Abstract:
BACKGROUND AND OBJECTIVE:A limited number of studies have evaluated the effects of oral contraceptives (OCs) on the quality of life (QOL) of polycystic ovary syndrome (PCOS) patients. This study aimed to compare the effects of using OCs containing levonorgestrel (LNG) and those containing desogestrel (DSG), cyproterone acetate (CPA) or drospirenone (DRSP) for 6 months on the QOL with PCOS. METHODS:In this crossover randomized controlled 6-arm trial, 200 eligible patients with PCOS scheduled for OC therapy were randomly assigned to one of the 6 study arms. All 6 arms include two 6-month treatment periods, one period with OCs containing LNG, and the other with each of the 3 OCs containing DSG, CPA, or DRSP. Outcomes of interest were the total score of QOL and its domains, which were assessed using a specific and valid health-related quality of life questionnaire for PCOS, which is consisted of six domains, including psychosocial-emotional, self-image, fertility, sexual function, hirsutism, and obesity- menstrual disorders. RESULTS:Finally, a total of 88 patients were analyzed for this study. The results showed that use of OCs containing DSG, CPA, and DRSP for 3 months was not associated with significant differences in the total scores of QOL compared to those OCs containing LNG, whereas, after 6 months of treatment, patients treated with OCs containing CPA had more improvements in their total scores of QOL, in comparison to OCs containing LNG (P < 0.042). We found no significant differences in QoL domains, including psychosocial-emotional, self-image, fertility, sexual function, hirsutism, and obesity-menstrual disorders after 3-6 months of treatment with DSG, CPA, or DRSP, compared to LNG. The sequence and period effects were not significant in any of the analyses at 3 and 6 months of treatment. The carry-over effect was not significant for most outcomes assessed. CONCLUSIONS:This crossover study demonstrated non-inferiority of OCs with newer generation progestins on different domains of QOL, in comparison with older compounds, although usage of products containing CPA was significantly associated with more improvement in total QOL of PCOS patients, compared to those containing LNG after 6-month of treatment. TRIAL REGISTRATION:IRCT201702071281N2 .
journal_name
Health Qual Life Outcomesjournal_title
Health and quality of life outcomesauthors
Amiri M,Nahidi F,Yarandi RB,Khalili D,Tohidi M,Tehrani FRdoi
10.1186/s12955-020-01544-4subject
Has Abstractpub_date
2020-08-31 00:00:00pages
293issue
1issn
1477-7525pii
10.1186/s12955-020-01544-4journal_volume
18pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The Minimal Clinically Important Difference (MCID) assesses what change on a measurement tool can be considered minimal clinically relevant. Although the recall period can influence questionnaire scores, it is unclear if it influences the MCID. This study is the first to examine longitudinally the impact of ...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-0950-7
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-11-176
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Patients with coronary heart disease (CHD) commonly present with more than one comorbid condition, contributing to poorer health-related quality of life (HRQoL). The aim of our study was to identify the associations between HRQoL and patient characteristics, vascular comorbidities and anxiety/depression diso...
journal_title:Health and quality of life outcomes
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journal_title:Health and quality of life outcomes
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doi:10.1186/s12955-017-0702-0
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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journal_title:Health and quality of life outcomes
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abstract:BACKGROUND:Many previous studies have reported factors that contribute to health-related quality of life (HRQoL) for a single skin disease. However, little is known about generalized factors associated with HRQoL across skin diseases. The objective of this study was to investigate overall HRQoL, and to identify factors...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-6-78
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,随机对照试验
doi:10.1186/1477-7525-11-1
更新日期:2013-01-02 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/1477-7525-11-88
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-12-91
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-5-6
更新日期:2007-01-30 00:00:00
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journal_title:Health and quality of life outcomes
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doi:10.1186/s12955-014-0149-5
更新日期:2014-10-29 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
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更新日期:2018-06-13 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-10-87
更新日期:2012-07-28 00:00:00
abstract:BACKGROUND:People suffering different types of stroke have differing demographic characteristics and survival. However, current estimates of disease burden are based on the same underlying assumptions irrespective of stroke type. We hypothesized that average Quality Adjusted Life Years (QALYs) lost from stroke would be...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-8-49
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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更新日期:2018-07-09 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-3-67
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-1077-6
更新日期:2019-01-22 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-018-0842-x
更新日期:2018-01-17 00:00:00
abstract:BACKGROUND:The Well-being Questionnaire (W-BQ) was designed to measure psychological well-being in people with diabetes. This study aimed to develop a Japanese version and a short form of the W-BQ. METHODS:A linguistic validation process produced a preliminary Japanese version of the 22-item W-BQ, which was distribute...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-4-40
更新日期:2006-07-03 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/1477-7525-9-73
更新日期:2011-09-20 00:00:00
abstract:BACKGROUND:The purpose of the study was to evaluate and compare the HRQOL of paediatric cancer in comparison to the healthy children across age groups, using PedsQLTM 4.0 Generic Core Scales and the PedsQL™ Cancer Module. METHOD:The PedsQLTM 4.0 Generic Core Scales and PedsQL Cancer Module 3.0 were administered on 56 ...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-10-52
更新日期:2012-05-18 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章,多中心研究
doi:10.1186/1477-7525-1-12
更新日期:2003-04-24 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/s12955-020-01376-2
更新日期:2020-05-07 00:00:00
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journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-4-90
更新日期:2006-11-27 00:00:00
abstract:BACKGROUND:While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV. METHODS:The present study focused on HIV in the context of childhood trauma and its impact on functionality and Quality of L...
journal_title:Health and quality of life outcomes
pub_type: 杂志文章
doi:10.1186/1477-7525-9-84
更新日期:2011-09-30 00:00:00