Correction to: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples.

abstract：:Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% of HCC patients are eligible for potentially curative therapies. Recently, cancer immunotherapy has emerged as ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fu Y,Liu S,Zeng S,Shen H

更新日期：2019-09-09 00:00:00

abstract：:Transplatin (TDDP), a trans-isomer of cisplatin (CDDP), is well known to have faint cytotoxicity because its geometric structure allows less adduct formation with DNA than does CDDP. However, TDDP might have the potential to enhance the anticancer effect of 5-fluorouracil (5-FU) as well as CDDP. In this study, five ga...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Nakata B,Yamagata S,Kanehara I,Shirasaka T,Hirakawa K

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cancer and ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang H,Li S,Yang X,Qiao B,Zhang Z,Xu Y

更新日期：2016-04-01 00:00:00

abstract：:Plant-derived phenolic compounds manifest many beneficial effects and can potentially inhibit several stages of carcinogenesis. In the present study, we investigated the efficacy of Emblica officinalis (E. officinalis) polyphenol fraction (EOP) on the induction of apoptosis in mouse and human carcinoma cell lineses an...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rajeshkumar NV,Pillai MR,Kuttan R

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is one of the frequently occurred malignancies in the world. To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. In the present study, we aimed to corroborate the oncogenic effect of miR-96 on CRC and to identify the spe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yue C,Chen J,Li Z,Li L,Chen J,Guo Y

更新日期：2020-11-12 00:00:00

abstract：:In the field of gut endocrinomas (carcinoids and relevant neoplasms), several classifications have been internationally accepted and utilized at varying frequency. The basis of the concepts regarding gut endocrinomas from which these classifications have been proposed were drawn from the different aspects. These inclu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Yakuwa Y,Osaka M

更新日期：1999-03-01 00:00:00

abstract：:Adjuvant chemotherapy for non-small-cell lung carcinoma (NSCLC) is a debated issue in clinical oncology. Although it is considered a standard for resected stage II-IIIA patients according to the available guidelines, many questions are still open. Among them, it should be acknowledged that the treatment for stage IB d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bonomi M,Pilotto S,Milella M,Massari F,Cingarlini S,Brunelli M,Chilosi M,Tortora G,Bria E

更新日期：2011-12-29 00:00:00

abstract：:The authors report one case of cauda equina paraganglioma and review the neurosurgical, radiological and pathological literatureon this rare tumour. Although it is difficult to distinguish preoperatively the paraganglioma from other tumours of the cauda equina, like neurinoma or ependymoma, this neuroendocrine tumour ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Caruso R,Wierzbicki V,Marrocco L,Salvati M

更新日期：2006-06-01 00:00:00

abstract：:Occult carcinoma cells in peripheral blood of breast cancer (BC) patients is generally associated with poor disease prognosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive method for revealing rare circulating cancer cells. The target mRNA must be carefully chosen, as it must be expressed on...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Pronzato P,Tognoni A,Falco E,Gianquinto D,Ansaldo V,Dessanti P,Fais F,Rosai J,Fedeli F

更新日期：2005-06-01 00:00:00

abstract：:We evaluated the effect of interferon-alpha2b as a chemosensitiser on HCT-15 cell line in treatment with doxorubicin. Chemosensitivity was determined by [3H]-thymidine incorporation and tetrazolium assays. The levels of expression of P-glycoprotein, Bcl-2 oncoprotein and HLA-ABC complex, and cell cycle/apoptosis analy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lucero Gritti MF,Beviacqua M,Bordenave RH,Rumi LS

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Lung cancer has long been the most dangerous malignant tumor among males in both well developed and poorly developed countries. Radiotherapy plays a critical role in the curative management of inoperable non-small cell lung cancer (NSCLC) and is also used as a post-surgical treatment in lung cancer patients....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tang Y,Cui Y,Li Z,Jiao Z,Zhang Y,He Y,Chen G,Zhou Q,Wang W,Zhou X,Luo J,Zhang S

更新日期：2016-01-12 00:00:00

abstract：:Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated sys...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan W,Zhang W,Jiang T

更新日期：2011-05-17 00:00:00

abstract：:Gastric cancer (GC) remains one of the most common types of malignant cancer, and the molecular mechanism underlying its metastasis is still largely unclear. MicroRNAs have emerged as important regulators of metastasis because of their ability to act on multiple signaling pathways. In our study, we found that miR-144 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu J,Xue H,Zhang J,Suo T,Xiang Y,Zhang W,Ma J,Cai D,Gu X

更新日期：2015-04-17 00:00:00

abstract：PURPOSE:The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. METHODS:Systematic c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin Y,Wang C,Zhong Y,Huang X,Peng L,Shan G,Wang K,Sun Q

更新日期：2013-08-13 00:00:00

abstract：:The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results were inconclusive and controversial. Our aim of this study was to evaluate this association by literature base...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Xie Y,Xian L

更新日期：2013-03-15 00:00:00

abstract：PURPOSE:To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of treatment. METHODS:A meta-analysis of randomized controlled trials (RCT)...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Viani GA,Manta GB,Fonseca EC,De Fendi LI,Afonso SL,Stefano EJ

更新日期：2009-01-06 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) posttranscriptionally regulate gene expression and thereby contribute to the modulation of numerous complex and disease-relevant cellular processes, including cell proliferation, cell motility, apoptosis and stress response. miRNA-31-5p is encoded on a genomic fragile site, 9p21.3, which i...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Que KT,Zhou Y,You Y,Zhang Z,Zhao XP,Gong JP,Liu ZJ

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao J,Ulekleiv CH,Halstensen TS

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND AND AIMS:Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdomain I of HER-2 extracellular domain. In this study, The effects of ChA21 on growth and apop...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang A,Xue H,Ling X,Gao Y,Yang F,Cheng L,Liu J,Wu Q

更新日期：2010-03-10 00:00:00

abstract：BACKGROUND:To determine the expression of bone morphogenetic protein-2 (BMP-2) and its receptors BMPRIA, BMPRIB, and BMPRII in epithelial ovarian cancer (EOC) and to analyze their influence on the prognosis of ovarian cancer patients. METHODS:Semi-quantitative RT-PCR and western blot were applied to detect the express...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ma Y,Ma L,Guo Q,Zhang S

更新日期：2010-06-30 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to chemotherapy still have an adverse prognosis. Hence, development of new therapeutic strategies is still...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kubista B,Schoefl T,Mayr L,van Schoonhoven S,Heffeter P,Windhager R,Keppler BK,Berger W

更新日期：2017-04-12 00:00:00

abstract：:Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than tha...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Di X,Nishizaki T,Harada K,Kajiwara K,Nakayama H,Ito H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing endogenous RNA (ceRNA) mechanisms. In this study, we exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qiao K,Ning S,Wan L,Wu H,Wang Q,Zhang X,Xu S,Pang D

更新日期：2019-10-17 00:00:00

abstract：:This study was undertaken to evaluate the statistical results of a large collected series of primary hepatic endocrinomas including carcinoids from extensive clinicopathologic aspect, and to provide the information to investigators engaged in this particular field of research. Primary hepatic endocrinomas variously te...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Poly C Binding Protein 1 (PCBP1) is an RNA-binding protein that binds and regulates translational activity of subsets of cellular mRNAs. Depletion of PCBP1 is implicated in various carcinomas, but the underlying mechanism in tumorigenesis remains elusive. METHODS:We performed a transcriptome-wide screen to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi H,Li H,Yuan R,Guan W,Zhang X,Zhang S,Zhang W,Tong F,Li L,Song Z,Wang C,Yang S,Wang H

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely u...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He A,Liu Y,Chen Z,Li J,Chen M,Liu L,Liao X,Lv Z,Zhan Y,Zhuang C,Lin J,Huang W,Mei H

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The latter can be induce...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Mele L,la Noce M,Paino F,Regad T,Wagner S,Liccardo D,Papaccio G,Lombardi A,Caraglia M,Tirino V,Desiderio V,Papaccio F

更新日期：2019-04-12 00:00:00

abstract：BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available ACh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pfitzinger PL,Fangmann L,Wang K,Demir E,Gürlevik E,Fleischmann-Mundt B,Brooks J,D'Haese JG,Teller S,Hecker A,Jesinghaus M,Jäger C,Ren L,Istvanffy R,Kühnel F,Friess H,Ceyhan GO,Demir IE

更新日期：2020-12-24 00:00:00