177 Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction.

Abstract:

PURPOSE:The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177 Lutetium (177 Lu) SPECT/CT imaging. METHODS:Three experiments [sphere-to-background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177 Lu-trichloride. SPECT/CT acquisitions were performed with the medium-energy low-penetration (MELP) collimator and 99m Tc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113-keV photopeak only, the 208-keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast-to-noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles. RESULTS:With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208-keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208-keV AC/SC reconstructions. CONCLUSION:177 Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208-keV photopeak, with AC and SC.

journal_name

J Appl Clin Med Phys

authors

Huizing DMV,Sinaasappel M,Dekker MC,Stokkel MPM,de Wit-van der Veen BJ

doi

10.1002/acm2.12991

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

272-277

issue

9

issn

1526-9914

journal_volume

21

pub_type

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