Correction to: Musashi2 promotes EGF-induced EMT in pancreatic cancer via ZEB1-ERK/MAPK signaling.

abstract：BACKGROUND:Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role of NR1B2 in KIRC. METHODS:NR1B2 expression in TCGA dat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yin L,Li W,Wang G,Shi H,Wang K,Yang H,Peng B

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor populations could predict clinicopathological factors of prognostic importance for cancer progression. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Donatello S,Hudson L,Cottell DC,Blanco A,Aurrekoetxea I,Shelly MJ,Dervan PA,Kell MR,Stokes M,Hill AD,Hopkins AM

更新日期：2011-04-26 00:00:00

abstract：:Axillary lymphadenectomy is a very important procedure in the staging of breast cancer patients. However, it is associated with a significant morbidity rate. On the other hand, using early diagnosis we can see a high number of cases where the lymph nodes are negatives. With the intention of avoiding unnecessary axilla...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zerwes FP,Frasson AL,Gutfilen B,Barbosa da Fonseca LM

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in diagnosis and treatment, the p...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhao Y,Zhu J,Shi B,Wang X,Lu Q,Li C,Chen H

更新日期：2019-07-11 00:00:00

abstract：BACKGROUND:Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofib...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Umezu H,Endo N

更新日期：2009-03-31 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the effect of downregulating Hedgehog pathway by GANT61 on human glioma cells, examine the consequent changes of temozolomide (TMZ)-induced effects and explore the molecular mechanisms. METHODS:The cytotoxicity of a Gli1/2 inhibitor, GANT61 was examined both alone an...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li J,Cai J,Zhao S,Yao K,Sun Y,Li Y,Chen L,Li R,Zhai X,Zhang J,Jiang C

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim to demonstrate the biological function of ANGPT...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen H,Xiao Q,Hu Y,Chen L,Jiang K,Tang Y,Tan Y,Hu W,Wang Z,He J,Liu Y,Cai Y,Yang Q,Ding K

更新日期：2017-06-12 00:00:00

abstract：:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kruger S,Ilmer M,Kobold S,Cadilha BL,Endres S,Ormanns S,Schuebbe G,Renz BW,D'Haese JG,Schloesser H,Heinemann V,Subklewe M,Boeck S,Werner J,von Bergwelt-Baildon M

更新日期：2019-06-19 00:00:00

abstract：BACKGROUND:Metastasis in breast cancer is a vital concern in treatment because most women with primary breast cancer have micrometastases to distant sites at diagnosis. As a member of the inhibitor of apoptosis protein (IAP) family, survivin has been proposed as an attractive target for new anticancer interventions. In...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Peng XC,Yang L,Yang LP,Mao YQ,Yang HS,Liu JY,Zhang DM,Chen LJ,Wei YQ

更新日期：2008-09-25 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) remain mostly unknown. METHODS:In this study, quantitative real-time PCR (qPCR) and western blotting ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang T,Chen WC,Shi PC,Liu MR,Jiang T,Song H,Wang JQ,Fan RZ,Pei DS,Song J

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid transporter 2 (LAT2), e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Feng M,Xiong G,Cao Z,Yang G,Zheng S,Qiu J,You L,Zheng L,Zhang T,Zhao Y

更新日期：2018-11-12 00:00:00

abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

更新日期：1998-09-01 00:00:00

abstract：:This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The bromodomain and extra-terminal domain (BET) inhibitor is a type of anti-tumor agent, currently being evaluated in phase I and II clinical trials for cancer therapy. It can decrease MYC expression levels and cause effective anti-tumor effects in diverse human cancers. However, its cytotoxic effect and rel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yin Y,Sun M,Zhan X,Wu C,Geng P,Sun X,Wu Y,Zhang S,Qin J,Zhuang Z,Liu Y

更新日期：2019-02-15 00:00:00

abstract：:Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than tha...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Di X,Nishizaki T,Harada K,Kajiwara K,Nakayama H,Ito H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

更新日期：2018-10-16 00:00:00

abstract：PURPOSE:There has been no satisfactory treatment for advanced melanoma until now. Targeted radionuclide therapy (TRNT) may be a promising option for this heretofore lethal disease. Our goal in this study was to synthesize 131I-N-(2-(diethylamino)ethyl)-5-(iodo-131I)picolinamide (131I-5-IPN) and evaluate its therapeutic...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Xu X,Yuan L,Gai Y,Liu Q,Yin L,Jiang Y,Wang Y,Zhang Y,Lan X

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

更新日期：2018-02-26 00:00:00

abstract：BACKGROUND:Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at iden...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Meenakshisundaram R,Gragnoli C

更新日期：2009-03-28 00:00:00

abstract：BACKGROUND:This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect to the International Commission on Radiation Units and Measurements (ICRU) Report 50. METHODS:Forty-fiv...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Andic F,Baz Cifci S,Ors Y,Niang U,Dirier A,Adli M

更新日期：2009-01-07 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma. PATIENTS AND METHODS:60 HILPs (G-A) were performed with mild HT plus L-PAM (10 mg/lt) +/- D-actimomycin; 74 HILP...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pace M,Gattai R,Matteini M,Mascitelli EM,Bechi P

更新日期：2008-11-12 00:00:00

abstract：BACKGROUND:While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hyakusoku H,Sano D,Takahashi H,Hatano T,Isono Y,Shimada S,Ito Y,Myers JN,Oridate N

更新日期：2016-01-12 00:00:00

abstract：:Antioxidant, antitumor and anticarcinogenic activity of gossypin (3,5,8,3',4'-pentahydroxy-7-O glucosyl flavone) was carried out. The compound needed for 50% inhibition of superoxide, hydroxyl and nitric oxide radicals was 3 microg/ml, 41 microg/ml and 12 microg/ml, respectively. Gossypin also impart 50% inhibition at...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babu BH,Jayram HN,Nair MG,Ajaikumar KB,Padikkala J

更新日期：2003-12-01 00:00:00

abstract：:This study was undertaken in order to verify if peri-operative serum lactate level changes, resulting from manipulation of the splanchnic circulation during pancreatectomy, reflected clinical outcome in twenty patients (9 males-11 females age 33 to 76) operated for pancreatic cancer. Lactate levels were evaluated at t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gruttadauria S,Marino IR,Vitale CH,Mandala L,Scott VL,Doria C

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously reported that cells expressing the K1 protein of human herpesvirus 8 (HHV-8) resist death through th...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Daniluk U,Kerros C,Tao RH,Wise JF,Ao X,Berkova Z,Samaniego F

更新日期：2012-08-28 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogenous group of hematological clonal malignancies. Patients belonging to the refractory anemia (RA) subtype are usually treated with recombinant human erythropoietin (EPO). Not all patients respond to EPO administration and they are strictly dependent on supportive therapy w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tsiara SN,Chaidos A,Gouva M,Christou L,Panteli K,Kapsali E,Bourantas KL

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:Women with ductal hyperplasia including usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH) have an increased risk of developing invasive ductal carcinoma (IDC) of breast. The importance of several molecular markers in breast cancer has been of considerable interest during recent years suc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Mao XY,Fan CF,Zheng HC,Wei J,Yao F,Jin F

更新日期：2010-08-16 00:00:00

abstract：OBJECTIVE:To explore the potential role of CpG motif-containing oligonucleotides (CpG-ODN) in modulating the expression of FasL in HepG2 and Fas in Jurkat cells in vitro, and to examine the effect of CpG-ODN treatment on the HepG2 cells-mediated Jurkat cell apoptosis in vitro. METHODS:The expressions of FasL in HepG2 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zheng J,Fu R,Li J,Wang X

更新日期：2011-05-03 00:00:00

abstract：BACKGROUND:When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are at high risk of such interactions because they commonly receive multiple medications. Moreover, mos...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ussai S,Petelin R,Giordano A,Malinconico M,Cirillo D,Pentimalli F

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lokman NA,Ho R,Gunasegaran K,Bonner WM,Oehler MK,Ricciardelli C

更新日期：2019-01-08 00:00:00