Retraction Note: Endoplasmic reticulum stress triggers Xanthoangelol-induced protective autophagy via activation of JNK/c-Jun Axis in hepatocellular carcinoma.

abstract：:Occult carcinoma cells in peripheral blood of breast cancer (BC) patients is generally associated with poor disease prognosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive method for revealing rare circulating cancer cells. The target mRNA must be carefully chosen, as it must be expressed on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Pronzato P,Tognoni A,Falco E,Gianquinto D,Ansaldo V,Dessanti P,Fais F,Rosai J,Fedeli F

更新日期：2005-06-01 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common tumour of the central nervous system in humans. Unfortunately its prognosis is poor and because of the lack of efficacious therapies, immunotherapy is a potential treatment. Transfer factors (TF) are low molecular weight dialysable products extracted from immune cells wh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pineda B,Estrada-Parra S,Pedraza-Medina B,Rodriguez-Ropon A,Pérez R,Arrieta O

更新日期：2005-12-01 00:00:00

abstract：:A single guanine insertion (1G/2G polymorphism) in the promoter of the matrix metalloproteinase (MMP-1) gene creates a binding site for the transcription factor and may affect the level of transcription of MMP-1. An elevated level of MMP-1 in cancer cells may facilitate their invasion and contribute to metastasis. To ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Przybylowska K,Zielinska J,Zadrozny M,Krawczyk T,Kulig A,Wozniak P,Rykala J,Kolacinska A,Morawiec Z,Drzewoski J,Blasiak J

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia (AML) is initiated and maintained by a unique, small subset of leukemia stem cells (LSCs). LSCs are characterized by unrestricted self-renewal and contribute to the malignancy of leukemia. Aberrant protein fucosylation is associated with AML progression. However, it is still less under...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu B,Ma H,Liu Q,Xiao Y,Pan S,Zhou H,Jia L

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Annexin A2 is increased in serous ovarian cancer and plays an essential role in ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an important role in the plasminogen activator system regulating plasmin production. The aim of this study was to investigate the potential uti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lokman NA,Ho R,Gunasegaran K,Bonner WM,Oehler MK,Ricciardelli C

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. The reduced expression of miR-3...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cui X,Zhao Z,Liu D,Guo T,Li S,Hu J,Liu C,Yang L,Cao Y,Jiang J,Liang W,Liu W,Li S,Wang L,Wang L,Gu W,Wu C,Chen Y,Li F

更新日期：2014-02-17 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) posttranscriptionally regulate gene expression and thereby contribute to the modulation of numerous complex and disease-relevant cellular processes, including cell proliferation, cell motility, apoptosis and stress response. miRNA-31-5p is encoded on a genomic fragile site, 9p21.3, which i...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Que KT,Zhou Y,You Y,Zhang Z,Zhao XP,Gong JP,Liu ZJ

更新日期：2018-11-06 00:00:00

abstract：:Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics that target the cyclin D-CDK4/6 complex and induce G1 phase arrest. These agents have demonstrated...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Luo J,Chen X,Yang Z,Mei X,Ma J,Zhang Z,Guo X,Yu X

更新日期：2020-09-15 00:00:00

abstract：:Intraoperative radiotherapy with a single dose of electrons (ELIOT) in the conservative treatment of breast cancer is a possibility under evaluation in clinical trials. The costs of the mobile linear accelerator with a robotic arm, used in intraoperative radiotherapy, are prohibitive for poor countries. The aim of thi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Frasson AL,Zerwes FP,Braga AP,Barbosa FS,Koch HA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:MicroRNAs have an important role in diverse biological processes including tumorigenesis. MiR-223 has been reported to be deregulated in several human cancer types. However, its biological role has not been functionally characterized in lung squamous cell carcinoma (LSCC). The following study investigates th...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Luo P,Wang Q,Ye Y,Zhang J,Lu D,Cheng L,Zhou H,Xie M,Wang B

更新日期：2019-02-12 00:00:00

abstract：BACKGROUND:Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Lang C,Wu Z,Dai Y,He S,Guo W,Huang S,Du H,Ren D,Peng X

更新日期：2019-09-05 00:00:00

abstract：:Identifying appropriate preclinical cancer models remains a major challenge in increasing the efficiency of drug development. A potential strategy to improve patient outcomes could be selecting the 'right' treatment in preclinical studies performed in patient-derived xenografts (PDXs) obtained by direct implants of su...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pompili L,Porru M,Caruso C,Biroccio A,Leonetti C

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family of transcription factors, has been reported for its role in the genesis and progression of tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor of poor survival in many solid ca...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang X,Lv QL,Huang YT,Zhang LH,Zhou HH

更新日期：2017-08-07 00:00:00

abstract：BACKGROUND:Metastasis via the lymphatic system is promoted by lymphangiogenesis. Alterations of the lymphatic channels during the progression of metastasis to regional lymph nodes (LNs) remain unexplored. To examine whether tumor-induced LN lymphangiogenesis controls metastasis to regional LNs, we investigated cervical...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ozasa R,Ohno J,Iwahashi T,Taniguchi K

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) is one of the metabolites that is derived from arachidonic acid and that is catalyzed by 15-lipoxygenase (15-LOX), and it has recently been reported to exhibit anti-cancer effects....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zong L,Chen K,Jiang Z,Chen X,Sun L,Ma J,Zhou C,Xu Q,Duan W,Han L,Lei J,Li X,Ma Q,Wang Z

更新日期：2017-12-11 00:00:00

abstract：:This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA). METHODS:mRNAs extracted from 35 pancreatic tubular adenocarcinoma tissues obtained by E...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ashida R,Nakata B,Shigekawa M,Mizuno N,Sawaki A,Hirakawa K,Arakawa T,Yamao K

更新日期：2009-06-16 00:00:00

abstract：BACKGROUND:The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tumor progression remain...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Zhang Z,Zhang Y,Cao Y,Wei H,Wu Z

更新日期：2018-02-26 00:00:00

abstract：:Cancer vaccine therapy represents a promising therapeutical option. Consistently, with these new treatment strategies, the use of dendritic cell vaccines is becoming increasingly widespread and currently in the forefront for cancer treatment. The purpose of this study was to evaluate the feasibility and safety of tumo...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ovali E,Dikmen T,Sonmez M,Yilmaz M,Unal A,Dalbasti T,Kuzeyli K,Erturk M,Omay SB

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. MicroRNAs (miRNAs) have been indicated as crucial actors in cancer biology. Accumulating evidence suggests that miRNAs can be used as diagnostic and prognostic markers for NSCLC. METHODS:The purpose of this study was to characterize a...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He X,Chen SY,Yang Z,Zhang J,Wang W,Liu MY,Niu Y,Wei XM,Li HM,Hu WN,Sun GG

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression. We and others find that YAP is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and associated with worse prognosis of patients. Activated pancreatic stel...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Z,Zhou C,Cheng L,Yan B,Chen K,Chen X,Zong L,Lei J,Duan W,Xu Q,Li X,Wang Z,Ma Q,Ma J

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Parallel to complex alteration in molecular and cellular events, enrichment of cancer stem cells (CSC) contributes significantly in deliberation and maintenance of cisplatin resistance. Cisplatin mediated CSC enrichment is well established in various cancers, yet the underlying mechanism is largely unknown. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Thakur B,Ray P

更新日期：2017-11-23 00:00:00

abstract：BACKGROUND:Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. METHODS:Use public database to screen the potential lncRNA crucial for metastasi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Huang W,Yuan Y,Li J,Wu J,Yu J,He Y,Wei Z,Zhang C

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgical resection followed by radiotherapy plus concurrent and adjuvant chemotherapy with temozolomide. T...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Abbruzzese C,Matteoni S,Persico M,Villani V,Paggi MG

更新日期：2020-01-31 00:00:00

abstract：:We report the long-term results of a series of patients affected by advanced epithelial ovarian cancer treated with the PEC combination (cisplatin 60 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 750 mg/m2, all at day 1, every 21 days). Response was evaluated after three cycles, and treatment continued in responsive...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Massacesi C,Bascioni R,Cellerino R,Scartozzi M,Bracci R,Alessandroni P,Antognoli S,Ciavattini A,De Nictolis M,Piga A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The primary glioblastoma multiforme (GBM) is the most malignant form of astrocytic tumor with an average survival of approximately 12-14 months. The search for novel and more efficient chemo-agents against this disease is urgent. Salinomycin induces broad anti-cancer effects; however, its role in GBM and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qin LS,Jia PF,Zhang ZQ,Zhang SM

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC. METHODS:The miRNA profiles of CD90+ and CD90- HCC c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang X,Jiang P,Shuai L,Chen K,Li Z,Zhang Y,Jiang Y,Li X

更新日期：2016-11-11 00:00:00

abstract：:Screening for ovarian cancer is an important step in improving ovarian cancer mortality. This is a report of screening for ovarian cancer using transvaginal sonography (TVS) on 2,095 asymptomatic women during the past four years. Ovarian tumors over 30 mm in diameter were detected in 87 women (4.2%). Fourteen tumors w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Misawa T,Asai M,Higashide K

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing endogenous RNA (ceRNA) mechanisms. In this study, we exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qiao K,Ning S,Wan L,Wu H,Wang Q,Zhang X,Xu S,Pang D

更新日期：2019-10-17 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical results, a certain percentage of patients do not respond to this kind of immunotherapy. In addition, in a fra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Camelliti S,Le Noci V,Bianchi F,Moscheni C,Arnaboldi F,Gagliano N,Balsari A,Garassino MC,Tagliabue E,Sfondrini L,Sommariva M

更新日期：2020-11-09 00:00:00