Abstract:
OBJECTIVES:To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer. DATA SOURCES:PubMed, Web of Science and Embase were searched for eligible studies up to September 2020. STUDY SELECTION:Cohort studies were included. DATA EXTRACTION AND SYNTHESIS:Two researchers independently reviewed the studies and extracted the data. Data synthesis was performed via systematic review and meta-analysis of eligible cohort studies. Meta-analysis was performed with the "metan" and "glst" commands in Stata 14.0. MAIN OUTCOMES AND MEASURES:Prostate cancer was the main outcome. It was classified as localised prostate cancer which included localised or non-aggressive cancers; advanced prostate cancer which included advanced or aggressive cancers; or fatal prostate cancer which included fatal/lethal cancers or prostate cancer-specific deaths. RESULTS:Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative risk (RR) was 0.91 (95% CI 0.84 to 0.98), I2= 53.2%) for the highest category of coffee consumption. There was a significant linear trend for the association (p=0.006 for linear trend), with a pooled RR of 0.988 (95% CI 0.981 to 0.995) for each increment of one cup of coffee per day. For localised, advanced and fatal prostate cancer, the pooled RRs were 0.93 (95% CI 0.87 to 0.99), 0.88 (95% CI 0.71 to 1.09) and 0.84 (95% CI 0.66 to 1.08), respectively. No evidence of publication bias was indicated in this meta-analysis. CONCLUSIONS:This study suggests that a higher intake of coffee may be associated with a lower risk of prostate cancer.
journal_name
BMJ Openjournal_title
BMJ openauthors
Chen X,Zhao Y,Tao Z,Wang Kdoi
10.1136/bmjopen-2020-038902subject
Has Abstractpub_date
2021-01-11 00:00:00pages
e038902issue
2issn
2044-6055pii
bmjopen-2020-038902journal_volume
11pub_type
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