Association of traumatic stress and posttraumatic stress disorder with carotid atherosclerosis: findings from the general population.

Abstract:

:Background: Cumulative evidence suggests that both traumatic stress and posttraumatic stress disorder (PTSD) are cross-sectionally and prospectively linked to cardiovascular disease (CVD). However, their association with proxy markers of atherosclerosis has hardly been investigated. Objective: The objective of this general population study was to relate traumatic stress and PTSD to carotid plaque and intima-media thickness (cIMT). Methods: 3119 adults from the general population were assessed regarding their traditional cardiovascular risk factors, and an ultrasound of the carotid arteries was performed in each participant. Based on a PTSD interview, every participant was assigned to one of three groups: no trauma; trauma, but no PTSD; and trauma with PTSD. The sample was stratified into five age groups. Results: Trauma exposure was reported by 54.5% of the sample and 2.0% had PTSD. Traumatized participants had increased odds of self-reported CVD events compared to those without trauma exposure, even when accounted for CVD risk factors and other covariates (odds ratio [OR] = 1.51; 95% confidence interval [CI]: 1.03-2.22). This association was driven by those aged 70 years or older. Only in those aged 40 to 49 years, there was an association between cIMT and PTSD. There were no further associations between carotid plaque or cIMT and traumatic stress or PTSD. Conclusions: Our findings in concert with prior research suggest that the association between traumatic stress, PTSD and atherosclerosis as well as its clinical endpoints is complex and remains inconclusive. :Antecedentes: La evidencia acumulada sugiere que tanto el estrés traumático como el trastorno de estrés postraumático (TEPT) están vinculados de manera transversal y prospectiva con la enfermedad cardiovascular (ECV). Sin embargo, apenas se ha investigado su asociación con marcadores indirectos de aterosclerosis.Objetivo: El objetivo de este estudio de población general fue relacionar el estrés traumático y el TEPT con la placa carotídea y el grosor de la íntima-media (GIMc).Métodos: Se evaluó a 3119 adultos de la población general respecto a factores de riesgo cardiovascular tradicionales y se realizó una ecografía de las arterias carótidas en cada participante. Basado en una entrevista de TEPT, cada participante fue asignado a uno de tres grupos: sin trauma; trauma, pero no TEPT; y trauma con TEPT. La muestra se estratificó en cinco grupos de edad.Resultados: El 54,5% de la muestra informó exposición al trauma y el 2,0% tenía TEPT. Los participantes traumatizados tenían mayores probabilidades de eventos de ECV auto-reportados en comparación con los sin exposición al trauma, incluso cuando se tienen en cuenta los factores de riesgo de ECV y otras covariables (razón de posibilidades [OR] = 1,51; intervalo de confianza [IC] del 95%: 1,03-2,22). Esta asociación fue mayormente determinada por personas de 70 años o más. Solo en los de 40 a 49 años, hubo una asociación entre cIMT y TEPT. No hubo más asociaciones entre la placa carotídea o el cIMT y el estrés traumático o el TEPT.Conclusiones: Nuestros hallazgos, en conjunto con investigaciones anteriores, sugieren que la asociación entre el estrés traumático, el TEPT y la aterosclerosis, así como sus criterios de valoración clínicos, es compleja y no es concluyente. :背景:累积证据表明, 创伤应激和创伤后应激障碍 (PTSD) 在横断面和前瞻性上均与心血管疾病 (CVD) 相关。然而, 极少研究它们与动脉粥样硬化代用标记物的关系。目的:这项对一般人群的研究旨在将创伤应激和PTSD与颈动脉斑块和内膜中层厚度 (cIMT) 相关联。方法:对3119名来自一般人群的成年者的传统心血管风险因素进行了评估, 并对每位参与者进行了颈动脉超声检查。根据PTSD访谈, 每位参与者都被分配至以下三组之一:无创伤组;经历创伤但无PTSD组;和经历创伤并患有PTSD组。样本被分为五个年龄组。结果:54.5%的样本报告了创伤暴露, 2.0%患有PTSD。即使控制了CVD风险因素和其他协变量, 创伤患者相较于无创伤暴露者的自我报告CVD事件发生几率增加 (优势比[OR] = 1.51; 95%置信区间[CI]:1.03-2.22) 。这个关联是由70岁或以上的人推动的。仅在40至49岁的人群中, cIMT与PTSD之间存在关联。颈动脉斑块或cIMT与创伤应激或PTSD之间没有进一步的关联。结论:我们的研究结果与先前研究一致表明, 创伤应激, PTSD与动脉粥样硬化之间的关联以及其临床终点尚不明确。.

journal_name

Eur J Psychotraumatol

authors

Spitzer C,Klinger-König J,Frenzel S,Schminke U,Völzke H,Lübke L,Grabe HJ

doi

10.1080/20008198.2020.1815280

subject

Has Abstract

pub_date

2020-10-14 00:00:00

pages

1815280

issue

1

issn

2000-8066

pii

1815280

journal_volume

11

pub_type

杂志文章
  • The relation between adverse childhood experiences and moral injury in the Canadian Armed Forces.

    abstract::Background: There is increasing evidence that moral injuries (MIs) may affect the mental health of Canadian Armed Forces (CAF) members and veterans. Despite knowledge suggesting that MIs are related to multiple negative mental health outcomes, including the onset of post-traumatic stress disorder (PTSD), it is unknown...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2018.1546084

    authors: Battaglia AM,Protopopescu A,Boyd JE,Lloyd C,Jetly R,O'Connor C,Hood HK,Nazarov A,Rhind SG,Lanius RA,McKinnon MC

    更新日期:2019-01-17 00:00:00

  • Post-migration factors and mental health outcomes in asylum-seeking and refugee populations: a systematic review.

    abstract::The present systematic review examined post-migration variables impacting upon mental health outcomes among asylum-seeking and refugee populations in Europe. It focuses on the effects of post-settlement stressors (including length of asylum process and duration of stay, residency status and social integration) and the...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章,评审

    doi:10.1080/20008198.2020.1793567

    authors: Gleeson C,Frost R,Sherwood L,Shevlin M,Hyland P,Halpin R,Murphy J,Silove D

    更新日期:2020-12-01 00:00:00

  • Sleep disturbances and PTSD: a perpetual circle?

    abstract:BACKGROUND:Sleep facilitates the consolidation of fear extinction memory. Nightmares and insomnia are hallmark symptoms of posttraumatic stress disorder (PTSD), possibly interfering with fear extinction and compromising recovery. A perpetual circle may develop when sleep disturbances increase the risk for PTSD and vice...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v3i0.19142

    authors: van Liempt S

    更新日期:2012-01-01 00:00:00

  • Prolonged grief: setting the research agenda.

    abstract:BACKGROUND:Prolonged grief disorder is proposed for the International Classification of Diseases (ICD-11), though it was rejected as a diagnosis for DSM-5. OBJECTIVE:This review outlines findings and defines important areas for future research viewed from a lifespan perspective. RESULTS:The development and psychometr...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v6.27303

    authors: Rosner R

    更新日期:2015-05-19 00:00:00

  • PTSD in ICD-10 and proposed ICD-11 in elderly with childhood trauma: prevalence, factor structure, and symptom profiles.

    abstract:BACKGROUND:The proposal for ICD-11 postulates major changes for posttraumatic stress disorder (PTSD) diagnosis, which needs investigation in different samples. AIMS:To investigate differences of PTSD prevalence and diagnostic agreement between ICD-10 and ICD-11, factor structure of proposed ICD-11 PTSD, and diagnostic...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v7.29700

    authors: Glück TM,Knefel M,Tran US,Lueger-Schuster B

    更新日期:2016-01-21 00:00:00

  • Trauma exposure, posttraumatic stress, and comorbidities in female adolescent offenders: findings and implications from recent studies.

    abstract:BACKGROUND:While males constitute the majority, female adolescent offenders are a sizeable minority of the overall delinquent population. Further, those females who become involved in delinquent activities appear to be doing so at a younger age, and they are involved in a wide range of criminal activities, including vi...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v3i0.17247

    authors: Foy DW,Ritchie IK,Conway AH

    更新日期:2012-01-01 00:00:00

  • Complex posttraumatic stress disorder (CPTSD) following captivity: a 24-year longitudinal study.

    abstract::Background: The World Health Organization(WHO) International Classification of Diseases, 11th version (ICD-11), has proposed a new trauma-related diagnosis of complex posttraumatic stress disorder (CPTSD), separate and distinct from posttraumatic stress disorder (PTSD). However, to date, no study has examined CPTSD ov...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2019.1616488

    authors: Zerach G,Shevlin M,Cloitre M,Solomon Z

    更新日期:2019-05-28 00:00:00

  • A randomized controlled trial of brief Somatic Experiencing for chronic low back pain and comorbid post-traumatic stress disorder symptoms.

    abstract::Background: It is well documented that comorbid post-traumatic stress disorder (PTSD) in chronic pain is associated with a more severe symptom profile with respect to pain, disability and psychological distress. However, very few intervention studies exist targeting both PTSD and pain. The current study is the first r...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2017.1331108

    authors: Andersen TE,Lahav Y,Ellegaard H,Manniche C

    更新日期:2017-05-30 00:00:00

  • Post-traumatic stress disorder moderates the relationship between trauma exposure and chronic pain.

    abstract::Background: Trauma exposure and post-traumatic stress disorder (PTSD) are risk factors for chronic pain. Objective: This study investigated how exposure to intentional and non-intentional traumatic events and PTSD are related to pain severity and outcome of treatment in chronic pain patients. Methods: We assessed expo...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2017.1375337

    authors: Siqveland J,Ruud T,Hauff E

    更新日期:2017-09-19 00:00:00

  • Psychometric properties of the Questionnaire for Secondary Traumatization.

    abstract:BACKGROUND:During the past several years, there has been a growing interest in the negative effects that providing therapy may have on therapists. Of special interest is a phenomenon called secondary traumatization, which can arise while working with traumatized clients. To develop a simple screening tool for secondary...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v5.21875

    authors: Weitkamp K,Daniels JK,Klasen F

    更新日期:2014-01-09 00:00:00

  • Psychometric properties of the PTSD Checklist for DSM-5: a pilot study.

    abstract:BACKGROUND:To date there is a lack of studies assessing the psychometric properties of the recently revised PTSD Checklist (PCL), the PTSD Checklist for DSM-5 (PCL-5). The aim of this pilot study was to examine the psychometric properties of the PCL-5 in parents of children with burns. METHODS:The participating parent...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v7.30165

    authors: Sveen J,Bondjers K,Willebrand M

    更新日期:2016-04-19 00:00:00

  • No gene-by-environment interaction of BDNF Val66Met polymorphism and childhood maltreatment on anxiety sensitivity in a mixed race adolescent sample.

    abstract::Background: Anxiety disorders in youth are attributable to multiple causal mechanisms, comprising biological vulnerabilities, such as genetics and temperament, and unfavourable environmental influences, such as childhood maltreatment (CM). Objective: A gene-environment (G x E) interaction study was conducted to determ...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2018.1472987

    authors: Martin L,Hemmings SMJ,Kidd M,Seedat S

    更新日期:2018-05-22 00:00:00

  • The validation of the Polish version of the Posttraumatic Diagnostic Scale and its factor structure.

    abstract:BACKGROUND:Posttraumatic Diagnostic Scale (PDS) is a self-descriptive measure developed to provide information regarding posttraumatic stress disorder (PTSD) diagnosis and symptom severity. OBJECTIVES:THE AIM OF THIS ARTICLE IS TO REPORT ON THE VALIDATION OF THE POLISH VERSION OF PDS AND TO TEST ITS FACTOR STRUCTURE W...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v3i0.18479

    authors: Dragan M,Lis-Turlejska M,Popiel A,Szumiał S,Dragan WŁ

    更新日期:2012-01-01 00:00:00

  • Exploring optimum cut-off scores to screen for probable posttraumatic stress disorder within a sample of UK treatment-seeking veterans.

    abstract::Background: Previous research exploring the psychometric properties of the scores of measures of posttraumatic stress disorder (PTSD) suggests there is variation in their functioning depending on the target population. To date, there has been little study of these properties within UK veteran populations. Objective: T...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2017.1398001

    authors: Murphy D,Ross J,Ashwick R,Armour C,Busuttil W

    更新日期:2017-11-13 00:00:00

  • A Bayesian network analysis of posttraumatic stress disorder symptoms in adults reporting childhood sexual abuse.

    abstract::Background: The network approach to mental disorders offers a novel framework for conceptualizing posttraumatic stress disorder (PTSD) as a causal system of interacting symptoms. Objective: In this study, we extended this work by estimating the structure of relations among PTSD symptoms in adults reporting personal hi...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2017.1341276

    authors: McNally RJ,Heeren A,Robinaugh DJ

    更新日期:2017-07-15 00:00:00

  • The Parent Trauma Response Questionnaire (PTRQ): development and preliminary validation.

    abstract::Background: Following a child's experience of trauma, parental response is thought to play an important role in either facilitating or hindering their psychological adjustment. However, the ability to investigate the role of parenting responses in the post-trauma period has been hampered by a lack of valid and reliabl...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2018.1478583

    authors: Williamson V,Hiller RM,Meiser-Stedman R,Creswell C,Dalgleish T,Fearon P,Goodall B,McKinnon A,Smith P,Wright I,Halligan SL

    更新日期:2018-06-20 00:00:00

  • Characteristics and efficacy of early psychological interventions in children and adolescents after single trauma: a meta-analysis.

    abstract:BACKGROUND:Single traumatising events are associated with an elevated rate of psychological disorders in children and adolescents. To date, it remains unclear whether early psychological interventions can reduce longer term psychological maladjustment. OBJECTIVE:To systematically review the literature to determine the...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v2i0.7858

    authors: Kramer DN,Landolt MA

    更新日期:2011-01-01 00:00:00

  • The psychological reactions after witnessing a killing in public in a Danish high school.

    abstract:BACKGROUND:School killings attract immense media and public attention but psychological studies surrounding these events are rare. OBJECTIVE:To examine the prevalence of posttraumatic stress disorder (PTSD) and possible risk factors of PTSD in 320 Danish high school students (mean age 18 years) 7 months after witnessi...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v4i0.19826

    authors: Elklit A,Kurdahl S

    更新日期:2013-01-01 00:00:00

  • Design, delivery, and evaluation of early interventions for children exposed to acute trauma.

    abstract:BACKGROUND:Exposure to acute, potentially traumatic events is an unfortunately common experience for children and adolescents. Posttraumatic stress (PTS) responses following acute trauma can have an ongoing impact on child development and well-being. Early intervention to prevent or reduce PTS responses holds promise b...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v5.22757

    authors: Kassam-Adams N

    更新日期:2014-07-02 00:00:00

  • Association of child maltreatment subtypes and long-term physical health in a German representative sample.

    abstract::Background: Child maltreatment is a major public problem, associated with enormous consequences on the individual and socioeconomic level. Studies show a clear impact of child maltreatment on long-term physical health. However, there is a lack of analyses comprising a wide variety of subtypes of maltreatment and addre...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2018.1510278

    authors: Clemens V,Huber-Lang M,Plener PL,Brähler E,Brown RC,Fegert JM

    更新日期:2018-09-07 00:00:00

  • Susceptibility to long-term misinformation effect outside of the laboratory.

    abstract:OBJECTIVE:To test the effect of misinformation outside of the laboratory and to explore correlates of the effect, including arousal, cognitive ability, and neuroticism. METHOD:About 2 months before deployment to Afghanistan, 249 soldiers enrolled in this study, which was embedded in a larger project. Two months after ...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v4i0.19864

    authors: Lommen MJ,Engelhard IM,van den Hout MA

    更新日期:2013-05-02 00:00:00

  • Exposing therapists to trauma-focused treatment in psychosis: effects on credibility, expected burden, and harm expectancies.

    abstract:BACKGROUND:Despite robust empirical support for the efficacy of trauma-focused treatments, the dissemination proves difficult, especially in relation to patients with comorbid psychosis. Many therapists endorse negative beliefs about the credibility, burden, and harm of such treatment. OBJECTIVE:This feasibility study...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v7.31712

    authors: van den Berg DP,van der Vleugel BM,de Bont PA,Thijssen G,de Roos C,de Kleine R,Kraan T,Ising H,de Jongh A,van Minnen A,van der Gaag M

    更新日期:2016-09-06 00:00:00

  • BEST FOR CAN - bringing empirically supported treatments to children and adolescents after child abuse and neglect: study protocol.

    abstract::Background: Despite a large body of evidence demonstrating the effectiveness of psychotherapy for posttraumatic stress for children and adolescents, the adoption of empirically supported treatments (ESTs) in routine care is low. Objective: This implementation study aims to evaluate the dissemination of Trauma-Focused ...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2020.1837531

    authors: Rosner R,Barke A,Albrecht B,Christiansen H,Ebert DD,Lechner-Meichsner F,Muche R,Zarski AC,Steil R

    更新日期:2020-11-26 00:00:00

  • Night-time rumination in PTSD: development and validation of a brief measure.

    abstract::Background: Pre-sleep cognitive activity and arousal have long been implicated in the maintenance of insomnia. However, despite high comorbidity between insomnia and posttraumatic stress disorder (PTSD), pre-sleep thoughts in PTSD and their associations with disturbed sleep, have not yet been investigated. Objective: ...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2019.1651476

    authors: Woodward E,Sachschal J,Beierl ET,Ehlers A

    更新日期:2019-08-27 00:00:00

  • Defining the index trauma in post-traumatic stress disorder patients with multiple trauma exposure: impact on severity scores and treatment effects of using worst single incident versus multiple traumatic events.

    abstract::Background: A diagnosis of post-traumatic stress disorder (PTSD) requires the identification of one or more traumatic events, designated the index trauma, which serves as the basis for assessment of severity of PTSD. In patients who have experienced more than one traumatic event, severity may depend on the exact defin...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2018.1486124

    authors: Priebe K,Kleindienst N,Schropp A,Dyer A,Krüger-Gottschalk A,Schmahl C,Steil R,Bohus M

    更新日期:2018-07-09 00:00:00

  • EMDR for children with medically related subthreshold PTSD: short-term effects on PTSD, blood-injection-injury phobia, depression and sleep.

    abstract::Background: Paediatric illness, injury and medical procedures are potentially traumatic experiences with a range of possible negative psychosocial consequences. To prevent psychosocial impairment and improve medical adherence, evidence-based psychotherapy should be offered if indicated. Eye movement desensitization an...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2019.1705598

    authors: Meentken MG,van der Mheen M,van Beynum IM,Aendekerk EWC,Legerstee JS,van der Ende J,Del Canho R,Lindauer RJL,Hillegers MHJ,Moll HA,Helbing WA,Utens EMWJ

    更新日期:2020-01-10 00:00:00

  • 311 disaster and mental health countermeasures.

    abstract::On 11 March 2011, a devastating earthquake struck off the coast of Japan, causing blustering tsunami that swept over the northeast coast of the country. Many struggled to evacuate from their homes, schools, and workplaces as 8- to 9-m-tall tsunami rapidly reached the coast within half an hour after the earthquake (Eme...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v5.26515

    authors: Kim Y

    更新日期:2014-12-09 00:00:00

  • Is traumatic stress research global? A bibliometric analysis.

    abstract:BACKGROUND:The representation of low- and middle-income countries (LMIC) in traumatic stress research is important to establish a global evidence base, build research capacity, and reduce the burden of unmet mental health needs around the world. Reviews of the traumatic stress literature up to 2002 showed trends toward...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v5.23269

    authors: Fodor KE,Unterhitzenberger J,Chou CY,Kartal D,Leistner S,Milosavljevic M,Nocon A,Soler L,White J,Yoo S,Alisic E

    更新日期:2014-02-20 00:00:00

  • State dissociation moderates response to dialectical behavior therapy for posttraumatic stress disorder in women with and without borderline personality disorder.

    abstract:BACKGROUND:Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere with successful treatment. However, most empirical studies do not substantiate this assumption. OBJECTIVE:The primary objective was to test whether state dissociation predicts the success of an ada...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.3402/ejpt.v7.30375

    authors: Kleindienst N,Priebe K,Görg N,Dyer A,Steil R,Lyssenko L,Winter D,Schmahl C,Bohus M

    更新日期:2016-07-06 00:00:00

  • The behavioural inhibition system, behavioural activation system and experiential avoidance as explanatory variables of comorbid chronic pain and posttraumatic stress symptoms.

    abstract::Background: The variables that underlie comorbid chronic pain and posttraumatic stress symptoms (PTSS) are not yet clearly established. Objective: The aim of the present study was to analyse the role of the behavioural inhibition system (BIS), behavioural approach system (BAS) and experiential avoidance (EA) in pain a...

    journal_title:European journal of psychotraumatology

    pub_type: 杂志文章

    doi:10.1080/20008198.2019.1581013

    authors: Serrano-Ibáñez ER,Ramírez-Maestre C,Esteve R,López-Martínez AE

    更新日期:2019-03-11 00:00:00