Transfection of IL-10 expression vectors into endothelial cultures attenuates alpha4beta7-dependent lymphocyte adhesion mediated by MAdCAM-1.

abstract：BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...

journal_title：BMC gastroenterology

authors： Habibzadeh P,Silawi M,Dastsooz H,Bahramjahan S,Ezzatzadegan Jahromi S,Ostovan VR,Yavarian M,Mofatteh M,Faghihi MA

更新日期：2020-05-08 00:00:00

abstract：BACKGROUND:Vedolizumab has become a standard treatment for the inflammatory bowel diseases ulcerative colitis (UC) and Crohn's disease (CD). However, there is an ongoing debate on the ideal individual treatment algorithms and means to predict treatment response are not routinely established. AIMS:We aimed to describe ...

journal_title：BMC gastroenterology

authors： Mühl L,Becker E,Müller TM,Atreya R,Atreya I,Neurath MF,Zundler S

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:Familial adenomatous polyposis (FAP) is a rare, autosomal dominant disease clinically characterized by the early onset of many adenomatous polyps throughout the colon, which turn into colon cancer, if left untreated. In FAP patients, polyps can also occur in the upper gastrointestinal (GI) tract, especially ...

journal_title：BMC gastroenterology

authors： Purchiaroni F,Nakajima T,Sakamoto T,Abe S,Saito Y

更新日期：2017-12-08 00:00:00

abstract：BACKGROUND:Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune response to commensal bacteria. However evidence regarding an infectious etiology in UC remains elusive...

journal_title：BMC gastroenterology

authors： Miner J,Gillan MM,Alex P,Centola M

更新日期：2005-01-24 00:00:00

abstract：BACKGROUND:Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst for...

journal_title：BMC gastroenterology

authors： Gerosa M,Chiarelli M,Guttadauro A,De Simone M,Tagliabue F,Costa M,Terragni S,Cioffi U

更新日期：2018-04-23 00:00:00

abstract：BACKGROUND:In Brazil, it is estimated that between 2.5 and 4.9% of the general population present anti-hepatitis C virus (HCV) antibodies, which corresponds to as many as 3.9 to 7.6 million chronic carriers. Chronic liver disease is associated with HCV infection in 20% to 58% of the Brazilian patients. The objective of...

journal_title：BMC gastroenterology

authors： Brandão AB,Fuchs SC

更新日期：2002-08-08 00:00:00

abstract：BACKGROUND:Patients with advanced cirrhosis of the liver typically display circulatory disturbance. Haemodynamic management may be critical for avoiding and treating functional renal failure in such patients. This study investigated the effects of plasma expansion with hyperoncotic albumin solution and the role of stat...

journal_title：BMC gastroenterology

authors： Umgelter A,Wagner K,Reindl W,Nurtsch N,Huber W,Schmid RM

更新日期：2008-08-27 00:00:00

abstract：BACKGROUND:MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-alpha and is a major determinant of lymphocyte trafficking to the gut in human inflammatory bowel disease (IBD). It has been suggested that both reactive oxygen and nitrogen metabolites...

journal_title：BMC gastroenterology

authors： Oshima T,Jordan P,Grisham MB,Alexander JS,Jennings M,Sasaki M,Manas K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Gastroparesis (Gp) is a poorly understood chronic gastrointestinal medical condition for which patient reported outcomes (PRO) are lacking. Previously developed symptoms scoring has been used for several decades. Using symptoms scores as a basis for documentation, 12 years of support/focus group patient feed...

journal_title：BMC gastroenterology

authors： Cutts T,Holmes S,Kedar A,Beatty K,K Mohammad M,Abell T

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:Perforation of the colon occurring during or shortly following colonoscopy or barium enema is a rare complication of collagenous colitis (CC). "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, with only five cases reported to date. We report herein an additio...

journal_title：BMC gastroenterology

authors： Mitchell A,Dugas A

更新日期：2016-10-06 00:00:00

abstract：BACKGROUND:Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the underlying etiology remains poorly defined. We assessed the correlation of symptomatic relief and healt...

journal_title：BMC gastroenterology

authors： Mönnikes H,Schwan T,van Rensburg C,Straszak A,Theek C,Lühmann R,Sander P,Tholen A

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Adult lactase non-persistence (LNP) is due to low lactase expression, resulting in lactose malabsorption (LM). LNP is a genetic trait, but is typically determined by LM markers including breath H2, blood glucose, and urinary galactose after a lactose tolerance test. Known validity of these markers using milk...

journal_title：BMC gastroenterology

authors： Shrestha A,Barnett MPG,Perry JK,Cameron-Smith D,Milan AM

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:To observe and compare the short term results and functional recovery of laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSCACRA) in the treatment of Adult slow transit constipation (STC) with two different reservoir length: short colonic reservoir and long colonic reservoir. ME...

journal_title：BMC gastroenterology

authors： Wei D,Cai J,Yang Y,Zhao T,Zhang H,Zhang C,Zhang Y,Zhang J,Cai F

更新日期：2015-03-18 00:00:00

abstract：BACKGROUND:High dose intravenous proton pump inhibitor after endoscopic therapy for peptic ulcer bleeding has been recommended as adjuvant therapy. Whether oral proton pump inhibitor can replace intravenous proton pump inhibitor in this setting is unknown. This study aims to compare the clinical efficacy of oral and in...

journal_title：BMC gastroenterology

authors： Yen HH,Yang CW,Su WW,Soon MS,Wu SS,Lin HJ

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Faecal calprotectin (FC) is one of the most widely used non-invasive tests for the diagnosis and assessment of Crohn's disease (CD) activity. Despite this, factors other than disease activity which affect levels have not been extensively reviewed. This is of importance when using FC in the diagnostic setting...

journal_title：BMC gastroenterology

authors： Mendall MA,Chan D,Patel R,Kumar D

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify...

journal_title：BMC gastroenterology

authors： ter Borg PC,Fekkes D,Vrolijk JM,van Buuren HR

更新日期：2005-03-24 00:00:00

abstract：BACKGROUND:Oral anticoagulants like the coumarin derivatives are characterised by a particularly narrow therapeutic range. Any interfering co-medication can pose a challenge to establishing a stable anticoagulant dosage regimen and thus present a serious risk for the patient. Here we describe two cases of patients on a...

journal_title：BMC gastroenterology

authors： Enderle C,Müller W,Grass U

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse model was constructed to investigate metabonomics of liver tissue and directly characterize metabolic ch...

journal_title：BMC gastroenterology

authors： Feng B,Wu S,Liu F,Gao Y,Dong F,Wei L

更新日期：2013-04-29 00:00:00

abstract：BACKGROUND:To perform a meta-analysis evaluating the diagnostic ability of fecal lactoferrin (FL) to distinguish inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS). METHODS:The Medline, EMBASE, Web of Science, Cochrane library and CNKI databases were systematically searched for studies that used FL c...

journal_title：BMC gastroenterology

authors： Zhou XL,Xu W,Tang XX,Luo LS,Tu JF,Zhang CJ,Xu X,Wu QD,Pan WS

更新日期：2014-07-07 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. We assessed the relevance of Slug in measuring the invasive potential of ESCC cells in vitro and in vivo in immunodeficient mice. METHODS:We utilized RNA interference to knockdown Slug gene expr...

journal_title：BMC gastroenterology

authors： Tang P,Yu Z,Zhang K,Wang Y,Ma Z,Zhang S,Chen D,Zhou Y

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:The normal physiology of the gastrointestinal tract has been only cursorily examined. Consequently, the pathophysiology of disturbances of the gastrointestinal functions is poorly known. Recurrent vomiting is one of many functional conditions for which it is difficult to find an explanation and to treat. In ...

journal_title：BMC gastroenterology

authors： Ohlsson B

更新日期：2006-10-21 00:00:00

abstract：BACKGROUND:Transarterial chemoembolization (TACE) and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma (HCC) patients respectively. High costs with adverse events (AE) of sorafenib might limit sorafenib dosage, further affecting therapeutic response. To attain greatest...

journal_title：BMC gastroenterology

authors： Hsiao WD,Peng CY,Chuang PH,Lai HC,Cheng KS,Chou JW,Chen YY,Yu CJ,Feng CL,Su WP,Chen SH,Kao JT

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Although the outcomes of caustic ingestion differ between children and adults, it is unclear whether such outcomes differ among adults as a function of their age. This retrospective study was performed to ascertain whether the clinical outcomes of caustic ingestion differ significantly between elderly and no...

journal_title：BMC gastroenterology

authors： Chang JM,Liu NJ,Pai BC,Liu YH,Tsai MH,Lee CS,Chu YY,Lin CC,Chiu CT,Cheng HT

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual stones have been reported, which can result in recurrent biliary symptoms, cholangitis, and pancreati...

journal_title：BMC gastroenterology

authors： Fujita A,Nakahara K,Michikawa Y,Morita R,Suetani K,Sato J,Igarashi Y,Araki R,Ikeda H,Matsunaga K,Watanabe T,Itoh F

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic decompensation with dysfunction of liver, skeletal- and heart muscle as well as brain. In anabolism, ne...

journal_title：BMC gastroenterology

authors： Das AM,Drache S,Janzen N,Franke A

更新日期：2012-08-30 00:00:00

abstract：BACKGROUND:Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of Crohn's disease (CD) and may occur with the onset of the disease or any time after the diagnosis incl...

journal_title：BMC gastroenterology

authors： Buck M,Dumic I,McDermott W,Nordstrom C,Dawan S,Virata A,Martin S,Hudson A,Milovanovic T,Nordin T

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis. AIMS:The aim of the present study was to evaluate bone density and metabolism in patien...

journal_title：BMC gastroenterology

authors： Lorinczy K,Lakatos G,Müllner K,Hritz I,Lakatos PL,Tulassay Z,Miheller P

更新日期：2011-05-19 00:00:00

abstract：BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....

journal_title：BMC gastroenterology

authors： Uberti F,Bardelli C,Morsanuto V,Ghirlanda S,Molinari C

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. ...

journal_title：BMC gastroenterology

authors： Fluhr G,Mayerle J,Weber E,Aghdassi A,Simon P,Gress T,Seufferlein T,Mössner J,Stallmach A,Rösch T,Müller M,Siegmund B,Büchner-Steudel P,Zuber-Jerger I,Kantowski M,Hoffmeister A,Rosendahl J,Linhart T,Maul J,Czakó L,

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall...

journal_title：BMC gastroenterology

authors： Tsaknakis B,Masri R,Amanzada A,Petzold G,Ellenrieder V,Neesse A,Kunsch S

更新日期：2018-08-02 00:00:00