Influence of the neonatal suppression of TSH production (neonatal hyperthyroidism) on response to TSH in adulthood.

Abstract:

:Six-day treatment of neonatal rats with T3 or T4 resulted in a considerable depression of T4 production in response to exogenous TSH in adulthood. This supports the hypothetical conclusion that hormonal imprinting, i.e. the presence of the hormone and its interaction with the cell during the period of receptor maturation, is important for receptor amplification, which accounts for normal response to the hormone in adulthood.

journal_name

J Endocrinol Invest

authors

Csaba G,Nagy SU

doi

10.1007/BF03348561

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

557-9

issue

6

eissn

0391-4097

issn

1720-8386

journal_volume

8

pub_type

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