Abstract:
PURPOSE:To present an open-source software (https://github.com/CHUSRadOncPhys/FluoMV) for monitoring intrafraction motion that is based on the visualization of superimposed contours of projected region-of-interests from DICOM RTSTRUCT files on cine-MV images acquired and displayed in real-time during radiation therapy delivery. Clinical use with prostate gold fiducial markers is presented. METHODS:Projections of regions of interest (ROI) in the reference frame of the electronic portal imaging device are computed offline for different gantry angles before the first treatment fraction. During treatment delivery, the contrast of portal images is automatically adjusted using a histogram equalization algorithm. The projections associated with the current gantry angle are then superimposed on the images in real time. This allows the therapist to evaluate if the imaged structures of interest remain within their respective contours during treatment delivery and to potentially interrupt the treatment if deemed necessary. The spatial accuracy of the method was evaluated by imaging a ball bearing phantom in a set-up where the position of the projected ROI is highly sensitive to gantry angle errors. The visibility of fiducial markers during one fraction of seven different volumetric modulated arc therapy (VMAT) prostate treatments is characterized. RESULTS:The geometric validation showed a negligible systematic error μ < 0.1 mm for the position of the projections. The random errors associated with the time accuracy of the gantry angle readout were characterized by standard deviations σ ≤ 0.6 mm. The VMAT clinical treatments showed that the fiducial markers were frequently visible, allowing for a meaningful clinical use. CONCLUSIONS:The results demonstrate that the method presented is sufficiently accurate to be used for intrafraction monitoring of patients. The fact that this method could be implemented on many modern linacs at little to no cost and with no additional dose delivered to the patients makes this solution very attractive for improving patient care and safety in radiation therapy.
journal_name
J Appl Clin Med Physjournal_title
Journal of applied clinical medical physicsauthors
Lessard R,Tremblay NM,Plourde MÉ,Guillot Mdoi
10.1002/acm2.12940subject
Has Abstractpub_date
2020-08-01 00:00:00pages
173-182issue
8issn
1526-9914journal_volume
21pub_type
杂志文章abstract::This paper aims to evaluate the impact of spectral filtration on image quality in a microcomputed tomography (micro-CT) system. A mouse phantom comprising 11rods for modeling lung, muscle, adipose, and bones was scanned with 17 s and 2min, respectively. The current (μA) for each scan was adjusted to achieve identical ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v17i1.5714
更新日期:2016-01-08 00:00:00
abstract::Studies have shown that source dwells within Varian's HDR CT/MR compatible ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to: 1) determine the reproducibility of the offset, 2) study the interobserv...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v12i4.3447
更新日期:2011-11-15 00:00:00
abstract::Wireless capsule endoscopy (WCE) is an effective technology that can be used to make a gastrointestinal (GI) tract diagnosis of various lesions and abnormalities. Due to a long time required to pass through the GI tract, the resulting WCE data stream contains a large number of frames which leads to a tedious job for c...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12662
更新日期:2019-08-01 00:00:00
abstract::It is important to improve the magnitude of dose variation that is caused by the interplay effect. The aim of this study was to investigate the impact of the number of breaths (NBs) to the dose variation for VMAT-SBRT to lung cancer. Data on respiratory motion and multileaf collimator (MLC) sequence were collected fro...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12264
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to describe our experience with 1.0T MR-SIM including characterization, quality assurance (QA) program, and features necessary for treatment planning. Staffing, safety, and patient screening procedures were developed. Utilization of an external laser positioning system (ELPS) and MR-compa...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v16i2.5201
更新日期:2015-03-08 00:00:00
abstract::Physical and dosimetric characteristics of HDMLC were studied for SRS6, 6, and 10 MV X-rays from Novalis Tx. This in-built tertiary collimator consists of 60 pairs (32 × 0.25 cm; 26 × 0.5 cm and 2 × 0.7 cm) of leaves. Properties of HDMLC studied included alignment, readout and radiation field congruence, radiation pen...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v12i3.3475
更新日期:2011-04-14 00:00:00
abstract::In radiation therapy, a secondary independent dose verification is an important component of a quality control system. Mobius3D calculates three-dimensional (3D) patient dose using reference beam data and a collapsed cone convolution algorithm and analyzes dose-volume histogram automatically. There are currently no pu...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12572
更新日期:2019-05-01 00:00:00
abstract::A low-energy (50 kV) X-ray tube used for the stereotactic irradiation of intracranial lesions has been in use since 1999. The unit is calibrated prior to every procedure and during periodic quality assurance (QA) tests. The unit uses an internal and an external scintillation detector to monitor dose as well as a conve...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v7i3.2238
更新日期:2006-08-24 00:00:00
abstract:PURPOSE:The purpose of this study was to optimize intra-voxel incoherent motion (IVIM) measurement in diffusion-weighted imaging (DWI) of breast cancer by separating perfusion and diffusion effects through the determination of an optimal threshold b-value, thus benign and cancerous breast tissues can be accurately diff...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12065
更新日期:2017-05-01 00:00:00
abstract::Radiochromic film has become an important tool to verify dose distributions in highly conformal radiation therapy such as IMRT. Recently, a new generation of these films, EBT3, has become available. EBT3 has the same composition and thickness of the sensitive layer of the previous EBT2 films, but its symmetric layer c...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v14i2.4111
更新日期:2013-03-04 00:00:00
abstract::We have developed a treatment planning protocol for intensity-modulated radiation therapy of the prostate using commercially available inverse planning software. Treatment plans were developed for ten patients using the Corvus version 3.8 planning system, testing various prescription options, including tissue types, d...
journal_title:Journal of applied clinical medical physics
pub_type: 临床试验,杂志文章
doi:10.1120/jacmp.v2i2.2614
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To investigate the effect of the marker placement on the correlation relationship between the motions of external markers and the internal target under different breathing patterns for several lung cancer patients. METHOD AND MATERIAL:To monitor and record simultaneous motions of internal target and associated...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v9i2.2758
更新日期:2008-04-16 00:00:00
abstract::We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissioning process for a 6X photon energy modeled using the analytical a...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v17i1.5452
更新日期:2016-01-08 00:00:00
abstract::In this study, we compared the amount of lung tissue irradiated when respiratory gating was imposed during expiration with the amount of lung tissue irradiated when gating was imposed during inspiration. Our hypothesis was that the amount of lung tissue spared increased as inspiration increased. Computed tomography (C...
journal_title:Journal of applied clinical medical physics
pub_type: 临床试验,杂志文章
doi:10.1120/jacmp.26.146
更新日期:2004-01-01 00:00:00
abstract::Substantial disagreement exists over appropriate PET segmentation techniques for non-small cell lung cancer. Currently, no segmentation algorithm explicitly considers tumor motion in determining tumor borders. We developed an automatic PET segmentation model as a function of target volume, motion extent, and source-to...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v15i1.4600
更新日期:2014-01-06 00:00:00
abstract::Four-dimensional computerized tomography (4DCT) is required for stereotactic ablative body radiotherapy (SABR) of mobile targets to account for tumor motion during treatment planning and delivery. In this study, we report on the impact of an image review quality assurance process performed prior to treatment planning ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12825
更新日期:2020-03-01 00:00:00
abstract::The purpose of this study is to find the uncertainties in the reconstruction of MR compatible ring-tandem intracavitary applicators of high-dose rate image-based brachytherapy treatment planning using rigid registration of 3D MR and CT image fusion. Tandem and ring reconstruction in MR image based brachytherapy planni...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v15i2.4206
更新日期:2014-03-06 00:00:00
abstract::The purpose of this study was to develop and evaluate a noninvasive method to assess rotation time in modern commercial computed tomography (CT) systems. The rotation time was measured at a selected nominal rotation time (400 ms) utilizing two types of solid-state detectors: the RTI's CT Dose Profiler (CTDP) and Unfor...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v15i1.4517
更新日期:2014-01-06 00:00:00
abstract:PURPOSE:The objective of this study was to evaluate the impact of the magnetic field regulation in conjunction with the volumetric repainting technique on the spot positions and range in pencil beam scanning proton therapy. METHODS:"Field regulation" - a feature to reduce the switching time between layers by applying ...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.13045
更新日期:2020-10-15 00:00:00
abstract::Atlas-based autosegmentation is an established tool for segmenting structures for CT-planned head and neck radiotherapy. MRI is being increasingly integrated into the planning process. The aim of this study is to assess the feasibility of MRI-based, atlas-based autosegmentation for organs at risk (OAR) and lymph node ...
journal_title:Journal of applied clinical medical physics
pub_type: 临床试验,杂志文章
doi:10.1120/jacmp.v17i4.6051
更新日期:2016-07-08 00:00:00
abstract::As proton therapy becomes increasingly popular, so does the need for Monte Carlo simulation studies involving accurate beam line modeling of proton treatment units. In this study, the 24 beam configurations of the Mevion S250 proton therapy system installed recently at our institution were modeled using the TOolkit fo...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12077
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:The aim of the current study was to evaluate the backscatter dose and energy spectrum from the Lipiodol with flattening filter (FF) and flattening filter-free (FFF) beams. Moreover, the backscatter range, that was defined as the backscatter distance (BD) are revealed. METHODS:6 MVX FF and FFF beams were delive...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12560
更新日期:2019-06-01 00:00:00
abstract::We investigate the role of adaptive radiation therapy in pediatric patients with diffuse pontine glioma and the impact of steroid-related weight gain on treatment parameters utilizing cone-beam CT. Fifteen patients with diffuse pontine glioma were treated with three-dimensional conformal radiation therapy and enrolled...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:
更新日期:2011-01-30 00:00:00
abstract::An inverse treatment planning (ITP) module on a commercial treatment planning system (TPS) (Helax AB, Uppsala, Sweden) is being used for an in-house clinical trial for treatment of nasopharyngeal cancer with contralateral parotid sparing. Intensity modulated radiation therapy (IMRT) fields are delivered by step and sh...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v3i2.2580
更新日期:2002-04-01 00:00:00
abstract::Intra-fraction organ motion during the dynamic delivery of IMRT treatment of lung tumors may cause unexpected hot/cold spots even within the target volume, due to the interplay effect between tumor motion and multi-leaf collimator (MLC) leaf motion. In the past, this has been investigated through theoretical analysis,...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v7i4.2222
更新日期:2006-11-28 00:00:00
abstract:PURPOSE:This study evaluates the feasibility of lung dose prediction based on target contour and patient anatomy for breast patients treated with proton therapy. METHODS:Fifty-two randomly selected patients were included in the cohort, who were treated to 50.4-66.4 Gy(RBE) to the left (36), right (15), or bilateral (1...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章,随机对照试验
doi:10.1002/acm2.12436
更新日期:2018-11-01 00:00:00
abstract::Recently, specific computed tomography (CT) scanners have been equipped with organ-based tube current modulation (TCM) technology. It is possible that organ-based TCM will replace the conventional dose-reduction technique of reducing the effective milliampere-second. The aim of this study was to determine if organ-bas...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v13i2.3731
更新日期:2012-03-08 00:00:00
abstract::In this work, the feasibility of using flattening filter free (FFF) beams in volumetric modulated arc therapy (VMAT) total body irradiation (TBI) treatment planning to decrease protracted beam-on times for these treatments was investigated. In addition, a methodology was developed to generate standardized VMAT TBI tre...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1002/acm2.12827
更新日期:2020-03-01 00:00:00
abstract::The purpose of this study was to investigate amplitude gating combined with a coached breathing strategy for 10 MV flattening filter-free (FFF) volumetric-modulated arc therapy (VMAT) on the Varian TrueBeam linac. Ten patient plans for VMAT SABR liver were created using the Eclipse treatment planning system (TPS). The...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v16i4.5350
更新日期:2015-07-08 00:00:00
abstract::Many head-and-neck cancer (HNC) patients treated with radiotherapy suffer significant anatomical changes due to tumor shrinkage or weight loss. The purpose of this study was to assess dose changes over target volumes and organs at risk during intensity-modulated radiotherapy for HNC patients. Sixteen HNC IMRT patients...
journal_title:Journal of applied clinical medical physics
pub_type: 杂志文章
doi:10.1120/jacmp.v13i6.3723
更新日期:2012-11-08 00:00:00