Correction to: Liquid biopsy and tumor heterogeneity in metastatic solid tumors: the potentiality of blood samples.

abstract：BACKGROUND:Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review. METHODS:Updated cohort studies on transdermal fentanyl and oral morphi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Xie DR,Jiang ZM,Ma W,Zhang YD,Bi ZF,Chen DL

更新日期：2010-06-09 00:00:00

abstract：:Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics that target the cyclin D-CDK4/6 complex and induce G1 phase arrest. These agents have demonstrated...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Luo J,Chen X,Yang Z,Mei X,Ma J,Zhang Z,Guo X,Yu X

更新日期：2020-09-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Sheng W,Shi X,Lin Y,Tang J,Jia C,Cao R,Sun J,Wang G,Zhou L,Dong M

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-kappaB) is a family of the genes that includes five members acting in events such as inflammat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Meteoglu I,Erdogdu IH,Meydan N,Erkus M,Barutca S

更新日期：2008-10-19 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast ca...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tao S,Chen Q,Lin C,Dong H

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jia Y,Guo Y,Jin Q,Qu H,Qi D,Song P,Zhang X,Wang X,Xu W,Dong Y,Liang Y,Quan C

更新日期：2020-02-24 00:00:00

abstract：:In papillary thyroid carcinoma lymphnode metastases at presentation do not seem to adversely affect survival, but do increase the risk of loco-regional tumor recurrence. The value of systematic versus selective lymphadenectomy is far less standardized, whereas the role of postoperative radioiodine in preventing either...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ducci M,Appetecchia M,Marzetti M

更新日期：1997-09-01 00:00:00

abstract：:Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao KM,Chen XC,Zhang JX,Wang Y,Yan W,You YP

更新日期：2015-03-04 00:00:00

abstract：BACKGROUND:While treatment failure in cases of head and neck squamous cell carcinoma (HNSCC) frequently takes the form of locoregional recurrences and distant metastasis, our understanding of the mechanisms of metastasis in HNSCC is limited. We initially performed the upstream and key nodes analysis together with whole...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hyakusoku H,Sano D,Takahashi H,Hatano T,Isono Y,Shimada S,Ito Y,Myers JN,Oridate N

更新日期：2016-01-12 00:00:00

abstract：:Several models have been generated to estimate breast cancer risk and to predict the probability to identify a BRCA1 or BRCA2 germ line mutation. Each model, based on a slightly different study design and purpose, takes into account a definite number of relevant parameters and ultimately pertains to a specific cohort ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pasini B,Casalis Cavalchini GC,Genovese T,Manoukian S

更新日期：2002-09-01 00:00:00

abstract：:Pretreatment of ethyl acetate extract of Phellinus rimosus (Berk) Pilat protected cisplatin induced nephrotoxicity in mice. Single dose of the extract (25 and 50 mg/kg body weight) decreased cisplatin induced serum creatinine and urea levels. The cisplatin depleted renal antioxidant defence system, such as activity of...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ajith TA,Jose N,Janardhanan KK

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Increasing evidence highlights the important roles of tripartite motif containing 24 (TRIM24) in tumor initiation and malignant progression in many tumors, including gastric cancer (GC). Although TRIM24 expression is remarkably upregulated during GC carcinogenesis, the molecular mechanisms underlying TRIM24 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fang Z,Zhang L,Liao Q,Wang Y,Yu F,Feng M,Xiang X,Xiong J

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

更新日期：2018-10-16 00:00:00

abstract：:To assess the relationship between serum concentrations of proinflammatory cytokines and prognosis of non small cell lung cancer (NSCLC), we evaluated the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1-beta) and interleukin-6 (IL-6) in 60 patients with untreated advanced NSCLC. Mean ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Vita F,Orditura M,Auriemma A,Infusino S,Catalano G

更新日期：1998-12-01 00:00:00

abstract：:Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and trea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Vecchione A,Gottardo F,Gomella LG,Wildemore B,Fassan Ms,Bragantini E,Pagano F,Baffa R

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Endometriosis is a gynecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Women with endometriosis have an increased risk of different types of malignancies, especially ovarian cancer and non-Hodgkin's lymphoma. Though there are several theorie...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Signorile PG,Baldi F,Bussani R,D'Armiento M,De Falco M,Baldi A

更新日期：2009-04-09 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. METHODS:We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay....

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li N,Guo W,Shi J,Xue J,Hu H,Xie D,Wu M,Cheng S

更新日期：2010-11-27 00:00:00

abstract：BACKGROUND:The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In this study, we investi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jang JE,Eom JI,Jeung HK,Chung H,Kim YR,Kim JS,Cheong JW,Min YH

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Gao J,Ulekleiv CH,Halstensen TS

更新日期：2016-09-26 00:00:00

abstract：:In a family consisting of 48 persons with high predisposition to familial stomach cancer (SCr), SCr was diagnosed in 8 persons (I-2; II-1,3,4; III-1,2,3,4). Moreover, one woman (III-8) had bilateral breast cancer and two (proband: IV-1 and her father's cousin: III-10) chronic gastritis. The proband, her father's cousi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Monakhov AS,Gulyaev AV,Savochkina IV,Hanson KP

更新日期：1997-12-01 00:00:00

abstract：:The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA seq...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Geng X,Li Q,Xu J,Tan Y,Xiao M,Song J,Liu F,Fang C,Wang H

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA). METHODS:mRNAs extracted from 35 pancreatic tubular adenocarcinoma tissues obtained by E...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ashida R,Nakata B,Shigekawa M,Mizuno N,Sawaki A,Hirakawa K,Arakawa T,Yamao K

更新日期：2009-06-16 00:00:00

abstract：BACKGROUND:Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for pat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang B,Wu A,Hu Y,Tao C,Wang JM,Lu Y,Xing R

更新日期：2019-07-01 00:00:00

abstract：:We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

更新日期：2000-09-01 00:00:00

abstract：:Few cases of malignant glucagonomas have been described in the literature. In this paper we present a case of a 77-year-old woman with necrolytic migratory erythema and high plasma glucagon and chromogranin A levels caused by a neuroendocrine tumour. An abdominal CT scan suggested a pancreatic lesion and two liver met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Appetecchia M,Ferretti E,Carducci M,Izzo F,Carpanese L,Marandino F,Terzoli E

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. MATERIALS AND METHODS:qRT-PCR and western blot were conducted to measure relev...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rong Z,Wang Z,Wang X,Qin C,Geng W

更新日期：2020-04-09 00:00:00

abstract：BACKGROUND:Survival of adults with B-Acute Lymphoblastic Leukemia requires accurate risk stratification of patients in order to provide the appropriate therapy. Contemporary techniques, using clinical and cytogenetic variables are incomplete for prognosis prediction. METHODS:To improve the classification of adult pati...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cruz-Rodriguez N,Combita AL,Enciso LJ,Raney LF,Pinzon PL,Lozano OC,Campos AM,Peñaloza N,Solano J,Herrera MV,Zabaleta J,Quijano S

更新日期：2017-02-28 00:00:00

abstract：:Axillary lymphadenectomy is a very important procedure in the staging of breast cancer patients. However, it is associated with a significant morbidity rate. On the other hand, using early diagnosis we can see a high number of cases where the lymph nodes are negatives. With the intention of avoiding unnecessary axilla...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zerwes FP,Frasson AL,Gutfilen B,Barbosa da Fonseca LM

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) is a mediator of tumor progression. However, whether the alterations of the intraperitoneal ECM prior to tumor establishment affects the malignant progression of ovarian cancer remains elusive. METHODS:Apolipoprotein (ApoE) knock-out mice was used to analyze the intraperitoneal EC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

更新日期：2018-02-20 00:00:00