Cav3.2 T-type calcium channels control acute itch in mice.

abstract：:Delivery is a complex biological process involving hormonal and mechanical stimuli that together condition the survival and development of the fetus out of the womb. Accordingly, changes in the time or way of being born are associated with an alteration of fundamental biological functions and hypothesized to promote t...

journal_title：Molecular brain

authors： Chiesa M,Ferrari DC,Ben-Ari Y

更新日期：2020-03-09 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection induces neuronal injuries, with almost 50% of infected individuals developing HIV-associated neurocognitive disorders (HAND). Although highly activate antiretroviral therapy (HAART) has significantly reduced the incidence of severe dementia, the overall prevalence of HAND r...

journal_title：Molecular brain

authors： Ru W,Tang SJ

更新日期：2017-08-29 00:00:00

abstract：:Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin r...

journal_title：Molecular brain

authors： Yohn CN,Gergues MM,Samuels BA

更新日期：2017-06-24 00:00:00

abstract：:In humans, dysfunctional primary cilia result in Bardet-Biedl syndrome (BBS), which presents with clinical features including intellectual disabilities, obesity, and retinal degeneration, and, in mouse models, the added feature of hydrocephalus. We observed increased Glial Fibrillary Acidic Protein (GFAP) immunoreacti...

journal_title：Molecular brain

authors： Singh M,Garrison JE,Wang K,Sheffield VC

更新日期：2019-05-09 00:00:00

abstract：:Selective attention modulates sensory cortical activity. It remains unclear how auditory cortical activity represents stimuli that differ behaviorally. We designed a cross-modality task in which mice made decisions to obtain rewards based on attended visual or auditory stimuli. We recorded auditory cortical activity i...

journal_title：Molecular brain

authors： Yao PT,Shen J,Chen L,Ge S,Xiong Q

更新日期：2019-10-17 00:00:00

abstract：BACKGROUND:Memory consolidation, reconsolidation, and extinction have been shown to require new gene expression. Poly ADP-ribosylation mediated by poly (ADP-ribose) polymerase-1 (PARP-1) is known to regulate transcription through histone modification. Recent studies have suggested that PARP-1 positively regulates the f...

journal_title：Molecular brain

authors： Inaba H,Tsukagoshi A,Kida S

更新日期：2015-10-15 00:00:00

abstract：:Common pathological features of amyotrophic lateral sclerosis (ALS) include cytoplasmic aggregation of several RNA-binding proteins. Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one another within motor neurons of sporadic ALS (sALS) patients, suggesting that there ...

journal_title：Molecular brain

authors： Hawley ZCE,Campos-Melo D,Strong MJ

更新日期：2017-10-02 00:00:00

abstract：:Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olf...

journal_title：Molecular brain

authors： Koebis M,Urata S,Shinoda Y,Okabe S,Yamasoba T,Nakao K,Aiba A,Furuichi T

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Constitutive and regulated internalization of cell surface proteins has been extensively investigated. The regulated internalization has been characterized as a principal mechanism for removing cell-surface receptors from the plasma membrane, and signaling to downstream targets of receptors. However, so far ...

journal_title：Molecular brain

authors： Fang XQ,Qiao H,Groveman BR,Feng S,Pflueger M,Xin WK,Ali MK,Lin SX,Xu J,Duclot F,Kabbaj M,Wang W,Ding XS,Santiago-Sim T,Jiang XH,Salter MW,Yu XM

更新日期：2015-11-19 00:00:00

abstract：:The anterior cingulate cortex (ACC) is involved in sensory, cognitive, and executive functions. Studies of synaptic transmission and plasticity in the ACC provide an understanding of basic cellular and molecular mechanisms for brain functions. Previous anatomic studies suggest complex local interactions among neurons ...

journal_title：Molecular brain

authors： Wu LJ,Li X,Chen T,Ren M,Zhuo M

更新日期：2009-10-15 00:00:00

abstract：:Transition metals, such as iron, copper, and zinc, play a very important role in life as the regulators of various physiochemical reactions in cells. Abnormal distribution and concentration of these metals in the body are closely associated with various diseases including ischemic seizure, Alzheimer's disease, diabete...

journal_title：Molecular brain

authors： Koh JY,Lee SJ

更新日期：2020-08-25 00:00:00

abstract：:Uncovering the mechanisms that regulate dendritic spine morphology has been limited, in part, by the lack of efficient and unbiased methods for analyzing spines. Here, we describe an automated 3D spine morphometry method and its application to spine remodeling in live neurons and spine abnormalities in a disease model...

journal_title：Molecular brain

authors： Swanger SA,Yao X,Gross C,Bassell GJ

更新日期：2011-10-07 00:00:00

abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors. Owing to the difficulty of clinical diagnosis, ASD without intellectual disability (i.e., high-functioning ASD) is often overlooked. MicroRNAs (miRNAs) have been recently recognized ...

journal_title：Molecular brain

authors： Nakata M,Kimura R,Funabiki Y,Awaya T,Murai T,Hagiwara M

更新日期：2019-10-21 00:00:00

abstract：:Tsukushi (TSK)-a small, secreted, leucine-rich-repeat proteoglycan-interacts with and regulates essential cellular signaling cascades. However, its functions in the mouse inner ear are unknown. In this study, measurement of auditory brainstem responses, fluorescence microscopy, and scanning electron microscopy reveale...

journal_title：Molecular brain

authors： Miwa T,Ohta K,Ito N,Hattori S,Miyakawa T,Takeo T,Nakagata N,Song WJ,Minoda R

更新日期：2020-03-03 00:00:00

abstract：:Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging. The analgesic effect of N-methyl-D-aspartate (NMDA) receptor antagonists and the morphine-associated increase in NMDA receptor activation suggest potential role of NMDA rec...

journal_title：Molecular brain

authors： Shen L,Wang W,Li S,Qin J,Huang Y

更新日期：2018-06-28 00:00:00

abstract：:Genomic variation includes single-nucleotide variants, small insertions or deletions (indels), and copy number variants (CNVs). CNVs affect gene expression by altering the genome structure and transposable elements within a region. CNVs are greater than 1 kb in size; hence, CNVs can produce more variation than can ind...

journal_title：Molecular brain

authors： Hama Y,Katsu M,Takigawa I,Yabe I,Matsushima M,Takahashi I,Katayama T,Utsumi J,Sasaki H

更新日期：2017-11-29 00:00:00

abstract：:Memories are stored within neuronal ensembles in the brain. Modern genetic techniques can be used to not only visualize specific neuronal ensembles that encode memories (e.g., fear, craving) but also to selectively manipulate those neurons. These techniques are now being expanded for the study of various types of memo...

journal_title：Molecular brain

authors： Sakaguchi M,Hayashi Y

更新日期：2012-09-21 00:00:00

abstract：:The alpha-isoform of calcium/calmodulin-dependent kinase II (αCaMKII) is a major synaptic kinase that undergoes autophosphorylation after NMDA receptor activation, switching the kinase into a calcium-independent activity state. This αCaMKII autophosphorylation is essential for NMDA receptor-dependent long-term potenti...

journal_title：Molecular brain

authors： Irvine EE,Danhiez A,Radwanska K,Nassim C,Lucchesi W,Godaux E,Ris L,Giese KP

更新日期：2011-01-28 00:00:00

abstract：BACKGROUND:Prolonged re-exposure to a fear-eliciting cue in the absence of an aversive event extinguishes the fear response to the cue, and has been clinically used as an exposure therapy. Arc (also known as Arg3.1) is implicated in synaptic and experience-dependent plasticity. Arc is regulated by the transcription fac...

journal_title：Molecular brain

authors： Onoue K,Nakayama D,Ikegaya Y,Matsuki N,Nomura H

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Adult neurogenesis, fundamental for cellular homeostasis in the mammalian olfactory epithelium, requires major shifts in gene expression to produce mature olfactory sensory neurons (OSNs) from multipotent progenitor cells. To understand these dynamic events requires identifying not only the genes involved bu...

journal_title：Molecular brain

authors： Heron PM,Stromberg AJ,Breheny P,McClintock TS

更新日期：2013-11-22 00:00:00

abstract：:Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort, spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also suffer from emotional anxiety and depression. However, few animal studies have investigated IBS-induced spontaneous pain and behavioral anxiety....

journal_title：Molecular brain

authors： Zhang MM,Liu SB,Chen T,Koga K,Zhang T,Li YQ,Zhuo M

更新日期：2014-06-16 00:00:00

abstract：BACKGROUND:The gamma-amino-butyric acid (GABA) system is a critical mediator of fear extinction process. GABA can induce "phasic" or "tonic" inhibition in neurons through synaptic or extrasynaptic GABAA receptors, respectively. However, role of the thalamic "tonic GABA inhibition" in cognition has not been explored. We...

journal_title：Molecular brain

authors： Paydar A,Lee B,Gangadharan G,Lee S,Hwang EM,Shin HS

更新日期：2014-05-29 00:00:00

abstract：:Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTPσ, PTPδ and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate neurons. However, roles of individual LAR-RPTP members have not been investigated using member-specific conditi...

journal_title：Molecular brain

authors： Han KA,Lee HY,Lim D,Shin J,Yoon TH,Liu X,Um JW,Choi SY,Ko J

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks. In spite of that, identification of their major cellular and molecular components has not been concluded so far. RESULTS:We addressed these iss...

journal_title：Molecular brain

authors： Pál I,Kardos J,Dobolyi Á,Héja L

更新日期：2015-06-05 00:00:00

abstract：BACKGROUND:Retinoid signaling pathways mediated by retinoic acid receptor (RAR)/retinoid × receptor (RXR)-mediated transcription play critical roles in hippocampal synaptic plasticity. Furthermore, recent studies have shown that treatment with retinoic acid alleviates age-related deficits in hippocampal long-term poten...

journal_title：Molecular brain

authors： Nomoto M,Takeda Y,Uchida S,Mitsuda K,Enomoto H,Saito K,Choi T,Watabe AM,Kobayashi S,Masushige S,Manabe T,Kida S

更新日期：2012-02-08 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated essential roles for alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and long-term potentiation (LTP). However, previous studies have also shown that alpha-CaMKII (+/-) heterozygous knockout mice display a dramatic decrease in anxiety-...

journal_title：Molecular brain

authors： Hasegawa S,Furuichi T,Yoshida T,Endoh K,Kato K,Sado M,Maeda R,Kitamoto A,Miyao T,Suzuki R,Homma S,Masushige S,Kajii Y,Kida S

更新日期：2009-03-04 00:00:00

abstract：BACKGROUND:Anxiety disorders are a highly prevalent and disabling class of psychiatric disorders. There is growing evidence implicating the glutamate system in the pathophysiology and treatment of anxiety disorders, though the molecular mechanism by which the glutamate system regulates anxiety-like behavior remains unc...

journal_title：Molecular brain

authors： Delawary M,Tezuka T,Kiyama Y,Yokoyama K,Inoue T,Hattori S,Hashimoto R,Umemori H,Manabe T,Yamamoto T,Nakazawa T

更新日期：2010-11-30 00:00:00

abstract：:The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2 h...

journal_title：Molecular brain

authors： Choi KH,Park MS,Kim HS,Kim KT,Kim HS,Kim JT,Kim BC,Kim MK,Park JT,Cho KH

更新日期：2015-02-11 00:00:00

abstract：:Microglia are macrophages resident in the central nervous system. C-X3-C motif chemokine receptor 1 (CX3CR1) is a Gαi-coupled seven-transmembrane protein exclusively expressed in the mononuclear phagocyte system including microglia, as well as intestinal and kidney macrophages. Cx3cr1CreERT2 mice express Cre recombina...

journal_title：Molecular brain

authors： Lee Y,Lee JW,Nam H,Yu SW

更新日期：2020-06-08 00:00:00

abstract：:We investigated whether enhanced interoceptive bodily states of fear would facilitate recognition of the fearful faces. Participants performed an emotional judgment task after a bodily imagery task inside a functional magnetic resonance imaging scanner. In the bodily imagery task, participants were instructed to imagi...

journal_title：Molecular brain

authors： Jung WM,Lee YS,Lee IS,Wallraven C,Ryu Y,Chae Y

更新日期：2020-11-23 00:00:00