Abstract:
BACKGROUNDS:There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. METHODS:Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD. RESULTS:A total of 60,965 participants were analyzed, including 11,844 from the US and 51,229 from China. The prevalence of NAFLD was 27.12% in the Chinese population and 36.08% in the US population (p < 0.001). The proportions of CKD and late stage CKD (stages 3-5) were higher in the US population than the Chinese one. NAFLD was independently associated with an increased risk of CKD in Chinese population, whereas in the US population, the NAFLD was not an independent risk factor of CKD. In subgroup analyses which excluded late stages CKD (stages 3-5), the risks of mild renal function decline became consistent: NAFLD was associated with early stages of CKD but not the late stages of CKD in both populations. CONCLUSION:NAFLD increased the risk of early stages of CKD in both Chinese and the US population. The conflicting results reported by previous studies might result from the different proportion of late stages of CKD.
journal_name
BMC Gastroenteroljournal_title
BMC gastroenterologyauthors
Zhang M,Lin S,Wang MF,Huang JF,Liu SY,Wu SM,Zhang HY,Wu ZM,Liu WY,Zhang DC,Hao CM,Zhu YY,Zheng MH,Wang XZdoi
10.1186/s12876-020-01278-zsubject
Has Abstractpub_date
2020-05-06 00:00:00pages
139issue
1issn
1471-230Xpii
10.1186/s12876-020-01278-zjournal_volume
20pub_type
杂志文章abstract:BACKGROUND:Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients with advanced liver disease. The aim of this study was to describe the use and impact of NSBB in pat...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-1155-1
更新日期:2020-01-06 00:00:00
abstract:BACKGROUND:Advances in intensive care support such as therapeutic hypothermia or new liver assist devices have been the mainstay of treatment attempting to bridge the gap from acute liver failure to liver transplantation, but the efficacy of the available devices in reducing mortality has been questioned. To address th...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-79
更新日期:2011-07-14 00:00:00
abstract:BACKGROUND:Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitative study was to further develop and finalize the items and support the content validity for the new ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-135
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Transient elastography (TE) is an innovative, noninvasive technique to assess liver fibrosis by measuring liver stiffness in patients with chronic liver diseases. The purpose of this study has been to explore the accuracy of TE and clinical parameters in predicting the presence of esophageal/gastric varices ...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-41
更新日期:2011-04-18 00:00:00
abstract:BACKGROUND:The assessment of Health Related Quality of Life (HRQOL) has been applied as a significant outcome indicator for patients with chronic diseases. No HRQOL study, however, has looked at HRQOL in patients with chronic gastritis and peptic ulcers. This paper focuses on comparing HRQOL in patients with chronic ga...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-149
更新日期:2014-08-20 00:00:00
abstract:BACKGROUND:The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) insertion as a bridge to surgery in these patients are still in debate. The aim of this study is to eva...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01273-4
更新日期:2020-04-19 00:00:00
abstract:BACKGROUND:Biliary atresia (BA) is a progressive inflammatory disorder of the extrahepatic bile ducts leading to the obliteration of bile flow. The purpose of this study was to determine serum adiponectin in BA patients and to investigate the relationship of adiponectin with clinical parameters and liver stiffness scor...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-16
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen Chlamydia could be involved in the pathogenes...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-10-19
更新日期:2010-02-16 00:00:00
abstract:BACKGROUND:HCC predominantly develops in the condition of chronic inflammation that has led to liver cirrhosis. A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with HCC in NCL in advanced stages are scarce. METHODS:A retrospective analysis was performed comparing...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-117
更新日期:2014-07-03 00:00:00
abstract:BACKGROUND:Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk of GIF in patient with SAP. This study was aimed to investigate risk factors related to GIF in the d...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-017-0587-8
更新日期:2017-02-14 00:00:00
abstract:BACKGROUND:Diminished bone mineral density (BMD) is of significant concern in pediatric inflammatory bowel disease (IBD). Exact etiology is debatable. The recognition of fibroblast growth factor 23 (FGF23), a phosphaturic hormone related to tumor necrosis factor alpha (TNF-α) makes it plausible to hypothesize its possi...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-44
更新日期:2012-05-02 00:00:00
abstract:BACKGROUND:It is believed that inflammatory bowel diseases (IBD) result from an imbalance in the intestinal immune response towards the luminal microbiome. Dectin-1 is a widely expressed pattern recognition receptor that recognizes fungi and upon recognition it mediates cytokine responses and skewing of the adaptive im...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-33
更新日期:2012-04-16 00:00:00
abstract:BACKGROUND:In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several non-hepatological conditions but for PBC and PSC no data are available. This study aimed to identify...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-11
更新日期:2005-03-24 00:00:00
abstract:BACKGROUND:A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, also called stellate cells, derived from fibrotic liver have been thoroughly characterized and corresp...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-30
更新日期:2004-12-03 00:00:00
abstract:BACKGROUND:Bowel symptoms are considered indicators of the presence of colorectal cancer and other bowel diseases. Self administered questionnaires that elicit information about lower bowel symptoms have not been assessed for reliability, although this has been done for upper bowel symptoms. Our aim was to develop a se...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-8-8
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gastrointestinal symptoms and is mostly misdiagnosed in many patients as malabsorption syndrome, inf...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01280-5
更新日期:2020-05-08 00:00:00
abstract:BACKGROUND:Gastric diseases are a worldwide problem in modern society, as reported in the USA, in the range of 0.5-2 episodes/year/person and an incidence of 5-100 episodes/1000/week according to seasons and age. There is convincing evidence that oxidative stress is involved in the pathogenesis of acute gastric injury....
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-016-0543-z
更新日期:2016-10-07 00:00:00
abstract:BACKGROUND:CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel. CASE PRESENTATION:Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and finally diagnosed with CMUSE. Capsule endoscopy was performed when general en...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-019-0962-8
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Dysphagia and feeding intolerance are common in neurologically handicapped children. The aim is to determine the etiologies of feeding intolerance in neurologically handicapped children who are intolerant of tube feedings. METHODS:Eighteen neurologically handicapped children, followed in the Tube Feeding Cl...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-4-19
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:We examined the intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pattern of neural sprouting in regenerating liver. METHODS:Male Wistar rats (age 9-13 weeks-w, weight 204-356 g), were submitted to two-thirds PH. Rats were sacrificed at postoperative days (d) 1, 3, 5,...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-014-0202-1
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Controversy exists regarding the role of PD1 and its ligand PD-L1 in chronic hepatitis B infection. In some studies, persistent HBV infection has been attributed to high levels of PD-1 and PD-L1 expression on HBV-specific T-cells and antigen-presenting cells (APCs) respectively. Other studies revealed that t...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-12-109
更新日期:2012-08-16 00:00:00
abstract:BACKGROUND:Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce infla...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230x-3-3
更新日期:2003-02-20 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populations are estimated to suffer from the disease with even higher prevalence in the group sharing metabo...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-018-0843-6
更新日期:2018-07-06 00:00:00
abstract:BACKGROUND:Apoptosis inhibitor of macrophage (AIM) and adipocytokines are involved in the metabolic syndrome, which has been putatively associated with the progression of chronic hepatitis C (CHC). However, the association between these cytokines and CHC is not fully elucidated. The aim of this study is to test whether...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-14-27
更新日期:2014-02-13 00:00:00
abstract:BACKGROUND:Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is...
journal_title:BMC gastroenterology
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1471-230X-10-129
更新日期:2010-11-03 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is defined as a multifactorial disorder associated with visceral hypersensitivity, altered gut motility and dysfunction of the brain-gut axis. Gut microbiota and its metabolites are proposed as possible etiological factors of IBS. Short chain fatty acids (SCFAs) induce both inh...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-021-01613-y
更新日期:2021-01-26 00:00:00
abstract:BACKGROUND:Cystic echinococcosis (CE) is one of emerging zoonotic parasitic diseases throughout the world, having significant medical and economic importance in developing countries. The western and northwestern China is considered as CE endemic areas. In northeastern China's Heilongjiang Province, the increasing numbe...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-015-0256-8
更新日期:2015-03-10 00:00:00
abstract:BACKGROUND:Imatinib mesylate has been the standard therapeutic treatment for chronic myeloid leukemia, advanced and metastatic gastrointestinal stromal tumor (GIST). It is well tolerated with mild adverse effects. Gynecomastia development during the course of treatment has been rarely reported. METHODS:Ninety-eight pa...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-11-116
更新日期:2011-11-02 00:00:00
abstract:BACKGROUND:Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports describe vascular compression as a cause of pseudoachalasia. CASE PRESENTATION:Here we present a case of...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/s12876-020-01198-y
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Helicobacter pylori, occurring throughout the world and causing gastroduodenal diseases, is one of the most common chronic bacterial agents in humans. The purpose of this study was to measure the general practitioners' (GPs) knowledge and practices pertaining to H. pylori infection. METHODS:A cross-sectiona...
journal_title:BMC gastroenterology
pub_type: 杂志文章
doi:10.1186/1471-230X-5-4
更新日期:2005-01-26 00:00:00