Abstract:
Background:PTSD is a chronic condition with high rates of comorbidity, but current treatment options are limited and not always effective. One novel approach is MDMA-assisted psychotherapy for people diagnosed with treatment-resistant PTSD, where MDMA is used as a catalyst to facilitate trauma processing during psychotherapy. The aim was to review all current research into MDMA-assisted psychotherapy for PTSD. Methods:Articles were identified through PubMed and Science Direct for items published up to 31st March 2019 using terms "treatments for PTSD", "drug treatments for PTSD", "MDMA", "MDMA pathway", "MDMA-assisted psychotherapy" and "MDMA-assisted psychotherapy for PTSD". Articles were identified through Google Scholar and subject-specific websites. Articles and relevant references cited in those articles were reviewed. Results:Small-scale studies have shown reduced psychological trauma, however there has been widespread misunderstanding of the aims and implications of this work, most commonly the notion that MDMA is a 'treatment for PTSD', which to date has not been researched. This has harmful consequences, namely dangerous media reporting and impeding research progression in an already controversial field. Conclusions:MDMA-assisted psychotherapy may help people who have experienced psychological trauma and who have not been able to resolve their problems through existing treatments, however more research is needed. If this is to get appropriate research attention, we must report this accurately and objectively.
journal_name
Ann Gen Psychiatryjournal_title
Annals of general psychiatryauthors
Morgan Ldoi
10.1186/s12991-020-00283-6subject
Has Abstractpub_date
2020-05-12 00:00:00pages
33issn
1744-859Xpii
283journal_volume
19pub_type
杂志文章,评审abstract:Background:Depression is highly underdiagnosed in primary care settings in Latvia. Screening for depression in primary care is potentially an efficient way to find undetected case s and improve diagnostics. We aimed to validate both a nine-item and two-item Patient Health Questionnaire (PHQ-9 and PHQ-2) in the Latvian ...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0203-5
更新日期:2018-08-02 00:00:00
abstract::Dromokaition Psychiatric Hospital opened its doors in 1887, following the donation made by Zorzis Dromokaitis from the island of Chios. Private donations and all forms of charities had contributed to a large extent in the establishment of hospitals across Greece, during the late 19th and the early 20th century. Dromok...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-015-0047-1
更新日期:2015-02-15 00:00:00
abstract:BACKGROUND:Conflicting evidence exists about the relationship between psychotic symptoms and suicidality in mood disorders. We aimed to investigate the lifetime suicidality and its relationship with dimensions of the psychotic spectrum over the lifespan among subjects with bipolar I (BD I) or major depressive disorder ...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-016-0101-7
更新日期:2016-06-21 00:00:00
abstract:BACKGROUND:The revised NEO Personality Inventory (NEO-PI-3) includes 240 items corresponding to the Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience) and subordinate dimensions (facets). It is suitable for use with adolescents and adults (12 years or o...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-014-0036-9
更新日期:2014-12-05 00:00:00
abstract::BACKGROUND: Evaluation of the referral, admission, treatment, and outcome of overseas patients admitted to a psychiatric hospital in central London. Ethical, legal and economic implications, and the involvement of consulates in the admission process, are discussed. METHOD: Assessment and review of overseas patients ad...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-4-4
更新日期:2005-02-14 00:00:00
abstract:BACKGROUND:Although behavioural dominance of the right hand in humans is likely to be under genetic control, departures from this population norm, i.e. left- or non-right-handedness, are believed to be influenced by environmental factors. Among many such environmental factors including, for example, low birth weight, t...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-7-2
更新日期:2008-01-30 00:00:00
abstract:OBJECTIVE:Treating tic disorder is challenging. No trial has ever examined whether twice weekly aripiprazole is effective for treating tic disorders. METHODS:Participants of this 8-week randomized controlled parallel-group clinical trial were a clinical sample of 36 children and adolescents with tic disorder. Yale glo...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-016-0112-4
更新日期:2016-08-30 00:00:00
abstract:Background:Major depressive disorder (MDD) is a recurrent illness with high rates of chronicity, treatment-resistance, and significant economic impact. S-Adenosylmethionine (SAMe), a molecule that is formed naturally in the human body, has shown antidepressant effects and may expand the available options for treating M...
journal_title:Annals of general psychiatry
pub_type: 杂志文章,评审
doi:10.1186/s12991-020-00298-z
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:Despite substantial research on the comorbidity of anxiety disorders including posttraumatic stress disorder (PTSD) and chronic pain, little is known about the mechanisms underlying these conditions that might be potentially similar. Evoked pain sensitivity is one factor that has been associated with several...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-014-0031-1
更新日期:2014-11-18 00:00:00
abstract:Background:Burden of caregivers of people with mental illness (PWMI) is considered to be a negative impact of the care provided by the family to the patient. However, little is known about the extent of the burden among caregivers of PWMI in Ethiopia. The aim of this study, therefore, is to assess the magnitude and ass...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-019-0233-7
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:The objective of this study was to assess sentinel event analysis and relative factors in different mental healthcare settings. In addition, the occurrence of sentinel events in different hospital settings was compared and potential risk factors contributing to sentinel events identified. METHODS:A total of...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-11-4
更新日期:2012-02-16 00:00:00
abstract:BACKGROUND:Despite marked costs and limited evidence regarding effectiveness, occupational therapy (OT) is widely applied in psychiatric settings and financed by health insurance companies in European countries. This pilot study investigated the antidepressive effects of adjuvant OT for patients with major depression i...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-016-0124-0
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:The Emotional Contagion Scale (ECS) is a self-report scale used to measure individual differences in susceptibility to converge towards the emotions expressed by others. The main aim of the present paper was to examine the psychometric properties of the Greek translation of the scale. METHODS:The Greek ECS ...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-7-14
更新日期:2008-08-21 00:00:00
abstract:Aim:This study aimed to detect if there were differences in compassion fatigue (CF) among nurses based on substance use and demographic variables of gender, marital status, type of health institution and income. Background:Compassion fatigue is considered an outcome of poorly handled stressful situations in which nurs...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0183-5
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:Several lines of evidence suggest that dysfunction of the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) contributes to the pathophysiology of pervasive developmental disorders (PDD). The purpose of this study was to investigate neuropsychological dysfunctions in both the DLPFC and OFC...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-12-31
更新日期:2013-10-08 00:00:00
abstract:Background:Positive psychology indicators like well-being and life satisfaction may play a pivotal role in pain-related outcomes. In this study, we aimed to examine the prospective associations of positive well-being and life satisfaction with pain severity. Methods and Subjects:This longitudinal study, with a follow-...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-019-0231-9
更新日期:2019-05-31 00:00:00
abstract:BACKGROUND:We investigated the association between serum proBDNF, a precursor of brain-derived neurotrophic factor (BDNF), and response to fluvoxamine in patients with major depressive disorder (MDD) using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR): physically h...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-13-19
更新日期:2014-07-09 00:00:00
abstract:Background:Treatment-resistant depression (TRD) may represent a substantial proportion of major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely assessed. Methods:Data were obtained from Optum Clinformatics™ Extended, a US claims database. Date of the first antidepressant (AD) dis...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-019-0248-0
更新日期:2019-09-30 00:00:00
abstract:Background:Despite the availability of effective antidepressants, about half of patients with major depressive disorder (MDD) display an inadequate response to their initial treatment. A large patient survey recently reported that 29.8% of MDD patients experiencing an inadequate treatment response felt frustrated about...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0189-z
更新日期:2018-05-11 00:00:00
abstract:BACKGROUND:The objective of this research was to examine treatment patterns and health-care costs associated with second-step pharmacotherapy in patients with major depressive disorder (MDD) who initiated monotherapy with a selective serotonin reuptake inhibitor (SSRI) in 2010. METHODS:This claims database study analy...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-13-8
更新日期:2014-03-19 00:00:00
abstract:Background:This study aimed to explore the resting-state fMRI changes in Chinese boys with low functioning autism spectrum disorder (LFASD) and the correlation with clinical symptoms. Methods:The current study acquired resting-state fMRI data from 15 Chinese boys with LFASD and 15 typically developing (TD) boys to exa...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0217-z
更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:The 'double-diamond copy' task is a simple paper and pencil test part of the Bender-Gestalt Test and the Mini Mental State Examination (MMSE). Although it is a widely used test, its method of scoring is crude and its psychometric properties are not adequately known. The aim of the present study was to develo...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-10-13
更新日期:2011-04-11 00:00:00
abstract:Background:Emergency Department (ED) visits for suicide attempts have been described worldwide; however, the populations studied were predominantly Western European, North American, or East Asian. This study aims to describe the epidemiology of ED patients presenting post-suicide attempt to an academic medical center i...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0191-5
更新日期:2018-05-25 00:00:00
abstract:Background:Over-standard methadone doses are generally needed in the treatment of heroin use disorder (HUD) patients that display concomitant high-severity psychopathological symptomatology. A flexible dosing regimen may lead to higher retention rates in dual disorder (DD), as we demonstrated in bipolar 1 HUD patients,...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-018-0185-3
更新日期:2018-04-18 00:00:00
abstract:INTRODUCTION:The World Health Organization (WHO) clearly states the importance of psychological well-being in the definition of health as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity". However, in the community, the lives of people with bipolar disorders...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-017-0152-4
更新日期:2017-07-11 00:00:00
abstract:Background:The challenges faced by professionals when working in the field of psychiatry require the development of adequate defensive and coping mechanisms. This study aimed to explore both coping strategies and defense mechanisms and their relationship in psychiatry trainees in Romania. Methods:A cross-sectional stu...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-020-00307-1
更新日期:2020-09-27 00:00:00
abstract:BACKGROUND:The relationship between violence and neurocognitive function in schizophrenia is unclear. We examined the backgrounds and neurocognitive functions of violent and nonviolent patients with schizophrenia to identify factors associated with serious violence. METHODS:Thirty male patients with schizophrenia who ...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-015-0086-7
更新日期:2015-12-21 00:00:00
abstract::Catatonia is a common syndrome that was first described in the literature by Karl Kahlbaum in 1874. The literature is still developing and remains unclear on many issues, especially classification, diagnosis, and pathophysiology. Clinicians caring for psychiatric patients with catatonic syndromes continue to face many...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-5-14
更新日期:2006-09-07 00:00:00
abstract:BACKGROUND:Several studies have proven that the experiences of being bullied or bullying others are associated with poor mental health among adolescent youths. Our study aims to investigate the relationship between the experience of the bully/victim and mental health among preadolescents and adolescents. METHODS:Subje...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/s12991-017-0160-4
更新日期:2017-10-18 00:00:00
abstract::BACKGROUND: Organic Brain Syndromes (OBS) are often missed in clinical practice. Determining their varied presentations may help in earlier detection, better management, and, assessing prognosis and outcome. We described the in-patient referrals of patients suffering from the psychiatric effects of organic states and ...
journal_title:Annals of general psychiatry
pub_type: 杂志文章
doi:10.1186/1744-859X-4-9
更新日期:2005-04-15 00:00:00