177 Lutetium SPECT/CT: Evaluation of collimator, photopeak and scatter correction.


PURPOSE:The goal of this study was to find the optimal combination of collimator, photopeak and scatter correction for 177 Lutetium (177 Lu) SPECT/CT imaging. METHODS:Three experiments [sphere-to-background ratios (SBR) 50:1, 10:1, and 2:1] were performed with the NEMA Image Quality phantom filled with 177 Lu-trichloride. SPECT/CT acquisitions were performed with the medium-energy low-penetration (MELP) collimator and 99m Tc/Krypton collimator. For each acquisition six reconstructions, all with attenuation correction (AC), were made: the 113-keV photopeak only, the 208-keV photopeak only and both photopeaks combined, each with or without scatter correction (SC). Image quality was assessed using contrast-to-noise ratios (CNR), quantification accuracy by means of recovery coefficients (RCs) and the spatial resolution using line profiles. RESULTS:With SBR 50:1 and 10:1, both collimators met the Rose criterion (CNR > 5), whereas the MELP collimator showed a higher CNR for the 2:1 ratio. The RCmean was higher with the MELP collimator, most explicit after the 208-keV AC/SC reconstruction for all acquisitions. The line profiles showed a better spatial resolution for the MELP collimator and the 208-keV AC/SC reconstructions. CONCLUSION:177 Lu SPECT/CT image quality and quantification was most optimal when acquired with the MELP collimator and reconstructed using the 208-keV photopeak, with AC and SC.


J Appl Clin Med Phys


Huizing DMV,Sinaasappel M,Dekker MC,Stokkel MPM,de Wit-van der Veen BJ




Has Abstract


2020-09-01 00:00:00










  • Reproducibility in patient-specific IMRT QA.

    abstract::The purpose of this study was to determine the reproducibility of patient-specific, intensity-modulated radiation therapy (IMRT) quality assurance (QA) results in a clinical setting. Six clinical patient plans were delivered to a variety of devices and analyses, including 1) radiographic film; 2) ion chamber; 3) 2D di...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: McKenzie EM,Balter PA,Stingo FC,Jones J,Followill DS,Kry SF

    更新日期:2014-05-08 00:00:00

  • A fast, independent dose check of HDR plans.

    abstract::High dose rate (HDR) brachytherapy often involves optimization routines to calculate the dwell times and positions of a radioactive source along specified applicator paths. These routines optimize the dwells in such a way as to deliver the prescribed dose at one or more points while satisfying various constraints. The...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Lachaine ME,Gorman JC,Palisca MG

    更新日期:2003-04-01 00:00:00

  • Assessment and management of radiotherapy beam intersections with the treatment couch.

    abstract::The impact of the treatment couch on a radiotherapy plan is rarely fully assessed during the treatment planning process. Incorporating a couch model into the treatment planning system (TPS) enables the planner to avoid or dosimetrically evaluate beam-couch intersections. In this work, we demonstrate how existing TPS t...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Van Prooijen M,Kanesalingam T,Islam MK,Heaton RK

    更新日期:2010-04-19 00:00:00

  • Assessment of PlanIQ Feasibility DVH for head and neck treatment planning.

    abstract:INTRODUCTION:Designing a radiation plan that optimally delivers both target coverage and normal tissue sparing is challenging. There are limited tools to determine what is dosimetrically achievable and frequently the experience of the planner/physician is relied upon to make these determinations. PlanIQ software provid...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Fried DV,Chera BS,Das SK

    更新日期:2017-09-01 00:00:00

  • Defining internal target volume using positron emission tomography for radiation therapy planning of moving lung tumors.

    abstract::Substantial disagreement exists over appropriate PET segmentation techniques for non-small cell lung cancer. Currently, no segmentation algorithm explicitly considers tumor motion in determining tumor borders. We developed an automatic PET segmentation model as a function of target volume, motion extent, and source-to...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Riegel AC,Bucci MK,Mawlawi OR,Ahmad M,Luo D,Chandler A,Pan T

    更新日期:2014-01-06 00:00:00

  • Deep learning and level set approach for liver and tumor segmentation from CT scans.

    abstract:PURPOSE:Segmentation of liver organ and tumors from computed tomography (CT) scans is an important task for hepatic surgical planning. Manual segmentation of liver and tumors is tedious, time-consuming, and biased to the clinician experience. Therefore, automatic segmentation of liver and tumors is highly desirable. It...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Alirr OI

    更新日期:2020-10-01 00:00:00

  • Independent calculation of dose from a helical TomoTherapy unit.

    abstract::A new calculation algorithm has been developed for independently verifying doses calculated by the TomoTherapy Hi.Art treatment planning system (TPS). The algorithm is designed to confirm the dose to a point in a high dose, low dose-gradient region. Patient data used by the algorithm include the radiological depth to ...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Gibbons JP,Smith K,Cheek D,Rosen I

    更新日期:2009-02-05 00:00:00

  • Dosimetric characteristics of a cubic-block-piled compensator for intensity-modulated radiation therapy in the Pinnacle radiotherapy treatment planning system.

    abstract::We examined the dose distributions generated by Pinnacle3 (Philips Radiation Oncology Systems, Milpitas, CA) for intensity-modulated radiotherapy (IMRT) plans using a cubic-block-piled compensator as the intensity modulator for 4-MV and 10-MV photon beams. The Pinnacle treatment planning system (TPS) uses an algorithm...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Sasaki K,Obata Y

    更新日期:2006-06-16 00:00:00

  • Comparison of the KonRad IMRT and XiO treatment planning systems.

    abstract::Reducing the treatment time for IMRT patients is highly desirable. The objective of this work was to evaluate the new clinical Siemens KonRad inverse treatment planning system (TPS) and compare it to the CMS XiO TPS with special emphasis on the segmentation efficiency. For head and neck, liver and prostate cancer pati...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Reitz B,Miften M

    更新日期:2008-07-14 00:00:00

  • Effect of RTOG breast/chest wall guidelines on dose-volume histogram parameters.

    abstract::Treatment planning for breast cancer has been traditionally based on clinical landmarks. The Radiation Therapy Oncology Group (RTOG) published consensus guidelines on contouring target volumes (TV) for the breast/chest wall and draining lymphatics. The effect of these guidelines on dosimetric parameters in surrounding...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Rudra S,Al-Hallaq HA,Feng C,Chmura SJ,Hasan Y

    更新日期:2014-03-06 00:00:00

  • Radiation treatment planning and delivery strategies for a pregnant brain tumor patient.

    abstract::The management of a pregnant patient in radiation oncology is an infrequent event requiring careful consideration by both the physician and physicist. The aim of this manuscript was to highlight treatment planning techniques and detail measurements of fetal dose for a pregnant patient recently requiring treatment for ...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Labby ZE,Barraclough B,Bayliss RA,Besemer AE,Dunkerley DAP,Howard SP

    更新日期:2018-09-01 00:00:00

  • Clinical validation of ring-mounted halcyon linac for lung SBRT: comparison to SBRT-dedicated C-arm linac treatments.

    abstract::Stereotactic body radiotherapy (SBRT) of lung tumors via the ring-mounted Halcyon Linac, a fast kilovoltage cone beam CT-guided treatment with coplanar geometry, a single energy 6MV flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a fast, safe, and feasible treatment modality for select...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Pokhrel D,Visak J,Critchfield LC,Stephen J,Bernard ME,Randall M,Kudrimoti M

    更新日期:2020-12-20 00:00:00

  • On the use of bolus for pacemaker dose measurement and reduction in radiation therapy.

    abstract::Special attention is required in planning and administering radiation therapy to patients with cardiac implantable electronic devices (CIEDs), such as pacemaker and defibrillator. The range of dose to CIEDs that can induce malfunction is large among CIEDs. Clinically significant defects have been reported at dose as l...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Yan H,Guo F,Zhu D,Stryker S,Trumpore S,Roberts K,Higgins S,Nath R,Chen Z,Liu W

    更新日期:2018-01-01 00:00:00

  • Production of neutrons in laminated barriers of radiotherapy rooms: comparison between the analytical methodology and Monte Carlo simulations.

    abstract::The necessity to build or adapt radiotherapy rooms in reduced areas leads to the search for unconventional solutions for shielding projects. In most cases, adding metals to the primary barriers is the best alternative to shield rooms properly. However, when photons with energies equal or higher than 10 MV interact wit...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Rezende GF,Da Rosa LA,Facure A

    更新日期:2014-11-08 00:00:00

  • Two-year experience with the commercial Gamma Knife Check software.

    abstract::The Gamma Knife Check software is an FDA approved second check system for dose calculations in Gamma Knife radiosurgery. The purpose of this study was to evaluate the accuracy and the stability of the commercial software package as a tool for independent dose verification. The Gamma Knife Check software version 8.4 wa...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Xu AY,Bhatnagar J,Bednarz G,Novotny J Jr,Flickinger J,Lunsford LD,Huq MS

    更新日期:2016-07-08 00:00:00

  • Dose variations in tumor volumes and organs at risk during IMRT for head-and-neck cancer.

    abstract::Many head-and-neck cancer (HNC) patients treated with radiotherapy suffer significant anatomical changes due to tumor shrinkage or weight loss. The purpose of this study was to assess dose changes over target volumes and organs at risk during intensity-modulated radiotherapy for HNC patients. Sixteen HNC IMRT patients...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Beltran M,Ramos M,Rovira JJ,Perez-Hoyos S,Sancho M,Puertas E,Benavente S,Ginjaume M,Giralt J

    更新日期:2012-11-08 00:00:00

  • Evaluation of the influence of tumor location and size on the difference of dose calculation between Ray Tracing algorithm and Fast Monte Carlo algorithm in stereotactic body radiotherapy of non-small cell lung cancer using CyberKnife.

    abstract::This study evaluated the extent of improvement in dose predication accuracy achieved by the Fast Monte Carlo algorithm (MC) compared to the Ray Tracing algorithm (RAT) in stereotactic body radiotherapy (SBRT) of non-small cell lung cancer (NSCLC), and how their differences were influenced by the tumor site and size. T...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Wu VW,Tam KW,Tong SM

    更新日期:2013-09-06 00:00:00

  • Characterization of an inorganic scintillator for small-field dosimetry in MR-guided radiotherapy.

    abstract:INTRODUCTION:Aim of this study is to dosimetrically characterize a new inorganic scintillator designed for magnetic resonance-guided radiotherapy (MRgRT) in the presence of 0.35 tesla magnetic field (B). METHODS:The detector was characterized in terms of signal to noise ratio (SNR), reproducibility, dose linearity, an...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Cusumano D,Placidi L,D'Agostino E,Boldrini L,Menna S,Valentini V,De Spirito M,Azario L

    更新日期:2020-09-01 00:00:00

  • A novel method for radiotherapy patient identification using surface imaging.

    abstract::Performing a procedure on the wrong patient or site is one of the greatest errors that can occur in medicine. The addition of automation has been shown to reduce errors in many processes. In this work we explore the use of an automated patient identification process using optical surface imaging for radiotherapy treat...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Wiant DB,Verchick Q,Gates P,Vanderstraeten CL,Maurer JM,Hayes TL,Liu H,Sintay BJ

    更新日期:2016-03-08 00:00:00

  • Bleeding detection in wireless capsule endoscopy videos - Color versus texture features.

    abstract::Wireless capsule endoscopy (WCE) is an effective technology that can be used to make a gastrointestinal (GI) tract diagnosis of various lesions and abnormalities. Due to a long time required to pass through the GI tract, the resulting WCE data stream contains a large number of frames which leads to a tedious job for c...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Pogorelov K,Suman S,Azmadi Hussin F,Saeed Malik A,Ostroukhova O,Riegler M,Halvorsen P,Hooi Ho S,Goh KL

    更新日期:2019-08-01 00:00:00

  • Development of a stereoscopic CT metal artifact management algorithm using gantry angle tilts for head and neck patients.

    abstract::Dental amalgams are a common source of artifacts in head and neck (HN) images. Commercial artifact reduction techniques have been offered, but are substantially ineffectual at reducing artifacts from dental amalgams, can produce additional artifacts, provide inaccurate HU information, or require extensive computation ...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Branco D,Kry S,Taylor P,Rong J,Zhang X,Peterson C,Frank S,Followill D

    更新日期:2020-08-01 00:00:00

  • Quantitative analysis of image quality for acceptance and commissioning of an MRI simulator with a semiautomatic method.

    abstract::Magnetic Resonance Imaging (MRI) simulation differs from diagnostic MRI in purpose, technical requirements, and implementation. We propose a semiautomatic method for image acceptance and commissioning for the scanner, the radiofrequency (RF) coils, and pulse sequences for an MRI simulator. The ACR MRI accreditation la...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Chen X,Dai J

    更新日期:2018-05-01 00:00:00

  • TOPAS Simulation of the Mevion S250 compact proton therapy unit.

    abstract::As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit fo...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Prusator M,Ahmad S,Chen Y

    更新日期:2017-05-01 00:00:00

  • Increased beam attenuation and surface dose by different couch inserts of treatment tables used in megavoltage radiotherapy.

    abstract::The use of solid carbon fiber table materials in radiotherapy has become more common with the implementation of image-guided radiotherapy (IGRT), since the solid materials give less imaging artifacts than the so-called tennis racket couchtops. The downside of the solid carbon fiber couch inserts is that they increase ...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Seppälä JK,Kulmala JA

    更新日期:2011-11-15 00:00:00

  • Understanding the impact of RapidArc therapy delivery errors for prostate cancer.

    abstract::The purpose of this study is to simulate random and systematic RapidArc delivery errors for external beam prostate radiotherapy plans in order to determine the dose sensitivity for each error type. Ten prostate plans were created with a single 360° arc. The DICOM files for these treatment plans were then imported into...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Oliver M,Bush K,Zavgorodni S,Ansbacher W,Beckham WA

    更新日期:2011-05-20 00:00:00

  • Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning.

    abstract:PURPOSE:We conducted this dosimetric analysis to evaluate the feasibility of a multi-center stereotactic body radiation therapy (SBRT) trial for renal cell carcinoma (RCC) using different SBRT platforms. MATERIALS/METHODS:The computed tomography (CT) simulation images of 10 patients with unilateral RCC previously trea...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Baydoun A,Vapiwala N,Ponsky LE,Awan M,Kassaee A,Sutton D,Podder TK,Zhang Y,Dobbins D,Muzic RF Jr,Traughber B,Machtay M,Ellis R

    更新日期:2018-03-14 00:00:00

  • Remote dosimetric auditing of clinical trials: The need for vendor specific models to convert images to dose.

    abstract:INTRODUCTION:A previous pilot study has demonstrated the feasibility of a novel image-based approach for remote dosimetric auditing of clinical trials. The approach uses a model to convert in-air acquired intensity modulated radiotherapy (IMRT) images to delivered dose inside a virtual phantom. The model was developed ...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Miri N,Vial P,Greer PB

    更新日期:2019-01-01 00:00:00

  • Design and dosimetry characteristics of a commercial applicator system for intra-operative electron beam therapy utilizing ELEKTA Precise accelerator.

    abstract::The design concept and dosimetric characteristics of a new applicator system for intraoperative radiation therapy (IORT) are presented in this work. A new hard-docking commercial system includes polymethylmethacrylate (PMMA) applicators with different diameters and applicator end angles and a set of secondary lead col...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Nevelsky A,Bernstein Z,Bar-Deroma R,Kuten A,Orion I

    更新日期:2010-07-19 00:00:00

  • Applying three different methods of measuring CTDIfree air to the extended CTDI formalism for wide-beam scanners (IEC 60601-2-44): A comparative study.

    abstract:PURPOSE:The weighted CT dose index (CTDIw ) has been extended for a nominal total collimation width (nT) greater than 40 mm and relies on measurements of CTDIfreeair. The purpose of this work was to compare three methods of measuring CTDIfreeair and subsequent calculations of CTDIw to investigate their clinical appropr...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Bujila R,Kull L,Danielsson M,Andersson J

    更新日期:2018-07-01 00:00:00

  • Voxel-based supervised machine learning of peripheral zone prostate cancer using noncontrast multiparametric MRI.

    abstract:PURPOSE:The aim of this study was to develop and assess the performance of supervised machine learning technique to classify magnetic resonance imaging (MRI) voxels as cancerous or noncancerous using noncontrast multiparametric MRI (mp-MRI), comprised of T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and...

    journal_title:Journal of applied clinical medical physics

    pub_type: 杂志文章


    authors: Gholizadeh N,Simpson J,Ramadan S,Denham J,Lau P,Siddique S,Dowling J,Welsh J,Chalup S,Greer PB

    更新日期:2020-10-01 00:00:00