Abstract：
BACKGROUND:Linezolid has been increasingly used in tertiary NICUs. The objectives of this study were to explore the indications of these linezolid prescriptions, to analyze a possible misuse and to provide solutions to avoid such misuse. METHODS:A monocentric retrospective cohort study included all neonates hospitalized in one tertiary NICU between January 1st, 2010 and December 31st, 2019 and who received at least one administration of linezolid. These data were confronted to epidemiological and antibiotic use data from the same NICU. Two independent pediatricians secondarily classified linezolid uses as adequate or not. RESULTS:During the study period, 66 infections in 57 patients led to linezolid use. Most patients were pre-term and 21 patients (37%) died. Infections were mainly related to methicillin-resistant coagulase negative staphylococci and were frequently either pneumoniae (35%) or isolated bacteremia (48%), including 25 persistent bacteremia (64% of the 39 bacteremia). Need for a better tissue distribution or first-line treatment failure were the main reasons to initiate linezolid. Linezolid was administered for a median duration of 7 [3;10] days. No side effects were reported. Twenty-two (33%) of the 66 linezolid prescriptions were retrospectively classified as inadequate. CONCLUSIONS:A rapid increase in linezolid prescriptions has been observed in our tertiary NICU, from 2014 to 2019, with 33% inadequate uses. This worrisome trend should lead to search for therapeutic alternatives and to work on antibiotic stewardship to prevent the emergence of new antimicrobial bacterial resistance.
journal_name
Antimicrob Resist Infect Controljournal_title
Antimicrobial resistance and infection controlauthors
Matrat L,Plaisant F,Barreto C,Claris O,Butin Mdoi
10.1186/s13756-020-00818-2subject
Has Abstractpub_date
2020-09-23 00:00:00pages
156issue
1issn
2047-2994pii
10.1186/s13756-020-00818-2journal_volume
9pub_type
杂志文章abstract：BACKGROUND:The extent of the occurrence of the plasmid-encoded colistin resistance genes mcr-1 and mcr-2 among humans is currently sparsely studied in Western Europe. OBJECTIVES:To determine the occurrence of MCR-producing Enterobacteriaceae in fecal samples of healthy humans with high occupational exposure to food an...
journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-017-0186-z
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
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abstract：:Despite improvements in hospital infection prevention and control, healthcare associated infections (HAIs) remain a challenge with significant patient morbidity, mortality, and cost for the healthcare system. In this review, we use a One Health framework (human, animal, and environmental health) to explain the epidemi...
journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章,评审
doi：10.1186/s13756-020-00737-2
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journal_title：Antimicrobial resistance and infection control
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doi：10.1186/s13756-018-0359-4
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abstract：BACKGROUND:Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance. This study aimed to describe current epidemiological trends of CNA proportions in Europe and to identify factors that ar...
journal_title：Antimicrobial resistance and infection control
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doi：10.1186/s13756-020-00750-5
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-018-0372-7
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0639-7
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0524-4
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0568-5
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-020-00708-7
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/2047-2994-1-8
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-020-00774-x
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章,多中心研究
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-020-0678-0
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-018-0337-x
更新日期：2018-04-03 00:00:00
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-020-00787-6
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0620-5
更新日期：2019-10-22 00:00:00
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-020-0693-1
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-017-0283-z
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journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0525-3
更新日期：2019-05-02 00:00:00
abstract：UNLABELLED: BACKGROUND:Cockroaches have been described as potential vectors for various pathogens for decades; although studies from neonatal intensive care units are scarce. This study assessed the vector potential of cockroaches (identified as Blatella germanica) in a neonatal intensive care unit setup in Tikur Anbe...
journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/2047-2994-1-12
更新日期：2012-03-16 00:00:00
abstract：Background:Antibiotic resistance is a major global public health threat. Antibiotic use can directly impact the antibiotic resistant genes (ARGs) profile of the human intestinal microbiome and consequently the environment through shedding. Methods:We determined the resistome of human feces, animal stools, human food a...
journal_title：Antimicrobial resistance and infection control
pub_type： 杂志文章
doi：10.1186/s13756-019-0645-9
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