Abstract：
PURPOSE:The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177 Lutetium (177 Lu) SPECT/CT imaging. METHODS:Three experiments [sphere-to-background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177 Lu-trichloride. SPECT/CT acquisitions were performed with the medium-energy low-penetration (MELP) collimator and 99m Tc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113-keV photopeak only, the 208-keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast-to-noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles. RESULTS:With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208-keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208-keV AC/SC reconstructions. CONCLUSION:177 Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208-keV photopeak, with AC and SC.
journal_name
J Appl Clin Med Physjournal_title
Journal of applied clinical medical physicsauthors
Huizing DMV,Sinaasappel M,Dekker MC,Stokkel MPM,de Wit-van der Veen BJdoi
10.1002/acm2.12991subject
Has Abstractpub_date
2020-09-01 00:00:00pages
272-277issue
9issn
1526-9914journal_volume
21pub_type
杂志文章abstract：:The necessity to build or adapt radiotherapy rooms in reduced areas leads to the search for unconventional solutions for shielding projects. In most cases, adding metals to the primary barriers is the best alternative to shield rooms properly. However, when photons with energies equal or higher than 10 MV interact wit...
journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：10.1120/jacmp.v15i6.5035
更新日期：2014-11-08 00:00:00
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journal_title：Journal of applied clinical medical physics
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更新日期：2013-11-04 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2016-09-08 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of applied clinical medical physics
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更新日期：2011-01-19 00:00:00
abstract：:Prostate cancer radiotherapy workflows, solely based on magnetic resonance imaging (MRI), are now in clinical use. In these workflows, intraprostatic gold fiducial markers (GFM) show similar signal behavior as calcifications and bleeding in T2-weighted MRI-images. Accurate GFM identification in MRI-only radiotherapy w...
journal_title：Journal of applied clinical medical physics
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更新日期：2018-11-01 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2009-02-05 00:00:00
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journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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doi：10.1120/jacmp.v16i6.5317
更新日期：2015-11-08 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2017-11-01 00:00:00
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journal_title：Journal of applied clinical medical physics
pub_type： 杂志文章
doi：
更新日期：2010-01-28 00:00:00
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journal_title：Journal of applied clinical medical physics
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更新日期：2012-07-05 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2016-11-08 00:00:00
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更新日期：2018-03-14 00:00:00
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journal_title：Journal of applied clinical medical physics
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of applied clinical medical physics
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journal_title：Journal of applied clinical medical physics
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更新日期：2018-09-01 00:00:00
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journal_title：Journal of applied clinical medical physics
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doi：10.1120/jacmp.v9i2.2758
更新日期：2008-04-16 00:00:00
