Advances in the diagnosis and management of IgG4 related disease.

Abstract:

:IgG4 related disease was recognized as a unified disease entity only 15 years ago. Awareness of IgG4 related disease has increased worldwide since then, and specialists are now familiar with most of its clinical manifestations. Involvement of the pancreato-biliary tract, retroperitoneum/aorta, head and neck, and salivary glands are the most frequently observed disease phenotypes, differing in epidemiological features, serological findings, and prognostic outcomes. In view of this multifaceted presentation, IgG4 related disease represents a great mimicker of many neoplastic, inflammatory, and infectious conditions. Histopathology remains key to diagnosis because reliable biomarkers are lacking. Recently released classification criteria will be invaluable in improving early recognition of the disease. IgG4 related disease is highly treatable and responds promptly to glucocorticoids, but it can lead to end stage organ failure and even death if unrecognized. Prolonged courses of corticosteroids are often needed to maintain remission because the disease relapses in most patients. Rapid advancement in our understanding of the pathophysiology of IgG4 related disease is leading to the identification of novel therapeutic targets and possible personalized approaches to treatment.

journal_name

BMJ

authors

Lanzillotta M,Mancuso G,Della-Torre E

doi

10.1136/bmj.m1067

subject

Has Abstract

pub_date

2020-06-16 00:00:00

pages

m1067

eissn

0959-8138

issn

1756-1833

journal_volume

369

pub_type

杂志文章,评审
  • Screening children from overseas for infections: is it justified?

    abstract:OBJECTIVES:To investigate current practice of screening children from abroad for infections after coming to the United Kingdom, and to make recommendations for future practice. DESIGN:A review of literature and a questionnaire sent to all health authorities and boards in the United Kingdom. SETTING:All health authori...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.301.6755.800

    authors: Shabde N,Waterston T

    更新日期:1990-10-06 00:00:00

  • Seventeen years' experience of a voluntarily based drug rationalisation programme in hospital.

    abstract::A study was carried out analysing the operation of a drug rationalisation programme in a central London teaching district that had evolved from experience over 17 years. Creation of a limited list of about 700 drugs had been achieved by local consensus. Drug selection was based on appraisal of efficacy, safety, and co...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.297.6646.465

    authors: Baker JA,Lant AF,Sutters CA

    更新日期:1988-08-13 00:00:00

  • Combined resynchronisation and implantable defibrillator therapy in left ventricular dysfunction: Bayesian network meta-analysis of randomised controlled trials.

    abstract:OBJECTIVE:To review the evidence base from randomised controlled trials of combined cardiac resynchronisation therapy and implantable cardioverter defibrillator therapy in left ventricular impairment and symptomatic heart failure. DESIGN:Bayesian network meta-analysis. DATA SOURCES:Medline, Embase, and Cochrane datab...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.39343.511389.BE

    authors: Lam SK,Owen A

    更新日期:2007-11-03 00:00:00

  • Melting the Iron Curtain: opportunities for public health collaboration through international joint ventures.

    abstract::The opportunities for international public health collaboration through joint business ventures between the USSR and Western nations, an arrangement that would benefit the public, industry, and the medical community, are discussed. Evidence indicates that the state of health of the Soviet population is declining rapi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.302.6777.633

    authors: Gellert GA,Kaznady SI

    更新日期:1991-03-16 00:00:00

  • Cost effectiveness of lowering cholesterol concentration with statins in patients with and without pre-existing coronary heart disease: life table method applied to health authority population.

    abstract:OBJECTIVES:To estimate the cost effectiveness of statins in lowering serum cholesterol concentration in people at varying risk of fatal cardiovascular disease and to explore the implications of changing the criteria for intervention on cost and cost effectiveness for a purchasing authority. DESIGN:A life table method ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7044.1443

    authors: Pharoah PD,Hollingworth W

    更新日期:1996-06-08 00:00:00

  • The SSSPIN study-spin in studies of spin: meta-research analysis.

    abstract:OBJECTIVES:To identify and calculate the prevalence of spin in studies of spin. DESIGN:Meta-research analysis (research on research). SETTING:35 studies of spin in the scientific literature. MAIN OUTCOME MEASURES:Spin, categorised as: reporting practices that distort the presentation and interpretation of results, c...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.l6202

    authors: Bero L,Chiu K,Grundy Q

    更新日期:2019-12-18 00:00:00

  • Distribution of NHS funds between fundholding and non-fundholding practices.

    abstract:OBJECTIVES:To estimate the amount spent on specific hospital care by health agencies in 1993-4 and compare it with the resources allocated to patients registered with fundholding practices for the same type of care. To investigate whether fundholding practices and health agencies pay different amounts for inpatient car...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.309.6946.30

    authors: Dixon J,Dinwoodie M,Hodson D,Dodd S,Poltorak T,Garrett C,Rice P,Doncaster I,Williams M

    更新日期:1994-07-02 00:00:00

  • Subacromial decompression surgery for adults with shoulder pain: a clinical practice guideline.

    abstract:CLINICAL QUESTION:Do adults with atraumatic shoulder pain for more than 3 months diagnosed as subacromial pain syndrome (SAPS), also labelled as rotator cuff disease, benefit from subacromial decompression surgery? This guideline builds on to two recent high quality trials of shoulder surgery. CURRENT PRACTICE:SAPS is...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.l294

    authors: Vandvik PO,Lähdeoja T,Ardern C,Buchbinder R,Moro J,Brox JI,Burgers J,Hao Q,Karjalainen T,van den Bekerom M,Noorduyn J,Lytvyn L,Siemieniuk RAC,Albin A,Shunjie SC,Fisch F,Proulx L,Guyatt G,Agoritsas T,Poolman RW

    更新日期:2019-02-06 00:00:00

  • Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis.

    abstract:OBJECTIVE:To compare the prevalence of antibody to and proviral DNA of the retrovirus HTLV-I in relatives of 11 British patients with tropical spastic paraparesis who had migrated from Jamaica before they developed symptoms, and to examine factors possibly related to transmission of HTLV-I. DESIGN:Migrant, family stud...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.300.6720.300

    authors: Cruickshank JK,Richardson JH,Morgan OS,Porter J,Klenerman P,Knight J,Newell AL,Rudge P,Dalgleish AG

    更新日期:1990-02-03 00:00:00

  • Congenital anomaly surveillance in England--ascertainment deficiencies in the national system.

    abstract:OBJECTIVE:Firstly, to assess the completeness of ascertainment in the National Congenital Anomaly System (NCAS), the basis for congenital anomaly surveillance in England and Wales, and its variation by defect, geographical area, and socioeconomic deprivation. Secondly, to assess the impact of the lack of data on pregna...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.38300.665301.3A

    authors: Boyd PA,Armstrong B,Dolk H,Botting B,Pattenden S,Abramsky L,Rankin J,Vrijheid M,Wellesley D

    更新日期:2005-01-01 00:00:00

  • Personalia and the current health crisis.

    abstract::Recent changes in the Russian government introduced by Boris Yeltsin include the appointment of Eduard Nechaev as health minister at the beginning of this year. The appointment received little publicity in the West, although his predecessor was sacked after only one year for failing to make any effort to improve healt...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.306.6882.909

    authors: Ryan M

    更新日期:1993-04-03 00:00:00

  • Differences in mortality after fracture of hip: the east Anglian audit.

    abstract:OBJECTIVE:To investigate differences between hospitals in clinical management of patients admitted with fractured hip and to relate these to mortality at 90 days. DESIGN:A prospective audit of process and outcome of care based on interviews with patients, abstraction from records with standard proforma, and follow up ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.310.6984.904

    authors: Todd CJ,Freeman CJ,Camilleri-Ferrante C,Palmer CR,Hyder A,Laxton CE,Parker MJ,Payne BV,Rushton N

    更新日期:1995-04-08 00:00:00

  • Consumers' estimation of calorie content at fast food restaurants: cross sectional observational study.

    abstract:OBJECTIVE:To investigate estimation of calorie (energy) content of meals from fast food restaurants in adults, adolescents, and school age children. DESIGN:Cross sectional study of repeated visits to fast food restaurant chains. SETTING:89 fast food restaurants in four cities in New England, United States: McDonald's...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.f2907

    authors: Block JP,Condon SK,Kleinman K,Mullen J,Linakis S,Rifas-Shiman S,Gillman MW

    更新日期:2013-05-23 00:00:00

  • Intravenous tissue plasminogen activator and size of infarct, left ventricular function, and survival in acute myocardial infarction.

    abstract:STUDY OBJECTIVE:To assess effect of intravenous recombinant tissue type plasminogen activator on size of infarct, left ventricular function, and survival in acute myocardial infarction. DESIGN:Double blind, randomised, placebo controlled prospective trial of patients with acute myocardial infarction within five hours ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.297.6660.1374

    authors: Van de Werf F,Arnold AE

    更新日期:1988-11-26 00:00:00

  • Outcomes of elective surgery undertaken in independent sector treatment centres and NHS providers in England: audit of patient outcomes in surgery.

    abstract:OBJECTIVE:To compare characteristics of patients and outcomes after elective surgery in independent sector treatment centres (ISTCs) and NHS providers. DESIGN:Follow-up study with outcomes reported by patients three to six months after surgery. SETTING:25 ISTCs and 72 NHS providers in England. Population Consecutive ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.d6404

    authors: Chard J,Kuczawski M,Black N,van der Meulen J,POiS Audit Steering Committee.

    更新日期:2011-10-19 00:00:00

  • Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome.

    abstract::Monocycline is the most widely prescribed systemic antibiotic for acne largely because it needs to be given only once or twice a day and seems not to induce resistance. Up to April 1994 11 cases of minocycline induced systemic lupus erythematosus and 16 cases of hepatitis had been reported to the Committee on Safety o...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.312.7024.169

    authors: Gough A,Chapman S,Wagstaff K,Emery P,Elias E

    更新日期:1996-01-20 00:00:00

  • Long term trends in prevalence of neural tube defects in Europe: population based study.

    abstract:STUDY QUESTION:What are the long term trends in the total (live births, fetal deaths, and terminations of pregnancy for fetal anomaly) and live birth prevalence of neural tube defects (NTD) in Europe, where many countries have issued recommendations for folic acid supplementation but a policy for mandatory folic acid f...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.h5949

    authors: Khoshnood B,Loane M,de Walle H,Arriola L,Addor MC,Barisic I,Beres J,Bianchi F,Dias C,Draper E,Garne E,Gatt M,Haeusler M,Klungsoyr K,Latos-Bielenska A,Lynch C,McDonnell B,Nelen V,Neville AJ,O'Mahony MT,Queisser-Luf

    更新日期:2015-11-24 00:00:00

  • Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies.

    abstract:OBJECTIVE:To determine outcomes at age 3 years in babies born before 27 completed weeks' gestation in 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks' gestation. DESIGN:Prospective national cohort studies, EPICure and EPICure 2. SETTING:Hospital and home based evaluations, ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e7961

    authors: Moore T,Hennessy EM,Myles J,Johnson SJ,Draper ES,Costeloe KL,Marlow N

    更新日期:2012-12-04 00:00:00

  • Industry funding of patient and health consumer organisations: systematic review with meta-analysis.

    abstract:OBJECTIVE:To investigate pharmaceutical or medical device industry funding of patient groups. DESIGN:Systematic review with meta-analysis. DATA SOURCES:Ovid Medline, Embase, Web of Science, Scopus, and Google Scholar from inception to January 2018; reference lists of eligible studies and experts in the field. ELIGIB...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析

    doi:10.1136/bmj.l6925

    authors: Fabbri A,Parker L,Colombo C,Mosconi P,Barbara G,Frattaruolo MP,Lau E,Kroeger CM,Lunny C,Salzwedel DM,Mintzes B

    更新日期:2020-01-22 00:00:00

  • Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis.

    abstract:OBJECTIVE:To compare the effectiveness of beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy in the treatment of patients with fever and neutropenia. DATA SOURCES:Medline, Embase, Lilacs, the Cochrane Library, and conference proceedings to 2002. References of included studies and contact wit...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bmj.326.7399.1111

    authors: Paul M,Soares-Weiser K,Leibovici L

    更新日期:2003-05-24 00:00:00

  • Progression of HIV disease in a haemophilic cohort followed for 11 years and the effect of treatment.

    abstract:OBJECTIVE:To describe the progression of HIV disease in a haemophilic cohort and to show the influence of treatment. DESIGN:11 year longitudinal clinical and laboratory study. SETTING:A haemophilia centre. PATIENTS:111 patients infected with HIV during October 1979 to July 1985. MAIN OUTCOME MEASURES:Symptoms of HI...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章

    doi:10.1136/bmj.303.6810.1093

    authors: Lee CA,Phillips AN,Elford J,Janossy G,Griffiths P,Kernoff P

    更新日期:1991-11-02 00:00:00

  • Comparison of elderly people's technique in using two dry powder inhalers to deliver zanamivir: randomised controlled trial.

    abstract:OBJECTIVE:To determine whether elderly people can learn to use the inhaler used to deliver zanamivir (Relenza Diskhaler) as effectively as the Turbohaler and to identify which aspects of inhaler technique are most problematic. DESIGN:Randomised, controlled, intervention study. SETTING:Wards for acute elderly care in ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bmj.322.7286.577

    authors: Diggory P,Fernandez C,Humphrey A,Jones V,Murphy M

    更新日期:2001-03-10 00:00:00

  • Twins and maternal smoking: ordeals for the fetal origins hypothesis? A cohort study.

    abstract:OBJECTIVE:To assess the direct and indirect effects of being a twin, maternal smoking, birth weight, and mother's height on blood pressure at ages 9 and 18 years. DESIGN:Longitudinal study. SUBJECTS:Cohort born in 1972-3. SETTING:Dunedin, New Zealand. MAIN OUTCOME MEASURE:Blood pressure at ages 9 and 18 years. RES...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.318.7188.897

    authors: Williams S,Poulton R

    更新日期:1999-04-03 00:00:00

  • The impact on general practitioners of the changing balance of care for elderly people living in institutions.

    abstract:OBJECTIVES:To describe utilisation of general practitioners by elderly people resident in communal establishments; to examine variations in general practitioner utilisation and estimate the likely impact of the "downsizing" of long stay provision in NHS hospitals. DESIGN:Secondary analyses of the survey of disability ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.317.7154.322

    authors: Kavanagh S,Knapp M

    更新日期:1998-08-01 00:00:00

  • Why Rudolph's nose is red: observational study.

    abstract:OBJECTIVE:To characterise the functional morphology of the nasal microcirculation in humans in comparison with reindeer as a means of testing the hypothesis that the luminous red nose of Rudolph, one of the most well known reindeer pulling Santa Claus's sleigh, is due to the presence of a highly dense and rich nasal mi...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.e8311

    authors: Ince C,van Kuijen AM,Milstein DM,Yürük K,Folkow LP,Fokkens WJ,Blix AS

    更新日期:2012-12-14 00:00:00

  • The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses.

    abstract:OBJECTIVES:To evaluate current processes by which young children presenting with a febrile illness but suspected of having serious bacterial infection are diagnosed and treated, and to develop and test a multivariable model to distinguish serious bacterial infections from self limiting non-bacterial illnesses. Design T...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.c1594

    authors: Craig JC,Williams GJ,Jones M,Codarini M,Macaskill P,Hayen A,Irwig L,Fitzgerald DA,Isaacs D,McCaskill M

    更新日期:2010-04-20 00:00:00

  • Use of magnetic resonance angiography to select candidates with recently symptomatic carotid stenosis for surgery: systematic review.

    abstract:OBJECTIVE:To determine if sufficient evidence exists to support the use of magnetic resonance angiography as a means of selecting patients with recently symptomatic high grade carotid stenosis for surgery. DESIGN:Systematic review of published research on the diagnostic performance of magnetic resonance angiography, 1...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,评审

    doi:10.1136/bmj.324.7331.198

    authors: Westwood ME,Kelly S,Berry E,Bamford JM,Gough MJ,Airey CM,Meaney JF,Davies LM,Cullingworth J,Smith MA

    更新日期:2002-01-26 00:00:00

  • Pity the poor gatekeeper: a transatlantic perspective on cost containment in clinical practice.

    abstract::This paper summarizes the key findings of a U.S. study of 48 primary care physicians acting as gatekeepers in a large health maintenance organization to determine the effects of their cost containment role on the doctor patient relationship. Taylor highlights some of the findings and conclusions that he believes are ...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章

    doi:10.1136/bmj.299.6711.1323

    authors: Taylor TR

    更新日期:1989-11-25 00:00:00

  • Cardiac rehabilitation for heart failure can improve quality of life and fitness.

    abstract::The studyTaylor RS, Walker S, Ciani O, et al. Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis. Health Technol Assess 2019;23:1-98.This project was funded by the NIHR Health Technology Assessment Programme (project number 15/80/30).To read the...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 评论,杂志文章

    doi:10.1136/bmj.l5456

    authors: Cook R,Davidson P,Martin R,NIHR Dissemination Centre.

    更新日期:2019-10-01 00:00:00

  • HIV prevention in Mexican schools: prospective randomised evaluation of intervention.

    abstract:OBJECTIVE:To assess effects on condom use and other sexual behaviour of an HIV prevention programme at school that promotes the use of condoms with and without emergency contraception. DESIGN:Cluster randomised controlled trial. SETTING:40 public high schools in the state of Morelos, Mexico. PARTICIPANTS:10 954 firs...

    journal_title:BMJ (Clinical research ed.)

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bmj.38796.457407.80

    authors: Walker D,Gutierrez JP,Torres P,Bertozzi SM

    更新日期:2006-05-20 00:00:00