structure of the thyroid-pituitary axis and the parathyroid glands have been examined in 1-month-old rats and compared with that of thiocyanate. MATERIALS AND METHODS:Three pregnant female groups were used; control, nicotine and thiocyanate. Treatment starte...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-013-0043-8

    authors: Abdelhafez AM,Eltony SA,Abdelhameed SY,Elgayar SA

    更新日期:2014-05-01 00:00:00

  • Follow-up evaluation of patients with Graves' disease treated by subtotal thyroidectomy and risk factor analysis for post-operative thyroid dysfunction.

    abstract::Eight-year follow-up evaluation and analysis of factors related to postoperative thyroid dysfunction were made in 216 patients with Graves' disease treated by subtotal thyroidectomy. The postoperative status of thyroid function were as follows according to hypersensitive TSH level: 65 patients (30.1%) were euthyroid, ...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03344945

    authors: Sugino K,Mimura T,Toshima K,Iwabuchi H,Kitamura Y,Kawano M,Ozaki O,Ito K

    更新日期:1993-03-01 00:00:00

  • Radioiodine therapy of metastatic lesions of differentiated thyroid cancer.

    abstract::Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章,评审

    doi:

    authors: Luster M,Hänscheid H,Freudenberg LS,Verburg FA

    更新日期:2012-01-01 00:00:00

  • Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans.

    abstract::Reduced cardiac mass and performances are present in GH deficiency and are counteracted by rhGH replacement. GH and IGF-I possess specific myocardial receptors and have been reported able to exert an acute inotropic effect. Synthetic GH secretagogues (GHS) possess specific pituitary and hypothalamic but even myocardia...

    journal_title:Journal of endocrinological investigation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF03343555

    authors: Bisi G,Podio V,Valetto MR,Broglio F,Bertuccio G,Del Rio G,Arvat E,Boghen MF,Deghenghi R,Muccioli G,Ong H,Ghigo E

    更新日期:1999-04-01 00:00:00

  • Oxytocin reduces the activity of N-methyl-D-aspartate receptors in cultured neurons.

    abstract::N-Methyl-D-Aspartate(NMDA)-sensitive glutamate receptors, are critically involved in the induction of the learning process. Activation of NMDA receptors by glutamate lead to massive influx of extracellular Ca2+, with ensuing activation of a variety of Ca(2+)-dependent enzymes, including protein kinase C. This triggers...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/BF03348959

    authors: Caruso S,Agnello C,Campo MG,Nicoletti F

    更新日期:1993-12-01 00:00:00

  • Investigating the effect of testosterone by itself and in combination with letrozole on 1,25-dihydroxy vitamin D and FGF23 in male rats.

    abstract:BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-018-0875-3

    authors: Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

    更新日期:2019-01-01 00:00:00

  • Primary hyperparathyroidism in pregnancy: observations from the Indian PHPT registry.

    abstract:PURPOSE:To present the data on primary hyperparathyroidism (PHPT) in pregnancy from India obtained from a large database maintained over 15 years. METHODS:We retrieved data of all women with gestational PHPT from the Indian PHPT registry between July 2005 and January 2020, and compared their clinical, biochemical, and...

    journal_title:Journal of endocrinological investigation

    pub_type: 杂志文章

    doi:10.1007/s40618-020-01441-z

    authors: Pal R,Bhadada SK,Gupta N,Behera A,Aggarwal N,Aggarwal A,Raviteja KV,Saikia UN,Kaur G,Arvindbhai SM,Walia R

    更新日期:2020-10-09 00:00:00