The impact of orthotopic neobladder vs ileal conduit urinary diversion after cystectomy on the survival outcomes in patients with bladder cancer: A propensity score matched analysis.

abstract：OBJECTIVE:To develop and validate a preoperative nomogram to predict pathological locally advanced disease (pLAD) of clinically localized upper urinary tract urothelial carcinoma (UTUC) treated with extirpative surgery. METHODS:In total, 1101 patients with cN0M0 UTUC (development cohort, n = 604; validation cohort, n ...

journal_title：Cancer medicine

authors： Yoshida T,Kobayashi T,Kawaura T,Miyake M,Ito K,Okuno H,Murota T,Makita N,Kawakita M,Kawa G,Kitawaki T,Fujimoto K,Matsuyama H,Shiina H,Azuma H,Ogawa O,Kinoshita H,Matsuda T

更新日期：2020-06-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK-positive anaplastic large-cell lymphoma (ALCL) cases are characterized by the t(2;5)(p23;q35) translocation, encoding for the aberrant fusion protein nucleophosmin (NPM)-ALK, whereas 5% of n...

journal_title：Cancer medicine

authors： Fontana D,Ceccon M,Gambacorti-Passerini C,Mologni L

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Vitamin D3 (VitD) deficiency is linked to increased incidence and worse survival in bladder cancer (BCa). In addition to cystectomy, patients are treated with cisplatin-based chemotherapy, however 30%-50% of patients do not benefit from this treatment. The effects of VitD deficiency on response to chemothera...

journal_title：Cancer medicine

authors： Bunch BL,Ma Y,Attwood K,Amable L,Luo W,Morrison C,Guru KA,Woloszynska-Read A,Hershberger PA,Trump DL,Johnson CS

更新日期：2019-05-01 00:00:00

abstract：:Conventional preoperative chemotherapy regimens have only limited efficacy in hormone receptor positive (HR+) breast cancer and new approaches are needed. We hypothesized that capecitabine, which is effective in metastatic breast cancer, may be an active preoperative treatment for HR+ breast cancer. Women with HR+, HE...

journal_title：Cancer medicine

authors： Tolaney SM,Jeong J,Guo H,Brock J,Morganstern D,Come SE,Golshan M,Bellon J,Winer EP,Krop IE

更新日期：2014-04-01 00:00:00

abstract：:Recent studies have demonstrated that therapy with (212) Pb-TCMC-trastuzumab resulted in (1) induction of apoptosis, (2) G2/M arrest, and (3) blockage of double-strand DNA damage repair in LS-174T i.p. (intraperitoneal) xenografts. To further understand the molecular basis of the cell killing efficacy of (212) Pb-TCMC...

journal_title：Cancer medicine

authors： Yong KJ,Milenic DE,Baidoo KE,Kim YS,Brechbiel MW

更新日期：2013-10-01 00:00:00

abstract：:Interferon-α2 reduces elevated blood cell counts and splenomegaly in patients with myeloproliferative neoplasms (MPN) and may restore polyclonal hematopoiesis. Its use is limited by inflammation-mediated toxicity, leading to treatment discontinuation in 10-30% of patients. Ruxolitinib, a potent anti-inflammatory agent...

journal_title：Cancer medicine

authors： Mikkelsen SU,Kjaer L,Bjørn ME,Knudsen TA,Sørensen AL,Andersen CBL,Bjerrum OW,Brochmann N,Fassi DE,Kruse TA,Larsen TS,Mourits-Andersen HT,Nielsen CH,Pallisgaard N,Thomassen M,Skov V,Hasselbalch HC

更新日期：2018-08-01 00:00:00

abstract：:RIG-I is associated with the occurrence and development of many tumors. However, the role of RIG-I in radiotherapy and chemotherapy in NPC has not been reported to date. In our study, RIG-I expression was significantly reduced in chemoradiotherapy-resistant NPC tissues and cells compared with that in therapy-sensitive...

journal_title：Cancer medicine

authors： Jing D,Zhou W,Shen L,Zhang Q,Xie WT,Shen E,Li Z,Shen LF,Sun LQ

更新日期：2019-10-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is an adverse effect of bone-targeted therapies, which are used to prevent symptomatic skeletal events following bone malignancy. We examined the association between ONJ and survival among cancer patients treated with bone-targeted agents. Using nationwide registries and databases in Den...

journal_title：Cancer medicine

authors： Corraini P,Heide-Jørgensen U,Schiødt M,Nørholt SE,Acquavella J,Sørensen HT,Ehrenstein V

更新日期：2017-10-01 00:00:00

abstract：:Success of cancer vaccination is strongly hampered by immune suppression in the tumor microenvironment (TME). Interleukin (IL)-6 is particularly and highly produced by triple-negative breast cancer (TNBC) cells, and has been considered as an important contributor to immune suppression in the TME. Therefore, we hypothe...

journal_title：Cancer medicine

authors： Singh M,Ramos I,Asafu-Adjei D,Quispe-Tintaya W,Chandra D,Jahangir A,Zang X,Aggarwal BB,Gravekamp C

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Although detecting ovarian cancer at early stage is a highly meaningful clinical goal, no studies have evaluated early stage disease presentation in a large community-based population and how it differs from that of late stage disease. METHODS:Electronic medical records were evaluated for women diagnosed wi...

journal_title：Cancer medicine

authors： Suh-Burgmann EJ,Alavi M

更新日期：2019-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in East Asia and China. Long noncoding RNAs (lncRNAs) are emerging as critical regulators that may be involved in the development and progression of cancers in humans. However, the contributions of lncRNAs to HCC development, m...

journal_title：Cancer medicine

authors： Cui H,Zhang Y,Zhang Q,Chen W,Zhao H,Liang J

更新日期：2017-12-01 00:00:00

abstract：:KIBRA was reported to be involved in various types of cancer and can be detected in blood. The purpose of this study was to investigate the relationship between the status of KIBRA methylation in peripheral blood leukocytes and gastric cancer (GC) risk. A case-control study was carried out to evaluate the association ...

journal_title：Cancer medicine

authors： Zhang Y,Zhou H,Sun H,Chen J,Huang D,Han X,Ren X,Lin S,Fan Q,Tian W,Zhao Y

更新日期：2018-06-01 00:00:00

abstract：:A number of lifestyle associated factors, such as high body mass index (BMI), low physical activity, and related metabolic disorders, are associated with increased risk of cancer at several sites. For urinary bladder cancer (BC), such studies show inconsistent results, which could result from inadequate adjustment for...

journal_title：Cancer medicine

authors： Hektoen HH,Robsahm TE,Andreassen BK,Stenehjem JS,Axcrona K,Mondul A,Gislefoss RE

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Metastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life-threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population. METHODS:Data were collected from mGCT patients receiving first-line platinum-ba...

journal_title：Cancer medicine

authors： Tran B,Ruiz-Morales JM,Gonzalez-Billalabeitia E,Patrikidou A,Amir E,Seidel C,Bokemeyer C,Fankhauser C,Hermanns T,Rumyantsev A,Tryakin A,Brito M,Fléchon A,Kwan EM,Cheng T,Castellano D,Garcia Del Muro X,Hamid AA,Ottavia

更新日期：2020-01-01 00:00:00

abstract：:Combined hepatocellular-cholangiocarcinoma (cHCC-CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients with ICC or cHCC-CC who underwent rese...

journal_title：Cancer medicine

authors： Song P,Midorikawa Y,Nakayama H,Higaki T,Moriguchi M,Aramaki O,Yamazaki S,Aoki M,Teramoto K,Takayama T

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Isocitrate dehydrogenase 1 (IDH1) has been proven as a prognostic and predictive marker in glioblastoma (GBM) patients. The purpose was to preoperatively predict IDH mutation status in GBM using multiregional radiomics features from multiparametric magnetic resonance imaging (MRI). METHODS:In this retrospectiv...

journal_title：Cancer medicine

authors： Li ZC,Bai H,Sun Q,Zhao Y,Lv Y,Zhou J,Liang C,Chen Y,Liang D,Zheng H

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Intensity-modulated radiotherapy (IMRT) provides excellent local control in nasopharyngeal carcinoma (NPC). We investigated whether simplifying 8th American Joint Committee on Cancer staging system T categories improves prognostic value. METHODS:We used 2191 NPC patients as a training set and 414 patients s...

journal_title：Cancer medicine

authors： Tang LL,Liang SB,Huang CL,Zhang F,Xu C,Mao YP,Tian L,Lin AH,Li L,Sun Y,Ma J

更新日期：2019-05-01 00:00:00

abstract：:The tumor immune infiltrate, as recently evaluated with the immunoscore methodology, has been reported to be related to colorectal cancer (CRC) progression. Nevertheless, results varied from different studies. A meta-analysis was conducted to solve this problem. We collected data from included studies to evaluate the ...

journal_title：Cancer medicine

authors： Sun G,Dong X,Tang X,Qu H,Zhang H,Zhao E

更新日期：2019-01-01 00:00:00

abstract：:Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. H...

journal_title：Cancer medicine

authors： Wang L,Li W,Li K,Guo Y,Liu D,Yao Z,Lin X,Li S,Jiang Z,Liu Q,Jiang Y,Zhang B,Chen L,Zhou F,Ren H,Lin D,Zhang D,Yeung SJ,Zhang H

更新日期：2018-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with a high incidence and poor prognosis. Exploration of the underlying mechanisms and effective prognostic indicators is conducive to clinical management and optimization of treatment. The RNA-seq and clinical phenotype data of HCC were retrieved from The C...

journal_title：Cancer medicine

authors： Zhang Q,Sun L,Zhang Q,Zhang W,Tian W,Liu M,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Within PrefHer (NCT01401166), patients and healthcare professionals (HCPs) preferred subcutaneous (SC) over intravenous (IV) trastuzumab. We undertook a prospective, observational time and motion study to quantify patients' time in infusion chairs and active HCP time in PrefHer. Patients with HER2-positive early breas...

journal_title：Cancer medicine

authors： De Cock E,Pivot X,Hauser N,Verma S,Kritikou P,Millar D,Knoop A

更新日期：2016-03-01 00:00:00

abstract：:Combined pulmonary fibrosis and emphysema (CPFE) is an important risk factor for lung cancer (LC), because most patients with CPFE are smokers. However, the histological characteristics of LC in patients with CPFE (LC-CPFE) remain unclear. We conducted this study to explore the clinicopathological characteristics of L...

journal_title：Cancer medicine

authors： Zhang M,Yoshizawa A,Kawakami S,Asaka S,Yamamoto H,Yasuo M,Agatsuma H,Toishi M,Shiina T,Yoshida K,Honda T,Ito KI

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Conventional protocols utilize core needle biopsy (CNB) or fine needle aspiration (FNA) to produce cell suspension for flow cytometry (FCM) is a diagnostic challenge for lymphoid malignancies. We aim to develop an alternative CNB rinsing technique (RT) to produce cell suspension for FCM during this mini-inva...

journal_title：Cancer medicine

authors： Chi PD,Liu YJ,Huang YH,Mao MJ,Wang Y,Li ZM,Li J

更新日期：2020-12-01 00:00:00

abstract：:Next-generation sequencing (NGS) has been proposed as a suitable tool for liquid biopsy in colorectal cancer (CRC), although most studies to date have focused almost exclusively on sequencing of panels of potential clinically actionable genes. We evaluated the clinical value of whole-exome sequencing (WES) of cell-fre...

journal_title：Cancer medicine

authors： Olmedillas-López S,García-Olmo DC,García-Arranz M,Peiró-Pastor R,Aguado B,García-Olmo D

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Whether adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations is associated with a reduced risk of pancreatic cancer remains controversial. Additionally, no study has investigated this association in the US population. Hence, we inves...

journal_title：Cancer medicine

authors： Zhang ZQ,Li QJ,Hao FB,Wu YQ,Liu S,Zhong GC

更新日期：2020-09-01 00:00:00

abstract：:The association of bevacizumab and irinotecan has been shown to display a quick efficacy in low-grade glioma (LGG), but most patients relapse within months after cessation of therapy. From October 2012 to March 2014, four patients have been treated with irinotecan-bevacizumab followed by a metronomic maintenance with ...

journal_title：Cancer medicine

authors： Heng MA,Padovani L,Dory-Lautrec P,Gentet JC,Verschuur A,Pasquier E,Figarella-Branger D,Scavarda D,André N

更新日期：2016-07-01 00:00:00

abstract：:Previous studies have shown that miRNAs involved in a number of biological processes, such as cell growth, development, differentiation, and apoptosis. The dysregulation of miRNA expression is associated with various diseases, including cervical cancer. However, the involvement of miR-3647-5p in the progression of tum...

journal_title：Cancer medicine

authors： Liu R,Qian M,Zhou T,Cui P

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Triple-negative apocrine carcinoma (TNAC) of the breast is a very rare type of breast cancer. Furthermore, the clinicopathological features, prognosis, and potential impact of treatment strategies in TNAC remain unclear. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program were u...

journal_title：Cancer medicine

authors： Wu W,Wu M,Peng G,Shi D,Zhang J

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-107 on the growth and metastasis of gastric cancer (GC) and elucidate the probable mechanisms. METHODS:The expression of miR-107 and FAT4 in GC tissues and cells were detected using qRT-PCR. Bioinformatics and dual luciferase reporter gene assays were used to analyze the relati...

journal_title：Cancer medicine

authors： Wang L,Li K,Wang C,Shi X,Yang H

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The role of Axl and LC3 as predictors of tumor recurrence and overall survival (OS) after hepatocellular carcinoma (HCC) resection remains unclear. METHODS:We retrospectively included 535 HCC patients who underwent hepatectomy from 2010 to 2014 in this study. Axl and the autophagy-related marker LC3 were im...

journal_title：Cancer medicine

authors： Hsu CC,Hsieh PM,Chen YS,Lo GH,Lin HY,Dai CY,Huang JF,Chuang WL,Chen YL,Yu ML,Lin CW

更新日期：2019-07-01 00:00:00