Abstract:
:Osteoporosis (OP) is a chronic metabolic bone disease characterized by the decrease of bone tissue per unit volume under the combined action of genetic and environmental factors, which leads to the decrease of bone strength, makes the bone brittle, and raises the possibility of bone fracture. However, the exact mechanism that determines the progression of OP remains to be underlined. There are hundreds of trillions of symbiotic bacteria living in the human gut, which have a mutually beneficial symbiotic relationship with the human body that helps to maintain human health. With the development of modern high-throughput sequencing (HTS) platforms, there has been growing evidence that the gut microbiome may play an important role in the programming of bone metabolism. In the present review, we discuss the potential mechanisms of the gut microbiome in the development of OP, such as alterations of bone metabolism, bone mineral absorption, and immune regulation. The potential of gut microbiome-targeted strategies in the prevention and treatment of OP was also evaluated. Cite this article: Bone Joint Res 2020;9(8):524-530.
journal_name
Bone Joint Resjournal_title
Bone & joint researchauthors
Li S,Mao Y,Zhou F,Yang H,Shi Q,Meng Bdoi
10.1302/2046-3758.98.BJR-2020-0089.R1subject
Has Abstractpub_date
2020-08-02 00:00:00pages
524-530issue
8issn
2046-3758pii
BJR-9-524journal_volume
9pub_type
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doi:10.1302/2046-3758.78.BJR-2017-0343.R2
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journal_title:Bone & joint research
pub_type: 杂志文章
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journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.33.2000250
更新日期:2014-03-19 00:00:00
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journal_title:Bone & joint research
pub_type: 杂志文章
doi:10.1302/2046-3758.29.2000179
更新日期:2013-09-18 00:00:00
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pub_type: 杂志文章
doi:10.1302/2046-3758.34.2000238
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pub_type: 杂志文章
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更新日期:2019-11-02 00:00:00
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更新日期:2019-12-03 00:00:00
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更新日期:2020-05-16 00:00:00
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