Signaling and regulation of G protein-coupled receptors in airway smooth muscle.

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...

journal_title：Respiratory research

authors： Witt S,Krauss E,Barbero MAN,Müller V,Bonniaud P,Vancheri C,Wells AU,Vasakova M,Pesci A,Klepetko W,Seeger W,Crestani B,Leidl R,Holle R,Schwarzkopf L,Guenther A

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. METHODS:At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT®) trial, patie...

journal_title：Respiratory research

authors： Hanania NA,Sharafkhaneh A,Celli B,Decramer M,Lystig T,Kesten S,Tashkin D

更新日期：2011-01-11 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...

journal_title：Respiratory research

authors： Sdralia ND,Patmanidi AL,Velentzas AD,Margaritis LH,Baltatzis GE,Hatzinikolaou DG,Stavridou A

更新日期：2009-09-10 00:00:00

abstract：BACKGROUND:Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate i...

journal_title：Respiratory research

authors： Grogono JC,Butler C,Izadi H,Moosavi SH

更新日期：2018-09-20 00:00:00

abstract：:In the present study, we used tumor necrosis factor-R1 knock out mice (TNF-alpha R1KO) to understand the roles of TNF-alpha on epithelial function in models of carrageenan-induced acute lung inflammation. In order to elucidate whether the observed anti-inflammatory status is related to the inhibition of TNF-alpha, we ...

journal_title：Respiratory research

authors： Mazzon E,Cuzzocrea S

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

journal_title：Respiratory research

authors： Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

更新日期：2006-01-12 00:00:00

abstract：BACKGROUND:Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibrosis. However, in allergic airways disease, the role of SP-D in airway remodeling remains unknown. Th...

journal_title：Respiratory research

authors： Ogawa H,Ledford JG,Mukherjee S,Aono Y,Nishioka Y,Lee JJ,Izumi K,Hollingsworth JW

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if EIF2AK4 mutations occur also in a family with autosomal dominantly inherited pulmonary arterial hypertension (HPAH) ...

journal_title：Respiratory research

authors： Eichstaedt CA,Song J,Benjamin N,Harutyunova S,Fischer C,Grünig E,Hinderhofer K

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased ...

journal_title：Respiratory research

authors： Englert JA,Cho MH,Lamb AE,Shumyatcher M,Barragan-Bradford D,Basil MC,Higuera A,Isabelle C,Vera MP,Dieffenbach PB,Fredenburgh LE,Kang JB,Bhatt AS,Antin JH,Ho VT,Soiffer RJ,Howrylak JA,Himes BE,Baron RM

更新日期：2019-01-21 00:00:00

abstract：:The pulmonary innate immune system is heavily implicated in the perpetual airway inflammation and impaired host defense characterizing Chronic Obstructive Pulmonary Disease (COPD). The airways of patients suffering from COPD are infiltrated by various immune and inflammatory cells including macrophages, neutrophils, T...

journal_title：Respiratory research

authors： Haczku A

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

journal_title：Respiratory research

authors： Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and...

journal_title：Respiratory research

authors： Noël A,Xiao R,Perveen Z,Zaman H,Le Donne V,Penn A

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:CpG oligodeoxynucleotides (CpG-ODN) are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore, type-I IFNs have been proposed to play a key role in mediating effects of CpG-ODN. The precise role of IFN-beta in the immunomodulatory effects of CpG-ODN is not known. ...

journal_title：Respiratory research

authors： Matheu V,Treschow A,Teige I,Navikas V,Issazadeh-Navikas S

更新日期：2005-03-05 00:00:00

abstract：BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...

journal_title：Respiratory research

authors： Parrot A,Antoine M,Khalil A,Théodore J,Mangiapan G,Bazelly B,Fartoukh M

更新日期：2008-08-05 00:00:00

abstract：:Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orch...

journal_title：Respiratory research

authors： Park SJ,Lee YC

更新日期：2010-06-16 00:00:00

abstract：BACKGROUND:In vivo, the airways are constantly subjected to oscillatory strain (due to tidal breathing during spontaneous respiration) and (in the event of mechanical ventilation) positive pressure. This exposure is especially problematic for the cartilage-free bronchial tree. The effects of cyclic stretching (other th...

journal_title：Respiratory research

authors： Le Guen M,Grassin-Delyle S,Naline E,Buenestado A,Brollo M,Longchampt E,Kleinmann P,Devillier P,Faisy C

更新日期：2016-11-14 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

journal_title：Respiratory research

authors： Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

更新日期：2009-11-25 00:00:00

abstract：BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

journal_title：Respiratory research

authors： Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

更新日期：2017-12-11 00:00:00

abstract：:Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host...

journal_title：Respiratory research

authors： Kesic MJ,Hernandez M,Jaspers I

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

journal_title：Respiratory research

authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-21 00:00:00

abstract：:The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed th...

journal_title：Respiratory research

authors： von Siemens SM,Jörres RA,Behr J,Alter P,Lutter J,Lucke T,Söhler S,Welte T,Watz H,Vogelmeier CF,Trudzinski F,Rief W,Herbig B,Kahnert K,COSYCONET study group.

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Mutations in the DNAI1 gene, encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive disorder with the prevalence of ~1/20,000. The estimates of the DNAI1 involvement in PCD pa...

journal_title：Respiratory research

authors： Ziętkiewicz E,Nitka B,Voelkel K,Skrzypczak U,Bukowy Z,Rutkiewicz E,Humińska K,Przystałowska H,Pogorzelski A,Witt M

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

journal_title：Respiratory research

authors： Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Deep inspirations (DI) have bronchodilatory and bronchoprotective effects in healthy human subjects, but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic air...

journal_title：Respiratory research

authors： Jonasson S,Swedin L,Lundqvist M,Hedenstierna G,Dahlén SE,Hjoberg J

更新日期：2008-02-28 00:00:00

abstract：BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

journal_title：Respiratory research

authors： Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary ...

journal_title：Respiratory research

authors： Rydell-Törmänen K,Uller L,Erjefält JS

更新日期：2006-12-14 00:00:00

abstract：BACKGROUND:Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. METHODS:Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT sca...

journal_title：Respiratory research

authors： Stockley RA,Parr DG,Piitulainen E,Stolk J,Stoel BC,Dirksen A

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS:PAH in rats was induced by a single subcut...

journal_title：Respiratory research

authors： Fedorowicz A,Mateuszuk Ł,Kopec G,Skórka T,Kutryb-Zając B,Zakrzewska A,Walczak M,Jakubowski A,Łomnicka M,Słomińska E,Chlopicki S

更新日期：2016-08-31 00:00:00

abstract：:By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also contributes to maintaining normal respiratory mechanics. In recent years, measurements of the rheological proper...

journal_title：Respiratory research

authors： Chen Z,Zhong M,Luo Y,Deng L,Hu Z,Song Y

更新日期：2019-12-04 00:00:00