Correction to: Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

abstract：:Survivin is a novel member of the inhibitor of apoptosis (IAP) protein family, and its aberrant expression in cancer cells has been shown to be associated with tumorigenesis, cancer progression, radiation/drug resistance and shorter patient survival. Survivin is also expressed in certain human adult tissues and cells,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang M,Yang J,Li F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS:The expression of YAP in CML cells was determine...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li H,Huang Z,Gao M,Huang N,Luo Z,Shen H,Wang X,Wang T,Hu J,Feng W

更新日期：2016-09-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Russano M,Napolitano A,Ribelli G,Iuliani M,Simonetti S,Citarella F,Pantano F,Dell'Aquila E,Anesi C,Silvestris N,Argentiero A,Solimando AG,Vincenzi B,Tonini G,Santini D

更新日期：2020-06-24 00:00:00

abstract：BACKGROUND:The importance of individual microRNAs (miRNAs) in tumor has been established in different cancers. However, their association with tumor chemoresistance has not been fully understood. Previously, we found two novel MDR-associated microRNAs (miRNAs). In this report, we investigated the combined effects of mi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhao L,Wang Y,Jiang L,He M,Bai X,Yu L,Wei M

更新日期：2016-02-03 00:00:00

abstract：:Preclinical research and ongoing clinical trials are validating epidermal growth factor receptor (EGFR) as a suitable molecular target in cancer therapy. Here we report the case of a 39-year-old non-smoking man with heavily pretreated stage IV bronchioloalveolar NSCLC who was treated with gefitinib ('Iressa', ZD1839) ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gelibter A,Ceribelli A,Milella M,Mottolese M,Vocaturo A,Cognetti F

更新日期：2003-09-01 00:00:00

abstract：:This study is aimed at evaluating the inhibitory effects of the association of hematoporphyrin and ultrasound at variable intensities with a fixed frequency of 1.1MHz in tumor nodules. Specifically, the effects were studied both in solid and ascitic S180 tumors transplanted in mice by clinical, cytochemical and ultras...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Quan-hong L,Shi-hui S,Ya-ping X,Hao Q,Jin-xuan Z,Yao-hui R,Meng L,Pan W

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) have been used successfully in clinical pilot studies. However, tumor-specific immunity and clinical responses were only induced in certain cancer patients. It has been well documented that immunotherapy efficacy can be optimized for responses using antigen pulsing. METHODS:The human l...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wei FQ,Sun W,Wong TS,Gao W,Wen YH,Wei JW,Wei Y,Wen WP

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly developed countries. Radiotherapy plays a critical role in the curative management of inoperable non-small cell lung cancer (NSCLC) and is also used as a post-surgical treatment in lung cancer patients....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tang Y,Cui Y,Li Z,Jiao Z,Zhang Y,He Y,Chen G,Zhou Q,Wang W,Zhou X,Luo J,Zhang S

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechanisms underlying the action of ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu L,Wu N,Wang Y,Zhang X,Xia B,Tang J,Cai J,Zhao Z,Liao Q,Wang J

更新日期：2019-02-28 00:00:00

abstract：:In the deletion mapping of chromosome (chr) 9 in head and neck lesions of the Indian patient population by microsatellite markers, we have identified four discrete areas (D1-D4) with high loss of heterozygosities (LOHs) viz. 9p24-p23 (D1), 9p22-p21 (D2), 9q11-q13 (D3) and 9q22.3 (D4) regions. The deletions in D2 and D...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tripathi A,Dasgupta S,Roy A,Sengupta A,Roy B,Roychowdhury S,Panda CK

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies have reported the selective antitumor effect of oleandrin on various tumor cells. In this study, we ai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ma Y,Zhu B,Liu X,Yu H,Yong L,Liu X,Shao J,Liu Z

更新日期：2015-10-06 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical results, a certain percentage of patients do not respond to this kind of immunotherapy. In addition, in a fra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Camelliti S,Le Noci V,Bianchi F,Moscheni C,Arnaboldi F,Gagliano N,Balsari A,Garassino MC,Tagliabue E,Sfondrini L,Sommariva M

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. METHODS:Immunohistochemistry was used to investigate Kindlin-2 expression in 177 pai...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin J,Lin W,Ye Y,Wang L,Chen X,Zang S,Huang A

更新日期：2017-09-29 00:00:00

abstract：:Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated sys...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan W,Zhang W,Jiang T

更新日期：2011-05-17 00:00:00

abstract：:In the present study we report twenty-nine patients with iatrogenic injuries and management during various operations for malignant conditions. The patients were reviewed in order to identify and study the incidence, type of treatment administered and outcome. The study group was composed of 29 patients with 31 iatrog...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Peker AE,Alagöl H,Ayyildiz A,Arik AI,Başay S

更新日期：2000-12-01 00:00:00

abstract：:Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anticancer agents because of their pleiotropic regulator function in cell differentiation, growth, proliferation a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bogos K,Renyi-Vamos F,Kovacs G,Tovari J,Dome B

更新日期：2008-07-14 00:00:00

abstract：BACKGROUND:The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epithelial differentiation, d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Paolini F,Amici C,Carosi M,Bonomo C,Di Bonito P,Venuti A,Accardi L

更新日期：2021-01-23 00:00:00

abstract：BACKGROUND:Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large number of clinical samples, especially for DNA rearrangements and copy number variations (CNVs). This...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Su D,Zhang D,Chen K,Lu J,Wu J,Cao X,Ying L,Jin Q,Ye Y,Xie Z,Xiong L,Mao W,Li F

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and rel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yin Y,Sun M,Zhan X,Wu C,Geng P,Sun X,Wu Y,Zhang S,Qin J,Zhuang Z,Liu Y

更新日期：2019-02-15 00:00:00

abstract：BACKGROUND:Recently, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, was discovered is a novel agent for suppressing bladder cancer. The aim of this study was to investigate the impact of LRIG1 on the biological features of aggressive bladder cancer cells and the possible m...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chang L,Shi R,Yang T,Li F,Li G,Guo Y,Lang B,Yang W,Zhuang Q,Xu H

更新日期：2013-12-08 00:00:00

abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxia Telangiectasia Mutated (ATM...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shen M,Xu Z,Xu W,Jiang K,Zhang F,Ding Q,Xu Z,Chen Y

更新日期：2019-04-08 00:00:00

abstract：:A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Przybylowska K,Zielinska J,Zadrozny M,Krawczyk T,Kulig A,Wozniak P,Rykala J,Kolacinska A,Morawiec Z,Drzewoski J,Blasiak J

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) hold great potential in both clinical application and basic research for the managements of cancer. However, it remains to be an enormous challenge to obtain efficient detection of pancreatic CTCs. New detection platforms for the detection of pancreatic CTCs are urgently requir...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao Y,Zhu Y,Zhang Z,Zhang C,Huang X,Yuan Z

更新日期：2016-04-12 00:00:00

abstract：:The present study assesses the adaptation of a group of female patients with either manifest or suspected breast cancer who have undergone Magnetic Resonance Imaging (MRI) after receiving psychological support. Several studies in literature have reported the effectiveness of such support in reducing anti-oxidant and d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Caruso A,Bongiorno L,Vallini L,Russo P,Tomao F,Grandinetti ML

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin (CLU), an antiapoptotic molecule, could be a potential predictor molecule for ovarian cancer and wh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hassan MK,Watari H,Han Y,Mitamura T,Hosaka M,Wang L,Tanaka S,Sakuragi N

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely u...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He A,Liu Y,Chen Z,Li J,Chen M,Liu L,Liao X,Lv Z,Zhan Y,Zhuang C,Lin J,Huang W,Mei H

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS:The changes of macrophage phenotypes after P...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (IAP) family, survivin has been proposed as an attractive target for new anticancer interventions. In...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Peng XC,Yang L,Yang LP,Mao YQ,Yang HS,Liu JY,Zhang DM,Chen LJ,Wei YQ

更新日期：2008-09-25 00:00:00