Abstract:
BACKGROUND:Linezolid has been increasingly used in tertiary NICUs. The objectives of this study were to explore the indications of these linezolid prescriptions, to analyze a possible misuse and to provide solutions to avoid such misuse. METHODS:A monocentric retrospective cohort study included all neonates hospitalized in one tertiary NICU between January 1st, 2010 and December 31st, 2019 and who received at least one administration of linezolid. These data were confronted to epidemiological and antibiotic use data from the same NICU. Two independent pediatricians secondarily classified linezolid uses as adequate or not. RESULTS:During the study period, 66 infections in 57 patients led to linezolid use. Most patients were pre-term and 21 patients (37%) died. Infections were mainly related to methicillin-resistant coagulase negative staphylococci and were frequently either pneumoniae (35%) or isolated bacteremia (48%), including 25 persistent bacteremia (64% of the 39 bacteremia). Need for a better tissue distribution or first-line treatment failure were the main reasons to initiate linezolid. Linezolid was administered for a median duration of 7 [3;10] days. No side effects were reported. Twenty-two (33%) of the 66 linezolid prescriptions were retrospectively classified as inadequate. CONCLUSIONS:A rapid increase in linezolid prescriptions has been observed in our tertiary NICU, from 2014 to 2019, with 33% inadequate uses. This worrisome trend should lead to search for therapeutic alternatives and to work on antibiotic stewardship to prevent the emergence of new antimicrobial bacterial resistance.
journal_name
Antimicrob Resist Infect Controljournal_title
Antimicrobial resistance and infection controlauthors
Matrat L,Plaisant F,Barreto C,Claris O,Butin Mdoi
10.1186/s13756-020-00818-2subject
Has Abstractpub_date
2020-09-23 00:00:00pages
156issue
1issn
2047-2994pii
10.1186/s13756-020-00818-2journal_volume
9pub_type
杂志文章abstract:BACKGROUND:The extent of the occurrence of the plasmid-encoded colistin resistance genes mcr-1 and mcr-2 among humans is currently sparsely studied in Western Europe. OBJECTIVES:To determine the occurrence of MCR-producing Enterobacteriaceae in fecal samples of healthy humans with high occupational exposure to food an...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0186-z
更新日期:2017-03-14 00:00:00
abstract:Background:Mycobacterium tuberculosis possesses five resuscitation-promoting factors, Rpf A to E, which are required for the resuscitation of dormancy in mycobacteria. This study explores the transcriptional profile of all five rpfs of M. tuberculosis, in response to sub-MIC concentration of rifampin, in multidrug and ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0273-1
更新日期:2017-11-14 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0245-5
更新日期:2017-08-29 00:00:00
abstract::Despite improvements in hospital infection prevention and control, healthcare associated infections (HAIs) remain a challenge with significant patient morbidity, mortality, and cost for the healthcare system. In this review, we use a One Health framework (human, animal, and environmental health) to explain the epidemi...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,评审
doi:10.1186/s13756-020-00737-2
更新日期:2020-06-01 00:00:00
abstract:Background:Despite many preventive measures, outbreaks with multi-drug resistant micro-organisms (MDROs) still occur. Moreover, current alert systems from healthcare organizations have shortcomings due to delayed or incomplete notifications, which may amplify the spread of MDROs by introducing infected patients into a ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0359-4
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance. This study aimed to describe current epidemiological trends of CNA proportions in Europe and to identify factors that ar...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00750-5
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abstract:Background:Data about the burden of extended-spectrum beta-lactamase (ESBL)-producing microorganisms in Africa are limited. Our study aimed to estimate the prevalence of human faecal ESBL carriage in the community of an informal urban settlement in Dar es Salaam (Tanzania, East Africa) by using environmental contaminat...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0292-y
更新日期:2018-01-06 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0372-7
更新日期:2018-07-09 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,评审
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0284-y
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abstract:BACKGROUND:The potentials of audit and feedback (AF) to improve healthcare are currently not exploited. To unlock the potentials of AF, this study focused on the process of making sense of audit data and translating data into actionable feedback by studying a specific AF-case: limiting antimicrobial resistance (AMR). T...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00794-7
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abstract:Objective:To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) healthcare-associated infections (HAI) in Egyptian hospitals reporting to the national HAI surveillance system. Methods:Design: Descriptive analysis of CRE HAIs and retrospective observational cohort study using national HAI survei...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0639-7
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abstract:Background:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through needlestick injury and lead to serio...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0524-4
更新日期:2019-05-20 00:00:00
abstract:Background:Cockroaches are one of the most important and frequent insects responsible for harboring, transmission and dissemination of human pathogens in the hospital environment. The present research was done to study the phenotypic and genotypic characterization of antibiotic resistance in the Methicillin-resistant S...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0505-7
更新日期:2019-03-13 00:00:00
abstract:Background:While decolonization of Staphylococcus aureus reduces surgical site infection (SSI) rates following hip and knee arthroplasty, its cost-effectiveness is uncertain. We sought to examine the cost-effectiveness of a decolonization protocol for Staphylococcus aureus prior to hip and knee replacement in Alberta c...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0568-5
更新日期:2019-07-11 00:00:00
abstract:OBJECTIVE:To determine the effect of exposure to remnants of a phagemid-containing E. coli, killed by treatment with a propanol-based hand rub, on antimicrobial resistance in E. coli isolates. METHODS:An in vitro model was developed in which a clinical E. coli isolate (EUR1) was exposed to remnants of an E. coli K-12 ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00708-7
更新日期:2020-03-16 00:00:00
abstract:UNLABELLED: BACKGROUND:Two MRSA surveillance components exist within the German national nosocomial infection surveillance system KISS: one for the whole hospital (i.e. only hospital based data and no rates for individual units) and one for ICU-based data (rates for each individual ICU). The objective of this study wa...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-1-8
更新日期:2012-02-13 00:00:00
abstract:BACKGROUND:Staphylococcus aureus (S. aureus), including methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA), is an eminent human pathogen that can colonize the human host and cause severe life-threatening infections. The development of a reliable, simple and rapid assay for detecting S. ...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00774-x
更新日期:2020-07-17 00:00:00
abstract:Background:Dispensary and use of antibiotics without prescriptions from qualified providers is a common practice in countries with poor pharmaceutical regulations and where due focus is not given to rational use. This practice is a main factor for the spread of antimicrobial resistance due to its non-reliance on pre-tr...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章,多中心研究
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更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms for neonatal intensive care units (NICUs) and extended hygiene measures based on screening results. It remains a matter of debate whether screening is worth t...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00804-8
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0171-6
更新日期:2017-01-17 00:00:00
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journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-0678-0
更新日期:2020-01-30 00:00:00
abstract:Background:The study aimed to evaluate the distribution of healthcare-associated infections (HAIs), the incidence rates and device utilization ratio (DUR) of device-associated infections (DAIs), as well as the distribution and patterns of antimicrobial resistance of the responsible pathogens. Methods:Eligible patients...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-018-0337-x
更新日期:2018-04-03 00:00:00
abstract::Regular and well-organized inspection of infection control is an essential element of an infection control program. The aim of this study was to identify the functional scope of weekly infection control team rounding (ICTR) in an acute care hospital. We conducted weekly ICTR between January 18 and December 26, 2018 to...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-00787-6
更新日期:2020-08-15 00:00:00
abstract:Background:Antibiotics require more prudent prescribing, dispensing and administration than other medicines because these medicines are at a greater risk of antimicrobial resistance (AMR). Studying the current medicine use practices and factors affecting the prescribing of an antibiotic would help decision makers to dr...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0620-5
更新日期:2019-10-22 00:00:00
abstract:BACKGROUND:The burden of healthcare-associated infection (HAI) is 2 to 18 times higher in developing countries. However, few data are available regarding infection prevention and control (IPC) process indicators in these countries. We evaluated hand hygiene (HH) facilities and compliance amongst healthcare workers (HCW...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-020-0693-1
更新日期:2020-02-11 00:00:00
abstract:Background:Diagnosis of C. difficile infection (CDI) is controversial because of the many laboratory methods available and their lack of ability to distinguish between carriage, mild or severe disease. Here we describe whether a low C. difficile toxin B nucleic acid amplification test (NAAT) cycle threshold (CT) can pr...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-017-0283-z
更新日期:2017-12-19 00:00:00
abstract:Background:Although surgical site infection after craniotomy (SSI-CRAN) is a serious complication, risk factors for its development have not been well defined. We aim to identify the risk factors for developing SSI-CRAN in a large prospective cohort of adult patients undergoing craniotomy. Methods:A series of consecut...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0525-3
更新日期:2019-05-02 00:00:00
abstract:UNLABELLED: BACKGROUND:Cockroaches have been described as potential vectors for various pathogens for decades; although studies from neonatal intensive care units are scarce. This study assessed the vector potential of cockroaches (identified as Blatella germanica) in a neonatal intensive care unit setup in Tikur Anbe...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/2047-2994-1-12
更新日期:2012-03-16 00:00:00
abstract:Background:Antibiotic resistance is a major global public health threat. Antibiotic use can directly impact the antibiotic resistant genes (ARGs) profile of the human intestinal microbiome and consequently the environment through shedding. Methods:We determined the resistome of human feces, animal stools, human food a...
journal_title:Antimicrobial resistance and infection control
pub_type: 杂志文章
doi:10.1186/s13756-019-0645-9
更新日期:2019-11-28 00:00:00