Tolvaptan-induced hypernatremia related to low serum potassium level accompanying high blood pressure in patients with acute decompensated heart failure.

Abstract:

BACKGROUNDS:Tolvaptan significantly increases urine volume in acute decompensated heart failure (ADHF); serum sodium level increases due to aquaresis in almost all cases. We aimed to elucidate clinical factors associated with hypernatremia in ADHF patients treated with tolvaptan. METHODS:We enrolled 117 ADHF patients treated with tolvaptan in addition to standard therapy. We examined differences in clinical factors at baseline between patients with and without hypernatremia in the initial three days of hospitalization. RESULTS:Systolic (p = 0.045) and diastolic (p = 0.004) blood pressure, serum sodium level (p = 0.002), and negative water balance (p = 0.036) were significantly higher and serum potassium level (p = 0.026) was significantly lower on admission day in patients with hypernatremia (n = 22). In multivariate regression analysis, hypernatremia was associated with low serum potassium level (p = 0.034). Among patients with serum potassium level ≤ 3.8 mEq/L, the cutoff value obtained using receiver operating characteristic curve analysis, those with hypernatremia related to tolvaptan treatment showed significantly higher diastolic blood pressure on admission day (p = 0.004). CONCLUSION:In tolvaptan treatment combined with standard therapy in ADHF patients, serum potassium level ≤ 3.8 mEq/L may be a determinant factor for hypernatremia development. Among hypokalemic patients, those with higher diastolic blood pressure on admission may be carefully managed to prevent hypernatremia.

journal_name

BMC Cardiovasc Disord

authors

Fukuoka H,Tachibana K,Shinoda Y,Minamisaka T,Inui H,Ueno K,Inoue S,Mine K,Ueda K,Hoshida S

doi

10.1186/s12872-020-01751-3

subject

Has Abstract

pub_date

2020-10-29 00:00:00

pages

467

issue

1

issn

1471-2261

pii

10.1186/s12872-020-01751-3

journal_volume

20

pub_type

杂志文章
  • Living with hypertrophic cardiomyopathy and an implantable defibrillator.

    abstract:BACKGROUND:ICDs efficiently terminate life-threatening arrhythmias, but complications occur during long-term follow-up. Patients' own perspective is largely unknown. The aim of the study was to describe experiences of hypertrophic cardiomyopathy (HCM) patients with implantable defibrillators (ICDs). METHODS:We analyze...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0553-y

    authors: Magnusson P,Jonsson J,Mörner S,Fredriksson L

    更新日期:2017-05-10 00:00:00

  • Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations.

    abstract:BACKGROUND:Neointimal formation in atherosclerosis has been subject for intense research. However, good animal models mimicking asymmetrical lesion formation in human subjects have been difficult to establish. The aim of this study was to develop a model which would lead to the formation of eccentric lesions under macr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-12-91

    authors: Kivelä A,Hartikainen J,Ylä-Herttuala S

    更新日期:2012-10-17 00:00:00

  • Impact of psychosocial factors on cardiovascular morbimortality: a prospective cohort study.

    abstract:BACKGROUND:Whilst it is well known that psychosocial determinants may contribute to cardiovascular diseases (CVD), data from specific groups are scarce. The present study aims to determine the contribution of psychosocial determinants in increasing the risk of cardiovascular events (myocardial infarction and stroke), a...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/1471-2261-14-135

    authors: Mejía-Lancheros C,Estruch R,Martínez-González MA,Salas-Salvadó J,Castañer O,Corella D,Arós F,Gómez-Gracia E,Fiol M,Lapetra J,Serra-Majem L,Pintó X,Ros E,Díez-Espino J,Basora J,Sorlí JV,Lamuela-Raventos RM,Ruiz-Gutiérrez

    更新日期:2014-10-03 00:00:00

  • Comparison of bioresorbable vs durable polymer drug-eluting stents in unprotected left main (from the RAIN-CARDIOGROUP VII Study).

    abstract:BACKGROUND:There are limited data regarding the impact of bioresorbable polymer drug eluting stent (BP-DES) compared to durable polymer drug eluting stent (DP-DES) in patients treated with percutaneous coronary intervention using ultrathin stents in left main or bifurcations. METHODS:In the RAIN registry (ClinicalTria...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12872-020-01420-5

    authors: Iannaccone M,Barbero U,De Benedictis M,Imori Y,Quadri G,Trabattoni D,Ryan N,Venuti G,Montabone A,Wojakowski W,Rognoni A,Helft G,Parma R,De Luca L,Autelli M,Boccuzzi G,Mattesini A,Templin C,Cerrato E,Wańha W,Smolka

    更新日期:2020-05-15 00:00:00

  • In-flight angina pectoris; an unusual presentation.

    abstract:BACKGROUND:An unusual case of typical angina which occurred on a long haul flight is presented. This case is notable as this was the index presentation, with no previous symptoms prior to this. Physiological changes at altitude can be marked, and include hypoxia, tachycardia and an increase in cardiac output. These cha...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-018-0797-1

    authors: Al-Janabi F,Mammen R,Karamasis G,Davies J,Keeble T

    更新日期:2018-04-05 00:00:00

  • Healthy hearts--a community-based primary prevention programme to reduce coronary heart disease.

    abstract:BACKGROUND:The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based intervention, for men and women aged between 45 and 64 years without pre-existing coronary heart disease, ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-8-18

    authors: Richardson G,van Woerden HC,Morgan L,Edwards R,Harries M,Hancock E,Sroczynsk S,Bowley M

    更新日期:2008-07-26 00:00:00

  • Serum TGF-β1 and SMAD3 levels are closely associated with coronary artery disease.

    abstract:BACKGROUND:Coronary artery disease (CAD) is one of the most common diseases leading to mortality and morbidity worldwide. There is considerable debate on whether serum transforming growth factor β1 (TGF-β1) levels are associated with long-term major adverse cardiovascular events in patients with CAD, and to date, no st...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-14-18

    authors: Chen C,Lei W,Chen W,Zhong J,Gao X,Li B,Wang H,Huang C

    更新日期:2014-02-17 00:00:00

  • Comparison of platelet reactivity between prasugrel and ticagrelor in patients with acute coronary syndrome: a meta-analysis.

    abstract:BACKGROUND:This meta-analysis aimed to compare the effects of prasugrel and ticagrelor on high (HTPR) and low on-treatment platelet reactivity (LTPR) in patients with acute coronary syndrome (ACS). METHODS:Eligible studies were retrieved from PubMed, Embase, and the Cochrane Library. HTPR and LTPR were evaluated on th...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12872-020-01603-0

    authors: Wen M,Li Y,Qu X,Zhu Y,Tian L,Shen Z,Yang X,Shi X

    更新日期:2020-10-01 00:00:00

  • Rheumatic mitral stenosis in children: more accelerated course in sub-Saharan patients.

    abstract:BACKGROUND:Mitral stenosis, one of the grave consequences of rheumatic heart disease, was generally considered to take decades to evolve. However, several studies from the developing countries have shown that mitral stenosis follows a different course from that seen in the developed countries. This study reports the pr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-13-95

    authors: Tadele H,Mekonnen W,Tefera E

    更新日期:2013-11-01 00:00:00

  • β-blockers after myocardial infarction and 1-year clinical outcome - a retrospective study.

    abstract:BACKGROUND:Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. β-blocker treatment is a key quality of care indicator in the Swedish national quality register for acute coronary care, Riks-HIA. Between...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01441-0

    authors: Hagsund T,Olsson SE,Smith JG,Madsen Hardig B,Wagner H

    更新日期:2020-04-09 00:00:00

  • Differences in metabolic profiles between bicuspid and tricuspid aortic stenosis in the setting of transcatheter aortic valve replacement.

    abstract:BACKGROUND:To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01491-4

    authors: Xiong TY,Liu C,Liao YB,Zheng W,Li YJ,Li X,Ou Y,Wang ZJ,Wang X,Li CM,Zhao ZG,Feng Y,Liu XJ,Chen M

    更新日期:2020-05-18 00:00:00

  • High levels of serum β2-microglobulin predict severity of coronary artery disease.

    abstract:BACKGROUND:The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardi...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0502-9

    authors: You L,Xie R,Hu H,Gu G,Zheng H,Zhang J,Yang X,He X,Cui W

    更新日期:2017-03-01 00:00:00

  • The BpTRU automatic blood pressure monitor compared to 24 hour ambulatory blood pressure monitoring in the assessment of blood pressure in patients with hypertension.

    abstract:BACKGROUND:Increasing evidence suggests that ABPM more closely predicts target organ damage than does clinic measurement. Future guidelines may suggest ABPM as routine in the diagnosis and monitoring of hypertension. This would create difficulties as this test is expensive and often difficult to obtain. The purpose of ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-5-18

    authors: Beckett L,Godwin M

    更新日期:2005-06-28 00:00:00

  • Prevalence and associated factors of hypertension among adults in Gondar, Northwest Ethiopia: a community based cross-sectional study.

    abstract:BACKGROUND:Hypertension is a growing public health problem in many developing countries including Ethiopia. However, its prevention and control has not yet received due attention. This study aimed to determine the prevalence and associated factors of hypertension among adults in Gondar city, North-West Ethiopia. METHO...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-12-113

    authors: Awoke A,Awoke T,Alemu S,Megabiaw B

    更新日期:2012-11-28 00:00:00

  • Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study.

    abstract:BACKGROUND:The increasing burden of cardiovascular diseases (CVD) in the ageing population of industrialized nations requires an intensive search for means of reducing this epidemic. In order to improve prevention, detection, therapy and prognosis of cardiovascular diseases on the population level in Eastern Germany, i...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-5-33

    authors: Greiser KH,Kluttig A,Schumann B,Kors JA,Swenne CA,Kuss O,Werdan K,Haerting J

    更新日期:2005-11-11 00:00:00

  • Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients.

    abstract:BACKGROUND:The relationship between vitamin D levels and peripheral arterial disease (PAD) remains unclear. We assessed the association of serum 25-hydroxyvitamin D (25(OH)D) levels with the prevalence of PAD in patients with type 2 diabetes mellitus(T2DM). METHODS:A total of 1018 T2DM patients participated in this cr...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-1125-0

    authors: Yuan J,Jia P,Hua L,Xin Z,Yang JK

    更新日期:2019-06-17 00:00:00

  • Genetic and ElectroNic medIcal records to predict oUtcomeS in Heart Failure patients (GENIUS-HF) - design and rationale.

    abstract:BACKGROUND:Studies adopting electronic medical records and genomic information are becoming widespread. Through this new modality in research, it is possible to study how genetic variants influence susceptibility towards chronic conditions and can improve patient care.Our aim is to develop a biobank with 2,000 heart fa...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-14-32

    authors: Gioli-Pereira L,Bernardez-Pereira S,Goulart Marcondes-Braga F,Rocha Spina JM,Muniz Miranda da Silva R,Evangelista Ferreira N,Bacal F,Fernandes F,Mansur AJ,Krieger JE,Costa Pereira A

    更新日期:2014-03-04 00:00:00

  • Up-regulating autophagy by targeting the mTOR-4EBP1 pathway: a possible mechanism for improving cardiac function in mice with experimental dilated cardiomyopathy.

    abstract:BACKGROUND:Autophagy plays a crucial role in the pathological process of cardiovascular diseases. However, little is known about the pathological mechanism underlying autophagy regulation in dilated cardiomyopathy (DCM). METHODS:We explored whether up-regulating autophagy could improve cardiac function in mice with ex...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01365-9

    authors: Jin B,Shi H,Zhu J,Wu B,Geshang Q

    更新日期:2020-02-04 00:00:00

  • A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report.

    abstract:BACKGROUND:Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids in the lysosomes with subsequent cellular and microvascular dysfunc...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-12-39

    authors: Pisani A,Imbriaco M,Zizzo C,Albeggiani G,Colomba P,Alessandro R,Iemolo F,Duro G

    更新日期:2012-06-08 00:00:00

  • Risk factors for coronary artery disease in patients undergoing elective coronary angiography in Jordan.

    abstract:BACKGROUND:Unhealthy lifestyle factors such as smoking, obesity, inactivity and type 2 diabetes are endemic in the Middle East. The public health consequences might be detrimental; however, local studies on risk factors for coronary artery disease (CAD) are scarce. METHODS:Patients referred for coronary angiography at...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0620-4

    authors: Al-Shudifat AE,Johannessen A,Azab M,Al-Shdaifat A,AbuMweis SS,Agraib LM,Tayyem RF

    更新日期:2017-07-11 00:00:00

  • Life's simple 7 and cardiovascular disease risk knowledge in Hong Kong.

    abstract:BACKGROUND:This study aimed at investigating the CV health and CV disease knowledge in terms of LS7 score among 3 age groups in Hong Kong. METHODS:A cross-sectional multicenter observational study was conducted to observe the CV health and disease risk knowledge in Hong Kong. Elderly subjects were recruited from 15 el...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12872-019-1171-7

    authors: Lee VWY,Fong FYH,Cheng FWT,Yan BPY

    更新日期:2019-08-02 00:00:00

  • Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging.

    abstract:BACKGROUND:It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS:Forty two patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic re...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/1471-2261-9-37

    authors: Yousef ZR,Foley PW,Khadjooi K,Chalil S,Sandman H,Mohammed NU,Leyva F

    更新日期:2009-08-09 00:00:00

  • Efficacy and safety of mineralocorticoid receptor antagonists for patients with heart failure and diabetes mellitus: a systematic review and meta-analysis.

    abstract:BACKGROUND:The aim of this study was to systematically assess the efficacy and safety of mineralocorticoid receptor antagonists (MRAs) for patients with heart failure (HF) and diabetes mellitus (DM). METHODS:We conducted a comprehensive search for controlled studies that evaluated the efficacy and safety of MRAs in pa...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,meta分析,评审

    doi:10.1186/s12872-016-0198-2

    authors: Chen MD,Dong SS,Cai NY,Fan MD,Gu SP,Zheng JJ,Yin HM,Zhou XH,Wang LX,Li CY,Zheng C

    更新日期:2016-01-29 00:00:00

  • A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting.

    abstract:BACKGROUND:The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk individuals. The aim of this meta-analysis was to assess the efficacy of allopurinol treatment in red...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12872-018-0881-6

    authors: Singh TP,Skalina T,Nour D,Murali A,Morrison S,Moxon JV,Golledge J

    更新日期:2018-07-11 00:00:00

  • Determinants of arterial stiffness progression in a Han-Chinese population in Taiwan: a 4-year longitudinal follow-up.

    abstract:BACKGROUND:Arterial stiffness predicts the future risk of macro- and micro-vascular diseases. Only a few studies have reported longitudinal changes. The present study aimed to investigate the progression rate of arterial stiffness and the factors influencing stiffness progression in a Han Chinese population residing in...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-015-0093-2

    authors: Lin LY,Liao YC,Lin HF,Lee YS,Lin RT,Hsu CY,Juo SH

    更新日期:2015-09-16 00:00:00

  • Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons.

    abstract:BACKGROUND:The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate w...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12872-015-0044-y

    authors: Zhai C,Cong H,Liu Y,Zhang Y,Liu X,Zhang H,Ren Z

    更新日期:2015-06-26 00:00:00

  • Medium-term outcomes of 78,808 patients after heart valve surgery in a middle-income country: a nationwide population-based study.

    abstract:BACKGROUND:Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival. METHODS:This was a retrospective study of 78,806 patients who underwent heart valve surgery be...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-017-0725-9

    authors: de Aquino Xavier RM,Azevedo VMP,Godoy PH,Migowski A,Ribeiro ALP,Chaves RBM,Correia MG,de Aquino Xavier C,de Aquino Hashimoto L,Weksler C,Silva NASE

    更新日期:2017-12-28 00:00:00

  • Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.

    abstract:BACKGROUND:Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population. METHODS:In our case-control study, we recruited 755 unrelated partici...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-016-0188-4

    authors: Liu O,Li J,Xin Y,Qin Y,Li H,Gong M,Liu Y,Wang X,Li J,Zhang H

    更新日期:2016-01-14 00:00:00

  • The role of Asprosin in patients with dilated cardiomyopathy.

    abstract:BACKGROUND:Asprosin is a novel fasting glucogenic adipokine discovered in 2016. Asprosin induces rapid glucose releases from the liver. However, its molecular mechanisms and function are still unclear. Adaptation of energy substrates from fatty acid to glucose is recently considered a novel therapeutic target in heart ...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-020-01680-1

    authors: Wen MS,Wang CY,Yeh JK,Chen CC,Tsai ML,Ho MY,Hung KC,Hsieh IC

    更新日期:2020-09-07 00:00:00

  • Disease burden and associated risk factors for metabolic syndrome among adults in Ethiopia.

    abstract:BACKGROUND:Metabolic Syndrome (MetS) and Non-communicable diseases (NCDs) are alarmingly increasing in low-income countries. Yet, very limited is known about the prevalence and risk factors associated with MetS in Ethiopia. METHODS:A cross-sectional study was conducted among adult outpatients (N = 325) at St. Paul's H...

    journal_title:BMC cardiovascular disorders

    pub_type: 杂志文章

    doi:10.1186/s12872-019-1201-5

    authors: Solomon S,Mulugeta W

    更新日期:2019-10-26 00:00:00