A study of the relationship between cardiac beta-adrenoceptor blockade and intrinsic sympathomimetic activity in rats depleted of catecholamines.

abstract：:1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sendeski MM

更新日期：2011-05-01 00:00:00

abstract：:1. This study aimed to investigate the protective effects of isosteviol against myocardial ischaemia-reperfusion (IR) injury and its effects on mitochondrial adenosine triphosphate (ATP)-sensitive potassium channel (mitoK(ATP)) activity in vitro. 2. Groups of eight guinea pigs were treated as follows: constant perfusi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xu D,Zhang S,Foster DJ,Wang J

更新日期：2007-05-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium admin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurihara O,Seino Y,Shibata Y,Matsushita M,Komiyama H,Kato K,Murakami D,Munakata R,Takano M,Miyauchi Y,Hata N,Shimizu W

更新日期：2016-11-01 00:00:00

abstract：:1. The effects of left ventricular repair (LVR) surgery for ischaemic or dilated cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. 2. The ischaemic cardiomyopathy (ICM) model used was as follows. Twenty-six rats developed ICM with a large akinetic left v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nishina T,Miwa S,Yuasa S,Nishimura K,Komeda M

更新日期：2002-08-01 00:00:00

abstract：:1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,Choo LK,Darroch S

更新日期：1989-06-01 00:00:00

abstract：:1. Total fluid and saline intakes were greater in spontaneously hypertensive rats (SHR) than in normotensive rats (NTR). 2. Total fluid and saline intake were significantly elevated in prehypertensive SHR, 5 weeks old, compared with age-matched NTR, and the intakes fell with age in both strains but remained considerab...

journal_title：Clinical and experimental pharmacology & physiology

authors： May CN,Parsons BJ

更新日期：1983-01-01 00:00:00

abstract：:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

journal_title：Clinical and experimental pharmacology & physiology

authors： McGrath BP,Sano N,Way D

更新日期：1990-04-01 00:00:00

abstract：:1. This study was designed to elucidate the effects of guar gum, a dietary fibre, on changes in prostanoid contents induced by 1,2-dimethylhydrazine, a carcinogenic agent, in rat colonic mucosa. 2. Prostanoid contents were determined using high performance liquid chromatography; five prostanoids, namely 6-keto-prostag...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kanamori S,Sugiyama S,Goto H,Hayakawa T,Shimomura Y,Ozawa T

更新日期：1995-10-01 00:00:00

abstract：:1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

journal_title：Clinical and experimental pharmacology & physiology

authors： Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

更新日期：2010-01-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:1. Rats and mice were vaccinated with Haemophilus influenzae in different vaccination schedules whereafter blood eosinophils were counted. In rats a single vaccination resulted in a dose-dependent effect on the blood eosinophil count in a pattern comparable with that after Bordetella pertussis vaccination. In a long-t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Terpstra GK,Raaijmakers JA,Kreukniet J

更新日期：1979-03-01 00:00:00

abstract：:Tiron functions as an effective antioxidant alleviating the intracellular reactive oxygen species (ROS) or the acute toxic metal overload. Previous studies have shown that cardiac myocyte apoptosis can be effectively inhibited by tiron administration in streptozotocin (STZ)-induced diabetic rats, primary neonatal rat ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang P,Zhang D,Qiu H,Yi X,Zhang Y,Cao Y,Zhao B,Xia Z,Wang C

更新日期：2017-07-01 00:00:00

abstract：:The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes-like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Toklu HZ,Bruce EB,Sakarya Y,Carter CS,Morgan D,Matheny MK,Kirichenko N,Scarpace PJ,Tümer N

更新日期：2016-09-01 00:00:00

abstract：:1. The present study investigates the contribution of the sympathetic and vagal parasympathetic systems to the tachycardic response of long-lasting (40 min) conditioned fear responses to context. 2. The conditioned fear response evoked by re-exposure to a footshock chamber was tested 10 min after intravenous injection...

journal_title：Clinical and experimental pharmacology & physiology

authors： Carrive P

更新日期：2006-12-01 00:00:00

abstract：:This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-ind...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodgson WC,Sikorski BW,King RG

更新日期：1992-01-01 00:00:00

abstract：:1. A rapid imaging technique with temporal resolution of about 1 ms was employed to describe cell-length changes during the isotonic contraction cycle of adult rat ventricular myocytes at 22 degrees C. 2. Parameters of cell contraction and relaxation were defined and values obtained under control conditions and after ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Delbridge LM,Harris PJ,Morgan TO

更新日期：1989-03-01 00:00:00

abstract：:1. Changes in membrane fluidity have been proposed to contribute to the pathogenesis of ethanol-induced hypertension possibly through changes in membrane lipid patterns, but reports are inconsistent. 2. In a controlled trial we documented ethanol-induced changes in blood pressure and composition of membrane lipids in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Puddey IB,Burke V,Croft K,Beilin LJ

更新日期：1995-09-01 00:00:00

abstract：:1. In cats anaesthetized with alpha-chloralose, electrical stimulation (ES) of the trigeminal ganglion produced a fall in blood pressure, a predominantly ipsilateral dilatation in the common carotid vascular bed and bilateral dilatation of the middle meningeal vascular bed. Section of the trigeminal root abolished the...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lambert GA,Michalicek J,Regaglia F

更新日期：1997-06-01 00:00:00

abstract：:1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Aydogdu N,Atmaca G,Yalcin O,Taskiran R,Tastekin E,Kaymak K

更新日期：2006-01-01 00:00:00

abstract：:The effects of naloxone on contractility and cardiac rhythm were studied in the rat isolated perfused heart during myocardial ischaemia and reperfusion. Pretreatment of the rat isolated perfused heart with naloxone abolished the reduction in left ventricular pressures and attenuated greatly the arrhythmias due to myoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhan ZY,Lee AY,Wong TM

更新日期：1985-07-01 00:00:00

abstract：:1. While it is believed that the mammalian distal nephron is not involved in uric acid transport, this has not been directly evaluated. Nevertheless, some studies are consistent with significant distal nephron transport. 2. As uric acid transport in man may be similar to the rat, undirectional uric acid permeability w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ray C,Carney S,Morgan T

更新日期：1997-09-01 00:00:00

abstract：:1. A comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. In most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bowman WC,Webb SN

更新日期：1976-11-01 00:00:00

abstract：:1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine-containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control inf...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macdonald G,Assef R,Watkins S,Burrell J

更新日期：1987-03-01 00:00:00

abstract：:1. To facilitate investigation of diverse rodent behaviours in rodents' home cages, we have developed an integrated modular platform, the SmartCage(™) system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic analysis and in vivo drug screening in a relatively higher-throughput and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Khroyan TV,Zhang J,Yang L,Zou B,Xie J,Pascual C,Malik A,Xie J,Zaveri NT,Vazquez J,Polgar W,Toll L,Fang J,Xie X

更新日期：2012-07-01 00:00:00

abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

更新日期：2010-12-01 00:00:00

abstract：:1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

更新日期：1989-04-01 00:00:00

abstract：:1. In order to find an anaesthesia with minimum perturbation to the metabolism of chylomicrons, the effects of seven different anaesthetic agents on clearance from plasma of chylomicron-like emulsions were compared. 2. Avertin, urethane, fentanyl, and a ketamine/xylazine mixture all slowed the removal from plasma of e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mortimer BC,Umeda Y,Elsegood CL,Redgrave TG

更新日期：1993-01-01 00:00:00

abstract：:1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan GJ

更新日期：1980-05-01 00:00:00